Keywords
Last Name

Thomas Van Dyke, PhD

TitleAdjunct Professor
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address100 E. Newton St Goldman SDM
Boston MA 02118
Phone(617) 638-4758
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Boston University School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mohamed Ali H, Berggreen E, Nguyen D, Wahab Ali R, Van Dyke TE, Hasturk H, Mustafa M. Dental plaque microbial profiles of children from Khartoum, Sudan, with congenital heart defects. J Oral Microbiol. 2017; 9(1):1281556. PMID: 28326155.
    View in: PubMed
  2. Freire MO, Dalli J, Serhan CN, Van Dyke TE. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 Jan 15; 198(2):718-728. PMID: 27994073.
    View in: PubMed
  3. Konermann A, Van Dyke T, Kantarci A, Jäger A. GABAB Receptors as Modulating Target for Inflammatory Responses of the Periodontal Ligament. Cell Mol Neurobiol. 2016 Nov 03. PMID: 27812916.
    View in: PubMed
  4. Kurgan S, Kansal S, Nguyen D, Stephens D, Koroneos Y, Hasturk H, Van Dyke TE, Kantarci A. Strain-Specific Impact of Fusobacterium nucleatum on Neutrophil Function. J Periodontol. 2017 Apr; 88(4):380-389. PMID: 27762731.
    View in: PubMed
  5. Lee CT, Teles R, Kantarci A, Chen T, McCafferty J, Starr JR, Brito LC, Paster BJ, Van Dyke TE. Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis. J Immunol. 2016 Oct 01; 197(7):2796-806. PMID: 27543615.
    View in: PubMed
  6. El-Sharkawy HM, Anees MM, Van Dyke TE. Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial. J Periodontol. 2016 Dec; 87(12):1418-1426. PMID: 27468795.
    View in: PubMed
  7. Mendes RT, Nguyen D, Stephens D, Pamuk F, Fernandes D, Van Dyke TE, Kantarci A. Endothelial Cell Response to Fusobacterium nucleatum. Infect Immun. 2016 Jul; 84(7):2141-8. PMID: 27185790.
    View in: PubMed
  8. Movila A, Ishii T, Albassam A, Wisitrasameewong W, Howait M, Yamaguchi T, Ruiz-Torruella M, Bahammam L, Nishimura K, Van Dyke T, Kawai T. Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions. J Bone Miner Res. 2016 Sep; 31(9):1688-700. PMID: 27082509.
    View in: PubMed
  9. Damgaard C, Kantarci A, Holmstrup P, Hasturk H, Nielsen CH, Van Dyke TE. Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-a, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1. J Periodontal Res. 2017 Apr; 52(2):246-254. PMID: 27146665.
    View in: PubMed
  10. Papathanasiou E, Kantarci A, Konstantinidis A, Gao H, Van Dyke TE. SOCS-3 Regulates Alveolar Bone Loss in Experimental Periodontitis. J Dent Res. 2016 Aug; 95(9):1018-25. PMID: 27126447.
    View in: PubMed
  11. Konermann A, Kantarci A, Wilbert S, Van Dyke T, Jäger A. Verification of ?-Amino-Butyric Acid (GABA) Signaling System Components in Periodontal Ligament Cells In Vivo and In Vitro. Cell Mol Neurobiol. 2016 Nov; 36(8):1353-1363. PMID: 26865191.
    View in: PubMed
  12. Sima C, Van Dyke TE. Therapeutic Targets for Management of Periodontitis and Diabetes. Curr Pharm Des. 2016; 22(15):2216-37. PMID: 26881443.
    View in: PubMed
  13. Zamakhchari MF, Sima C, Sama K, Fine N, Glogauer M, Van Dyke TE, Gyurko R. Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation. Am J Pathol. 2016 Mar; 186(3):659-70. PMID: 26747235.
    View in: PubMed
  14. Wang CW, Colas RA, Dalli J, Arnardottir HH, Nguyen D, Hasturk H, Chiang N, Van Dyke TE, Serhan CN. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. Infect Immun. 2016 Mar; 84(3):658-65. PMID: 26667839.
    View in: PubMed
  15. Steffens JP, Coimbra LS, Rossa C, Kantarci A, Van Dyke TE, Spolidorio LC. Androgen receptors and experimental bone loss - an in vivo and in vitro study. Bone. 2015 Dec; 81:683-90. PMID: 26450018.
    View in: PubMed
  16. Muluke M, Gold T, Kiefhaber K, Al-Sahli A, Celenti R, Jiang H, Cremers S, Van Dyke T, Schulze-Späte U. Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss. J Dent Res. 2016 Feb; 95(2):223-9. PMID: 26450512.
    View in: PubMed
  17. Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3ß-C/EBPß pathway. Nat Commun. 2015; 6:8272. PMID: 26374165.
    View in: PubMed
  18. Kang EH, Lee JT, Lee HJ, Lee JY, Chang SH, Cho HJ, Choi BY, Ha YJ, Park KU, Song YW, Van Dyke TE, Lee YJ. Chronic Periodontitis Is Associated With Spinal Dysmobility in Patients With Ankylosing Spondylitis. J Periodontol. 2015 Dec; 86(12):1303-13. PMID: 26291296.
    View in: PubMed
  19. Herrera BS, Kantarci A, Zarrough A, Hasturk H, Leung KP, Van Dyke TE. LXA4 actions direct fibroblast function and wound closure. Biochem Biophys Res Commun. 2015 Sep 4; 464(4):1072-7. PMID: 26188508.
    View in: PubMed
  20. Steffens JP, Wang X, Starr JR, Spolidorio LC, Van Dyke TE, Kantarci A. Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III. J Periodontol. 2015 Oct; 86(10):1116-25. PMID: 26062840.
    View in: PubMed
  21. Kantarci A, Hasturk H, Van Dyke TE. Animal models for periodontal regeneration and peri-implant responses. Periodontol 2000. 2015 Jun; 68(1):66-82. PMID: 25867980.
    View in: PubMed
  22. Kholy KE, Genco RJ, Van Dyke TE. Oral infections and cardiovascular disease. Trends Endocrinol Metab. 2015 Jun; 26(6):315-21. PMID: 25892452.
    View in: PubMed
  23. Hasturk H, Abdallah R, Kantarci A, Nguyen D, Giordano N, Hamilton J, Van Dyke TE. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1123-33. PMID: 25792445.
    View in: PubMed
  24. Van Dyke TE. Group A. Reactor Paper. Plaque control: home remedies practiced in developing countries. J Int Acad Periodontol. 2015 Jan; 17(1 Suppl):16. PMID: 25764585.
    View in: PubMed
  25. Ciancio S, Slot DE, Van Dyke T, Al Bayaty F, Aswapati NW, Joshi V, Kendall K, Leung K, Patel N, Pradhan S, Senevirante C, Takashiba S, Vidhale P. Group A. Consensus paper. Plaque control--home remedies practiced in developing countries. J Int Acad Periodontol. 2015 Jan; 17(1 Suppl):17-20. PMID: 25764586.
    View in: PubMed
  26. Elabdeen HR, Mustafa M, Hasturk H, Klepac-Ceraj V, Ali RW, Paster BJ, Van Dyke T, Bolstad AI. Subgingival microbial profiles of Sudanese patients with aggressive periodontitis. J Periodontal Res. 2015 Oct; 50(5):674-82. PMID: 25487558.
    View in: PubMed
  27. Herrera BS, Hasturk H, Kantarci A, Freire MO, Nguyen O, Kansal S, Van Dyke TE. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infect Immun. 2015 Feb; 83(2):792-801. PMID: 25486994.
    View in: PubMed
  28. Van Dyke TE, Hasturk H, Kantarci A, Freire MO, Nguyen D, Dalli J, Serhan CN. Proresolving nanomedicines activate bone regeneration in periodontitis. J Dent Res. 2015 Jan; 94(1):148-56. PMID: 25389003.
    View in: PubMed
  29. Ayilavarapu S, Kantarci A, Hasturk H, Van Dyke TE. IPLA2 mRNA expression by human neutrophils in type 2 diabetes and chronic periodontitis. J Int Acad Periodontol. 2014 Oct; 16(4):121-6. PMID: 25654966.
    View in: PubMed
  30. Damgaard C, Holmstrup P, Van Dyke TE, Nielsen CH. The complement system and its role in the pathogenesis of periodontitis: current concepts. J Periodontal Res. 2015 Jun; 50(3):283-93. PMID: 25040158.
    View in: PubMed
  31. Naqvi AZ, Hasturk H, Mu L, Phillips RS, Davis RB, Halem S, Campos H, Goodson JM, Van Dyke TE, Mukamal KJ. Docosahexaenoic Acid and Periodontitis in Adults: A Randomized Controlled Trial. J Dent Res. 2014 Aug; 93(8):767-73. PMID: 24970858.
    View in: PubMed
  32. Martin CR, Zaman MM, Gilkey C, Salguero MV, Hasturk H, Kantarci A, Van Dyke TE, Freedman SD. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. PLoS One. 2014; 9(6):e98773. PMID: 24892762.
    View in: PubMed
  33. Borgnakke WS, Chapple IL, Genco RJ, Armitage G, Bartold PM, D'Aiuto F, Eke PI, Giannobile WV, Kocher T, Kornman KS, Lang NP, Madianos PN, Murakami S, Nishimura F, Offenbacher S, Preshaw PM, Rahman AU, Sanz M, Slots J, Tonetti MS, Van Dyke TE. The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems. J Evid Based Dent Pract. 2014 Sep; 14(3):127-32. PMID: 25234213.
    View in: PubMed
  34. Gaffen SL, Herzberg MC, Taubman MA, Van Dyke TE. Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease. Adv Dent Res. 2014 May; 26(1):30-7. PMID: 24736702.
    View in: PubMed
  35. Zhu M, Belkina AC, DeFuria J, Carr JD, Van Dyke TE, Gyurko R, Nikolajczyk BS. B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation. J Leukoc Biol. 2014 Aug; 96(2):349-57. PMID: 24782490.
