Keywords
Last Name

John H. Connor, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-0339
ORCID ORCID Icon0000-0002-8867-7256
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
My laboratory studies the virus-host interaction. We take a variety of approaches from genetic to systems biology to biochemistry and molecular biology. We are studying how viruses take over the cellular protein synthesis apparatus, how cells effectively fight virus infection, and how the host responds to infection with viruses that cause hemorrhagic fever.

 Self-Described Keywords
  • antiviral drugs
  • hemorrhagic fever viruses
  • microarray analysis
  • molecular biology
  • orthopoxvirus
  • protein biochemistry
  • reverse genetics
  • rhabdovirus
  • signal transduction
  • virology
  • virus-host interaction
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Olsen ME, Connor JH. Hypusination of eIF5A as a Target for Antiviral Therapy. DNA Cell Biol. 2017 Jan 12. PMID: 28080131.
    View in: PubMed
  2. Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH. In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genomics. 2016 Sep 05; 17:707. PMID: 27595844.
    View in: PubMed
  3. Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH. Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication. MBio. 2016 Jul 26; 7(4). PMID: 27460797.
    View in: PubMed
  4. Wilson MR, Fedewa G, Stenglein MD, Olejnik J, Rennick LJ, Nambulli S, Feldmann F, Duprex WP, Connor JH, Mühlberger E, DeRisi JL. Multiplexed Metagenomic Deep Sequencing To Analyze the Composition of High-Priority Pathogen Reagents. mSystems. 2016 Jul-Aug; 1(4). PMID: 27822544.
    View in: PubMed
  5. Fawcett H, Ünlü MS, Connor JH. New Approaches for Virus Detection through Multidisciplinary Partnerships. ACS Infect Dis. 2016 Jun 10; 2(6):378-81. PMID: 27627625.
    View in: PubMed
  6. Scherr SM, Daaboul GG, Trueb J, Sevenler D, Fawcett H, Goldberg B, Connor JH, Ünlü MS. Real-Time Capture and Visualization of Individual Viruses in Complex Media. ACS Nano. 2016 Feb 23; 10(2):2827-33. PMID: 26760677.
    View in: PubMed
  7. Seymour E, Daaboul GG, Zhang X, Scherr SM, Ünlü NL, Connor JH, Ünlü MS. DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens. Anal Chem. 2015 Oct 20; 87(20):10505-12. PMID: 26378807.
    View in: PubMed
  8. Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques. J Virol. 2015 Oct; 89(19):9875-85. PMID: 26202230.
    View in: PubMed
  9. Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ. Transcriptional Profiling of the Immune Response to Marburg Virus Infection. J Virol. 2015 Oct; 89(19):9865-74. PMID: 26202234.
    View in: PubMed
  10. Mire CE, Geisbert JB, Versteeg KM, Mamaeva N, Agans KN, Geisbert TW, Connor JH. A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs. J Infect Dis. 2015 Oct 1; 212 Suppl 2:S384-8. PMID: 25957964.
    View in: PubMed
  11. Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH. Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA. Assay Drug Dev Technol. 2015 Jan-Feb; 13(1):34-43. PMID: 25646658.
    View in: PubMed
  12. Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014; 15:960. PMID: 25377889.
    View in: PubMed
  13. Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH. Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus. PLoS Negl Trop Dis. 2014; 8(7):e3061. PMID: 25079789.
    View in: PubMed
  14. Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA. Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. PLoS Pathog. 2014 Jun; 10(6):e1004213. PMID: 24967809.
    View in: PubMed
  15. Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014; 3. PMID: 24966209.
    View in: PubMed
  16. Daaboul GG, Lopez CA, Chinnala J, Goldberg BB, Connor JH, Unlü MS. Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: a model for Ebola and Marburg detection. ACS Nano. 2014 Jun 24; 8(6):6047-55. PMID: 24840765.
    View in: PubMed
  17. Rozelle DK, Filone CM, Dower K, Connor JH. Vaccinia reporter viruses for quantifying viral function at all stages of gene expression. J Vis Exp. 2014; (87). PMID: 24894622.
    View in: PubMed
  18. Rozelle DK, Filone CM, Kedersha N, Connor JH. Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication. Mol Cell Biol. 2014 Jun; 34(11):2003-16. PMID: 24662051.
    View in: PubMed
  19. Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog. 2014 Feb; 10(2):e1003904. PMID: 24516381.
    View in: PubMed
  20. Reddington AP, Trueb JT, Freedman DS, Tuysuzoglu A, Daaboul GG, Lopez CA, Karl WC, Connor JH, Fawcett H, Ünlu MS. An interferometric reflectance imaging sensor for point of care viral diagnostics. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3276-83. PMID: 24271115.
