Yuriy serves as director of BU Microarray Core Resource facility since 2007. Prior to joining BU, Yuriy was a post-doctoral associate with Dr. John Essigmann at MIT where he used animal models to study transcriptional networks affected by a human hepatocarcinogen Aflatoxin B1 and by chemoprevention agents that suppress aflatoxin-induced carcinogenesis.
Yuriy earned a Ph.D. in Biochemistry from the Department of Chemistry at Wayne State University in the laboratory of Dr. Romano, where he studied mechanisms of DNA replication, mutagenesis and repair of carcinogenic lesions. Prior to that he received a M.S. in biotechnology from Moscow Academy of Fine Chemical Technology and worked in Moscow State Scientific Center GNIIGenetica where he studied plant toxins and took part in development of immunotoxins for potential use in cancer therapy and organ transplantation.
Diversity, Equity, Inclusion and Accessibility
As Director of a BUMC Core service I embrace diversity, equity and inclusion, including faculty and staff who are historically underrepresented in science and medicine and also members of the LBGTQ+ community. We ensure that all faculty, staff and students feel welcome to the Core services and are treated equitably and with dignity and respect. In 2021 I hired, trained, promoted and mentor Christopher Williams (URM), who pursues MPH degree at BU SPH and works full time at Single Cell Sequencing Core.
Member
Boston University
BU-BMC Cancer Center
Director
Boston University Chobanian & Avedisian School of Medicine
Microarray Resource Core
Member
Boston University
Genome Science Institute
Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Sun Y, Benmhammed H, Al Abdullatif S, Habara A, Fu E, Brady J, Williams C, Ilinski A, Sharma A, Mahdaviani K, Alekseyev YO, Campbell JD, Steinberg MH, Cui S. PGC-1a agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease. Sci Adv. 2024 Aug 02; 10(31):eadn8750.View Related Profiles. PMID: 39083598; PMCID: PMC11290485; DOI: 10.1126/sciadv.adn8750;
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Steiner D, Sultan L, Sullivan T, Liu H, Zhang S, LeClerc A, Alekseyev YO, Liu G, Mazzilli SA, Zhang J, Rieger-Christ K, Burks EJ, Beane J, Lenburg ME. Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics. bioRxiv. 2024 Jun 10.View Related Profiles. PMID: 38915565; PMCID: PMC11195124; DOI: 10.1101/2024.06.07.597993;
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Turcinovic J, Kuhfeldt K, Sullivan M, Landaverde L, Platt JT, Alekseyev YO, Doucette-Stamm L, Hamer DH, Klapperich C, Landsberg HE, Connor JH. Transmission Dynamics and Rare Clustered Transmission Within an Urban University Population Before Widespread Vaccination. J Infect Dis. 2024 Feb 14; 229(2):485-492.View Related Profiles. PMID: 37856283
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Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nat Commun. 2024 Jan 31; 15(1):878.View Related Profiles. PMID: 38296993; PMCID: PMC10831093; DOI: 10.1038/s41467-024-45165-7;
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Chakraborty A, Kim A, AlAbdullatif S, Campbell JD, Alekseyev YO, Kaplan U, Dambal V, Ligresti G, Trojanowska M. Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport. Res Sq. 2024 Jan 24.View Related Profiles. PMID: 38343832; PMCID: PMC10854286; DOI: 10.21203/rs.3.rs-3808970/v1;
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Hume AJ, Olejnik J, White MR, Huang J, Turcinovic J, Heiden B, Bawa PS, Williams CJ, Gorham NG, Alekseyev YO, Connor JH, Kotton DN, Mühlberger E. Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality. Pathogens. 2024 Jan 09; 13(1).View Related Profiles. PMID: 38251369; PMCID: PMC10818917; DOI: 10.3390/pathogens13010062;
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Pavel AB, Garrison C, Luo L, Liu G, Taub D, Xiao J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Geraci MW, Sciurba F, Schwartz DA, Kaminski N, Beane J, Spira A, Lenburg ME, Campbell JD. Integrative genetic and genomic networks identify microRNA associated with COPD and ILD. Sci Rep. 2023 Aug 11; 13(1):13076.View Related Profiles. PMID: 37567908; PMCID: PMC10421936; DOI: 10.1038/s41598-023-39751-w;
