Keywords
Last Name

David Hing-Kwei Chui, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 414-1018
ORCID ORCID Icon0000-0002-1475-7309
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

TitleActive Staff Hospital Privileges
InstitutionBoston Medical Center
DepartmentPathology & Laboratory Medicine

 Awards and Honors

Start-EndDescription
1971-1976Medical Research Council of Canada: Scholar
1980American Society for Clinical Investigation: elected to membership
1980-1984BLOOD: Editorial Board member
1987-1991NIH: Hematology Study Section
1991Association of American Physicians: elected to membership
2002The Thalassemia Foundation of Canada: Hour Glass Award
2007-2016The Best Doctors in America
2011McGill University Alumni Association: D. Lorne Gales Award
 Research Expertise & Professional Interests
Expertise includes: Globin gene mutations; Hemoglobin diseases; Thalassmeias; and Regulation of fetal hemoglobin expression.

 Self-Described Keywords
  • Genetics
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boucher MO, Chui DH, Woda BA, Newburger PE. Mild Microcytic Anemia in an Infant with a Compound Heterozygosity for Hb C (HBB: c.19G?>?A) and Hb Osu Christiansborg (HBB: c.157G?>?A). Hemoglobin. 2016 Jun; 40(3):208-9. PMID: 27117572.
    View in: PubMed
  2. Vathipadiekal V, Alsultan A, Baltrusaitis K, Farrell JJ, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Suliman A, Patra PK, Milton JN, Farrer LA, Chui DH, Al-Ali AK, Sebastiani P, Steinberg MH. Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia. Am J Hematol. 2016 Jun; 91(6):E308-11. PMID: 27185208.
    View in: PubMed
  3. Luo HY, Chui DH. Diverse hematological phenotypes of ß-thalassemia carriers. Ann N Y Acad Sci. 2016 Mar; 1368(1):49-55. PMID: 27123947.
    View in: PubMed
  4. Shaikho EM, Habara AH, Alsultan A, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Patra PK, Sebastiani P, Baltrusaitis K, Farrell JJ, Jiang Z, Luo HY, Chui DH, Al-Ali AK, Steinberg MH. Variants of ZBTB7A (LRF) and its ß-globin gene cluster binding motifs in sickle cell anemia. Blood Cells Mol Dis. 2016 Jul; 59:49-51. PMID: 27282567.
    View in: PubMed
  5. Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Théberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Ünal S, Gümrük F, Akar N, Basak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH. The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) ß(0) -thalassaemia homozygotes. Br J Haematol. 2016 Mar; 172(6):958-65. PMID: 26771086.
    View in: PubMed
  6. Dai Y, Sangerman J, Luo HY, Fucharoen S, Chui DH, Faller DV, Perrine SP. Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms. Blood Cells Mol Dis. 2016 Jan; 56(1):62-9. PMID: 26603726.
    View in: PubMed
  7. Akinbami AO, Campbell AD, Han ZJ, Luo HY, Chui DH, Steinberg MH. Hereditary Persistence of Fetal Hemoglobin Caused by Single Nucleotide Promoter Mutations in Sickle Cell Trait and Hb SC Disease. Hemoglobin. 2016; 40(1):64-5. PMID: 26372199.
    View in: PubMed
  8. Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310. PMID: 26002792.
    View in: PubMed
  9. Unal S, Chui DH, Gumruk F. Fanconi's Anemia Effect or Sickle Cell Anemia Effect: That is the Question. Hemoglobin. 2015; 39(4):287-9. PMID: 25976779.
    View in: PubMed
  10. Sebastiani P, Farrell JJ, Alsultan A, Wang S, Edward HL, Shappell H, Bae H, Milton JN, Baldwin CT, Al-Rubaish AM, Naserullah Z, Al-Muhanna F, Alsuliman A, Patra PK, Farrer LA, Ngo D, Vathipadiekal V, Chui DH, Al-Ali AK, Steinberg MH. BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia. Blood Cells Mol Dis. 2015 Mar; 54(3):224-30. PMID: 25703683.
    View in: PubMed
  11. Unal S, Chui DH, Luo HY, Okur H, Oymak Y, Gumruk F. The first report of a homozygous codons 9/10 (+T) ß-thalassemia mutation in a Turkish patient. Hemoglobin. 2015; 39(1):66-8. PMID: 25572182.