    View in: PubMed
  36. Van Dyke TE. Commentary: periodontitis is characterized by an immuno-inflammatory host-mediated destruction of bone and connective tissues that support the teeth. J Periodontol. 2014 Apr; 85(4):509-11. PMID: 24678865.
    View in: PubMed
  37. Scarparo RK, Dondoni L, Böttcher DE, Grecca FS, Figueiredo JA, Kantarci A, Van Dyke TE, Batista EL. Intracanal delivery of Resolvin E1 controls inflammation in necrotic immature rat teeth. J Endod. 2014 May; 40(5):678-82. PMID: 24767563.
    View in: PubMed
  38. Steffens JP, Herrera BS, Coimbra LS, Stephens DN, Rossa C, Spolidorio LC, Kantarci A, Van Dyke TE. Testosterone regulates bone response to inflammation. Horm Metab Res. 2014 Mar; 46(3):193-200. PMID: 24526374.
    View in: PubMed
  39. Hasturk H, Kantarci A, Ghattas M, Dangaria SJ, Abdallah R, Morgan EF, Diekwisch TG, Ashman A, Van Dyke T. The use of light/chemically hardened polymethylmethacrylate, polyhydroxylethylmethacrylate, and calcium hydroxide graft material in combination with polyanhydride around implants and extraction sockets in minipigs: Part II: histologic and micro-CT evaluations. J Periodontol. 2014 Sep; 85(9):1230-9. PMID: 24502615.
    View in: PubMed
  40. Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2014 Feb; 64(1):57-80. PMID: 24320956.
    View in: PubMed
  41. Dondoni L, Scarparo RK, Kantarci A, Van Dyke TE, Figueiredo JA, Batista EL. Effect of the pro-resolution lipid mediator Resolvin E1 (RvE1) on pulp tissues exposed to the oral environment. Int Endod J. 2014 Sep; 47(9):827-34. PMID: 24298979.
    View in: PubMed
  42. Gao A, Van Dyke TE. Role of suppressors of cytokine signaling 3 in bone inflammatory responses. Front Immunol. 2014 Jan 10; 4:506. PMID: 24454312.
    View in: PubMed
  43. Gyurko R, Van Dyke TE. The role of polyunsaturated ?-3 fatty acid eicosapentaenoic acid-derived resolvin E1 (RvE1) in bone preservation. Crit Rev Immunol. 2014; 34(4):347-57. PMID: 24941160.
    View in: PubMed
  44. Van Dyke TE, Starr JR. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc. 2013; 2(6):e000657. PMID: 24342998.
    View in: PubMed
  45. Janket SJ, Baird AE, Jones JA, Jackson EA, Surakka M, Tao W, Meurman JH, Van Dyke TE. Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort. J Clin Periodontol. 2014 Feb; 41(2):131-40. PMID: 24354534.
    View in: PubMed
  46. Zenobia C, Hasturk H, Nguyen D, Van Dyke TE, Kantarci A, Darveau RP. Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model. Infect Immun. 2014 Feb; 82(2):650-9. PMID: 24478080.
    View in: PubMed
  47. Batista EL, Kantarci AI, Hasturk H, Van Dyke TE. Alternative splicing generates a diacylglycerol kinase a transcript that acts as a dominant-negative modulator of superoxide production in localized aggressive periodontitis. J Periodontol. 2014 Jul; 85(7):934-43. PMID: 24171497.
    View in: PubMed
  48. Freire MO, Van Dyke TE. Natural resolution of inflammation. Periodontol 2000. 2013 Oct; 63(1):149-64. PMID: 23931059.
    View in: PubMed
  49. Subramanian S, Emami H, Vucic E, Singh P, Vijayakumar J, Fifer KM, Alon A, Shankar SS, Farkouh M, Rudd JH, Fayad ZA, Van Dyke TE, Tawakol A. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol. 2013 Dec 24; 62(25):2382-91. PMID: 24070911.
    View in: PubMed
  50. Herrera BS, Bastos AS, Coimbra LS, Teixeira SA, Rossa C, Van Dyke TE, Muscara MN, Spolidorio LC. Peripheral blood mononuclear phagocytes from patients with chronic periodontitis are primed for osteoclast formation. J Periodontol. 2014 Apr; 85(4):e72-81. PMID: 24059638.
    View in: PubMed
  51. Xue Y, Xing Z, Bolstad AI, Van Dyke TE, Mustafa K. Co-culture of human bone marrow stromal cells with endothelial cells alters gene expression profiles. Int J Artif Organs. 2013 Oct 3; 36(9):650-62. PMID: 23918270.
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  52. Hasturk H, Nguyen DH, Sherzai H, Song X, Soukos N, Bidlack FB, Van Dyke TE. Comparison of the impact of scaler material composition on polished titanium implant abutment surfaces. J Dent Hyg. 2013 Aug; 87(4):200-11. PMID: 23986413.
    View in: PubMed
  53. Mustafa M, Zarrough A, Bolstad AI, Lygre H, Mustafa K, Hasturk H, Serhan C, Kantarci A, Van Dyke TE. Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol. 2013 Sep 15; 305(6):C673-9. PMID: 23864609.
    View in: PubMed
  54. Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000. 2013 Jun; 62(1):203-17. PMID: 23574467.
    View in: PubMed
  55. Socransky SS, Haffajee AD, Teles R, Wennstrom JL, Lindhe J, Bogren A, Hasturk H, van Dyke T, Wang X, Goodson JM. Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change. J Clin Periodontol. 2013 Aug; 40(8):771-80. PMID: 23710672.
    View in: PubMed
  56. Zhu M, Van Dyke TE, Gyurko R. Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1. FASEB J. 2013 Aug; 27(8):3344-53. PMID: 23629863.
    View in: PubMed
  57. Browne RW, Kantarci A, LaMonte MJ, Andrews CA, Hovey KM, Falkner KL, Cekici A, Stephens D, Genco RJ, Scannapieco FA, Van Dyke TE, Wactawski-Wende J. Performance of multiplex cytokine assays in serum and saliva among community-dwelling postmenopausal women. PLoS One. 2013; 8(4):e59498. PMID: 23577067.
    View in: PubMed
  58. Tonetti MS, Van Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013 Apr; 40 Suppl 14:S24-9. PMID: 23627332.
    View in: PubMed
  59. Van Dyke TE, van Winkelhoff AJ. Infection and inflammatory mechanisms. J Clin Periodontol. 2013 Apr; 40 Suppl 14:S1-7. PMID: 23627321.
    View in: PubMed
  60. Van Dyke TE, van Winkelhoff AJ. Infection and inflammatory mechanisms. J Periodontol. 2013 Apr; 84(4 Suppl):S1-7. PMID: 23631571.
    View in: PubMed
  61. Tonetti MS, Van Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013 Apr; 84(4 Suppl):S24-9. PMID: 23631582.
    View in: PubMed
  62. Gao A, Kantarci A, Herrera BS, Gao H, Van Dyke TE. Correction: A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts. PeerJ. 2013; 1. PMID: 24191232.
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  63. Gao A, Kantarci A, Herrera BS, Herrera B, Gao H, Van Dyke TE. A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts. PeerJ. 2013; 1:e51. PMID: 23638389.
    View in: PubMed
  64. Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN, Van Dyke TE, Gyurko R. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013 Jan 15; 190(2):689-94. PMID: 23241890.
    View in: PubMed
  65. Berker E, Kantarci A, Hasturk H, Van Dyke TE. Blocking proinflammatory cytokine release modulates peripheral blood mononuclear cell response to Porphyromonas gingivalis. J Periodontol. 2013 Sep; 84(9):1337-45. PMID: 23173823.
    View in: PubMed
  66. Gao L, Cyurko R, Van Dyke T. [Attenuation of experimental peritonitis and periodontitis in human chemokine-like receptor 1 (CMKLR1 or hChemR23) transgenic mice]. Beijing Da Xue Xue Bao. 2012 Jun 18; 44(3):469-74. PMID: 22692323.
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  67. Hasturk H, Kantarci A, Van Dyke TE. Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol. 2012; 3:118. PMID: 22623923.
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  68. Goodson JM, Haffajee AD, Socransky SS, Kent R, Teles R, Hasturk H, Bogren A, Van Dyke T, Wennstrom J, Lindhe J. Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol. 2012 Jun; 39(6):526-36. PMID: 22512461.
    View in: PubMed
  69. Rocha Dde M, Zenóbio EG, Van Dyke T, Silva KS, Costa FO, Soares RV. Differential expression of salivary glycoproteins in aggressive and chronic periodontitis. J Appl Oral Sci. 2012 Mar-Apr; 20(2):180-5. PMID: 22666834.
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  70. Colombo AP, Bennet S, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst FE, Paster BJ. Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. J Periodontol. 2012 Oct; 83(10):1279-87. PMID: 22324467.
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  71. Van Dyke TE. The impact of genotypes and immune reactivity on peri-implant inflammation: Identification and therapeutic use of anti-inflammatory drugs and immunomodulators. Eur J Oral Implantol. 2012; 5 Suppl:S51-60. PMID: 22834394.
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  72. Hasturk H, Kantarci A, Van Dyke TE. Paradigm shift in the pharmacological management of periodontal diseases. Front Oral Biol. 2012; 15:160-76. PMID: 22142963.
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  73. Karima MM, Van Dyke TE. Enamel matrix derivative promotes superoxide production and chemotaxis but reduces matrix metalloproteinase-8 expression by polymorphonuclear leukocytes. J Periodontol. 2012 Jun; 83(6):780-6. PMID: 22050547.
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  74. Fredman G, Oh SF, Ayilavarapu S, Hasturk H, Serhan CN, Van Dyke TE. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One. 2011; 6(9):e24422. PMID: 21935407.
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  75. Baloul SS, Gerstenfeld LC, Morgan EF, Carvalho RS, Van Dyke TE, Kantarci A. Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication-facilitated tooth movement. Am J Orthod Dentofacial Orthop. 2011 Apr; 139(4 Suppl):S83-101. PMID: 21435543.
