Keywords
Last Name

Caroline A. Genco, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Disease
Address650 Albany St
Boston MA 02118
Phone(617) 414-5305
ORCID ORCID Icon0000-0001-7772-4216
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Work in Dr. Genco’s laboratory is focused on three areas; 1) Innate Immune Responses to Mucosal Pathogens; 2) Regulatory Mechanisms in Bacterial Pathogens; and 3) Pathogen Induced Chronic Inflammatory Disorders.

1) Innate Immune Responses to Mucosal Pathogens:
We are examining the interactions of several mucosal pathogens with both phagocytic and non-phagocytic cells. Work with N. gonorrhoeae has established that distinct proinflammatory responses are observed in different compartments of the female lower genital tract (endocervical, ectocervical and vaginal cell lines). Using these cell lines we have demonstrated that infection with N. gonorrhoeae inhibits the apoptotic response of these cells. N. gonorrhoeae may thus establish infection by inhibiting the apoptotic response to infection, thereby resisting killing from both the host cell and the innate immune response. Current studies are focused on defining the role of toll-like receptors and intracellular signaling receptors in N. gonorrhoeae induced proinflammatory responses in epithelial cells. Work with P. gingivalis has demonstrated the invasive capabilities of these organisms for endothelial cells and has defined specific cell signaling pathways involved in this response. We have shown that 2 adhesins of this organism, the major and minor fimbriae proteins bind to and signal through TLR2 for an inflammatory response in human aortic endothelial cells. Furthermore both the major and minor fimbriae proteins can signal through TLR4 if the accessory proteins MD2 and CD14 are present. Our recent studies are focused on defining intracellular signaling receptors and pathways utilized by P. gingivalis to induce IL-1ß secretion in endothelial cells.

2) Regulatory Mechanisms in Bacterial Pathogens:
This work is focused on understanding mechanisms utilized for bacterial colonization, and in particular in the ability of in vivo environmental factors to modulate bacterial gene expression. Transcriptional regulatory mechanisms have been defined on a global level in the pathogenic Neisseria species. We have established that the expression of virulence factors in these organisms is controlled by a global regulatory protein (ferric uptake regulator protein, Fur). We have established that the transcriptional regulatory protein Fur controls the expression of numerous genes that are required for the virulence of N. meningitidis and N. gonorrhoeae and have established that many of these genes are expressed in vivo during mucosal gonococcal infection in both men and women. Current studies are aimed at examining the regulation and expression of Fur-regulated genes in vitro, and in vivo directly in clinical specimens. We have also recently identified a novel mechanism for Fur-mediated regulation through small regulatory RNAs (sRNA) in both N. meningitidis and N. gonorrhoeae. We have established that in N. meningitidis the sRNA, NrrF functions independently of the cofactor RNA-binding protein, Hfq. Current studies are focused on defining how NrrF functions independently of Hfq and on identifying additional sRNAs using high-density oligonucleotide microarrays together with computational analysis.

3) Pathogen Induced Chronic Inflammatory Disorders:
Chronic inflammation culminates in devastating events, results in significant host pathology, and is associated with a number of human diseases including autoimmune diseases, infectious diseases, neoplastic diseases, and inflammatory atherosclerosis. Our studies focus on two pathogens associated with chronic inflammation, Chlamydia pneumoniae and Porphyromonas gingivalis. C. pneumoniae is a respiratory pathogen that causes a mild, usually asymptomatic pneumonia. P. gingivalis induces a local host inflammatory response that results in inflammatory bone destruction, which is manifested as periodontal disease. Normally, the acute inflammatory response is self-limited, working to contain these infections until the adaptive immune response is activated. However, under some circumstances, a chronic inflammatory state can ensue, resulting in additional host pathology. Recently, both C. pneumoniae and P. gingivalis have been implicated in the pathogenesis of chronic inflammatory plaque formation although how these pathogens induce and maintain chronic inflammation is not well defined. Our laboratory has defined the role of specific innate immune signaling pathways in immune cells that contribute collectively to pathogen-induced chronic inflammation. We are examining in vitro model systems for platelets, endothelial cells, and macrophages. Using defined animal models of inflammation we are characterizing the roles of innate immune pathways in inflammatory processes in vivo. Enhanced understanding of the roles of specific innate immune signaling pathways, which participate in proinflammatory mediator expression and functional immune responses will provide a promising avenue for novel therapies for chronic inflammatory disorders.