    View in: PubMed
  12. Edward HL, Pisani LA, Rodriguez-Romero WE, Chaves-Villalobos J, Garcia-Quesada J, Harris NS, Luo HY, Steinberg MH, Forget BG, Chui DH. Hb Youngstown [ß101(G3)Glu???Ala; HBB: c.305A > C]: An unstable hemoglobin variant causing severe hemolytic anemia. Hemoglobin. 2014; 38(6):381-4. PMID: 25347256.
    View in: PubMed
  13. Griffin PJ, Sebastiani P, Edward H, Baldwin CT, Gladwin MT, Gordeuk VR, Chui DH, Steinberg MH. The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol. 2014 Nov; 89(11):1019-23. PMID: 25042611.
    View in: PubMed
  14. Patthamalai P, Fuchareon S, Chaneiam N, Ghalie RG, Chui DH, Boosalis MS, Perrine SP. A phase 2 trial of HQK-1001 in HbE-ß thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014 Mar 20; 123(12):1956-7. PMID: 24652964.
    View in: PubMed
  15. Steinberg MH, Chui DH. HbC disorders. Blood. 2013 Nov 21; 122(22):3698. PMID: 24263962.
    View in: PubMed
  16. Alsultan A, Alabdulaali MK, Griffin PJ, Alsuliman AM, Ghabbour HA, Sebastiani P, Albuali WH, Al-Ali AK, Chui DH, Steinberg MH. Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign. Br J Haematol. 2014 Feb; 164(4):597-604. PMID: 24224700.
    View in: PubMed
  17. Inati A, Kahale M, Perrine SP, Chui DH, Taher AT, Koussa S, Abi Nasr T, Abbas HA, Ghalie RG. A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in ß-thalassaemia intermedia. Br J Haematol. 2014 Feb; 164(3):456-8. PMID: 24224649.
    View in: PubMed
  18. Steinberg MH, Chui DH, Dover GJ, Sebastiani P, Alsultan A. Fetal hemoglobin in sickle cell anemia: a glass half full? Blood. 2014 Jan 23; 123(4):481-5. PMID: 24222332.
    View in: PubMed
  19. Shi Y, Kulbacki E, Chui DH, Wang E. Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease. Eur J Haematol. 2013 Sep; 91(3):284-5. PMID: 23672282.
    View in: PubMed
  20. Croteau SE, Luo HY, Lehmann LE, Chui DH, Neufeld EJ. Novel dominant ß-thalassemia: Hb Boston-Kuwait [codon 139/140(+T)]. Pediatr Blood Cancer. 2013 Oct; 60(10):E131-4. PMID: 23776097.
    View in: PubMed
  21. Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85. PMID: 23723449.
    View in: PubMed
  22. Alsultan A, Ngo D, Bae H, Sebastiani P, Baldwin CT, Melista E, Suliman AM, Albuali WH, Nasserullah Z, Luo HY, Chui DH, Steinberg MH, Al-Ali AK. Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-ß(0) thalassemia. Am J Hematol. 2013 Jun; 88(6):531-2. PMID: 23483609.
    View in: PubMed
  23. Ngo D, Bae H, Steinberg MH, Sebastiani P, Solovieff N, Baldwin CT, Melista E, Safaya S, Farrer LA, Al-Suliman AM, Albuali WH, Al Bagshi MH, Naserullah Z, Akinsheye I, Gallagher P, Luo HY, Chui DH, Farrell JJ, Al-Ali AK, Alsultan A. Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis. 2013 Jun; 51(1):22-6. PMID: 23465615.
    View in: PubMed
  24. Marks A, Luo HY, Chui DH, Greenberg J. Hemoglobin Shady Grove: a novel fetal methemoglobin variant. Pediatr Blood Cancer. 2013 Aug; 60(8):E55-6. PMID: 23460588.
    View in: PubMed
  25. Inati A, Abbas HA, Al-Danaf J, Souaid M, Kahale M, Koussa S, Abou Nasr T, Davis L, Luo HY, Chui DH. Identification of the first mutation in a BRE motif of the ß-globin gene and its inheritance with two other a-globin gene mutations in a Lebanese family. Hemoglobin. 2013; 37(2):171-5. PMID: 23470150.
