Bjorn Reinhard, Dr. rer. nat.
Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Technical University Munchen
MS, Technical University Munchen



Research in the Reinhard Lab focuses on new optical materials and their application to interrogate fundamental life processes. We are exploring the interface between nanotechnology and biological systems. For an overview of current research projects, please visit our group’s website. Recents techniques/materials developed in the Nano-Bio Interface Lab include:

Plasmon ruler RNase A cleavage assay: (A) The RNA plasmon rulers are bound to the surface of a glass flow chamber using a BSA (bovin serum albumin)-Biotin-NeutrAvidin surface chemistry. Upon addition of RNase A, the RNA tether is cleaved, and the dimer converted into a monomer. (B) Single RNA plasmon ruler cleavage trajectory (recorded at 96 Hz). (I) The plasmon ruler is first incubated in buffer containing spermidine at defined concentrations (0 -5 mM), (II) the buffer is exchanged with a 1 nM RNase A solution, causing (III) a strong drop in intensity upon RNA cleavage. Inset: Number of cleavage events for flushing with/without enzyme. ?tcl is defined as the time between enzyme addition and cleavage. For more information, refer to: L.R. Skewis & B.M. Reinhard, Nano Lett., 8, 214 (2008).

Plasmon Coupling Microscopy: Gold nanoparticle labeled surface receptors (left) and spectral signature (right) as function of interparticle distance. (a) For interparticle separations ? larger than the particle diameter D, the near-field interactions between the particles is small and the resonance wavelength ?res is that of an individual particle. (b) For interparticle separations ? < D the plasmons in the individual particles couple and the resonance wavelength ?res red-shifts with decreasing separation. This spectral shift is observable as an increase in the intensity ratio R = I580nm/I530nm.

Multiscale Nanoparticle Cluster Arrays (NCAs): SEM images from extracts of nanoparticle cluster arrays with varying diameters of e-beam defined binding size D = 50 nm (a), 80 nm (b), 100 nm (c), 130 nm (d), 200 nm (e). The SEM images confirm that through control of the diameter of the e-beam fabricated binding site the cluster size can be continuously varied. The enlargement of an individual cluster in (f) shows junctions and crevices between nearly touching particles constituting a high degree of roughness on the nanoscale.

The Reinhard group utilizes a variety of techniques including:
-Spectroscopy: Raman, SERS, Single Molecule Fluorescence, Plasmon
-Live Cell Imaging
-Nanofabrication
-Transmission Electron Microscopy
-Scanning Electron Microscopy
-Cell Culture Facility
-Fluorescence Plate Readers
-Nanoparticle Synthesis/Functionalization/Integration
-The Photonics Center
-Center of Nanoscience and Nanobiotechnology

Director
Boston University College of Arts and Sciences
Nano-Bio Interface Laboratory



2010 NSF Career Award
2006 Call to Nanobiocenter at Odense University, Denmark (Declined)
2006 Juan de la Cierva Award
2005 DFG Research Scholarship
2004 Otto Wipprecht Fellowship
2004 Scholarship for the 51st Annual Western Spectroscopy Association Conference
1995 Award of the German Chemical Industry Fund


GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic Tissues
11/08/2017 - 10/31/2022 (Multi-PI)
PI: Bjorn Reinhard, Dr. rer. nat.
NIH/National Institute of Allergy & Infectious Diseases
1R01AI132111-01A1

Plasmon Coupling Correlation Spectroscopy
05/01/2018 - 04/30/2021 (PI)
National Science Foundation
CHE-1808241

OP: Plasmonic Enhancement of Chiral Forces for Enantiomer Separation
09/01/2016 - 08/31/2019 (PI)
National Science Foundation
CHE-1609778

Plasmonically Enhanced Stimulated Coherent Spectroscopy
07/15/2016 - 06/30/2019 (Co-PI)
PI: Lawrence D. Ziegler, PhD
National Science Foundation
CHE-1609952

Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor
05/01/2014 - 04/30/2019 (PI)
NIH/National Cancer Institute
5R01CA138509-10

MRI Development of a Holographic Nanoscale Optics Instrument
08/15/2014 - 07/31/2018 (Co-PI)
National Science Foundation
DMR-1429437