    View in: PubMed
  21. Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLoS Negl Trop Dis. 2013; 7(4):e2171. PMID: 23638192.
    View in: PubMed
  22. Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33. PMID: 23521799.
    View in: PubMed
  23. Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. J Virol. 2013 Apr; 87(8):4445-60. PMID: 23388707.
    View in: PubMed
  24. Hodges EN, Connor JH. Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction. Methods. 2013 Feb; 59(2):180-7. PMID: 23009810.
    View in: PubMed
  25. Hodges EN, Heinrich BS, Connor JH. A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription. J Virol. 2012 Aug; 86(16):8884-9. PMID: 22674990.
    View in: PubMed
  26. Johnston SC, Lin KL, Connor JH, Ruthel G, Goff A, Hensley LE. In vitro inhibition of monkeypox virus production and spread by Interferon-ß. Virol J. 2012; 9:5. PMID: 22225589.
    View in: PubMed
  27. Yurt A, Daaboul GG, Connor JH, Goldberg BB, Ünlü MS. Single nanoparticle detectors for biological applications. Nanoscale. 2012 Feb 7; 4(3):715-26. PMID: 22214976.
    View in: PubMed
  28. Dunn EF, Connor JH. HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis. Prog Mol Biol Transl Sci. 2012; 106:223-50. PMID: 22340720.
    View in: PubMed
  29. Scott C. Benson Lily Lee, Wanguo Wei, Feng Ni, Julian David Janna Olmos, Kyle R. Strom, Aaron B. Beeler, Ken Chih-Chien Cheng, James Inglese, Smitha Kota, Virginia Takahashi, A. Donny Strosberg, Connor JH, Bushkin GG, Snyder JK. Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds. Heterocycles 84 No. 1. 2012; 135–155.
  30. Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40. PMID: 22205744.
    View in: PubMed
  31. Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Honko A, Xia Y, Connor JH, Hensley LE. Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. J Infect Dis. 2011 Nov; 204 Suppl 3:S1043-52. PMID: 21987740.
    View in: PubMed
  32. Yanik AA, Cetin AE, Huang M, Artar A, Mousavi SH, Khanikaev A, Connor JH, Shvets G, Altug H. Seeing protein monolayers with naked eye through plasmonic Fano resonances. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11784-9. PMID: 21715661.
    View in: PubMed
  33. Dower K, Rubins KH, Hensley LE, Connor JH. Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. Antiviral Res. 2011 Jul; 91(1):72-80. PMID: 21569797.
    View in: PubMed
  34. Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). J Vis Exp. 2011; (51). PMID: 21587155.
    View in: PubMed
  35. Lopez CA, Daaboul GG, Vedula RS, Ozkumur E, Bergstein DA, Geisbert TW, Fawcett HE, Goldberg BB, Connor JH, Unlü MS. Label-free multiplexed virus detection using spectral reflectance imaging. Biosens Bioelectron. 2011 Apr 15; 26(8):3432-7. PMID: 21342761.
    View in: PubMed
  36. Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. J Virol. 2011 Feb; 85(4):1581-93. PMID: 21147913.
    View in: PubMed
  37. Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TW, Connor JH, Altug H. An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media. Nano Lett. 2010 Dec 8; 10(12):4962-9. PMID: 21053965.
    View in: PubMed
  38. Dunn EF, Connor JH. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. J Virol. 2011 Jan; 85(1):422-31. PMID: 20980511.
    View in: PubMed
  39. Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, Hensley LE, Connor JH. Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Res. 2010 Aug; 87(2):187-94. PMID: 20452380.
    View in: PubMed
  40. Ozkumur E, Lopez CA, Yalcin A, Connor JH, Chiari M, Unlu MS. Spectral Reflectance Imaging for a Multiplexed, High-Throughput, Label-Free, and Dynamic Biosensing Platform Journal of Selected Topics in Quantum Electronics. 2010; PP(99):1-12.
  41. Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol. 2009 Nov; 83(22):11665-72. PMID: 19740993.
    View in: PubMed
  42. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76. PMID: 19587008.
    View in: PubMed
  43. Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009 Feb 13; 284(7):4500-9. PMID: 19088071.
    View in: PubMed
  44. Pettit Kneller EL, Connor JH, Lyles DS. hnRNPs Relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009 Jan; 83(2):770-80. PMID: 19004954.
    View in: PubMed
  45. Izquierdo-Useros N, Naranjo-Gómez M, Archer J, Hatch SC, Erkizia I, Blanco J, Borràs FE, Puertas MC, Connor JH, Fernández-Figueras MT, Moore L, Clotet B, Gummuluru S, Martinez-Picado J. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood. 2009 Mar 19; 113(12):2732-41. PMID: 18945959.
    View in: PubMed
  46. Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008 Mar; 82(5):2286-94. PMID: 18094194.