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  76. Herrera BS, Martins-Porto R, Maia-Dantas A, Campi P, Spolidorio LC, Costa SK, Van Dyke TE, Gyurko R, Muscara MN. iNOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature-induced periodontitis in rats. J Periodontol. 2011 Nov; 82(11):1608-15. PMID: 21417589.
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  77. Van Dyke TE. Proresolving lipid mediators: potential for prevention and treatment of periodontitis. J Clin Periodontol. 2011 Mar; 38 Suppl 11:119-25. PMID: 21323709.
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  78. Hasturk H, Kantarci A, Ghattas M, Schmidt M, Giordano RA, Ashman A, Diekwisch TG, Van Dyke T. The use of light/chemically hardened polymethylmethacrylate, polyhydroxyethylmethacrylate, and calcium hydroxide graft material in combination with polyanhydride around implants in minipigs: part I: immediate stability and function. J Periodontol. 2011 Sep; 82(9):1339-52. PMID: 21342001.
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  79. Price AM, Nunn M, Oppenheim FG, Van Dyke TE. De novo bone formation after the sinus lift procedure. J Periodontol. 2011 Sep; 82(9):1245-55. PMID: 21235336.
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  80. Sima C, Rhourida K, Van Dyke TE, Gyurko R. Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo. J Periodontal Res. 2010 Dec; 45(6):748-56. PMID: 20682016.
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  81. Stashenko P, Van Dyke T, Tully P, Kent R, Sonis S, Tanner AC. Inflammation and genetic risk indicators for early periodontitis in adults. J Periodontol. 2011 Apr; 82(4):588-96. PMID: 21054222.
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  82. Herrera BS, Martins-Porto R, Campi P, Holzhausen M, Teixeira SA, Mendes GD, Costa SK, Gyurko R, Van Dyke TE, Spolidório LC, Muscará MN. Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats. Arch Oral Biol. 2011 Jan; 56(1):41-7. PMID: 20864089.
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  83. Genco RJ, Van Dyke TE. Prevention: Reducing the risk of CVD in patients with periodontitis. Nat Rev Cardiol. 2010 Sep; 7(9):479-80. PMID: 20725103.
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  84. Fredman G, Van Dyke TE, Serhan CN. Resolvin E1 regulates adenosine diphosphate activation of human platelets. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):2005-13. PMID: 20702811.
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  85. Qvarnstrom M, Janket SJ, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE, Meurman JH. Association of salivary lysozyme and C-reactive protein with metabolic syndrome. J Clin Periodontol. 2010 Sep; 37(9):805-11. PMID: 20666873.
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  86. Ekstein J, Shapira L, Van Dyke TE. [The pathogenesis of periodontal disease: a paradigm shift]. Refuat Hapeh Vehashinayim. 2010 Jul; 27(3):35-9, 63. PMID: 21485556.
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  87. El-Sharkawy H, Aboelsaad N, Eliwa M, Darweesh M, Alshahat M, Kantarci A, Hasturk H, Van Dyke TE. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin. J Periodontol. 2010 Nov; 81(11):1635-43. PMID: 20572767.
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  88. Zawawi KH, Kantarci A, Schulze-Späte U, Fujita T, Batista EL, Amar S, Van Dyke TE. Moesin-induced signaling in response to lipopolysaccharide in macrophages. J Periodontal Res. 2010 Oct; 45(5):589-601. PMID: 20546116.
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  89. de Santana RB, de Mattos CM, Francischone CE, Van Dyke T. Superficial topography and porosity of an absorbable barrier membrane impacts soft tissue response in guided bone regeneration. J Periodontol. 2010 Jun; 81(6):926-33. PMID: 20380512.
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  90. Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia. 2010 Jul; 53(7):1461-71. PMID: 20383694.
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  91. Janket S, Meurman JH, Baird AE, Qvarnström M, Nuutinen P, Ackerson LK, Hong J, Muthukrishnan P, Van Dyke TE. Salivary immunoglobulins and prevalent coronary artery disease. J Dent Res. 2010 Apr; 89(4):389-94. PMID: 20177131.
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  92. Ayilavarapu S, Kantarci A, Fredman G, Turkoglu O, Omori K, Liu H, Iwata T, Yagi M, Hasturk H, Van Dyke TE. Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils. J Immunol. 2010 Feb 1; 184(3):1507-15. PMID: 20053941.
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  93. Jagannathan M, Hasturk H, Liang Y, Shin H, Hetzel JT, Kantarci A, Rubin D, McDonnell ME, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J Immunol. 2009 Dec 1; 183(11):7461-70. PMID: 19917698.
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  94. Ohira T, Arita M, Omori K, Recchiuti A, Van Dyke TE, Serhan CN. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem. 2010 Jan 29; 285(5):3451-61. PMID: 19906641.
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  95. Yagi M, Kantarci A, Iwata T, Omori K, Ayilavarapu S, Ito K, Hasturk H, Van Dyke TE. PDK1 regulates chemotaxis in human neutrophils. J Dent Res. 2009 Dec; 88(12):1119-24. PMID: 19892919.
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  96. Santana RB, de Mattos CM, Van Dyke T. Efficacy of combined regenerative treatments in human mandibular class II furcation defects. J Periodontol. 2009 Nov; 80(11):1756-64. PMID: 19905945.
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  97. Colombo AP, Boches SK, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst F, Paster BJ. Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J Periodontol. 2009 Sep; 80(9):1421-32. PMID: 19722792.
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  98. Iwata T, Kantarci A, Yagi M, Jackson T, Hasturk H, Kurihara H, Van Dyke TE. Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. J Periodontol. 2009 Aug; 80(8):1300-6. PMID: 19656030.
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  99. Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol. 2009 Jul; 80(7):1021-32. PMID: 19563277.
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  100. Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. Am J Cardiol. 2009 Jul 1; 104(1):59-68. PMID: 19576322.
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  101. Dornelles FN, Santos DS, Van Dyke TE, Calixto JB, Batista EL, Campos MM. In vivo up-regulation of kinin B1 receptors after treatment with Porphyromonas gingivalis lipopolysaccharide in rat paw. J Pharmacol Exp Ther. 2009 Sep; 330(3):756-63. PMID: 19561153.
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  102. Van Dyke TE. Resolution of inflammation-unraveling mechanistic links between periodontitis and cardiovascular disease. J Dent. 2009 Aug; 37(8):S582-3. PMID: 19501948.
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  103. Gapski R, Hasturk H, Van Dyke TE, Oringer RJ, Wang S, Braun TM, Giannobile WV. Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial. J Clin Periodontol. 2009 Feb; 36(2):149-56. PMID: 19207891.
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  104. Offenbacher S, Beck JD, Moss K, Mendoza L, Paquette DW, Barrow DA, Couper DJ, Stewart DD, Falkner KL, Graham SP, Grossi S, Gunsolley JC, Madden T, Maupome G, Trevisan M, Van Dyke TE, Genco RJ. Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol. 2009 Feb; 80(2):190-201. PMID: 19186958.
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  105. Cobb CM, Costerton JW, Van Dyke TE. Have we become so focused on inflammation and host response that we have neglected the role of bacteria in initiating periodontal disease? Compend Contin Educ Dent. 2009 Jan-Feb; 30(1):46, 48. PMID: 19263764.
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  106. Van Dyke TE. The etiology and pathogenesis of periodontitis revisited. J Appl Oral Sci. 2009 Jan-Feb; 17(1). PMID: 19148397.
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  107. Shin H, Zhang Y, Jagannathan M, Hasturk H, Kantarci A, Liu H, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. B cells from periodontal disease patients express surface Toll-like receptor 4. J Leukoc Biol. 2009 Apr; 85(4):648-55. PMID: 19118102.
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  108. Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko R. An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Br J Pharmacol. 2008 Dec; 155(8):1214-23. PMID: 18806821.
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  109. Sebaoun JD, Kantarci A, Turner JW, Carvalho RS, Van Dyke TE, Ferguson DJ. Modeling of trabecular bone and lamina dura following selective alveolar decortication in rats. J Periodontol. 2008 Sep; 79(9):1679-88. PMID: 18771369.
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  110. Shahidi P, Jacobson Z, Dibart S, Pourati J, Nunn ME, Barouch K, Van Dyke TE. Efficacy of a new papilla generation technique in implant dentistry: a preliminary study. Int J Oral Maxillofac Implants. 2008 Sep-Oct; 23(5):926-34. PMID: 19014164.
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  111. Van Dyke TE, Kornman KS. Inflammation and factors that may regulate inflammatory response. J Periodontol. 2008 Aug; 79(8 Suppl):1503-7. PMID: 18673003.
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  112. Van Dyke TE. The management of inflammation in periodontal disease. J Periodontol. 2008 Aug; 79(8 Suppl):1601-8. PMID: 18673016.
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  113. Kornman KS, Van Dyke TE. Bringing light to the heat: "inflammation and periodontal diseases: a reappraisal". J Periodontol. 2008 Aug; 79(8):1313. PMID: 18672978.
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  114. Van Dyke TE. Inflammation and periodontal diseases: a reappraisal. J Periodontol. 2008 Aug; 79(8 Suppl):1501-2. PMID: 18673002.
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  115. Seabra RC, Costa FO, Costa JE, Van Dyke T, Soares RV. Impact of clinical experience on the accuracy of probing depth measurements. Quintessence Int. 2008 Jul-Aug; 39(7):559-65. PMID: 19107263.
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  116. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008 May; 8(5):349-61. PMID: 18437155.
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  117. Qvarnstrom M, Janket S, Jones JA, Nuutinen P, Baird AE, Nunn ME, Van Dyke TE, Meurman JH. Salivary lysozyme and prevalent hypertension. J Dent Res. 2008 May; 87(5):480-4. PMID: 18434581.
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  118. Omori K, Ohira T, Uchida Y, Ayilavarapu S, Batista EL, Yagi M, Iwata T, Liu H, Hasturk H, Kantarci A, Van Dyke TE. Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. J Leukoc Biol. 2008 Jul; 84(1):292-301. PMID: 18390927.
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  119. Davé S, Van Dyke T. The link between periodontal disease and cardiovascular disease is probably inflammation. Oral Dis. 2008 Mar; 14(2):95-101. PMID: 18302669.
