Keywords
Last Name

Herbert T. Cohen, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7322
ORCID ORCID Icon0000-0003-1900-8718
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionNephrology

 Research Expertise & Professional Interests
Dr. Cohen’s laboratory is addressing the molecular basis of renal cancer, renal cystic disease and renal development and offers special expertise in gene expression mechanisms, signal transduction, protein-protein interactions, transcription factors, and renal epithelial cell biology. The laboratory has identified the first member of new protein family, the Jade family of proteins, on the basis of its interaction with the von Hippel-Lindau tumor suppressor pVHL. pVHL protein is a key component of the cellular oxygen-sensing system. VHL is also the major renal cancer gene in adults. Jade-1 is a novel, growth suppressive plant homeodomain transcription factor that is the first protein found to be stabilized by pVHL. Jade-1 is also a ubiquitin ligase and key component of histone acetylation complexes. Interestingly, Jade-1 is stabilized by VHL protein in a manner that correlates with risk of renal manifestations in von Hippel-Lindau disease, which includes a cystic renal disease phenotype. A wider role for Jade-1 in renal cyst formation was therefore sought. Jade-1 is regulated by the product of the major gene for autosomal dominant polycystic kidney disease (ADPKD), polycystin-1, in a manner that is also disease relevant and physiologic. Importantly, Jade-1 serves as a critical ubiquitin ligase for the oncoprotein beta-catenin, which also plays critical roles in renal cancer, renal cyst formation and renal development. In part by controlling transcription and beta-catenin ubiquitination, Jade-1 and related family members are likely to be particularly important in many contexts. .

Techniques:
Cancer biology and epithelial cell biology approaches, advanced molecular biology approaches, protein-protein interactions, yeast 2-hybrid screening, protein ubiquitination assays, protein-DNA interactions, transcription assays, gene expression mechanisms including microarrays, confocal microscopy, transgenic and knockout mice.