    View in: PubMed
  26. Whyte D, Forget B, Chui DH, Luo HY, Pashankar F. Massive splenic infarction in an adolescent with hemoglobin S-HPFH. Pediatr Blood Cancer. 2013 Jul; 60(7):E49-51. PMID: 23281181.
    View in: PubMed
  27. Verhovsek MM, Chui DH. Pulse oximetry screening for critical congenital heart defects. Lancet. 2012 Oct 13; 380(9850):1305-6; author reply 1306. PMID: 23063278.
    View in: PubMed
  28. Alsultan A, Ngo DA, Farrell JJ, Akinsheye I, Solovieff N, Ghabbour HA, Al-Ali A, Alsuliman A, Al-Baghshi M, Albu-Ali W, Alabdulaali M, Baldwin CT, Farrer LA, Luo H, Melista E, Safaya S, Nwaru M, Chui DH, Steinberg MH. A functional promoter polymorphism of the d-globin gene is a specific marker of the Arab-Indian haplotype. Am J Hematol. 2012 Aug; 87(8):824-6. PMID: 22641479.
    View in: PubMed
  29. Han ZJ, Lapuz C, Rovenger JF, Dreyfus PA, Vispo BG, Ou CN, Luo HY, Chui DH, Gallivan MV. Compound heterozygosity for Hb S [ß6(A3)Glu?Val] and Hb Kenya (A?81Leu-ß86Ala) in a Ugandan woman. Hemoglobin. 2012; 36(3):270-5. PMID: 22384817.
    View in: PubMed
  30. Verhovsek M, Shah NR, Wilcox I, Koenig SC, Barros T, Thornburg CD, Steinberg MH, Luo HY, Chui DH. Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete ß-globin gene cluster. Pediatr Blood Cancer. 2012 Nov; 59(5):941-4. PMID: 22294483.
    View in: PubMed
  31. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87. PMID: 22187428.
    View in: PubMed
  32. Akinsheye I, Solovieff N, Ngo D, Malek A, Sebastiani P, Steinberg MH, Chui DH. Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. Am J Hematol. 2012 Feb; 87(2):217-9. PMID: 22139998.
    View in: PubMed
  33. Verhovsek M, So CC, O'Shea T, Gibney GT, Ma ES, Steinberg MH, Chui DH. Is HbA2 level a reliable diagnostic measurement for ß-thalassemia trait in people with iron deficiency? Am J Hematol. 2012 Jan; 87(1):114-6. PMID: 22038702.
    View in: PubMed
  34. Ngo DA, Aygun B, Akinsheye I, Hankins JS, Bhan I, Luo HY, Steinberg MH, Chui DH. Fetal haemoglobin levels and haematological characteristics of compound heterozygotes for haemoglobin S and deletional hereditary persistence of fetal haemoglobin. Br J Haematol. 2012 Jan; 156(2):259-64. PMID: 22017641.
    View in: PubMed
  35. Alsultan A, Solovieff N, Aleem A, AlGahtani FH, Al-Shehri A, Osman ME, Kurban K, Bahakim H, Al-Momen AK, Baldwin CT, Chui DH, Steinberg MH. Fetal hemoglobin in sickle cell anemia: Saudi patients from the Southwestern province have similar HBB haplotypes but higher HbF levels than African Americans. Am J Hematol. 2011 Jul; 86(7):612-4. PMID: 21630302.
    View in: PubMed
  36. Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, Chui DH, Steinberg MH. Fetal hemoglobin in sickle cell anemia. Blood. 2011 Jul 7; 118(1):19-27. PMID: 21490337.
    View in: PubMed
  37. Giardine B, Borg J, Higgs DR, Peterson KR, Philipsen S, Maglott D, Singleton BK, Anstee DJ, Basak AN, Clark B, Costa FC, Faustino P, Fedosyuk H, Felice AE, Francina A, Galanello R, Gallivan MV, Georgitsi M, Gibbons RJ, Giordano PC, Harteveld CL, Hoyer JD, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis MN, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye JS, Wiemann C, Zukic B, Chui DH, Wajcman H, Hardison RC, Patrinos GP. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet. 2011 Apr; 43(4):295-301. PMID: 21423179.