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  120. Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol. 2008 Feb; 35(2):89-105. PMID: 18199146.
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  121. Couper DJ, Beck JD, Falkner KL, Graham SP, Grossi SG, Gunsolley JC, Madden T, Maupome G, Offenbacher S, Stewart DD, Trevisan M, Van Dyke TE, Genco RJ. The Periodontitis and Vascular Events (PAVE) pilot study: recruitment, retention, and community care controls. J Periodontol. 2008 Jan; 79(1):80-9. PMID: 18166096.
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  122. Beck JD, Couper DJ, Falkner KL, Graham SP, Grossi SG, Gunsolley JC, Madden T, Maupome G, Offenbacher S, Stewart DD, Trevisan M, Van Dyke TE, Genco RJ. The Periodontitis and Vascular Events (PAVE) pilot study: adverse events. J Periodontol. 2008 Jan; 79(1):90-6. PMID: 18166097.
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  123. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007 Nov 15; 179(10):7021-9. PMID: 17982093.
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  124. Zafiropoulos GG, Hoffmann O, Kasaj A, Willershausen B, Weiss O, Van Dyke TE. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta-tricalcium phosphate bone substitute or bovine-derived xenograft. J Periodontol. 2007 Nov; 78(11):2216-25. PMID: 17970691.
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  125. Janket SJ, Jones JA, Meurman JH, Baird AE, Van Dyke TE. Oral infection, hyperglycemia, and endothelial dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Feb; 105(2):173-9. PMID: 17905606.
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  126. Tanner AC, Kent R, Kanasi E, Lu SC, Paster BJ, Sonis ST, Murray LA, Van Dyke TE. Clinical characteristics and microbiota of progressing slight chronic periodontitis in adults. J Clin Periodontol. 2007 Nov; 34(11):917-30. PMID: 17877747.
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  127. Ding Y, Kantarci A, Badwey JA, Hasturk H, Malabanan A, Van Dyke TE. Phosphorylation of pleckstrin increases proinflammatory cytokine secretion by mononuclear phagocytes in diabetes mellitus. J Immunol. 2007 Jul 1; 179(1):647-54. PMID: 17579087.
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  128. Dhar V, Jain A, Van Dyke TE, Kohli A. Prevalence of dental caries and treatment needs in the school-going children of rural areas in Udaipur district. J Indian Soc Pedod Prev Dent. 2007 Jul-Sep; 25(3):119-21. PMID: 17951926.
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  129. Herrmann JM, Bernardo J, Long HJ, Seetoo K, McMenamin ME, Batista EL, Van Dyke TE, Simons ER. Sequential chemotactic and phagocytic activation of human polymorphonuclear neutrophils. Infect Immun. 2007 Aug; 75(8):3989-98. PMID: 17526745.
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  130. Dhar V, Jain A, Van Dyke TE, Kohli A. Prevalence of gingival diseases, malocclusion and fluorosis in school-going children of rural areas in Udaipur district. J Indian Soc Pedod Prev Dent. 2007 Apr-Jun; 25(2):103-5. PMID: 17660647.
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  131. El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, Van Dyke TE. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol. 2007 Apr; 78(4):661-9. PMID: 17397313.
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  132. Van Dyke TE. Control of inflammation and periodontitis. Periodontol 2000. 2007; 45:158-66. PMID: 17850455.
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  133. Van Dyke TE. Cellular and molecular susceptibility determinants for periodontitis. Periodontol 2000. 2007; 45:10-3. PMID: 17850445.
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  134. Nassar H, Kantarci A, van Dyke TE. Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation. Periodontol 2000. 2007; 43:233-44. PMID: 17214841.
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  135. Dietrich T, Kaye EK, Nunn ME, Van Dyke T, Garcia RI. Gingivitis susceptibility and its relation to periodontitis in men. J Dent Res. 2006 Dec; 85(12):1134-7. PMID: 17122168.
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  136. Gyurko R, Siqueira CC, Caldon N, Gao L, Kantarci A, Van Dyke TE. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol. 2006 Nov 15; 177(10):7250-6. PMID: 17082643.
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  137. Ding Y, Kantarci A, Hasturk H, Trackman PC, Malabanan A, Van Dyke TE. Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes. J Leukoc Biol. 2007 Feb; 81(2):520-7. PMID: 17095613.
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  138. Ariel A, Fredman G, Sun YP, Kantarci A, Van Dyke TE, Luster AD, Serhan CN. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006 Nov; 7(11):1209-16. PMID: 17013391.
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  139. Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal-Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A, Firatli E, Sheff M, Hasturk H, Van Dyke TE, Trackman PC. Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. J Pathol. 2006 Sep; 210(1):59-66. PMID: 16841303.
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  140. Janket SJ, Jones J, Rich S, Miller D, Wehler CJ, Van Dyke TE, Garcia R, Meurman JH. The effects of xerogenic medications on oral mucosa among the Veterans Dental Study participants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Feb; 103(2):223-30. PMID: 17234540.
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  141. Tanner AC, Paster BJ, Lu SC, Kanasi E, Kent R, Van Dyke T, Sonis ST. Subgingival and tongue microbiota during early periodontitis. J Dent Res. 2006 Apr; 85(4):318-23. PMID: 16567551.
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  142. Hasturk H, Kantarci A, Ebrahimi N, Andry C, Holick M, Jones VL, Van Dyke TE. Topical H2 antagonist prevents periodontitis in a rabbit model. Infect Immun. 2006 Apr; 74(4):2402-14. PMID: 16552070.
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  143. Miyamoto T, Kumagai T, Jones JA, Van Dyke TE, Nunn ME. Compliance as a prognostic indicator: retrospective study of 505 patients treated and maintained for 15 years. J Periodontol. 2006 Feb; 77(2):223-32. PMID: 16460248.
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  144. Janket SJ, Meurman JH, Nuutinen P, Qvarnström M, Nunn ME, Baird AE, Van Dyke TE, Jones JA. Salivary lysozyme and prevalent coronary heart disease: possible effects of oral health on endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):433-4. PMID: 16424364.
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  145. Kantarci A, Hasturk H, Van Dyke TE. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000. 2006; 40:144-63. PMID: 16398691.
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  146. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J. 2006 Feb; 20(2):401-3. PMID: 16373400.
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  147. Janket SJ, Wightman A, Baird AE, Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res. 2005 Dec; 84(12):1154-9. PMID: 16304446.
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  148. Kantarci A, Van Dyke TE. Resolution of inflammation in periodontitis. J Periodontol. 2005 Nov; 76(11 Suppl):2168-74. PMID: 16277590.
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  149. Fujita T, Kantarci A, Warbington ML, Zawawi KH, Hasturk H, Kurihara H, Van Dyke TE. CD38 expression in neutrophils from patients with localized aggressive periodontitis. J Periodontol. 2005 Nov; 76(11):1960-5. PMID: 16274316.
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  150. Van Dyke TE. The clinical significance of new therapies for the management of periodontal disease. J Int Acad Periodontol. 2005 Oct; 7(4 Suppl):191-6. PMID: 16248275.
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  151. Gibson FC, Savelli J, Van Dyke TE, Genco CA. Gingipain-specific IgG in the sera of patients with periodontal disease is necessary for opsonophagocytosis of Porphyromonas gingivalis. J Periodontol. 2005 Oct; 76(10):1629-36. PMID: 16253083.
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  152. Kantarci A, Van Dyke TE. Lipoxin signaling in neutrophils and their role in periodontal disease. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):289-99. PMID: 15979867.
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  153. Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, Malabanan A, Trackman PC, Badwey JA, Van Dyke TE. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol. 2005 Oct; 78(4):862-70. PMID: 16081595.
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  154. Herrmann JM, Kantarci A, Long H, Bernardo J, Hasturk H, Wray LV, Simons ER, Van Dyke TE. Simultaneous measurements of cytoplasmic Ca2+ responses and intracellular pH in neutrophils of localized aggressive periodontitis (LAP) patients. J Leukoc Biol. 2005 Sep; 78(3):612-9. PMID: 15937144.
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  155. Berker E, Kantarci A, Hasturk H, Van Dyke TE. Effect of neutrophil apoptosis on monocytic cytokine response to Porphyromonas gingivalis lipopolysaccharide. J Periodontol. 2005 Jun; 76(6):964-71. PMID: 15948692.
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  156. Van Dyke TE, Cutler CW, Kowolik M, Singer RS, Buchanan W, Biesbrock AR. Effect of topical cimetidine rinse on gingival crevicular neutrophil leukocyte function. J Periodontol. 2005 Jun; 76(6):998-1005. PMID: 15948697.
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  157. Litkowski LJ, Christensen SE, Adamson DN, Van Dyke T, Han SH, Newman KB. Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. Clin Ther. 2005 Apr; 27(4):418-29. PMID: 15922815.
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  158. Tanner AC, Kent R, Van Dyke T, Sonis ST, Murray LA. Clinical and other risk indicators for early periodontitis in adults. J Periodontol. 2005 Apr; 76(4):573-81. PMID: 15857098.
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  159. Batista EL, Warbington M, Badwey JA, Van Dyke TE. Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). J Cell Biochem. 2005 Mar 1; 94(4):774-93. PMID: 15578578.
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  160. Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone. 2005 Mar; 36(3):472-9. PMID: 15777672.
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  161. Fujita T, Zawawi KH, Kurihara H, Van Dyke TE. CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase. Cell Signal. 2005 Feb; 17(2):167-75. PMID: 15494208.
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  162. Van Dyke TE, Sheilesh D. Risk factors for periodontitis. J Int Acad Periodontol. 2005 Jan; 7(1):3-7. PMID: 15736889.
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  163. Van Dyke T, Litkowski LJ, Kiersch TA, Zarringhalam NM, Zheng H, Newman K. Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of postoperative pain: a double-blind, placebo- and active-controlled parallel-group study. Clin Ther. 2004 Dec; 26(12):2003-14. PMID: 15823764.