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Xu K, Diaz AA, Duan F, Lee M, Xiao X, Liu H, Liu G, Cho MH, Gower AC, Alekseyev YO, Spira A, Aberle DR, Washko GR, Billatos E, Lenburg ME. Bronchial gene expression alterations associated with radiological bronchiectasis. Eur Respir J. 2023 Jan; 61(1).View Related Profiles. PMID: 36229050; PMCID: PMC9881226; DOI: 10.1183/13993003.00120-2022;
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Moreira JD, Gower AC, Xue L, Alekseyev Y, Smith KK, Choi SH, Ayalon N, Farb MG, Tenan K, LeClerc A, Levy D, Benjamin EJ, Lenburg ME, Mitchell RN, Padera RF, Fetterman JL, Gopal DM. Systematic dissection, preservation, and multiomics in whole human and bovine hearts. Cardiovasc Pathol. 2023; 63:107495.View Related Profiles. PMID: 36334690; PMCID: PMC10031913; DOI: 10.1016/j.carpath.2022.107495;
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Garland LL, Guillen-Rodriguez J, Hsu CH, Davis LE, Szabo E, Husted CR, Liu H, LeClerc A, Alekseyev YO, Liu G, Bauman JE, Spira AE, Beane J, Wojtowicz M, Chow HS. Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers. Cancers (Basel). 2022 Jun 11; 14(12).View Related Profiles. PMID: 35740559; PMCID: PMC9221101; DOI: 10.3390/cancers14122893;
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Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles. PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;
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Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang JB, Tian H, Zhu S, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA, Qiu WQ. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell. 2021 11; 20(11):e13501.View Related Profiles. PMID: 34687487; PMCID: PMC8590103; DOI: 10.1111/acel.13501;
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Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD. Thorax. 2022 01; 77(1):31-39.View Related Profiles. PMID: 33972452
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Podnar JW, Pantano L, Zeller MJ, Kolling FW, Zhang Y, Alekseyev YO, Niece J, Deiderick H, Fan J, Xuei X, Kieleczawa J, Levine SS, Herbert ZT, Adams M. Cross-Site Evaluation of Commercial Sanger Sequencing Chemistries. J Biomol Tech. 2020 09; 31(3):88-93. PMID: 32831655; PMCID: PMC7351326; DOI: 10.7171/jbt.20-3103-002;
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Herbert ZT, Thimmapuram J, Xie S, Kershner JP, Kolling FW, Ringelberg CS, LeClerc A, Alekseyev YO, Fan J, Podnar JW, Stevenson HS, Sommerville G, Gupta S, Berkeley M, Koeman J, Perera A, Scott AR, Grenier JK, Malik J, Ashton JM, Pivarski KL, Wang X, Kuffel G, Mesa TE, Smith AT, Shen J, Takata Y, Volkert TL, Love JA, Zhang Y, Wang J, Xuei X, Adams M, Levine SS. Multisite Evaluation of Next-Generation Methods for Small RNA Quantification. J Biomol Tech. 2020 07; 31(2):47-56. PMID: 31966025; PMCID: PMC6953595; DOI: 10.7171/jbt.20-3102-001;
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Podnar JW, Kolling FW, Zeller MJ, Zhang Y, Thimmapuram J, Alekseyev YO, Deiulio A, Niece J, Deiderick H, Fan J, Xuei X, Pantano L, Levine SS, Herbert ZT, Adams M, Kieleczawa J. Cross Site Evaluation of Sanger Sequencing Dye Chemistries. J Biomol Tech. 2019 Dec; 30(Suppl):S46. PMID: 31896979
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Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 05 06; 9(1):6978.View Related Profiles. PMID: 31061400; PMCID: PMC6502805; DOI: 10.1038/s41598-019-43295-3;
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Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019 04; 53(4).View Related Profiles. PMID: 30846474
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Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018 09 01; 50(9):705-713.View Related Profiles. PMID: 29932825; PMCID: PMC6172616; DOI: 10.1152/physiolgenomics.00092.2017;