 Self-Described Keywords
  • host pathogen interactions
  • infectious diseases
  • inflammation
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog. 2014 Jul; 10(7):e1004215.
    View in: PubMed
  2. Yu C, Lopez CA, Hu H, Xia Y, Freedman DS, Reddington AP, Daaboul GG, Unlü MS, Genco CA. A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein fur. PLoS One. 2014; 9(5):e96832.
    View in: PubMed
  3. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1ß regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64.
    View in: PubMed
  4. Daou N, Yu C, McClure R, Gudino C, Reed GW, Genco CA. Neisseria prophage repressor implicated in gonococcal pathogenesis. Infect Immun. 2013 Oct; 81(10):3652-61.
    View in: PubMed
  5. Barth K, Remick DG, Genco CA. Disruption of immune regulation by microbial pathogens and resulting chronic inflammation. J Cell Physiol. 2013 Jul; 228(7):1413-22.
    View in: PubMed
  6. Miles B, Scisci E, Carrion J, Sabino GJ, Genco CA, Cutler CW. Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen. J Leukoc Biol. 2013 Aug; 94(2):281-9.
    View in: PubMed
  7. McClure R, Balasubramanian D, Sun Y, Bobrovskyy M, Sumby P, Genco CA, Vanderpool CK, Tjaden B. Computational analysis of bacterial RNA-Seq data. Nucleic Acids Res. 2013 Aug; 41(14):e140.
    View in: PubMed
  8. Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57.
    View in: PubMed
  9. Weinberg EO, Genco CA. Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis. Circulation. 2012 Oct 2; 126(14):1678-80.
    View in: PubMed
  10. Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.
    View in: PubMed
  11. Carrion J, Scisci E, Miles B, Sabino GJ, Zeituni AE, Gu Y, Bear A, Genco CA, Brown DL, Cutler CW. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J Immunol. 2012 Sep 15; 189(6):3178-87.
    View in: PubMed
  12. Yu C, Genco CA. Fur-mediated global regulatory circuits in pathogenic Neisseria species. J Bacteriol. 2012 Dec; 194(23):6372-81.
    View in: PubMed
  13. Madrigal AG, Barth K, Papadopoulos G, Genco CA. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012; 8(6):e1002723.
    View in: PubMed
  14. Yu C, Genco CA. Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae. J Bacteriol. 2012 Apr; 194(7):1730-42.
    View in: PubMed
  15. Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). J Vis Exp. 2011; (51).
    View in: PubMed
  16. Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC, Hamilton JA, Genco CA. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 2011 Mar; 215(1):52-9.
    View in: PubMed
  17. Hayashi C, Gudino CV, Gibson FC, Genco CA. Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010 Oct; 25(5):305-16.
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  18. Hayashi C, Madrigal AG, Liu X, Ukai T, Goswami S, Gudino CV, Gibson FC, Genco CA. Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun. 2010; 2(4):334-43.
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  19. Mellin JR, McClure R, Lopez D, Green O, Reinhard B, Genco C. Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis. Microbiology. 2010 Aug; 156(Pt 8):2316-26.
    View in: PubMed
  20. Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun. 2009 Sep; 77(9):3602-10.
    View in: PubMed
  21. Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54.
    View in: PubMed
  22. Agarwal S, Sebastian S, Szmigielski B, Rice PA, Genco CA. Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J Bacteriol. 2008 May; 190(9):3129-39.
    View in: PubMed
  23. Davey M, Liu X, Ukai T, Jain V, Gudino C, Gibson FC, Golenbock D, Visintin A, Genco CA. Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs. J Immunol. 2008 Feb 15; 180(4):2187-95.
    View in: PubMed
  24. Gibson FC, Ukai T, Genco CA. Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis. Front Biosci. 2008; 13:2041-59.
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  25. Isabella V, Wright LF, Barth K, Spence JM, Grogan S, Genco CA, Clark VL. cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae. Microbiology. 2008 Jan; 154(Pt 1):226-39.
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  26. Ukai T, Yumoto H, Gibson FC, Genco CA. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun. 2008 Feb; 76(2):812-9.
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  27. Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson FC, Genco CA. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis. 2008 Jan; 196(1):146-54.
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  28. Mellin JR, Goswami S, Grogan S, Tjaden B, Genco CA. A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis. J Bacteriol. 2007 May; 189(10):3686-94.
    View in: PubMed
  29. Gibson FC, Genco CA. Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: disparate diseases with commonalities in pathogenesis through TLRs. Curr Pharm Des. 2007; 13(36):3665-75.