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  164. Bimstein E, Sapir S, Houri-Haddad Y, Dibart S, Van Dyke TE, Shapira L. The relationship between Porphyromonas gingivalis infection and local and systemic factors in children. J Periodontol. 2004 Oct; 75(10):1371-6. PMID: 15562915.
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  165. Preshaw PM, Hefti AF, Novak MJ, Michalowicz BS, Pihlstrom BL, Schoor R, Trummel CL, Dean J, Van Dyke TE, Walker CB, Bradshaw MH. Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial. J Periodontol. 2004 Aug; 75(8):1068-76. PMID: 15455733.
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  166. Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl GL, Serhan CN, Badwey JA. A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J Immunol. 2004 Aug 1; 173(3):2091-8. PMID: 15265945.
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  167. Froum S, Weinberg M, Novak J, Mailhot J, Mellonig J, Van Dyke T, McClain P, Papapanou PN, Childers G, Ciancio S, Blieden T, Polson A, Greenstein G, Yukna R, Wallace ML, Patters M, Wagener C. A multicenter study evaluating the sensitization potential of enamel matrix derivative after treatment of two infrabony defects. J Periodontol. 2004 Jul; 75(7):1001-8. PMID: 15341359.
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  168. Dave S, Batista EL, Van Dyke TE. Cardiovascular disease and periodontal diseases: commonality and causation. Compend Contin Educ Dent. 2004 Jul; 25(7 Suppl 1):26-37. PMID: 15645884.
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  169. Casavecchia P, Uzel MI, Kantarci A, Hasturk H, Dibart S, Hart TC, Trackman PC, Van Dyke TE. Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report. J Periodontol. 2004 May; 75(5):770-8. PMID: 15212361.
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  170. Iontcheva I, Amar S, Zawawi KH, Kantarci A, Van Dyke TE. Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun. 2004 Apr; 72(4):2312-20. PMID: 15039356.
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  171. Donley CL, Badovinac R, Sapir S, Shapira L, Houri Y, Kantarci A, Warbington ML, Dibart S, Van Dyke TE, Needleman HL, Karimbux N, Bimstein E. IgG antibody levels to Porphyromonas gingivalis and clinical measures in children. J Periodontol. 2004 Feb; 75(2):221-8. PMID: 15068109.
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  172. Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN. A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol. 2004 Feb 1; 172(3):1856-61. PMID: 14734770.
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  173. Fujita T, Shiba H, Van Dyke TE, Kurihara H. Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells. Cell Biol Int. 2004; 28(4):281-6. PMID: 15109984.
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  174. Hasturk H, Nunn M, Warbington M, Van Dyke TE. Efficacy of a fluoridated hydrogen peroxide-based mouthrinse for the treatment of gingivitis: a randomized clinical trial. J Periodontol. 2004 Jan; 75(1):57-65. PMID: 15025217.
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  175. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 Dec 15; 171(12):6856-65. PMID: 14662892.
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  176. Li Y, Xu L, Hasturk H, Kantarci A, DePalma SR, Van Dyke TE. Localized aggressive periodontitis is linked to human chromosome 1q25. Hum Genet. 2004 Feb; 114(3):291-7. PMID: 14673644.
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  177. Oyaizu K, Kantarci A, Maeda H, Batista EL, Hasturk H, Murayama Y, Badwey JA, Van Dyke TE. Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. J Periodontal Res. 2003 Oct; 38(5):488-95. PMID: 12941073.
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  178. Jain A, Batista EL, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003 Oct; 71(10):6012-8. PMID: 14500522.
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  179. Gyurko R, Boustany G, Huang PL, Kantarci A, Van Dyke TE, Genco CA, Gibson FC. Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis. Infect Immun. 2003 Sep; 71(9):4917-24. PMID: 12933833.
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  180. Guzman S, Karima M, Wang HY, Van Dyke TE. Association between interleukin-1 genotype and periodontal disease in a diabetic population. J Periodontol. 2003 Aug; 74(8):1183-90. PMID: 14514232.
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  181. Dibart S, Capri D, Kachouh I, Van Dyke T, Nunn ME. Crown lengthening in mandibular molars: a 5-year retrospective radiographic analysis. J Periodontol. 2003 Jun; 74(6):815-21. PMID: 12886991.
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  182. Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol. 2003 Jul 1; 23(7):1245-9. PMID: 12763762.
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  183. Buchmann R, Müller RF, Van Dyke TE, Lange DE. Change of antibiotic susceptibility following periodontal therapy. A pilot study in aggressive periodontal disease. J Clin Periodontol. 2003 Mar; 30(3):222-9. PMID: 12631180.
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  184. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003 Feb; 82(2):82-90. PMID: 12562878.
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  185. Kantarci A, Van Dyke TE. Lipoxins in chronic inflammation. Crit Rev Oral Biol Med. 2003; 14(1):4-12. PMID: 12764016.
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  186. Kantarci A, Oyaizu K, Van Dyke TE. Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. J Periodontol. 2003 Jan; 74(1):66-75. PMID: 12593599.
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  187. Delima AJ, Van Dyke TE. Origin and function of the cellular components in gingival crevice fluid. Periodontol 2000. 2003; 31:55-76. PMID: 12656996.
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  188. Buchmann R, Hasilik A, Van Dyke TE, Lange DE. Amplified crevicular leukocyte activity in aggressive periodontal disease. J Dent Res. 2002 Oct; 81(10):716-21. PMID: 12351672.
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  189. Kantarci A, Van Dyke TE. Neutrophil-mediated host response to Porphyromonas gingivalis. J Int Acad Periodontol. 2002 Oct; 4(4):119-25. PMID: 12670091.
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  190. Buchmann R, Hasilik A, Van Dyke TE, Lange DE. Resolution of crevicular fluid leukocyte activity in patients treated for aggressive periodontal disease. J Periodontol. 2002 Sep; 73(9):995-1002. PMID: 12296600.
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  191. Catalanotto FA, Quissell D, Rekow D, Van Dyke TE. Local, regional, and global partnerships in developing a research program. J Dent Educ. 2002 Aug; 66(8):942-8; discussion 949-51. PMID: 12214842.
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  192. Van Dyke TE, Offenbacher S, Braswell L, Lessem J. Enhancing the value of scaling and root-planing: Arestin clinical trial results. J Int Acad Periodontol. 2002 Jul; 4(3):72-6. PMID: 12670085.
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  193. Newman HN, Van Dyke TE. The relationship between oral infections and systemic disease. J Int Acad Periodontol. 2002 Jul; 4(3):71. PMID: 12670084.
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  194. Oringer RJ, Van Dyke TE, Lessem J. The challenge of treating periodontal patients who smoke--the efficacy of Arestin. J Int Acad Periodontol. 2002 Jul; 4(3):89-94. PMID: 12670087.
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  195. Buchmann R, Nunn ME, Van Dyke TE, Lange DE. Aggressive periodontitis: 5-year follow-up of treatment. J Periodontol. 2002 Jun; 73(6):675-83. PMID: 12083543.
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  196. Buchmann R, Hasilik A, Nunn ME, Van Dyke TE, Lange DE. PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase-alpha-1-proteinase inhibitor complex. J Clin Periodontol. 2002 Jun; 29(6):563-72. PMID: 12296784.
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  197. Van Dyke TE. The oral/dental/craniofacial complex as a model for inflammatory disease. Compend Contin Educ Dent. 2002 May; 23(5):465-8, 470, 472 passim; quiz 476. PMID: 12060964.
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  198. Van Dyke T, Paquette D, Grossi S, Braman V, Massaro J, D'Agostino R, Dibart S, Friden P. Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study. J Clin Periodontol. 2002 Feb; 29(2):168-76. PMID: 11895545.
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  199. Nassar H, Chou HH, Khlgatian M, Gibson FC, Van Dyke TE, Genco CA. Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Infect Immun. 2002 Jan; 70(1):268-76. PMID: 11748192.
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  200. Henke CJ, Villa KF, Aichelmann-Reidy ME, Armitage GC, Eber RM, Genco RJ, Killoy WJ, Miller DP, Page RC, Polson AM, Ryder MI, Silva SJ, Somerman MJ, Van Dyke TE, Wolff LF, Evans CJ, Finkelman RD. An economic evaluation of a chlorhexidine chip for treating chronic periodontitis: the CHIP (chlorhexidine in periodontitis) study. J Am Dent Assoc. 2001 Nov; 132(11):1557-69. PMID: 11806071.
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  201. Williams RC, Paquette DW, Offenbacher S, Adams DF, Armitage GC, Bray K, Caton J, Cochran DL, Drisko CH, Fiorellini JP, Giannobile WV, Grossi S, Guerrero DM, Johnson GK, Lamster IB, Magnusson I, Oringer RJ, Persson GR, Van Dyke TE, Wolff LF, Santucci EA, Rodda BE, Lessem J. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol. 2001 Nov; 72(11):1535-44. PMID: 11759865.
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  202. Shibata K, Warbington ML, Gordon BJ, Kurihara H, Van Dyke TE. Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis. J Periodontol. 2001 Aug; 72(8):1052-8. PMID: 11525437.
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  203. Mickels N, McManus C, Massaro J, Friden P, Braman V, D'Agostino R, Oppenheim F, Warbington M, Dibart S, Van Dyke T. Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis. J Clin Periodontol. 2001 May; 28(5):404-10. PMID: 11350502.
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  204. Amar S, Oyaisu K, Li L, Van Dyke T. Moesin: a potential LPS receptor on human monocytes. J Endotoxin Res. 2001; 7(4):281-6. PMID: 11717582.
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  205. Van Dyke TE, Tohme ZN. Periodontal diagnosis: evaluation of current concepts and future needs. J Int Acad Periodontol. 2000 Jul; 2(3):71-8. PMID: 12666964.
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  206. Hokett SD, Cuenin MF, O'Neal RB, Brennan WA, Strong SL, Runner RR, McPherson JC, Van Dyke TE. Pluronic polyol effects on human gingival fibroblast attachment and growth. J Periodontol. 2000 May; 71(5):803-9. PMID: 10872963.
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  207. Shibata K, Warbington ML, Gordon BJ, Kurihara H, Van Dyke TE. Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis. J Periodontol. 2000 May; 71(5):797-802. PMID: 10872962.
