Keywords
Last Name

Yuriy O. Alekseyev, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address72 E. Concord St Evans Building
Boston MA 02118
Phone(617) 414-1369
ORCID ORCID Icon0000-0001-6105-8861
Other Positions
TitleDirector
InstitutionBoston University School of Medicine
DepartmentMicroarray Resource Core

 Research Expertise & Professional Interests
Yuriy serves as director of BU Microarray Core Resource facility since 2007. Prior to joining BU, Yuriy was a post-doctoral associate with Dr. John Essigmann at MIT where he used animal models to study transcriptional networks affected by a human hepatocarcinogen Aflatoxin B1 and by chemoprevention agents that suppress aflatoxin-induced carcinogenesis.

Yuriy earned a Ph.D. in Biochemistry from the Department of Chemistry at Wayne State University in the laboratory of Dr. Romano, where he studied mechanisms of DNA replication, mutagenesis and repair of carcinogenic lesions. Prior to that he received a M.S. in biotechnology from Moscow Academy of Fine Chemical Technology and worked in Moscow State Scientific Center GNIIGenetica where he studied plant toxins and took part in development of immunotoxins for potential use in cancer therapy and organ transplantation.

 Self-Described Keywords
  • sequencing
  • Microarrays
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Colletti NJ, Liu H, Gower AC, Alekseyev YO, Arendt CW, Shaw MH. TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations. Front Immunol. 2016; 7:88. PMID: 27014268.
    View in: PubMed
  2. Huang D, He X, Zou J, Guo P, Jiang S, Lv N, Alekseyev Y, Luo L, Luo Z. Negative regulation of Bmi-1 by AMPK and implication in cancer progression. Oncotarget. 2016 Feb 02; 7(5):6188-200. PMID: 26717043.
    View in: PubMed
  3. Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13. PMID: 26507575.
    View in: PubMed
  4. Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501. PMID: 26468118.
    View in: PubMed
  5. Coleman MA, Sasi SP, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev YO, Yan X, Goukassian DA. Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1947-63. PMID: 26408534.
    View in: PubMed
  6. Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's). Arthritis Rheumatol. 2015 May; 67(8):2233-9. PMID: 25939343.
    View in: PubMed
  7. Shanker S, Paulson A, Edenberg HJ, Peak A, Perera A, Alekseyev YO, Beckloff N, Bivens NJ, Donnelly R, Gillaspy AF, Grove D, Gu W, Jafari N, Kerley-Hamilton JS, Lyons RH, Tepper C, Nicolet CM. Evaluation of commercially available RNA amplification kits for RNA sequencing using very low input amounts of total RNA. J Biomol Tech. 2015 Apr; 26(1):4-18. PMID: 25649271.
    View in: PubMed
  8. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176. PMID: 25540039.
    View in: PubMed
  9. Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb; 21(2):164-71. PMID: 25519487.
    View in: PubMed
  10. McGrath-Morrow SA, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S. Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status. Cytokine. 2014 Jan; 65(1):4-9. PMID: 24139870.
    View in: PubMed
  11. van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 2014 Jan; 69(1):14-23. PMID: 23925644.
    View in: PubMed
  12. Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42. PMID: 23471465.
    View in: PubMed
  13. Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012; 4(8):67. PMID: 22937864.
    View in: PubMed
  14. Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res (Phila). 2011 Jun; 4(6):803-17. PMID: 21636547.
    View in: PubMed
  15. Panchenko MP, Siddiquee Z, Dombkowski DM, Alekseyev YO, Lenburg ME, Walker JD, Macgillivray TE, Preffer FI, Stone JR. Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol. 2010 Sep; 177(3):1562-72. PMID: 20696773.
    View in: PubMed
  16. Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78. PMID: 20086175.
    View in: PubMed
  17. Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8. PMID: 19952278.
    View in: PubMed
  18. Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene. 2009 May 7; 28(18):1993-2002. PMID: 19347029.
    View in: PubMed
  19. Neeley WL, Delaney S, Alekseyev YO, Jarosz DF, Delaney JC, Walker GC, Essigmann JM. DNA polymerase V allows bypass of toxic guanine oxidation products in vivo. J Biol Chem. 2007 Apr 27; 282(17):12741-8. PMID: 17322566.
    View in: PubMed
  20. Alekseyev YO, Hamm ML, Essigmann JM. Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo. Carcinogenesis. 2004 Jun; 25(6):1045-51. PMID: 14742311.
    View in: PubMed
  21. Alekseyev YO, Romano LJ. Effects of benzo[a]pyrene adduct stereochemistry on downstream DNA replication in vitro: evidence for different adduct conformations within the active site of DNA polymerase I (Klenow fragment). Biochemistry. 2002 Apr 2; 41(13):4467-79. PMID: 11914095.
    View in: PubMed
  22. Dzantiev L, Alekseyev YO, Morales JC, Kool ET, Romano LJ. Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase-DNA complex. Biochemistry. 2001 Mar 13; 40(10):3215-21. PMID: 11258938.
    View in: PubMed
  23. Alekseyev YO, Dzantiev L, Romano LJ. Effects of benzo[a]pyrene DNA adducts on Escherichia coli DNA polymerase I (Klenow fragment) primer-template interactions: evidence for inhibition of the catalytically active ternary complex formation. Biochemistry. 2001 Feb 20; 40(7):2282-90. PMID: 11329298.
    View in: PubMed
  24. Alekseyev YO, Romano LJ. In vitro replication of primer-templates containing benzo[a]pyrene adducts by exonuclease-deficient Escherichia coli DNA polymerase I (Klenow fragment): effect of sequence context on lesion bypass. Biochemistry. 2000 Aug 29; 39(34):10431-8. PMID: 10956033.
    View in: PubMed
  25. Tonevitskii AG, Toptygin AIu, Agapov II, Rakhmanova VA, Shamshiev AT, Alekseev IuO, Pfueller U, Frankel A. [Production of biologically active recombinant ricin B-chain]. Mol Biol (Mosk). 1995 Mar-Apr; 29(2):398-406. PMID: 7783743.
    View in: PubMed
  26. Tonevitsky AG, Alekseyev YO, Temiakov DE, Shamshiev AT, Agapov II. Interaction of Isoforms of Lectin from Viscum album with Monoclonal Antibody against a Catalitic Subunit. Biotechnology. 1995; (11):25-31.
  27. Tonevitsky AG, Temiakov DE, Moisenovich MM, Shamshiev AT, Agapov II, Alekseyev YO, Egorova SG, Kharitonenkov IG. Cytotoxic Activity of the Immunotoxin on the Basis of the Catalitic Subunits of Ricin and Ricin Agglutinin and Monoclonal Antibody to 35 KDa Antigen of Human Melanoma. Biotechnology. 1995; (11):31-35.
  28. Tonevitsky AG, Alekseyev YO, Shamshiev AT, Ryzhavskaya AS, Temiakov DE, Agapov II. Study of Changes in the Structure of the Plant Toxin MLI during the Adsorption on Immunological Plate and after a Treatment with Various Denaturation Agents with the Help of Monoclonal Antibodies. Biotechnology. 1995; (11):35-40.
  29. Tonevitsky AG, Rakhmanova VA, Agapov II, Shamshiev AT, Usacheva EA, Prokoph'ev SA, Denisenko ON, Alekseev YuO, Pfueller U. The interactions of anti-MLI monoclonal antibodies with isoforms of the lectin from Viscum album. Immunol Lett. 1995 Jan; 44(1):31-4. PMID: 7721340.
    View in: PubMed
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