    View in: PubMed
  38. Farrell JJ, Sherva RM, Chen ZY, Luo HY, Chu BF, Ha SY, Li CK, Lee AC, Li RC, Li CK, Yuen HL, So JC, Ma ES, Chan LC, Chan V, Sebastiani P, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood. 2011 May 5; 117(18):4935-45. PMID: 21385855.
    View in: PubMed
  39. Wang W, Brugnara C, Snyder C, Wynn L, Rogers Z, Kalinyak K, Brown C, Qureshi A, Bigelow C, Neumayr L, Smith-Whitley K, Chui DH, Delahunty M, Woolson R, Steinberg M, Telen M, Kesler K. The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial. Br J Haematol. 2011 Mar; 152(6):771-6. PMID: 21275961.
    View in: PubMed
  40. So CC, Chan AY, Luo HY, Verhovsek M, Chui DH, Ling SC, Chan LC. Hb A2 Hong Kong - A novel d-globin variant in a Chinese family masks the diagnosis of ß-thalassemia trait. Hemoglobin. 2011; 35(2):162-5. PMID: 21417575.
    View in: PubMed
  41. Verhovsek M, Henderson MP, Cox G, Luo HY, Steinberg MH, Chui DH. Unexpectedly low pulse oximetry measurements associated with variant hemoglobins: a systematic review. Am J Hematol. 2010 Nov; 85(11):882-5. PMID: 20890907.
    View in: PubMed
  42. Perrine SP, Castaneda SA, Chui DH, Faller DV, Berenson RJ, Siritanaratku N, Fucharoen S. Fetal globin gene inducers: novel agents and new potential. Ann N Y Acad Sci. 2010 Aug; 1202:158-64. PMID: 20712788.
    View in: PubMed
  43. Phylipsen M, Harteveld CL, de Metz M, Gallivan MV, Arkesteijn SG, Luo HY, Chui DH, Giordano PC. New and known ß-thalassemia determinants masked by known and new d gene defects [Hb A(2)-Ramallah or d6(A3)Glu?Gln, GAG>>CAG]. Hemoglobin. 2010; 34(5):445-50. PMID: 20854118.
    View in: PubMed
  44. Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood. 2010 Mar 4; 115(9):1815-22. PMID: 20018918.
    View in: PubMed
  45. Koenig SC, Becirevic E, Hellberg MS, Li MY, So JC, Hankins JS, Ware RE, McMahon L, Steinberg MH, Luo HY, Chui DH. Sickle cell disease caused by heterozygosity for Hb S and novel LCR deletion: Report of two patients. Am J Hematol. 2009 Sep; 84(9):603-6. PMID: 19650141.
    View in: PubMed
  46. Thornburg CD, Steinberg MH, Chui DH. Hemoglobin SE disease in Maine, and severe thalassemia in New Hampshire. J Pediatr Hematol Oncol. 2009 Apr; 31(4):307. PMID: 19346889.
    View in: PubMed
  47. Chen Z, Luo HY, Steinberg MH, Chui DH. BCL11A represses HBG transcription in K562 cells. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):144-9. PMID: 19153051.
    View in: PubMed
  48. Wilcox I, Boettger K, Greene L, Malek A, Davis L, Steinberg MH, Luo HY, Chui DH. Hemoglobin Kenya composed of alpha- and ((A)gammabeta)-fusion-globin chains, associated with hereditary persistence of fetal hemoglobin. Am J Hematol. 2009 Jan; 84(1):55-8. PMID: 19006227.
    View in: PubMed
  49. Zhao Z, Timofeev N, Hartley SW, Chui DH, Fucharoen S, Perls TT, Steinberg MH, Baldwin CT, Sebastiani P. Imputation of missing genotypes: an empirical evaluation of IMPUTE. BMC Genet. 2008; 9:85. PMID: 19077279.
    View in: PubMed
  50. Moradkhani K, Préhu C, Old J, Henderson S, Balamitsa V, Luo HY, Poon MC, Chui DH, Wajcman H, Patrinos GP. Mutations in the paralogous human alpha-globin genes yielding identical hemoglobin variants. Ann Hematol. 2009 Jun; 88(6):535-43. PMID: 18923834.