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  208. Walker SJ, Van Dyke TE, Rich S, Kornman KS, di Giovine FS, Hart TC. Genetic polymorphisms of the IL-1alpha and IL-1beta genes in African-American LJP patients and an African-American control population. J Periodontol. 2000 May; 71(5):723-8. PMID: 10872952.
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  209. Pouliot M, Clish CB, Petasis NA, Van Dyke TE, Serhan CN. Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry. 2000 Apr 25; 39(16):4761-8. PMID: 10769133.
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  210. Hokett SD, Cuenin MF, Peacock ME, Thompson SH, Van Dyke TE. Non-Hodgkin's lymphoma and periodontitis. A case report. J Periodontol. 2000 Mar; 71(3):504-9. PMID: 10776941.
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  211. Hart TC, Hart PS, Michalec MD, Zhang Y, Firatli E, Van Dyke TE, Stabholz A, Zlotogorski A, Shapira L, Soskolne WA, Zlorogorski A. Haim-Munk syndrome and Papillon-Lefèvre syndrome are allelic mutations in cathepsin C. J Med Genet. 2000 Feb; 37(2):88-94. PMID: 10662807.
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  212. Takashiba S, Van Dyke TE, Amar S, Murayama Y, Soskolne AW, Shapira L. Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor kappaB. Infect Immun. 1999 Nov; 67(11):5573-8. PMID: 10531202.
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  213. Soolari AS, Champagne C, Punzi JS, Amar S, Van Dyke TE. Serum modulation of neutrophil response to Porphyromonas gingivalis LPS in periodontal disease. J Int Acad Periodontol. 1999 Oct; 1(4):101-9. PMID: 12666954.
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  214. de La Coste A, Mignon A, Fabre M, Gilbert E, Porteu A, Van Dyke T, Kahn A, Perret C. Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice. Cancer Res. 1999 Oct 1; 59(19):5017-22. PMID: 10519417.
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  215. de Santana RB, Gusman HC, Van Dyke TE. The response of human buccal maxillary furcation defects to combined regenerative techniques--two controlled clinical studies. J Int Acad Periodontol. 1999 Jul; 1(3):69-77. PMID: 10833286.
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  216. Tohme ZN, Amar S, Van Dyke TE. Moesin functions as a lipopolysaccharide receptor on human monocytes. Infect Immun. 1999 Jul; 67(7):3215-20. PMID: 10377093.
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  217. Liao MJ, Van Dyke T. Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev. 1999 May 15; 13(10):1246-50. PMID: 10346813.
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  218. Hart TC, Price JA, Bobby PL, Pettenati MJ, Shashi V, Von Kap Herr C, Van Dyke TE. Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. Genomics. 1999 Mar 1; 56(2):233-5. PMID: 10051413.
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  219. Genco CA, Van Dyke T, Amar S. Animal models for Porphyromonas gingivalis-mediated periodontal disease. Trends Microbiol. 1998 Nov; 6(11):444-9. PMID: 9846362.
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  220. Shapira L, Champagne C, Van Dyke TE, Amar S. Strain-dependent activation of monocytes and inflammatory macrophages by lipopolysaccharide of Porphyromonas gingivalis. Infect Immun. 1998 Jun; 66(6):2736-42. PMID: 9596741.
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  221. Dibart S, Eftimiadi C, Socransky S, Taubman MA, Van Dyke TE. Rapid evaluation of serum and gingival crevicular fluid immunoglobulin G subclass antibody levels in patients with early-onset periodontitis using checkerboard immunoblotting. Oral Microbiol Immunol. 1998 Jun; 13(3):166-72. PMID: 10093531.
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  222. Menassa G, Van Dyke TE. Periodontal diagnosis: current status and future directions. Int Dent J. 1998 Jun; 48(3 Suppl 1):275-81. PMID: 9779109.
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  223. Van Dyke TE. Thwarting host immune responses in periodontal disease. Trends Microbiol. 1998 Mar; 6(3):88-9. PMID: 9582928.
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  224. Champagne CM, Vaikuntam J, Warbington ML, Rose L, Daniel MA, Van Dyke TE. Cytoskeletal actin reorganization in neutrophils from patients with localized juvenile periodontitis. J Periodontol. 1998 Feb; 69(2):209-18. PMID: 9526921.
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  225. Shapira L, Sylvia VL, Halabi A, Soskolne WA, Van Dyke TE, Dean DD, Boyan BD, Schwartz Z. Bacterial lipopolysaccharide induces early and late activation of protein kinase C in inflammatory macrophages by selective activation of PKC-epsilon. Biochem Biophys Res Commun. 1997 Nov 26; 240(3):629-34. PMID: 9398616.
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  226. Dennison DK, Van Dyke TE. The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000. 1997 Jun; 14:54-78. PMID: 9567966.
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  227. Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 1997 Feb 13; 385(6617):637-40. PMID: 9024662.
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  228. Hart TC, Stabholz A, Meyle J, Shapira L, Van Dyke TE, Cutler CW, Soskolne WA. Genetic studies of syndromes with severe periodontitis and palmoplantar hyperkeratosis. J Periodontal Res. 1997 Jan; 32(1 Pt 2):81-9. PMID: 9085215.
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  229. Landi L, Amar S, Polins AS, Van Dyke TE. Host mechanisms in the pathogenesis of periodontal disease. Curr Opin Periodontol. 1997; 4:3-10. PMID: 9655015.
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  230. Pan H, Yin C, Van Dyke T. Apoptosis and cancer mechanisms. Cancer Surv. 1997; 29:305-27. PMID: 9338106.
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  231. Amar S, Chung KM, Nam SH, Karatzas S, Myokai F, Van Dyke TE. Markers of bone and cementum formation accumulate in tissues regenerated in periodontal defects treated with expanded polytetrafluoroethylene membranes. J Periodontal Res. 1997 Jan; 32(1 Pt 2):148-58. PMID: 9085226.
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  232. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res. 1997 Jan; 32(1 Pt 2):115-9. PMID: 9085220.
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  233. Takashiba S, Van Dyke TE, Amar S. Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate. Oral Microbiol Immunol. 1996 Dec; 11(6):420-4. PMID: 9467376.
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  234. Almog DM, Handelman SL, Black PM, Van Dyke TE. A survey of faculty practices in U.S. dental schools. N Y State Dent J. 1996 Dec; 62(10):25-9. PMID: 9002735.
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  235. Champagne CM, Holt SC, Van Dyke TE, Gordon BJ, Shapira L. Lipopolysaccharide isolated from Porphyromonas gingivalis grown in hemin-limited chemostat conditions has a reduced capacity for human neutrophil priming. Oral Microbiol Immunol. 1996 Oct; 11(5):319-25. PMID: 9028257.
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  236. Daniel MA, Van Dyke TE. Alterations in phagocyte function and periodontal infection. J Periodontol. 1996 Oct; 67(10 Suppl):1070-5. PMID: 8910825.
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  237. Soskolne WA, Stabholz A, van Dyke TE, Hart TC, Meyle J. Partial expression of the Papillon-Lefèvre syndrome in 2 unrelated families. J Clin Periodontol. 1996 Aug; 23(8):764-9. PMID: 8877663.
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  238. Cutler CW, Eke PI, Genco CA, Van Dyke TE, Arnold RR. Hemin-induced modifications of the antigenicity and hemin-binding capacity of Porphyromonas gingivalis lipopolysaccharide. Infect Immun. 1996 Jun; 64(6):2282-7. PMID: 8675338.
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  239. Shapira L, Soskolne WA, Van Dyke TE. Prostaglandin E2 secretion, cell maturation, and CD14 expression by monocyte-derived macrophages from localized juvenile periodontitis patients. J Periodontol. 1996 Mar; 67(3):224-8. PMID: 8708953.
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  240. Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van Dyke T. Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev. 1996 Feb 1; 10(3):245-60. PMID: 8595876.
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  241. Yamamoto M, Kawabata K, Fujihashi K, McGhee JR, Van Dyke TE, Bamberg TV, Hiroi T, Kiyono H. Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol. 1996 Jan; 148(1):331-9. PMID: 8546223.
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  242. Amar S, Petrungaro P, Amar A, Van Dyke TE. Immunolocalization of bone matrix macromolecules in human tissues regenerated from periodontal defects treated with expanded polytetrafluoroethylene membranes. Arch Oral Biol. 1995 Jul; 40(7):653-61. PMID: 7575238.
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  243. Shapira L, Champagne C, Gordon B, Amar S, Van Dyke TE. Lipopolysaccharide priming of superoxide release by human neutrophils: role of membrane CD14 and serum LPS binding protein. Inflammation. 1995 Jun; 19(3):289-95. PMID: 7543075.
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  244. Bowen WH, Caton JG, Clarkson BH, Edgar WM, Featherstone JD, Littleton PA, Van Dyke TE. Summary of panel discussion. 1--Is there a conflict between the postgraduate education of the clinician and the academic researcher? J Dent Educ. 1995 May; 59(5):564-6. PMID: 7636042.
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  245. Takashiba S, Van Dyke TE, Shapira L, Amar S. Lipopolysaccharide-inducible and salicylate-sensitive nuclear factor(s) on human tumor necrosis factor alpha promoter. Infect Immun. 1995 Apr; 63(4):1529-34. PMID: 7890420.
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  246. Amar S, Van Dyke TE, Eugster HP, Schultze N, Koebel P, Bluethmann H. Tumor necrosis factor (TNF)-induced cutaneous necrosis is mediated by TNF receptor 1. J Inflamm. 1995-1996; 47(4):180-9. PMID: 9144075.
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  247. Murayama Y, Kurihara H, Nagai A, Dompkowski D, Van Dyke TE. Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. Periodontol 2000. 1994 Oct; 6:116-24. PMID: 9673175.
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  248. Schenkein HA, Van Dyke TE. Early-onset periodontitis: systemic aspects of etiology and pathogenesis. Periodontol 2000. 1994 Oct; 6:7-25. PMID: 9673167.
