Keywords
Last Name

Sam Thiagalingam, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionMolecular Medicine (Biomolecular Medicine Unit)
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 638-6013
ORCID ORCID Icon0000-0001-5211-266X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

 Awards and Honors

Start-EndDescription
2000-2002Smith Family Foundation/The Medical Foundation: New Investigator Award (Dolphin Trust Investigator)
2001-2005Department of Defense BCRP, USAMRMC: Career Development Award
2006-2008NARSAD/Brain & Behavior Research Foundation: NARSAD Independent Investigator Award - 2006/2007 NARSAD Dr. Walter F. Nichols Investigator
2008-2011Susan G. Komen for the Cure : Investigator Initiated Research Award
 Research Expertise & Professional Interests
Dr. Thiagalingam is an expert cancer geneticist and was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression. He was a lead researcher in the team that first identified a family of five novel SMAD genes. He also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. Recently, his studies found that intact hyperactive TGFß-Smad signaling is required to sustain “epigenetic memory” responsible for epithelial-mesenchymal transition (EMT), a critical step during conversion to malignant cancer. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the “big picture” of interconnected network of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems.

 Self-Described Keywords
  • Cancer genetics
  • cancer metastasis
  • EMT
  • Epigenetics
  • signaling pathways
  • SMAD genes
  • TGFß
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Nohesara S, Ghadirivasfi M, Barati M, Ghasemzadeh MR, Narimani S, Mousavi-Behbahani Z, Joghataei M, Soleimani M, Taban M, Mehrabi S, Thiagalingam S, Abdolmaleky HM. Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes. Am J Med Genet B Neuropsychiatr Genet. 2016 Dec; 171(8):1180-1189. PMID: 27753212.
    View in: PubMed
  2. Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):638-43. PMID: 26739564.
    View in: PubMed
  3. Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13. PMID: 26507575.
    View in: PubMed
  4. Abdolmaleky HM, Pajouhanfar S, Faghankhani M, Joghataei MT, Mostafavi A, Thiagalingam S. Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec; 168(8):687-96. PMID: 26285059.
    View in: PubMed
  5. Papageorgis P, Ozturk S, Lambert AW, Neophytou CM, Tzatsos A, Wong CK, Thiagalingam S, Constantinou AI. Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis. Breast Cancer Res. 2015; 17:98. PMID: 26208975.
    View in: PubMed
  6. Abdolmaleky HM, Zhou JR, Thiagalingam S. An update on the epigenetics of psychotic diseases and autism. Epigenomics. 2015; 7(3):427-49. PMID: 26077430.
    View in: PubMed
  7. Abdolmaleky HM, Nohesara S, Ghadirivasfi M, Lambert AW, Ahmadkhaniha H, Ozturk S, Wong CK, Shafa R, Mostafavi A, Thiagalingam S. DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. Schizophr Res. 2014 Feb; 152(2-3):373-80. PMID: 24411530.
    View in: PubMed
  8. Lambert AW, Ozturk S, Thiagalingam S. Integrin signaling in mammary epithelial cells and breast cancer. ISRN Oncol. 2012; 2012:493283. PMID: 22523705.
    View in: PubMed
  9. Abdolmaleky HM, Thiagalingam S. Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis? Epigenomics. 2011 Dec; 3(6):679-83. PMID: 22126286.
    View in: PubMed
  10. Nohesara S, Ghadirivasfi M, Mostafavi S, Eskandari MR, Ahmadkhaniha H, Thiagalingam S, Abdolmaleky HM. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res. 2011 Nov; 45(11):1432-8. PMID: 21820670.
    View in: PubMed
  11. Ghadirivasfi M, Nohesara S, Ahmadkhaniha HR, Eskandari MR, Mostafavi S, Thiagalingam S, Abdolmaleky HM. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Jul; 156B(5):536-45. PMID: 21598376.
    View in: PubMed
  12. Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, Thiagalingam S. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 2011 Jul; 129(2-3):183-90. PMID: 21550210.
    View in: PubMed
  13. Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert AW, Abdolmaleky HM, Zhou JR, Thiagalingam S. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res. 2011 Feb 1; 71(3):998-1008. PMID: 21245094.
    View in: PubMed
  14. Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78. PMID: 20086175.
    View in: PubMed
  15. Gao F, Ponte JF, Levy M, Papageorgis P, Cook NM, Ozturk S, Lambert AW, Thiagalingam A, Abdolmaleky HM, Sullivan BA, Thiagalingam S. hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation. Cancer Biol Ther. 2009 Apr; 8(7):548-56. PMID: 19252416.
    View in: PubMed
  16. Gao F, Ponte JF, Papageorgis P, Levy M, Ozturk S, Lambert AW, Pan H, Chinnappan D, Cheng KH, Thiagalingam A, Abdolmaleky HM, Thiagalingam S. hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells. Cancer Biol Ther. 2009 Apr; 8(7):627-35. PMID: 19242126.
    View in: PubMed
  17. Abdolmaleky HM, Zhou JR, Thiagalingam S, Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics. 2008 Dec; 9(12):1809-23. PMID: 19072640.
    View in: PubMed
  18. Abdolmaleky HM, Smith CL, Zhou JR, Thiagalingam S. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods Mol Biol. 2008; 448:187-212. PMID: 18370235.
    View in: PubMed