    View in: PubMed
  51. Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, Chan LC, Fucharoen G, Fucharoen S, Barbosa CG, Vardarajan BN, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. Blood Cells Mol Dis. 2008 Nov-Dec; 41(3):255-8. PMID: 18691915.
    View in: PubMed
  52. Gibney GT, Panhuysen CI, So JC, Ma ES, Ha SY, Li CK, Lee AC, Li CK, Yuen HL, Lau YL, Johnson DM, Farrell JJ, Bisbee AB, Farrer LA, Steinberg MH, Chan LC, Chui DH. Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong. Am J Hematol. 2008 Jun; 83(6):458-64. PMID: 18266208.
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  53. Chen Z, Luo HY, Basran RK, Hsu TH, Mang DW, Nuntakarn L, Rosenfield CG, Patrinos GP, Hardison RC, Steinberg MH, Chui DH. A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F. Mol Cell Biol. 2008 Jul; 28(13):4386-93. PMID: 18443038.
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  54. Basran RK, Reiss UM, Luo HY, Ware RE, Chui DH. Beta-thalassemia intermedia due to compound heterozygosity for two beta-globin gene promoter mutations, including a novel TATA box deletion. Pediatr Blood Cancer. 2008 Feb; 50(2):363-6. PMID: 16732578.
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  55. Tubman VN, Bennett CM, Luo HY, Chui DH, Heeney MM. Sickle cell disease caused by Hb S/Québec-CHORI: treatment with hydroxyurea and response. Pediatr Blood Cancer. 2007 Aug; 49(2):207-10. PMID: 17551985.
    View in: PubMed
  56. Masiello D, Heeney MM, Adewoye AH, Eung SH, Luo HY, Steinberg MH, Chui DH. Hemoglobin SE disease: a concise review. Am J Hematol. 2007 Jul; 82(7):643-9. PMID: 17278112.
    View in: PubMed
  57. Waye JS, Chui DH. Hb Evora [alpha 2-35, Ser-->Pro], a novel hemoglobin variant associated with an alpha-thalassemia phenotype. Haematologica. 2007 May; 92(5):e68. PMID: 17562600.
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  58. Giardine B, van Baal S, Kaimakis P, Riemer C, Miller W, Samara M, Kollia P, Anagnou NP, Chui DH, Wajcman H, Hardison RC, Patrinos GP. HbVar database of human hemoglobin variants and thalassemia mutations: 2007 update. Hum Mutat. 2007 Feb; 28(2):206. PMID: 17221864.
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  59. Luo HY, Adewoye AH, Pilichowska M, Li MY, Basran RK, Steinberg MH, Chui DH. Two new alpha-thalassemia frameshift mutations. Hemoglobin. 2007; 31(2):135-9. PMID: 17486494.
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  60. Shinoda G, Umeda K, Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T. alpha4-Integrin(+) endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells. Blood. 2007 Mar 15; 109(6):2406-15. PMID: 17090646.
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  61. Andersson BA, Wering ME, Luo HY, Basran RK, Steinberg MH, Smith HP, Chui DH. Sickle cell disease due to compound heterozygosity for Hb S and a novel 7.7-kb beta-globin gene deletion. Eur J Haematol. 2007 Jan; 78(1):82-5. PMID: 17038017.
    View in: PubMed
  62. Umeda K, Heike T, Nakata-Hizume M, Niwa A, Arai M, Shinoda G, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T. Sequential analysis of alpha- and beta-globin gene expression during erythropoietic differentiation from primate embryonic stem cells. Stem Cells. 2006 Dec; 24(12):2627-36. PMID: 16888280.
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  63. Luo HY, Heeney M, Wang WC, Eung SH, Ware RE, Steinberg MH, Chui DH. Hemoglobinopathies mimicking Hb S/beta-thalassemia: Hb S/S with alpha-thalassemia and Hb S/Volga. Am J Hematol. 2006 May; 81(5):361-5. PMID: 16628724.