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  249. Basquill PJ, Steflik DE, Brennan WA, Horner J, Van Dyke TE. Evaluation of the effects of diagnostic radiation on titanium dental implant osseointegration in the micropig. J Periodontol. 1994 Sep; 65(9):872-80. PMID: 7990025.
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  250. Shapira L, Warbington M, Van Dyke TE. TNF alpha and IL-1 beta in serum of LJP patients with normal and defective neutrophil chemotaxis. J Periodontal Res. 1994 Sep; 29(5):371-3. PMID: 7799217.
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  251. Shapira L, Takashiba S, Champagne C, Amar S, Van Dyke TE. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes. J Immunol. 1994 Aug 15; 153(4):1818-24. PMID: 7519214.
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  252. Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ. Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. Genomics. 1994 Jul 1; 22(1):246-7. PMID: 7959783.
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  253. Shapira L, Smidt A, Van Dyke TE, Barak V, Soskolne AW, Brautbar C, Sela MN, Bimstein E. Sequential manifestation of different forms of early-onset periodontitis. A case report. J Periodontol. 1994 Jun; 65(6):631-5. PMID: 8083797.
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  254. Hart TC, Shapira L, Van Dyke TE. Neutrophil defects as risk factors for periodontal diseases. J Periodontol. 1994 May; 65(5 Suppl):521-9. PMID: 8046568.
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  255. Shapira L, Takashiba S, Amar S, Van Dyke TE. Porphyromonas gingivalis lipopolysaccharide stimulation of human monocytes: dependence on serum and CD14 receptor. Oral Microbiol Immunol. 1994 Apr; 9(2):112-7. PMID: 7516534.
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  256. Shapira L, Gordon B, Warbington M, Van Dyke TE. Priming effect of Porphyromonas gingivalis lipopolysaccharide on superoxide production by neutrophils from healthy and rapidly progressive periodontitis subjects. J Periodontol. 1994 Feb; 65(2):129-33. PMID: 8158509.
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  257. Hart TC, Champagne C, Zhou J, Van Dyke TE. Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. Mamm Genome. 1994 Feb; 5(2):123-4. PMID: 8180475.
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  258. Van Dyke TE, Vaikuntam J. Neutrophil function and dysfunction in periodontal disease. Curr Opin Periodontol. 1994; 19-27. PMID: 8032460.
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  259. Kalmar JR, Van Dyke TE. Effect of bacterial products on neutrophil chemotaxis. Methods Enzymol. 1994; 236:58-87. PMID: 7968641.
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  260. Bramanti TE, Holt SC, Ebersole JL, Van Dyke T. Regulation of Porphyromonas gingivalis virulence: hemin limitation effects on the outer membrane protein (OMP) expression and biological activity. J Periodontal Res. 1993 Nov; 28(6 Pt 2):464-6. PMID: 8263714.
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  261. Dragolich WE, Pashley DH, Brennan WA, O'Neal RB, Horner JA, Van Dyke TE. An in vitro study of dentinal tubule occlusion by ferric oxalate. J Periodontol. 1993 Nov; 64(11):1045-51. PMID: 8295089.
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  262. Singh G, O'Neal RB, Brennan WA, Strong SL, Horner JA, Van Dyke TE. Surgical treatment of induced peri-implantitis in the micro pig: clinical and histological analysis. J Periodontol. 1993 Oct; 64(10):984-9. PMID: 8277409.
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  263. Shapira L, Takashiba S, Kalmar JR, Van Dyke TE, Barak V, Soskolne WA. Rapid fluorometric quantification of monocyte attachment in tissue culture wells. J Immunol Methods. 1993 Sep 27; 165(1):93-8. PMID: 8409472.
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  264. Takashiba S, Shapira L, Amar S, Van Dyke TE. Cloning and characterization of human TNF alpha promoter region. Gene. 1993 Sep 15; 131(2):307-8. PMID: 8406029.
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  265. Shahan MH, Chuang AH, Brennan WA, Dirksen TR, Van Dyke TE, McPherson JC. The effect of chlorhexidine irrigation on tensile wound strength. J Periodontol. 1993 Aug; 64(8):719-22. PMID: 8410610.
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  266. Kurihara H, Murayama Y, Warbington ML, Champagne CM, Van Dyke TE. Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis. Infect Immun. 1993 Aug; 61(8):3137-42. PMID: 8335344.
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  267. Van Dyke TE, Lester MA, Shapira L. The role of the host response in periodontal disease progression: implications for future treatment strategies. J Periodontol. 1993 Aug; 64(8 Suppl):792-806. PMID: 8410619.
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  268. Peacock ME, Sutherland DE, Schuster GS, Brennan WA, O'Neal RB, Strong SL, Van Dyke TE. The effect of nicotine on reproduction and attachment of human gingival fibroblasts in vitro. J Periodontol. 1993 Jul; 64(7):658-65. PMID: 8366415.
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  269. Daniel MA, McDonald G, Offenbacher S, Van Dyke TE. Defective chemotaxis and calcium response in localized juvenile periodontitis neutrophils. J Periodontol. 1993 Jul; 64(7):617-21. PMID: 8396175.
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  270. Guy SC, McQuade MJ, Scheidt MJ, McPherson JC, Rossmann JA, Van Dyke TE. In vitro attachment of human gingival fibroblasts to endosseous implant materials. J Periodontol. 1993 Jun; 64(6):542-6. PMID: 8393107.
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  271. Shapira L, van Dyke TE, Hart TC. A localized absence of interleukin-4 triggers periodontal disease activity: a novel hypothesis. Med Hypotheses. 1992 Dec; 39(4):319-22. PMID: 1494319.
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  272. McCollum J, O'Neal RB, Brennan WA, Van Dyke TE, Horner JA. The effect of titanium implant abutment surface irregularities on plaque accumulation in vivo. J Periodontol. 1992 Oct; 63(10):802-5. PMID: 1403586.
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  273. Steidley KE, Thompson SH, McQuade MJ, Strong SL, Scheidt MJ, Van Dyke TE. A comparison of T4:T8 lymphocyte ratio in the periodontal lesion of healthy and HIV-positive patients. J Periodontol. 1992 Sep; 63(9):753-6. PMID: 1361945.
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  274. Van Dyke TE. New agents in the chemical control of plaque and gingivitis--reaction paper. J Dent Res. 1992 Jul; 71(7):1457-8. PMID: 1629464.
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  275. Tripathi SC, Van Dyke TE. Characterization of GP110, a neutrophil surface protein. Infect Immun. 1992 Jul; 60(7):3015-6. PMID: 1612770.
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  276. Tyagi SR, Uhlinger DJ, Lambeth JD, Champagne C, Van Dyke TE. Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis. Infect Immun. 1992 Jun; 60(6):2481-7. PMID: 1316876.
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  277. Hamilton JN, Thompson SH, Scheidt MJ, McQuade MJ, Van Dyke T, Plowman K. Correlation of subclinical candidal colonization of the dorsal tongue surface with the Walter Reed staging scheme for patients infected with HIV-1. Oral Surg Oral Med Oral Pathol. 1992 Jan; 73(1):47-51. PMID: 1534883.
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  278. Cuenin MF, Scheidt MJ, O'Neal RB, Strong SL, Pashley DH, Horner JA, Van Dyke TE. An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. J Periodontol. 1991 Nov; 62(11):668-73. PMID: 1753319.
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  279. Peacock ME, Brennan WA, Strong SL, Prior RF, O'Neal RB, Van Dyke TE. Angioedema as a complication in periodontal surgery: report of a case. J Periodontol. 1991 Oct; 62(10):643-5. PMID: 1770424.
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  280. Nosal G, Scheidt MJ, O'Neal R, Van Dyke TE. The penetration of lavage solution into the periodontal pocket during ultrasonic instrumentation. J Periodontol. 1991 Sep; 62(9):554-7. PMID: 1658291.
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  281. Hickey JS, O'Neal RB, Scheidt MJ, Strong SL, Turgeon D, Van Dyke TE. Microbiologic characterization of ligature-induced peri-implantitis in the microswine model. J Periodontol. 1991 Sep; 62(9):548-53. PMID: 1941494.
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  282. Kurihara H, Nishimura F, Kokeguchi S, Kato K, Van Dyke TE, Murayama Y. Monoclonal antibody to a specific antigen from Wolinella recta ATCC 33238. FEMS Microbiol Lett. 1991 Jul 15; 66(1):33-6. PMID: 1936935.
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  283. Kerns DG, Scheidt MJ, Pashley DH, Horner JA, Strong SL, Van Dyke TE. Dentinal tubule occlusion and root hypersensitivity. J Periodontol. 1991 Jul; 62(7):421-8. PMID: 1920008.
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  284. Alleyn CD, O'Neal RB, Strong SL, Scheidt MJ, Van Dyke TE, McPherson JC. The effect of chlorhexidine treatment of root surfaces on the attachment of human gingival fibroblasts in vitro. J Periodontol. 1991 Jul; 62(7):434-8. PMID: 1920010.
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  285. Cutler CW, Eke P, Arnold RR, Van Dyke TE. Defective neutrophil function in an insulin-dependent diabetes mellitus patients. A case report. J Periodontol. 1991 Jun; 62(6):394-401. PMID: 1651389.
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  286. Brown TA, Byres L, Gardner M, Van Dyke TE. Subclass and molecular form of immunoglobulin A antibodies to Actinobacillus actinomycetemcomitans in juvenile periodontitis. Infect Immun. 1991 Mar; 59(3):1126-30. PMID: 1997415.
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  287. Hale TM, Boretsky BB, Scheidt MJ, McQuade MJ, Strong SL, Van Dyke TE. Evaluation of titanium dental implant osseointegration in posterior edentulous areas of micro swine. J Oral Implantol. 1991; 17(2):118-24. PMID: 1811062.
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  288. Hanks CT, Syed SA, Craig RG, Hartrick JM, Van Dyke TE. Modeling bacterial damage to pulpal cells in vitro. J Endod. 1991 Jan; 17(1):21-5. PMID: 1895035.