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Herbert ZT, Kershner JP, Butty VL, Thimmapuram J, Choudhari S, Alekseyev YO, Fan J, Podnar JW, Wilcox E, Gipson J, Gillaspy A, Jepsen K, BonDurant SS, Morris K, Berkeley M, LeClerc A, Simpson SD, Sommerville G, Grimmett L, Adams M, Levine SS. Cross-site comparison of ribosomal depletion kits for Illumina RNAseq library construction. BMC Genomics. 2018 Mar 15; 19(1):199. PMID: 29703133; PMCID: PMC6389247; DOI: 10.1186/s12864-018-4585-1;
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Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13.View Related Profiles. PMID: 26507575; PMCID: PMC4715959; DOI: 10.1158/1541-7786.MCR-15-0079;
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Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501.View Related Profiles. PMID: 26468118; PMCID: PMC4675833; DOI: 10.1093/carcin/bgv150;
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Coleman MA, Sasi SP, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev YO, Yan X, Goukassian DA. Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1947-63.View Related Profiles. PMID: 26408534; PMCID: PMC4698384; DOI: 10.1152/ajpheart.00050.2015;
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Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's). Arthritis Rheumatol. 2015 May; 67(8):2233-9.View Related Profiles. PMID: 25939343; PMCID: PMC4519398; DOI: 10.1002/art.39185;
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Shanker S, Paulson A, Edenberg HJ, Peak A, Perera A, Alekseyev YO, Beckloff N, Bivens NJ, Donnelly R, Gillaspy AF, Grove D, Gu W, Jafari N, Kerley-Hamilton JS, Lyons RH, Tepper C, Nicolet CM. Evaluation of commercially available RNA amplification kits for RNA sequencing using very low input amounts of total RNA. J Biomol Tech. 2015 Apr; 26(1):4-18. PMID: 25649271; PMCID: PMC4310221; DOI: 10.7171/jbt.15-2601-001;
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Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles. PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;
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Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb; 21(2):164-71.View Related Profiles. PMID: 25519487; PMCID: PMC4338344; DOI: 10.1261/rna.046060.114;
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McGrath-Morrow SA, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S. Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status. Cytokine. 2014 Jan; 65(1):4-9. PMID: 24139870; PMCID: PMC3875154; DOI: 10.1016/j.cyto.2013.09.021;
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van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 2014 Jan; 69(1):14-23.View Related Profiles. PMID: 23925644; PMCID: PMC3888587; DOI: 10.1136/thoraxjnl-2012-202878;
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Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles. PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;
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Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012; 4(8):67.View Related Profiles. PMID: 22937864; PMCID: PMC4064320; DOI: 10.1186/gm368;
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Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res (Phila). 2011 Jun; 4(6):803-17.View Related Profiles. PMID: 21636547; PMCID: PMC3694393; DOI: 10.1158/1940-6207.CAPR-11-0212;
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Panchenko MP, Siddiquee Z, Dombkowski DM, Alekseyev YO, Lenburg ME, Walker JD, Macgillivray TE, Preffer FI, Stone JR. Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol. 2010 Sep; 177(3):1562-72.View Related Profiles. PMID: 20696773; PMCID: PMC2928985; DOI: 10.2353/ajpath.2010.100327;
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Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78.View Related Profiles. PMID: 20086175; PMCID: PMC2946209; DOI: 10.1158/0008-5472.CAN-09-1872;