Nanoplasmonic Metamaterial Filters
01/01/2016 - 12/31/2016 (PI)
EMD Millipore


Identification of Signals Required for the Establishment of HIV Infection and Latency
09/02/2015 - 08/31/2016 (PI)
Boston Medical Center Corporation NIH NIAID
1R56AI118682-01

New Optoplasmonic Materials for Next Generation Energy Systems
09/01/2013 - 08/31/2016 (PI)
Department of Energy
DE-SC0010679

Multiparametric Optical Microbe Sensing with Engineered Photonic-Plasmonic Nanostructures
08/15/2012 - 07/31/2015 (PI)
National Science Foundation
CBET-1159552

Showing 10 of 14 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic Tissues 1R01AI132111-01A1
2018 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-10 29
2017 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-09 29
2016 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-08 29
2015 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-07 29
2014 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 2R01CA138509-06 29
2013 Elucidating Non-Virus Encoded HIV Capture through Artificial Virus Nanoparticles 1R56AI104393-01A1 1
2013 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-05 29
2012 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-04 29
2011 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-03 29
Showing 10 of 14 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zhang R, Hong Y, Reinhard BM, Liu P, Wang R, Dal Negro L. Plasmonic Nanotrough Networks for Scalable Bacterial Raman Biosensing. ACS Appl Mater Interfaces. 2018 Aug 22; 10(33):27928-27935. PMID: 30051708.
     
  2. Lerch S, Reinhard BM. Effect of interstitial palladium on plasmon-driven charge transfer in nanoparticle dimers. Nat Commun. 2018 Apr 23; 9(1):1608. PMID: 29686266.
     
  3. Khanehzar A, Fraire JC, Xi M, Feizpour A, Xu F, Wu L, Coronado EA, Reinhard BM. Nanoparticle-cell interactions induced apoptosis: a case study with nanoconjugated epidermal growth factor. Nanoscale. 2018 Apr 05; 10(14):6712-6723. PMID: 29589623.
     
  4. Xi M, Reinhard BM. Localized surface plasmon coupling between mid-IR-resonant ITO nanocrystals. The Journal of Physical Chemistry C. 2018; 122(10):5698-5704. View Publication
     
  5. Feizpour A, Stelter D, Wong C, Akiyama H, Gummuluru S, Keyes T, Reinhard BM. Membrane Fluidity Sensing on the Single Virus Particle Level with Plasmonic Nanoparticle Transducers. ACS Sens. 2017 Oct 27; 2(10):1415-1423.View Related Profiles. PMID: 28933537.
     
  6. Nazari M, Xi M, Lerch S, Alizadeh MH, Ettinger C, Akiyama H, Gillespie C, Gummuluru S, Erramilli S, Reinhard BM. Plasmonic Enhancement of Selective Photonic Virus Inactivation. Sci Rep. 2017 Sep 20; 7(1):11951.View Related Profiles. PMID: 28931903.
     
  7. Alizadeh MH, Reinhard BM. Highly efficient and broadband optical polarizers based on dielectric nanowires. Opt Express. 2017 Sep 18; 25(19):22897-22904. PMID: 29041595.
     
  8. Zhao X, Alizadeh MH, Reinhard BM. Generating optical birefringence and chirality in silicon nanowire dimers. ACS Photonics. 2017; 4(9):2265-2273. View Publication
     
  9. Ferreira MFS, Castro-Camus E, Ottaway DJ, López-Higuera JM, Feng X, Jin W, Jeong Y, Picqué N, Tong L, Reinhard BM, Pellegrino PM, Méndez A, Diem M, Vollmer F, Quan Q. Roadmap on optical sensors. J Opt. 2017 Aug; 19(8). PMID: 29375751; DOI: 10.1088/2040-8986/aa7419;.
     
  10. Lerch S, Reinhard BM. Spectral signatures of charge transfer in assemblies of molecularly-linked plasmonic nanoparticles. Int J Mod Phys B. 2017 Sep 30; 31(24). PMID: 29391660; DOI: 10.1142/s0217979217400021;.
     
Showing 10 of 89 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 89 publications over 15 distinct years, with a maximum of 11 publications in 2011

YearPublications
20032
20041
20054
20073
20084
20094
20108
201111
20129
20136
20146
201510
201610
20177
20184
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Plasmon Coupling Microscopy
BioPlasmonics
Artificial Virus Nanoparticles
Nanoscale Biophysics
Cell Membrane Organization and Signaling
Contact for Mentoring:


590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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