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  64. Chan AY, Luo HY, Wang W, Chui DH, Ma ES, Chan LC, Chong SS. Diagnostic pitfall in PCR-based alpha-thalassemia genotyping resulting from a (G->C) polymorphism at nucleotide 71 3' to the alpha2-globin gene termination codon. Clin Chem. 2006 Mar; 52(3):536-7. PMID: 16510436.
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  65. Law HY, Luo HY, Wang W, Ho JF, Najmabadi H, Ng IS, Steinberg MH, Chui DH, Chong SS. Determining the cause of patchwork HBA1 and HBA2 genes: recurrent gene conversion or crossing over fixation events. Haematologica. 2006 Mar; 91(3):297-302. PMID: 16503550.
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  66. Chui DH, Cunningham MJ, Luo HY, Wolfe LC, Neufeld EJ, Steinberg MH. Screening and counseling for thalassemia. Blood. 2006 Feb 15; 107(4):1735-7. PMID: 16461765.
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  67. Umeda K, Heike T, Yoshimoto M, Shinoda G, Shiota M, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T. Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation. Stem Cells. 2006 May; 24(5):1348-58. PMID: 16410394.
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  68. Luo HY, Tang W, Eung SH, Coad JE, Canfield P, Keller F, Crowell EH, Steinberg MH, Chui DH. Dominantly inherited beta thalassaemia intermedia caused by a new single nucleotide deletion in exon 2 of the beta globin gene: Hb morgantown (beta91 CTG>CG). J Clin Pathol. 2005 Oct; 58(10):1110-2. PMID: 16189162.
    View in: PubMed
  69. Luo HY, Boudreaux J, Steinberg MH, Chui DH. Patients with thalassemia in the United States. Blood. 2005 Jun 15; 105(12):4896-7. PMID: 15933066.
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  70. Chui DH. Alpha-thalassaemia and population health in Southeast Asia. Ann Hum Biol. 2005 Mar-Apr; 32(2):123-30. PMID: 16096207.
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  71. Lau ET, Kwok YK, Luo HY, Leung KY, Lee CP, Lam YH, Chui DH, Tang MH. Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood. Prenat Diagn. 2005 Feb; 25(2):123-8. PMID: 15712347.
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  72. Chui DH. Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. Ann N Y Acad Sci. 2005; 1054:25-32. PMID: 16339648.
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  73. Basran RK, Patterson M, Walker L, Nakamura LM, Eng B, Chui DH, Waye JS. Prenatal diagnosis of hemoglobinopathies in Ontario, Canada. Ann N Y Acad Sci. 2005; 1054:507-10. PMID: 16339708.
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  74. Luo HY, Irving I, Prior J, Lim E, Eung SH, Skelton TP, Erber WN, Steinberg MH, Chui DH. Hemoglobin Titusville, a low oxygen affinity variant hemoglobin, in a family of Northern European background. Am J Hematol. 2004 Dec; 77(4):384-6. PMID: 15551405.
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  75. Luo HY, Adewoye AH, Eung SH, Skelton TP, Quillen K, McMahon L, Steinberg MH, Chui DH. A novel sickle hemoglobin: hemoglobin S-south end. J Pediatr Hematol Oncol. 2004 Nov; 26(11):773-6. PMID: 15543018.
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  76. Ding C, Chiu RW, Lau TK, Leung TN, Chan LC, Chan AY, Charoenkwan P, Ng IS, Law HY, Ma ES, Xu X, Wanapirak C, Sanguansermsri T, Liao C, Ai MA, Chui DH, Cantor CR, Lo YM. MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10762-7. PMID: 15247415.
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  77. Umeda K, Heike T, Yoshimoto M, Shiota M, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T. Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro. Development. 2004 Apr; 131(8):1869-79. PMID: 15084470.
    View in: PubMed
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  83. Patterson M, Walker L, Chui DH, Lafferty JD, McFarlane A, Waye JS. Identification of a new hemoglobin variant: Hb St. Joseph's [beta77(EF1)His-->Leu]. Hemoglobin. 2003 Aug; 27(3):181-3. PMID: 12908803.
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  84. Wang W, Ma ES, Chan AY, Chui DH, Chong SS. Multiple minisequencing screen for seven southeast Asian nondeletional alpha-thalassemia mutations. Clin Chem. 2003 May; 49(5):800-3. PMID: 12709372.