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Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles. PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;
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Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene. 2009 May 7; 28(18):1993-2002.View Related Profiles. PMID: 19347029; PMCID: PMC2679420; DOI: 10.1038/onc.2009.63;
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Neeley WL, Delaney S, Alekseyev YO, Jarosz DF, Delaney JC, Walker GC, Essigmann JM. DNA polymerase V allows bypass of toxic guanine oxidation products in vivo. J Biol Chem. 2007 Apr 27; 282(17):12741-8. PMID: 17322566
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Alekseyev YO, Hamm ML, Essigmann JM. Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo. Carcinogenesis. 2004 Jun; 25(6):1045-51. PMID: 14742311
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Alekseyev YO, Romano LJ. Effects of benzo[a]pyrene adduct stereochemistry on downstream DNA replication in vitro: evidence for different adduct conformations within the active site of DNA polymerase I (Klenow fragment). Biochemistry. 2002 Apr 2; 41(13):4467-79. PMID: 11914095
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Dzantiev L, Alekseyev YO, Morales JC, Kool ET, Romano LJ. Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase-DNA complex. Biochemistry. 2001 Mar 13; 40(10):3215-21. PMID: 11258938
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Alekseyev YO, Dzantiev L, Romano LJ. Effects of benzo[a]pyrene DNA adducts on Escherichia coli DNA polymerase I (Klenow fragment) primer-template interactions: evidence for inhibition of the catalytically active ternary complex formation. Biochemistry. 2001 Feb 20; 40(7):2282-90. PMID: 11329298
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Alekseyev YO, Romano LJ. In vitro replication of primer-templates containing benzo[a]pyrene adducts by exonuclease-deficient Escherichia coli DNA polymerase I (Klenow fragment): effect of sequence context on lesion bypass. Biochemistry. 2000 Aug 29; 39(34):10431-8. PMID: 10956033
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Tonevitskii AG, Toptygin AIu, Agapov II, Rakhmanova VA, Shamshiev AT, Alekseev IuO, Pfueller U, Frankel A. [Production of biologically active recombinant ricin B-chain]. Mol Biol (Mosk). 1995 Mar-Apr; 29(2):398-406. PMID: 7783743
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Tonevitsky AG, Alekseyev YO, Temiakov DE, Shamshiev AT, Agapov II. Interaction of Isoforms of Lectin from Viscum album with Monoclonal Antibody against a Catalitic Subunit. Biotechnology. 1995; (11):25-31.
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Tonevitsky AG, Alekseyev YO, Shamshiev AT, Ryzhavskaya AS, Temiakov DE, Agapov II. Study of Changes in the Structure of the Plant Toxin MLI during the Adsorption on Immunological Plate and after a Treatment with Various Denaturation Agents with the Help of Monoclonal Antibodies. Biotechnology. 1995; (11):35-40.
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Tonevitsky AG, Temiakov DE, Moisenovich MM, Shamshiev AT, Agapov II, Alekseyev YO, Egorova SG, Kharitonenkov IG. Cytotoxic Activity of the Immunotoxin on the Basis of the Catalitic Subunits of Ricin and Ricin Agglutinin and Monoclonal Antibody to 35 KDa Antigen of Human Melanoma. Biotechnology. 1995; (11):31-35.
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Tonevitsky AG, Rakhmanova VA, Agapov II, Shamshiev AT, Usacheva EA, Prokoph'ev SA, Denisenko ON, Alekseev YuO, Pfueller U. The interactions of anti-MLI monoclonal antibodies with isoforms of the lectin from Viscum album. Immunol Lett. 1995 Jan; 44(1):31-4. PMID: 7721340
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 1995 | 5 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 1 |
| 2004 | 1 |
| 2007 | 1 |
| 2009 | 2 |
| 2010 | 2 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 3 |
| 2014 | 2 |
| 2015 | 5 |
| 2016 | 2 |
| 2018 | 3 |
| 2019 | 3 |
| 2020 | 2 |
| 2021 | 3 |
| 2022 | 2 |
| 2023 | 2 |
| 2024 | 6 |