    View in: PubMed
  30. Shaik YB, Grogan S, Davey M, Sebastian S, Goswami S, Szmigielski B, Genco CA. Expression of the iron-activated nspA and secY genes in Neisseria meningitidis group B by Fur-dependent and -independent mechanisms. J Bacteriol. 2007 Jan; 189(2):663-9.
    View in: PubMed
  31. Al-Qutub MN, Braham PH, Karimi-Naser LM, Liu X, Genco CA, Darveau RP. Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharide. Infect Immun. 2006 Aug; 74(8):4474-85.
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  32. Mydel P, Takahashi Y, Yumoto H, Sztukowska M, Kubica M, Gibson FC, Kurtz DM, Travis J, Collins LV, Nguyen KA, Genco CA, Potempa J. Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog. 2006 Jul; 2(7):e76.
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  33. Bartolini E, Frigimelica E, Giovinazzi S, Galli G, Shaik Y, Genco C, Welsch JA, Granoff DM, Grandi G, Grifantini R. Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection. Mol Microbiol. 2006 May; 60(4):963-72.
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  34. Takahashi Y, Davey M, Yumoto H, Gibson FC, Genco CA. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol. 2006 May; 8(5):738-57.
    View in: PubMed
  35. Gibson FC, Yumoto H, Takahashi Y, Chou HH, Genco CA. Innate immune signaling and Porphyromonas gingivalis-accelerated atherosclerosis. J Dent Res. 2006 Feb; 85(2):106-21.
    View in: PubMed
  36. Liu X, Olczak T, Guo HC, Dixon DW, Genco CA. Identification of amino acid residues involved in heme binding and hemoprotein utilization in the Porphyromonas gingivalis heme receptor HmuR. Infect Immun. 2006 Feb; 74(2):1222-32.
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  37. Miyamoto T, Yumoto H, Takahashi Y, Davey M, Gibson FC, Genco CA. Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun. 2006 Feb; 74(2):1376-80.
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  38. Yumoto H, Chou HH, Takahashi Y, Davey M, Gibson FC, Genco CA. Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4 by bacterial fimbria-dependent invasion. Infect Immun. 2005 Dec; 73(12):8050-9.
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  39. Gibson FC, Savelli J, Van Dyke TE, Genco CA. Gingipain-specific IgG in the sera of patients with periodontal disease is necessary for opsonophagocytosis of Porphyromonas gingivalis. J Periodontol. 2005 Oct; 76(10):1629-36.
    View in: PubMed
  40. Chou HH, Yumoto H, Davey M, Takahashi Y, Miyamoto T, Gibson FC, Genco CA. Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun. 2005 Sep; 73(9):5367-78.
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  41. Agarwal S, King CA, Klein EK, Soper DE, Rice PA, Wetzler LM, Genco CA. The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection. Infect Immun. 2005 Jul; 73(7):4281-7.
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  42. Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone. 2005 Mar; 36(3):472-9.
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  43. Olczak T, Simpson W, Liu X, Genco CA. Iron and heme utilization in Porphyromonas gingivalis. FEMS Microbiol Rev. 2005 Jan; 29(1):119-44.
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  44. Sztukowska M, Sroka A, Bugno M, Banbula A, Takahashi Y, Pike RN, Genco CA, Travis J, Potempa J. The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities. Mol Microbiol. 2004 Dec; 54(5):1393-408.
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  45. Grifantini R, Frigimelica E, Delany I, Bartolini E, Giovinazzi S, Balloni S, Agarwal S, Galli G, Genco C, Grandi G. Characterization of a novel Neisseria meningitidis Fur and iron-regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes. Mol Microbiol. 2004 Nov; 54(4):962-79.
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  46. Liu X, Sroka A, Potempa J, Genco CA. Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR. Biol Chem. 2004 Nov; 385(11):1049-57.
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  47. Gibson FC, Hong C, Chou HH, Yumoto H, Chen J, Lien E, Wong J, Genco CA. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Jun 8; 109(22):2801-6.
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  48. Gibson FC, Gonzalez DA, Wong J, Genco CA. Porphyromonas gingivalis-specific immunoglobulin G prevents P. gingivalis-elicited oral bone loss in a murine model. Infect Immun. 2004 Apr; 72(4):2408-11.
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  49. Simpson W, Olczak T, Genco CA. Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis. Acta Biochim Pol. 2004; 51(1):253-62.
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  50. Gyurko R, Boustany G, Huang PL, Kantarci A, Van Dyke TE, Genco CA, Gibson FC. Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis. Infect Immun. 2003 Sep; 71(9):4917-24.