  19. Pan H, Gao F, Papageorgis P, Abdolmaleky HM, Faller DV, Thiagalingam S. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression. Cancer Biol Ther. 2007 Oct; 6(10):1638-43. PMID: 18245958.
    View in: PubMed
  20. Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, Pan H, Papageorgis P, Ponte JF, Sivaraman V, Tsuang MT, Thiagalingam S. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet. 2006 Nov 1; 15(21):3132-45. PMID: 16984965.
    View in: PubMed
  21. Thiagalingam S. A cascade of modules of a network defines cancer progression. Cancer Res. 2006 Aug 1; 66(15):7379-85. PMID: 16885330.
    View in: PubMed
  22. Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, Thiagalingam S, Tsuang MT. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5; 134B(1):60-6. PMID: 15717292.
    View in: PubMed
  23. Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF, Chinnappan D, Nemani P, Sidransky D, Thiagalingam S. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res. 2005 Apr 1; 11(7):2466-70. PMID: 15814621.
    View in: PubMed
  24. Pan H, Califano J, Ponte JF, Russo AL, Cheng KH, Thiagalingam A, Nemani P, Sidransky D, Thiagalingam S. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res. 2005 Mar 1; 65(5):1664-9. PMID: 15753360.
    View in: PubMed
  25. Abdolmaleky HM, Thiagalingam S, Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics. 2005; 5(3):149-60. PMID: 15952869.
    View in: PubMed
  26. Cheng KH, Ponte JF, Thiagalingam S. Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display. Cancer Res. 2004 Mar 1; 64(5):1639-46. PMID: 14996722.
    View in: PubMed
  27. Thiagalingam S, Cheng KH, Lee HJ, Mineva N, Thiagalingam A, Ponte JF. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann N Y Acad Sci. 2003 Mar; 983:84-100. PMID: 12724214.
    View in: PubMed
  28. Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol. 2002 Jan; 14(1):65-72. PMID: 11790983.
    View in: PubMed
  29. Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B, Lengauer C. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2698-702. PMID: 11226302.
    View in: PubMed
  30. Fink SP, Swinler SE, Lutterbaugh JD, Massagué J, Thiagalingam S, Kinzler KW, Vogelstein B, Willson JK, Markowitz S. Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res. 2001 Jan 1; 61(1):256-60. PMID: 11196171.
    View in: PubMed
  31. Thiagalingam S. Molecular detection of smad2/smad4 alterations in colorectal tumors. Methods Mol Med. 2001; 50:149-65. PMID: 21318824.
    View in: PubMed
  32. Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ, Kinzler KW, Vogelstein B, Willson JK, Markowitz S. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 1999 Jan 15; 59(2):320-4. PMID: 9927040.
    View in: PubMed
  33. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec; 1(1):3-11. PMID: 9659898.
    View in: PubMed
  34. He TC, da Costa LT, Thiagalingam S. Homeosis and polyposis: a tale from the mouse. Bioessays. 1997 Jul; 19(7):551-5. PMID: 9230687.
    View in: PubMed
  35. Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S. Frequency of Smad gene mutations in human cancers. Cancer Res. 1997 Jul 1; 57(13):2578-80. PMID: 9205057.
    View in: PubMed
  36. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet. 1996 Jul; 13(3):343-6. PMID: 8673134.
    View in: PubMed
  37. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mad-related genes in the human. Nat Genet. 1996 Jul; 13(3):347-9. PMID: 8673135.
    View in: PubMed
  38. Thiagalingam S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JK, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B. Evaluation of the FHIT gene in colorectal cancers. Cancer Res. 1996 Jul 1; 56(13):2936-9. PMID: 8674044.
    View in: PubMed
  39. Thiagalingam S, Kinzler KW, Vogelstein B. PAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6062-6. PMID: 7597081.
    View in: PubMed
  40. Tokino T, Thiagalingam S, el-Deiry WS, Waldman T, Kinzler KW, Vogelstein B. p53 tagged sites from human genomic DNA. Hum Mol Genet. 1994 Sep; 3(9):1537-42. PMID: 7833908.
    View in: PubMed
  41. Pietenpol JA, Tokino T, Thiagalingam S, el-Deiry WS, Kinzler KW, Vogelstein B. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):1998-2002. PMID: 8134338.
    View in: PubMed
  42. Thiagalingam S, Grossman L. The multiple roles for ATP in the Escherichia coli UvrABC endonuclease-catalyzed incision reaction. J Biol Chem. 1993 Aug 25; 268(24):18382-9. PMID: 8349713.
    View in: PubMed
  43. Grossman L, Thiagalingam S. Nucleotide excision repair, a tracking mechanism in search of damage. J Biol Chem. 1993 Aug 15; 268(23):16871-4. PMID: 8349576.
    View in: PubMed
  44. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 1993 Apr 29; 362(6423):857-60. PMID: 8479525.
    View in: PubMed
  45. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science. 1992 May 8; 256(5058):827-30. PMID: 1589764.
    View in: PubMed
  46. Thiagalingam S, Grossman L. Both ATPase sites of Escherichia coli UvrA have functional roles in nucleotide excision repair. J Biol Chem. 1991 Jun 15; 266(17):11395-403. PMID: 1828249.
    View in: PubMed
  47. Oh EY, Claassen L, Thiagalingam S, Mazur S, Grossman L. ATPase activity of the UvrA and UvrAB protein complexes of the Escherichia coli UvrABC endonuclease. Nucleic Acids Res. 1989 Jun 12; 17(11):4145-59. PMID: 2525700.
    View in: PubMed
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