Martin H. Steinberg, MD
Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

MD, Tufts University School of Medicine




Martin H Steinberg, MD, is a hematologist/internist whose clinical and research focus has been on disorders of the red blood cell with special emphasis on sickle cell disease. He has published 450 articles and 3 textbooks on the science and clinical features of sickle cell disease and related disorders. A graduate of Cornell University and Tufts University School of Medicine he completed post-graduate training in New York and Boston. He conducts basic, translational and clinical studies devoted to understanding the pathophysiology and genetic basis of sickle cell phenotypic heterogeneity. He modeled the HbF concentration among red blood cells showing that only patients with very high HbF levels were likely to have major benefit, therefor setting a standard for HbF induction therapies. He identified cis- and trans-acting elements that help explain the high HbF levels of Saudi patients from the Eastern Province whose sickle hemoglobin gene is associated with the Arab-Indian haplotype. Using candidate gene, genome-wide association studies and next-generation sequencing to understand the genetic determinants of sickle cell disease heterogeneity, Dr. Steinberg and his coworkers modeled disease severity and selected subphenotypes of disease to discover hitherto unsuspected genetic associations. He has also reimagined the pathophysiologic features of sickle cell anemia, establishing with his collaborators a new widely accepted paradigm that the pathophysiology of sickle cell disease is a combination of both sickle vasoocclusion and intravascular hemolysis that has important prognostic and therapeutic implications. He also reported the first of a new class of hemoglobin disorders, the thalassemic hemoglobinopathies, wherein a single exonic mutation causes both a variant hemoglobin but also phenotype of thalassemia because of hemoglobin hyper-instability and catabolism.

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Professor
Boston University School of Medicine
Pediatrics


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Center of Excellence in Sickle Cell Disease


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Research Training in Blood Diseases and Resources
06/01/2014 - 05/31/2020 (Multi-PI)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007501-36

Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2017 - 03/31/2020 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI
5R01HL133350-02

Severity Index for Sickle Cell anemia in the Eastern Province of Saudi Arabia
01/01/2013 - 12/31/2018 (PI)
King Faisal University


A prototype diagnostic for cellular fetal hemoglobin in sickle cell disease
08/01/2016 - 01/31/2018 (Subcontract PI)
MyoSyntax Corporation NIH NHLBI
1R43HL134529-01

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Genetic Basis of Fetal Hemoglobin in Saudi Sickle Cell Anemia
01/02/2012 - 12/31/2016 (PI)
University of Dammam Saudi Arabia


Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01

A prototype diagnostic for cellular fetal hemoglobin in sickle cell disease
08/15/2014 - 01/30/2016 (Subcontract PI)
MyoSyntax Corporation NIH NHLBI
1R43HL124679-01

Gene Polymorphism in Chronic Sickle Cell Lung Disease
01/01/2005 - 12/31/2009 (Dept Sponsor)
NIH/National Heart, Lung, and Blood Institute
5 K23 HL79003 05

Genetic Modulation of Sickle Cell Anemia
05/01/2006 - 04/30/2009 (PI)
NIH/Fogarty International Center
5 R03 TW07189 03

Showing 10 of 13 results. Show All Results

Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2017 - 03/31/2021 (Activity-level PI)
PI: George J. Murphy, PhD
NIH-NHLBI
5R01HL133350-03

BTRP Admin Core
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
5U54 HL070819-08

BTRP Clinical Trials
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
5U54 HL070819-07

BTRP Research Scholar
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
5U54 HL070819-07

BTRP Subcontracts
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
5U54 HL070819-08

BTRP Training Supplement
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
2U54 HL070819-06

CSSC Admin Core
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
2U54 HL070819-06

CSSC Butyrate
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
2U54 HL070819-06

CSSC Clinical Core
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
2U54 HL070819-06

CSSC Geno-Pheno Core Lab
04/01/2008 - 03/31/2012 (PI)
NIH-NHLBI
2U54 HL070819-06

Showing 10 of 19 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2020 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-04 11
2019 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-03 11
2018 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-02 11
2018 Research Training in Blood Diseases and Resources 5T32HL007501-36 119
2017 Mechanisms of cis-acting HbF regulation in sickle cell anemia 1R01HL133350-01A1 11
2017 Research Training in Blood Diseases and Resources 5T32HL007501-35 119
2016 A prototype diagnostic for cellular fetal hemoglobin in sickle cell disease 1R43HL134529-01
2016 Research Training in Blood Diseases and Resources 5T32HL007501-34 119
2015 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-05 16
2015 Research Training in Blood Diseases and Resources 5T32HL007501-33 119
Showing 10 of 73 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Al-Ali AK, Alsulaiman A, Alzahrani AJ, Obeid OT, Vatte CB, Cyrus C, Alnafie AN, Alali RA, Alfarhan M, Mozeleski B, Steinberg MH. Prevalence and Diversity of Haplotypes of Sickle Cell Disease in the Eastern Province of Saudi Arabia. Hemoglobin. 2020 Mar; 44(2):78-81. PMID: 32448003
     
  2. Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Res. 2020 07; 46:101803.View Related Profiles. PMID: 32442913
     
  3. Steinberg MH. Treating sickle cell anemia: A new era dawns. Am J Hematol. 2020 Jan 10. PMID: 31925819
     
  4. Willen SM, McNeil JB, Rodeghier M, Kerchberger VE, Shaver CM, Bastarache JA, Steinberg MH, DeBaun MR, Ware LB. Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia. Am J Hematol. 2020 Jan 09. PMID: 31919880
     
  5. Dai Y, Shaikho EM, Perez J, Wilson CA, Liu LY, White MR, Farrell JJ, Chui DHK, Sebastiani P, Steinberg MH. BCL2L1 is associated with ?-globin gene expression. Blood Adv. 2019 10 22; 3(20):2995-3001.View Related Profiles. PMID: 31648320
     
  6. Steinberg MH. "Sickling" in vertebrates: Animal studies vs. sickle cell disease. Blood Rev. 2019 07; 36:88-94. PMID: 31084943
     
  7. Steinberg MH. Primary polymerization prevention. Blood. 2019 04 25; 133(17):1797-1798. PMID: 31023742
     
  8. Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg MH, Engel JD, Cui S. Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis. Blood. 2019 05 30; 133(22):2455-2459.View Related Profiles. PMID: 30992270
     
  9. Milton JN, Shaikho EM, Steinberg MH. Haemolysis in sickle cell anaemia: effects of polymorphisms in a-globin gene regulatory elements. Br J Haematol. 2019 07; 186(2):363-364.View Related Profiles. PMID: 30854637
     
  10. Steinberg MH, Schechter AN. Airlie House legend. Am J Hematol. 2018 12; 93(12):1566-1567. PMID: 30242871
     
Showing 10 of 341 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 307 publications over 41 distinct years, with a maximum of 15 publications in 2011

YearPublications
19803
19817
19828
19838
19846
19853
19865
19876
19883
19891
19902
199114
19923
19935
19947
19956
19968
19977
19983
19997
20005
20019
20022
20036
20047
200510
200612
20079
200813
200912
20108
201115
201213
201312
201413
201511
20169
201714
20186
20195
20204

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

fetal hemoglobin
genomics
sickle cell
SNPs

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 East Concord Street
Boston MA 02118
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