 Self-Described Keywords
  • cell biology
  • growth & development
  • kidney diseases
  • kidney neoplasms
  • molecular biology
  • neoplasms
  • polycystic kidney diseases
  • signal transduction
  • transcription factors
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Havasi A, Lu W, Cohen HT, Beck LH, Wang Z, Igwebuike C, Borkan SC. Blocking Peptides & Molecular Mimicry as Treatment for Kidney Disease. Am J Physiol Renal Physiol. 2016 Sep 21; ajprenal.00601.2015. PMID: 27654896.
    View in: PubMed
  2. Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):638-43. PMID: 26739564.
    View in: PubMed
  3. Komers R, Xu B, Fu Y, McClelland A, Kantharidis P, Mittal A, Cohen HT, Cohen DM. Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment. PLoS One. 2014; 9(5):e96987. PMID: 24827579.
    View in: PubMed
  4. Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT. Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Res. 2013 Sep 1; 73(17):5371-80. PMID: 23824745.
    View in: PubMed
  5. Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71. PMID: 23001567.
    View in: PubMed
  6. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16. PMID: 18806787.
    View in: PubMed
  7. Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Côté J, Panchenko MV. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem. 2008 Oct 24; 283(43):28817-26. PMID: 18684714.
    View in: PubMed
  8. Basu A, Contreras AG, Datta D, Flynn E, Zeng L, Cohen HT, Briscoe DM, Pal S. Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. Cancer Res. 2008 Jul 15; 68(14):5689-98. PMID: 18632621.
    View in: PubMed
  9. Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH. Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Am J Hematol. 2007 Mar; 82(3):179-84. PMID: 17034027.
    View in: PubMed
  10. Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med. 2005 Dec 8; 353(23):2477-90. PMID: 16339096.
    View in: PubMed
  11. Zhou MI, Foy RL, Chitalia VC, Zhao J, Panchenko MV, Wang H, Cohen HT. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):11035-40. PMID: 16046545.
    View in: PubMed
  12. Xu H, Tian W, Lindsley JN, Oyama TT, Capasso JM, Rivard CJ, Cohen HT, Bagnasco SM, Anderson S, Cohen DM. EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Am J Physiol Renal Physiol. 2005 Apr; 288(4):F855-66. PMID: 15561974.
    View in: PubMed
  13. Panchenko MV, Zhou MI, Cohen HT. von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. J Biol Chem. 2004 Dec 31; 279(53):56032-41. PMID: 15502158.
    View in: PubMed
  14. Zhou MI, Wang H, Foy RL, Ross JJ, Cohen HT. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer Res. 2004 Feb 15; 64(4):1278-86. PMID: 14973063.
    View in: PubMed
  15. Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 2003 Nov 27; 3:31. PMID: 14641932.
    View in: PubMed
  16. Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem. 2002 Oct 18; 277(42):39887-98. PMID: 12169691.
    View in: PubMed
  17. Datta K, Nambudripad R, Pal S, Zhou M, Cohen HT, Mukhopadhyay D. Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer. J Biol Chem. 2000 Jul 7; 275(27):20700-6. PMID: 10748176.
    View in: PubMed
  18. Cohen HT, Zhou M, Welsh AM, Zarghamee S, Scholz H, Mukhopadhyay D, Kishida T, Zbar B, Knebelmann B, Sukhatme VP. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem Biophys Res Commun. 1999 Dec 9; 266(1):43-50. PMID: 10581162.
    View in: PubMed
  19. Cohen HT. Advances in the molecular basis of renal neoplasia. Curr Opin Nephrol Hypertens. 1999 May; 8(3):325-31. PMID: 10456263.
    View in: PubMed
  20. Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen HT, Kim E, Walz G. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol. 1999 May; 19(5):3423-34. PMID: 10207066.
    View in: PubMed
  21. Pal S, Claffey KP, Cohen HT, Mukhopadhyay D. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. J Biol Chem. 1998 Oct 9; 273(41):26277-80. PMID: 9756852.
    View in: PubMed
  22. Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res. 1998 Jan 15; 58(2):226-31. PMID: 9443397.
    View in: PubMed
  23. Scholz H, Bossone SA, Cohen HT, Akella U, Strauss WM, Sukhatme VP. A far upstream cis-element is required for Wilms' tumor-1 (WT1) gene expression in renal cell culture. J Biol Chem. 1997 Dec 26; 272(52):32836-46. PMID: 9407061.
    View in: PubMed
  24. Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol Cell Biol. 1997 Sep; 17(9):5629-39. PMID: 9271438.
    View in: PubMed
  25. Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP. Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem. 1997 Jan 31; 272(5):2901-13. PMID: 9006935.
    View in: PubMed
  26. Satoh T, Cohen HT, Katz AI. Different mechanisms of renal Na-K-ATPase regulation by protein kinases in proximal and distal nephron. Am J Physiol. 1993 Sep; 265(3 Pt 2):F399-405. PMID: 8214099.
    View in: PubMed
  27. Satoh T, Cohen HT, Katz AI. Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids. J Clin Invest. 1993 Feb; 91(2):409-15. PMID: 8381820.
    View in: PubMed
  28. Katz AI, Satoh T, Takemoto F, Cohen HT. Novel pathways of Na-K-ATPase regulation in kidney cells. Contrib Nephrol. 1993; 101:7-11. PMID: 8385596.
    View in: PubMed
  29. Satoh T, Ominato M, Cohen HT, Katz AI. Role of the phospholipase C-protein kinase C pathway in proximal tubule Na-K-ATPase regulation. Trans Assoc Am Physicians. 1993; 106:196-200. PMID: 8036742.
    View in: PubMed
  30. Cohen HT, Sukhatme VP. Molecular biology in nephrology: an overview with emphasis on the study of renal cancer. Semin Nephrol. 1992 Nov; 12(6):495-505. PMID: 1335610.
    View in: PubMed
  31. Cohen HT, Takemoto F, Satoh T, Katz AI. Renal adrenergic receptors: localization of [125I]prazosin binding sites along the microdissected rat nephron. Can J Physiol Pharmacol. 1992 Jul; 70(7):1016-20. PMID: 1451023.
    View in: PubMed
  32. Takemoto F, Cohen HT, Satoh T, Katz AI. Dopamine inhibits Na/K-ATPase in single tubules and cultured cells from distal nephron. Pflugers Arch. 1992 Jul; 421(4):302-6. PMID: 1357625.
    View in: PubMed
  33. Satoh T, Cohen HT, Katz AI. Intracellular signaling in the regulation of renal Na-K-ATPase. I. Role of cyclic AMP and phospholipase A2. J Clin Invest. 1992 May; 89(5):1496-500. PMID: 1349027.
    View in: PubMed
  34. Satoh T, Cohen HT, Katz AI. Regulation of renal Na-K-ATPase by eicosanoids: central role of the cytochrome P450-monooxygenase pathway. Trans Assoc Am Physicians. 1992; 105:86-92. PMID: 1339239.
    View in: PubMed
  35. Takemoto F, Satoh T, Cohen HT, Katz AI. Localization of dopamine-1 receptors along the microdissected rat nephron. Pflugers Arch. 1991 Oct; 419(3-4):243-8. PMID: 1660593.
    View in: PubMed
  36. Cohen HT, Spiegel DM. Air-exposed urine dipsticks give false-positive results for glucose and false-negative results for blood. Am J Clin Pathol. 1991 Sep; 96(3):398-400. PMID: 1877540.
    View in: PubMed
  37. Cohen HT, Katz AI. Adrenergic receptors and catecholamine effects on sodium transport in the mammalian nephron. Semin Nephrol. 1991 Mar; 11(2):110-9. PMID: 1674621.
    View in: PubMed
  38. Cohen HT, Singh AK, Kasinath BS, Lewis EJ. Red-cell surface charge in patients with nephrotic syndrome. Lancet. 1988 Jun 25; 1(8600):1459. PMID: 2898609.
    View in: PubMed
Herbert's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department