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  85. Lafferty JD, Waye JS, Chui DH, Crawford L, Raby A, Richardson H. Good practice guidelines for laboratory investigation of hemoglobinopathies. Lab Hematol. 2003; 9(4):237-45. PMID: 14649467.
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  87. Chui DH, Fucharoen S, Chan V. Hemoglobin H disease: not necessarily a benign disorder. Blood. 2003 Feb 1; 101(3):791-800. PMID: 12393486.
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  90. Waye JS, Walker L, Patterson M, Chui DH. Identification of two new beta-thalassemia splice mutations: IVS-I-1 (G-->C) and IVS-I (-2) (A-->C). Hemoglobin. 2002 Feb; 26(1):87-9. PMID: 11939519.
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  91. Ma SK, Ma V, Chan AY, Chan LC, Chui DH. Routine screening of (--(SEA)) alpha-thalassemia deletion by an enzyme-linked immunosorbent assay for embryonic zeta-globin chains. Acta Haematol. 2002; 108(1):8-12. PMID: 12145460.
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  93. Lorey F, Charoenkwan P, Witkowska HE, Lafferty J, Patterson M, Eng B, Waye JS, Finklestein JZ, Chui DH. Hb H hydrops foetalis syndrome: a case report and review of literature. Br J Haematol. 2001 Oct; 115(1):72-8. PMID: 11722414.
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  94. Su YY, Gordon CT, Ye TZ, Perkins AC, Chui DH. Human ERMAP: an erythroid adhesion/receptor transmembrane protein. Blood Cells Mol Dis. 2001 Sep-Oct; 27(5):938-49. PMID: 11783959.
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  95. Waye JS, Eng B, Patterson M, Walker L, Carcao MD, Olivieri NF, Chui DH. Hemoglobin H (Hb H) disease in Canada: molecular diagnosis and review of 116 cases. Am J Hematol. 2001 Sep; 68(1):11-5. PMID: 11559931.
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  96. Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH. Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures. Prenat Diagn. 2001 Jul; 21(7):529-39. PMID: 11494285.
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  98. Waye JS, Chui DH. The alpha-globin gene cluster: genetics and disorders. Clin Invest Med. 2001 Apr; 24(2):103-9. PMID: 11368147.
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  99. Chan LC, Ma SK, Chan AY, Ha SY, Waye JS, Lau YL, Chui DH. Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia? J Clin Pathol. 2001 Apr; 54(4):317-20. PMID: 11304851.
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  100. Horsley SW, Daniels RJ, Anguita E, Raynham HA, Peden JF, Villegas A, Vickers MA, Green S, Waye JS, Chui DH, Ayyub H, MacCarthy AB, Buckle VJ, Gibbons RJ, Kearney L, Higgs DR. Monosomy for the most telomeric, gene-rich region of the short arm of human chromosome 16 causes minimal phenotypic effects. Eur J Hum Genet. 2001 Mar; 9(3):217-25. PMID: 11313762.
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  101. Leung KF, Au WY, Chan AY, Chan LC, Waye JS, Chui DH, Ma SK. Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family. Clin Lab Haematol. 2001 Feb; 23(1):53-5. PMID: 11422231.
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  102. Lorey F, Cunningham G, Vichinsky EP, Lubin BH, Witkowska HE, Matsunaga A, Azimi M, Sherwin J, Eastman J, Farina F, Waye JS, Chui DH. Universal newborn screening for Hb H disease in California. Genet Test. 2001; 5(2):93-100. PMID: 11551109.
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  103. Eng B, Patterson M, Walker L, Chui DH, Waye JS. Detection of severe nondeletional alpha-thalassemia mutations using a single-tube multiplex ARMS assay. Genet Test. 2001; 5(4):327-9. PMID: 11960579.
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  104. Lafferty JD, Crowther MA, Waye JS, Chui DH. A reliable screening test to identify adult carriers of the (--SEA) alpha zero-thalassemia deletion. Detection of embryonic zeta-globin chains by enzyme-linked immunosorbent assay. Am J Clin Pathol. 2000 Dec; 114(6):927-31. PMID: 11338482.
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