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  51. Grifantini R, Sebastian S, Frigimelica E, Draghi M, Bartolini E, Muzzi A, Rappuoli R, Grandi G, Genco CA. Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B. Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9542-7.
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  52. Gonzalez D, Tzianabos AO, Genco CA, Gibson FC. Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model. Infect Immun. 2003 Apr; 71(4):2283-7.
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  53. Genco CA, Maloy WL, Kari UP, Motley M. Antimicrobial activity of magainin analogues against anaerobic oral pathogens. Int J Antimicrob Agents. 2003 Jan; 21(1):75-8.
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  54. Niederman R, Kelderman H, Socransky S, Ostroff G, Genco C, Kent R, Stashenko P. Enhanced neutrophil emigration and Porphyromonas gingivalis reduction following PGG-glucan treatment of mice. Arch Oral Biol. 2002 Aug; 47(8):613-8.
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  55. Sebastian S, Agarwal S, Murphy JR, Genco CA. The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways. J Bacteriol. 2002 Jul; 184(14):3965-74.
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  56. Khlgatian M, Nassar H, Chou HH, Gibson FC, Genco CA. Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun. 2002 Jan; 70(1):257-67.
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  57. Nassar H, Chou HH, Khlgatian M, Gibson FC, Van Dyke TE, Genco CA. Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Infect Immun. 2002 Jan; 70(1):268-76.
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  58. Gibson FC, Genco CA. Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1. Infect Immun. 2001 Dec; 69(12):7959-63.
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  59. Olczak T, Dixon DW, Genco CA. Binding specificity of the Porphyromonas gingivalis heme and hemoglobin receptor HmuR, gingipain K, and gingipain R1 for heme, porphyrins, and metalloporphyrins. J Bacteriol. 2001 Oct; 183(19):5599-608.
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  60. Sroka A, Sztukowska M, Potempa J, Travis J, Genco CA. Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J Bacteriol. 2001 Oct; 183(19):5609-16.
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  61. Fichorova RN, Desai PJ, Gibson FC, Genco CA. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect Immun. 2001 Sep; 69(9):5840-8.
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  62. Genco CA, Dixon DW. Emerging strategies in microbial haem capture. Mol Microbiol. 2001 Jan; 39(1):1-11.
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  63. Forng RY, Champagne C, Simpson W, Genco CA. Environmental cues and gene expression in Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Dis. 2000 Nov; 6(6):351-65.
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  64. Simpson W, Olczak T, Genco CA. Characterization and expression of HmuR, a TonB-dependent hemoglobin receptor of Porphyromonas gingivalis. J Bacteriol. 2000 Oct; 182(20):5737-48.
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  65. Desai PJ, Garges E, Genco CA. Pathogenic neisseriae can use hemoglobin, transferrin, and lactoferrin independently of the tonB locus. J Bacteriol. 2000 Oct; 182(19):5586-91.
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  66. Simpson W, Wang CY, Mikolajczyk-Pawlinska J, Potempa J, Travis J, Bond VC, Genco CA. Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis. Infect Immun. 1999 Oct; 67(10):5012-20.
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  67. Egal M, Conrad M, MacDonald DL, Maloy WL, Motley M, Genco CA. Antiviral effects of synthetic membrane-active peptides on herpes simplex virus, type 1. Int J Antimicrob Agents. 1999 Sep; 13(1):57-60.
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  68. Holt SC, Kesavalu L, Walker S, Genco CA. Virulence factors of Porphyromonas gingivalis. Periodontol 2000. 1999 Jun; 20:168-238.
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  69. Sebastian S, Genco CA. FbpC is not essential for iron acquisition in Neisseria gonorrhoeae. Infect Immun. 1999 Jun; 67(6):3141-5.
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  70. Genco CA, Potempa J, Mikolajczyk-Pawlinska J, Travis J. Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. Clin Infect Dis. 1999 Mar; 28(3):456-65.
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  71. Genco CA, Van Dyke T, Amar S. Animal models for Porphyromonas gingivalis-mediated periodontal disease. Trends Microbiol. 1998 Nov; 6(11):444-9.
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  72. Deshpande RG, Khan MB, Genco CA. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun. 1998 Nov; 66(11):5337-43.
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  73. Genco CA, Odusanya BM, Potempa J, Mikolajczyk-Pawlinska J, Travis J. A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun. 1998 Sep; 66(9):4108-14.