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  289. Malmstrom HS, Fritz ME, Timmis DP, Van Dyke TE. Osseo-integrated implant treatment of a patient with rapidly progressive periodontitis. A case report. J Periodontol. 1990 May; 61(5):300-4. PMID: 2352107.
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  290. Koretsky AP, Brosnan MJ, Chen LH, Chen JD, Van Dyke T. NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3112-6. PMID: 2326269.
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  291. Offenbacher S, Odle BM, Green MD, Mayambala CS, Smith MA, Fritz ME, van Dyke TE, Yeh KC, Sena FJ. Inhibition of human periodontal prostaglandin E2 synthesis with selected agents. Agents Actions. 1990 Mar; 29(3-4):232-8. PMID: 2111080.
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  292. Van Dyke TE, Warbington M, Gardner M, Offenbacher S. Neutrophil surface protein markers as indicators of defective chemotaxis in LJP. J Periodontol. 1990 Mar; 61(3):180-4. PMID: 2319438.
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  293. Van Dyke TE, Hoop GA. Neutrophil function and oral disease. Crit Rev Oral Biol Med. 1990; 1(2):117-33. PMID: 2152247.
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  294. Cuff MJ, McQuade MJ, Scheidt MJ, Sutherland DE, Van Dyke TE. The presence of nicotine on root surfaces of periodontally diseased teeth in smokers. J Periodontol. 1989 Oct; 60(10):564-9. PMID: 2681674.
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  295. Kern DA, McQuade MJ, Scheidt MJ, Hanson B, Van Dyke TE. Effectiveness of sodium fluoride on tooth hypersensitivity with and without iontophoresis. J Periodontol. 1989 Jul; 60(7):386-9. PMID: 2778607.
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  296. McGuire JR, McQuade MJ, Rossmann JA, Garnick JJ, Sutherland DE, Scheidt MJ, Van Dyke TE. Cotinine in saliva and gingival crevicular fluid of smokers with periodontal disease. J Periodontol. 1989 Apr; 60(4):176-81. PMID: 2656979.
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  297. Van Dyke TE, Offenbacher S, Kalmar J, Arnold RR. Neutrophil defects and host-parasite interactions in the pathogenesis of localized juvenile periodontitis. Adv Dent Res. 1988 Nov; 2(2):354-8. PMID: 3271029.
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  298. Van Dyke TE, Offenbacher S, Place D, Dowell VR, Jones J. Refractory periodontitis: mixed infection with Bacteroides gingivalis and other unusual Bacteroides species. A case report. J Periodontol. 1988 Mar; 59(3):184-9. PMID: 3162983.
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  299. Offenbacher S, Costopoulos SV, Odle BM, Van Dyke TE. Microbial colonization patterns of loosely adherent subgingival plaque in adult periodontitis. J Clin Periodontol. 1988 Jan; 15(1):53-9. PMID: 3422245.
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  300. Van Dyke TE, Wilson-Burrows C, Offenbacher S, Henson P. Association of an abnormality of neutrophil chemotaxis in human periodontal disease with a cell surface protein. Infect Immun. 1987 Sep; 55(9):2262-7. PMID: 3305369.
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  301. Offenbacher S, Scott SS, Odle BM, Wilson-Burrows C, Van Dyke TE. Depressed leukotriene B4 chemotactic response of neutrophils from localized juvenile periodontitis patients. J Periodontol. 1987 Sep; 58(9):602-6. PMID: 2821216.
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  302. Kalmar JR, Arnold RR, van Dyke TE. Direct interaction of Actinobacillus actinomycetemcomitans with normal and defective (LJP) neutrophils. J Periodontal Res. 1987 May; 22(3):179-81. PMID: 2955093.
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  303. Braswell LD, Van Dyke TE. The etiology and pathogenesis of periodontal disease. Dentistry. 1987 Apr; 7(2):22-5. PMID: 3472861.
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  304. Van Dyke TE, Braswell L, Offenbacher S. Inhibition of gingivitis by topical application of ebselen and rosmarinic acid. Agents Actions. 1986 Dec; 19(5-6):376-7. PMID: 3825758.
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  305. Genco RJ, Van Dyke TE, Levine MJ, Nelson RD, Wilson ME. 1985 Kreshover lecture. Molecular factors influencing neutrophil defects in periodontal disease. J Dent Res. 1986 Dec; 65(12):1379-91. PMID: 3023465.
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  306. Van Dyke TE, Zinney W, Winkel K, Taufiq A, Offenbacher S, Arnold RR. Neutrophil function in localized juvenile periodontitis. Phagocytosis, superoxide production and specific granule release. J Periodontol. 1986 Nov; 57(11):703-8. PMID: 3031262.
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  307. Van Dyke TE, Dowell VR, Offenbacher S, Snyder W, Hersh T. Potential role of microorganisms isolated from periodontal lesions in the pathogenesis of inflammatory bowel disease. Infect Immun. 1986 Sep; 53(3):671-7. PMID: 3462153.
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  308. Offenbacher S, Odle BM, Van Dyke TE. The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res. 1986 Mar; 21(2):101-12. PMID: 2937899.
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  309. Offenbacher S, Odle B, van Dyke T. The microbial morphotypes associated with periodontal health and adult periodontitis: composition and distribution. J Clin Periodontol. 1985 Oct; 12(9):736-49. PMID: 3863843.
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  310. Van Dyke TE, Schweinebraten M, Cianciola LJ, Offenbacher S, Genco RJ. Neutrophil chemotaxis in families with localized juvenile periodontitis. J Periodontal Res. 1985 Sep; 20(5):503-14. PMID: 2934535.
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  311. Van Dyke TE. Role of the neutrophil in oral disease: receptor deficiency in leukocytes from patients with juvenile periodontitis. Rev Infect Dis. 1985 May-Jun; 7(3):419-25. PMID: 3895356.
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  312. Van Dyke TE, Levine MJ, Genco RJ. Neutrophil function and oral disease. J Oral Pathol. 1985 Feb; 14(2):95-120. PMID: 3920369.
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  313. Van Dyke TE, Taubman MA, Ebersole JL, Haffajee AD, Socransky SS, Smith DJ, Genco RJ. The Papillon-Lefèvre syndrome: neutrophil dysfunction with severe periodontal disease. Clin Immunol Immunopathol. 1984 Jun; 31(3):419-29. PMID: 6232030.
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  314. Van Dyke TE. Neutrophil receptor modulation in the pathogenesis of periodontal diseases. J Dent Res. 1984 Mar; 63(3):452-4. PMID: 6583245.
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  315. Offenbacher S, Odle BM, Gray RC, Van Dyke TE. Crevicular fluid prostaglandin E levels as a measure of the periodontal disease status of adult and juvenile periodontitis patients. J Periodontal Res. 1984 Jan; 19(1):1-13. PMID: 6232362.
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  316. Van Dyke TE, Levine MJ, Tabak LA, Genco RJ. Juvenile periodontitis as a model for neutrophil function: reduced binding of the complement chemotactic fragment, C5a. J Dent Res. 1983 Aug; 62(8):870-2. PMID: 6575033.
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  317. Van Dyke TE, Horoszewicz HU, Genco RJ. The polymorphonuclear leukocyte (PMNL) locomotor defect in juvenile periodontitis. Study of random migration, chemokinesis and chemotaxis. J Periodontol. 1982 Nov; 53(11):682-7. PMID: 6960166.
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  318. Van Dyke TE, Levine MJ, Al-Hashimi I, Genco RJ. Periodontal diseases and impaired neutrophil function. J Periodontal Res. 1982 Sep; 17(5):492-4. PMID: 6218280.
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  319. Van Dyke TE, Bartholomew E, Genco RJ, Slots J, Levine MJ. Inhibition of neutrophil chemotaxis by soluble bacterial products. J Periodontol. 1982 Aug; 53(8):502-8. PMID: 6956714.
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  320. Van Dyke TE, Reilly AA, Genco RJ. Regression line analysis of neutrophil chemotaxis. Immunopharmacology. 1982 Feb; 4(1):23-39. PMID: 6800976.
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  321. Sierra F, Leza A, Marashi F, Plumb M, Rickles R, Van Dyke T, Clark S, Wells J, Stein GS, Stein JL. Human histone genes are interspersed with members of the Alu family and with other transcribed sequences. Biochem Biophys Res Commun. 1982 Jan 29; 104(2):785-92. PMID: 6280702.
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  322. Van Dyke TE, Levine MJ, Tabak LA, Genco RJ. Reduced chemotactic peptide binding in juvenile periodontitis: a model for neutrophil function. Biochem Biophys Res Commun. 1981 Jun 16; 100(3):1278-84. PMID: 6268085.
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  323. McMullen JA, Van Dyke TE, Horoszewicz HU, Genco RJ. Neutrophil chemotaxis in individuals with advanced periodontal disease and a genetic predisposition to diabetes mellitus. J Periodontol. 1981 Apr; 52(4):167-73. PMID: 6939837.
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  324. Genco RJ, Van Dyke TE, Park B, Ciminelli M, Horoszewicz H. Neutrophil chemotaxis impairment in juvenile periodontitis: evaluation of specificity, adherence, deformability, and serum factors. J Reticuloendothel Soc. 1980 Dec; 28(Suppl):81s-91s. PMID: 7441644.
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  325. Van Dyke TE, Horoszewicz HU, Cianciola LJ, Genco RJ. Neutrophil chemotaxis dysfunction in human periodontitis. Infect Immun. 1980 Jan; 27(1):124-32. PMID: 7358424.
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  326. Van Dyke TE, Reilly AA, Horoszewicz H, Gagliardi N, Genco RJ. A rapid, semi-automated procedure for the evaluation of leukocyte locomotion in the micropore filter assay. J Immunol Methods. 1979; 31(3-4):271-82. PMID: 392011.
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  327. Levine MJ, Herzberg MC, Levine MS, Ellison SA, Stinson MW, Li HC, van Dyke T. Specificity of salivary-bacterial interactions: role of terminal sialic acid residues in the interaction of salivary glycoproteins with Streptococcus sanguis and Streptococcus mutans. Infect Immun. 1978 Jan; 19(1):107-15. PMID: 415001.
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