    View in: PubMed
  47. Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007 May 25; 362(1):109-19. PMID: 17258257.
    View in: PubMed
  48. Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007 Mar; 5(3):542-50. PMID: 17166246.
    View in: PubMed
  49. Whitlow ZW, Connor JH, Lyles DS. Preferential translation of vesicular stomatitis virus mRNAs is conferred by transcription from the viral genome. J Virol. 2006 Dec; 80(23):11733-42. PMID: 17005665.
    View in: PubMed
  50. Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006 Aug; 15(8):1893-906. PMID: 16877710.
    View in: PubMed
  51. Connor JH, McKenzie MO, Lyles DS. Role of residues 121 to 124 of vesicular stomatitis virus matrix protein in virus assembly and virus-host interaction. J Virol. 2006 Apr; 80(8):3701-11. PMID: 16571787.
    View in: PubMed
  52. Connor JH, Lyles DS. Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation. J Biol Chem. 2005 Apr 8; 280(14):13512-9. PMID: 15705563.
    View in: PubMed
  53. Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol. 2004 Oct 1; 342(5):1625-36. PMID: 15364586.
    View in: PubMed
  54. Connor JH, Naczki C, Koumenis C, Lyles DS. Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo. J Virol. 2004 Sep; 78(17):8960-70. PMID: 15308693.
    View in: PubMed
  55. Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem. 2004 Feb 27; 279(9):7685-91. PMID: 14670976.
    View in: PubMed
  56. Connor JH, Lyles DS. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J Virol. 2002 Oct; 76(20):10177-87. PMID: 12239292.
    View in: PubMed
  57. Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J Biol Chem. 2002 Aug 2; 277(31):27716-24. PMID: 12016225.
    View in: PubMed
  58. Morishita W, Connor JH, Xia H, Quinlan EM, Shenolikar S, Malenka RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001 Dec 20; 32(6):1133-48. PMID: 11754843.
    View in: PubMed
  59. Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 2001 Oct; 21(20):6841-50. PMID: 11564868.
    View in: PubMed
  60. Connor JH, Weiser DC, Li S, Hallenbeck J, Shenolikar S. Growth Arrest and DNA Damage-Induced Protein, GADD34, Assembles a Novel Signaling Complex Containing Protein Phosphatase-1 and Inhibitor-1. Mol. Cell. Biol. 2001; 21:6841-6850.
  61. Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM. Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. J Neurosci. 2000 Nov 1; 20(21):7880-7. PMID: 11050107.
    View in: PubMed
  62. Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nat Neurosci. 2000 Sep; 3(9):881-6. PMID: 10966618.
    View in: PubMed
  63. Connor JH, Frederick D, Huang Hb, Yang J, Helps NR, Cohen PT, Nairn AC, DePaoli-Roach A, Tatchell K, Shenolikar S. Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. J Biol Chem. 2000 Jun 23; 275(25):18670-5. PMID: 10748125.
    View in: PubMed
  64. Terry-Lorenzo RT, Inoue M, Connor JH, Haystead TA, Armbruster BN, Gupta RP, Oliver CJ, Shenolikar S. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J Biol Chem. 2000 Jan 28; 275(4):2439-46. PMID: 10644697.
    View in: PubMed
  65. Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. J Biol Chem. 1999 Aug 6; 274(32):22366-72. PMID: 10428807.
    View in: PubMed
  66. Beullens M, Van Eynde A, Vulsteke V, Connor J, Shenolikar S, Stalmans W, Bollen M. Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. J Biol Chem. 1999 May 14; 274(20):14053-61. PMID: 10318819.
    View in: PubMed
  67. Connor JH, Quan HN, Ramaswamy NT, Zhang L, Barik S, Zheng J, Cannon JF, Lee EY, Shenolikar S. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. J Biol Chem. 1998 Oct 16; 273(42):27716-24. PMID: 9765309.
    View in: PubMed
  68. Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science. 1998 Jun 19; 280(5371):1940-2. PMID: 9632393.
    View in: PubMed
  69. Connor JH, Quan H, Oliver C, Shenolikar S. Inhibitor-1, a regulator of protein phosphatase 1 function. Methods Mol Biol. 1998; 93:41-58. PMID: 9664526.
    View in: PubMed
  70. Endo S, Connor JH, Forney B, Zhang L, Ingebritsen TS, Lee EY, Shenolikar S. Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. Biochemistry. 1997 Jun 10; 36(23):6986-92. PMID: 9188695.
    View in: PubMed
  71. Endo S, Xiaozhen Z, Connor JH, Wang B, Shenolikar S. Multiple Structural Elements Define the Specificity of Recombinant Human Inhibitor-1 as a Protein Phosphatase Inhibitor. Biochemistry. 1996; 35:5220-5228.
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