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  74. Deshpande RG, Khan M, Genco CA. Invasion strategies of the oral pathogen porphyromonas gingivalis: implications for cardiovascular disease. Invasion Metastasis. 1998-1999; 18(2):57-69.
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  75. Wang CY, Bond VC, Genco CA. Identification of a second endogenous Porphyromonas gingivalis insertion element. J Bacteriol. 1997 Jun; 179(11):3808-12.
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  76. Forng RY, Ekechukwu CR, Subbarao S, Morse SA, Genco CA. Promoter mapping and transcriptional regulation of the iron-regulated Neisseria gonorrhoeae fbpA gene. J Bacteriol. 1997 May; 179(9):3047-52.
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  77. Njoroge T, Genco RJ, Sojar HT, Hamada N, Genco CA. A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells. Infect Immun. 1997 May; 65(5):1980-4.
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  78. Desai PJ, Angerer A, Genco CA. Analysis of Fur binding to operator sequences within the Neisseria gonorrhoeae fbpA promoter. J Bacteriol. 1996 Aug; 178(16):5020-3.
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  79. Cutler CW, Eke PI, Genco CA, Van Dyke TE, Arnold RR. Hemin-induced modifications of the antigenicity and hemin-binding capacity of Porphyromonas gingivalis lipopolysaccharide. Infect Immun. 1996 Jun; 64(6):2282-7.
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  80. Genco CA, Desai PJ. Iron acquisition in the pathogenic Neisseria. Trends Microbiol. 1996 May; 4(5):179-84.
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  81. Desai PJ, Nzeribe R, Genco CA. Binding and accumulation of hemin in Neisseria gonorrhoeae. Infect Immun. 1995 Dec; 63(12):4634-41.
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  82. Lynn WH, Genco CA, Forng RY. Analysis of the insertion characteristics of Tn4351 during high frequency transposition of Porphyromonas gingivalis. NDA J. 1995 Dec; 46(2):15-7.
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  83. Genco CA, Simpson W, Forng RY, Egal M, Odusanya BM. Characterization of a Tn4351-generated hemin uptake mutant of Porphyromonas gingivalis: evidence for the coordinate regulation of virulence factors by hemin. Infect Immun. 1995 Jul; 63(7):2459-66.
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  84. Genco CA, Schifferle RE, Njoroge T, Forng RY, Cutler CW. Resistance of a Tn4351-generated polysaccharide mutant of Porphyromonas gingivalis to polymorphonuclear leukocyte killing. Infect Immun. 1995 Feb; 63(2):393-401.
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  85. Genco CA. Regulation of hemin and iron transport in Porphyromonas gingivalis. Adv Dent Res. 1995 Feb; 9(1):41-7.
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  86. Cutler CW, Kalmar JR, Genco CA. Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis. Trends Microbiol. 1995 Feb; 3(2):45-51.
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  87. Genco CA. Preface: molecular and cellular basis for microbial pathogenesis. Adv Dent Res. 1995 Feb; 9(1):29-30.
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  88. Genco CA, Odusanya BM, Brown G. Binding and accumulation of hemin in Porphyromonas gingivalis are induced by hemin. Infect Immun. 1994 Jul; 62(7):2885-92.
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  89. Genco CA, Berish SA, Chen CY, Morse S, Trees DL. Genetic diversity of the iron-binding protein (Fbp) gene of the pathogenic and commensal Neisseria. FEMS Microbiol Lett. 1994 Feb 15; 116(2):123-9.
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  90. Genco CA, Arko RJ. Animal chamber models for study of host-parasite interactions. Methods Enzymol. 1994; 235:120-40.
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  91. Genco CA, Kapczynski DR, Cutler CW, Arko RJ, Arnold RR. Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model. Infect Immun. 1992 Apr; 60(4):1447-54.
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  92. Genco CA, Chen CY, Arko RJ, Kapczynski DR, Morse SA. Isolation and characterization of a mutant of Neisseria gonorrhoeae that is defective in the uptake of iron from transferrin and haemoglobin and is avirulent in mouse subcutaneous chambers. J Gen Microbiol. 1991 Jun; 137(6):1313-21.
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  93. Genco CA, Cutler CW, Kapczynski D, Maloney K, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun. 1991 Apr; 59(4):1255-63.
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  94. Berish SA, Mietzner TA, Mayer LW, Genco CA, Holloway BP, Morse SA. Molecular cloning and characterization of the structural gene for the major iron-regulated protein expressed by Neisseria gonorrhoeae. J Exp Med. 1990 May 1; 171(5):1535-46.
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