John Connor | Profiles RNS

John H. Connor, PhD

Associate Professor

Boston University School of Medicine

Dept of Microbiology

PhD, Duke University

Websites

	Microbiology Faculty
	Dr. John H. Connor Laboratory
	Immunology Training Program Faculty
	National Emerging Infectious Diseases Laboratories Faculty
	Public Relations - BU Experts

ORCID : 0000-0002-8867-7256

My laboratory studies the virus-host interaction. We take a variety of approaches from genetic to systems biology to biochemistry and molecular biology. We are studying how viruses take over the cellular protein synthesis apparatus, how cells effectively fight virus infection, and how the host responds to infection with viruses that cause hemorrhagic fever.

Faculty
Boston University
National Emerging Infectious Disease Lab

Member
Boston University
Genome Science Institute

Member
Boston University
Bioinformatics Graduate Program

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

SBIR Phase II: High-Throughput and Scalable Nanoparticle Characterization for Life Sciences Applications
08/15/2018 - 07/31/2020 (Subcontract PI)
Nanoview Diagnostics Inc. National Science Fdn
IIP-1831192

Genetic probing of residues involved in ebolavirus glycoprotein entry
07/01/2018 - 06/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI135517-02

role for polyamines in Ebola Virus Replication
02/01/2016 - 01/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI121933-02

Assessment of infection route and vulnerability of neural precursor classes to Zika virus
09/30/2016 - 08/31/2018 (Multi-PI)
PI: John H. Connor, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS101151-02

Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Fever
08/01/2011 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI096159-05

Elimination of pathogenic IgE in cystic fribrosis
08/01/2016 - 05/01/2018 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-05

Inclusivity and Exclusivity Testing of advanced assays for fever of unknown origin
04/13/2017 - 04/12/2018 (Subcontract PI)
Becton, Dickinson and Company DOD Naval Res Lab

Point-of-Care Nanotechnology Diagnostic for Differential Fever Diagnosis
10/01/2015 - 10/31/2017 (Subcontract PI)
Becton, Dickinson and Company Paul G. Allen Fdn

Biomarker Discovery
03/10/2015 - 02/28/2017 (Subcontract PI)
Johns Hopkins University Applied Physics Laboratory LLC, The Ntl Intel - IARPA

I/UCRC Collaborative Research
07/01/2011 - 02/28/2017 (SP Co-PI of Sub-Project / SP)
I/UCRC: Industry Memberships

Showing 10 of 18 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2020	Advancement of poxvirus inhibitor	1R01AI151559-01
2020	Advancement of poxvirus inhibitor	1R01AI151559-01
2019	Genetic probing of residues involved in ebolavirus glycoprotein entry	5R21AI135517-02	1
2018	Genetic probing of residues involved in ebolavirus glycoprotein entry	1R21AI135517-01	1
2017	Assessment of infection route and vulnerability of neural precursor classes to Zika virus	5R21NS101151-02	3
2017	Role for polyamines in Ebola Virus Replication	5R21AI121933-02	7
2016	Assessment of infection route and vulnerability of neural precursor classes to Zika virus	1R21NS101151-01	3
2016	Role for polyamines in Ebola Virus Replication	1R21AI121933-01	7
2015	Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve	5R01AI096159-05	18
2014	Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve	5R01AI096159-04	18

Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gold AS, Feitosa-Suntheimer F, Asad S, Adeoye B, Connor JH, Colpitts TM. Examining the Role of Niemann-Pick C1 Protein in the Permissiveness of Aedes Mosquitoes to Filoviruses. ACS Infect Dis. 2020 Jul 15.View Related Profiles.

Connor, John
Colpitts, Tonya

PMID: 32609483; DOI: 10.1021/acsinfecdis.0c00018;

Speranza E, Caballero I, Honko AN, Johnson JC, Bohannon JK, Evans DeWald L, Gerhardt DM, Sword J, Hensley LE, Bennett RS, Connor JH. Previremic Identification of Ebola or Marburg Virus Infection Using Integrated Host-Transcriptome and Viral Genome Detection. mBio. 2020 06 16; 11(3).View Related Profiles.

Honko, Anna
Connor, John

PMID: 32546624

Greenberg A, Huber BR, Liu DX, Logue JP, Hischak AMW, Hart RJ, Abbott M, Isic N, Hisada YM, Mackman N, Bennett RS, Hensley LE, Connor JH, Crossland NA. Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: A Longitudinal Study of Zaire Ebolavirus Strain Kikwit (EBOV/Kik). Am J Pathol. 2020 07; 190(7):1449-1460.View Related Profiles.

Huber, Bertrand
Connor, John
Crossland, Nicholas

PMID: 32275904

Yurdakul C, Avci O, Matlock A, Devaux AJ, Quintero MV, Ozbay E, Davey RA, Connor JH, Karl WC, Tian L, Ünlü MS. High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles. ACS Nano. 2020 02 25; 14(2):2002-2013.View Related Profiles.

Connor, John
Davey, Robert

PMID: 32003974

Sebba D, Lastovich AG, Kuroda M, Fallows E, Johnson J, Ahouidi A, Honko AN, Fu H, Nielson R, Carruthers E, Diédhiou C, Ahmadou D, Soropogui B, Ruedas J, Peters K, Bartkowiak M, Magassouba N, Mboup S, Ben Amor Y, Connor JH, Weidemaier K. A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases. Sci Transl Med. 2018 12 12; 10(471).View Related Profiles.

Honko, Anna
Connor, John

PMID: 30541788

Speranza E, Ruibal P, Port JR, Feng F, Burkhardt L, Grundhoff A, Günther S, Oestereich L, Hiscox JA, Connor JH, Muñoz-Fontela C. T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans. J Infect Dis. 2018 11 22; 218(suppl_5):S508-S518.View Related Profiles.

Feng, Feng
Connor, John

PMID: 29986035

Cross RW, Speranza E, Borisevich V, Widen SG, Wood TG, Shim RS, Adams RD, Gerhardt DM, Bennett RS, Honko AN, Johnson JC, Hensley LE, Geisbert TW, Connor JH. Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans. J Infect Dis. 2018 11 22; 218(suppl_5):S486-S495.View Related Profiles.

Honko, Anna
Connor, John

PMID: 30476250

Olsen ME, Cressey TN, Mühlberger E, Connor JH. Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression. J Virol. 2018 10 15; 92(20).View Related Profiles.

Muhlberger, Elke
Connor, John

PMID: 30045993

Ruedas JB, Arnold CE, Palacios G, Connor JH. Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway. J Virol. 2018 10 01; 92(19). PMID: 30021890

Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH. Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication". MBio. 2018 06 05; 9(3).View Related Profiles.

Mire, Chad
Filone, Claire Marie
Rozelle, Dan
Connor, John

PMID: 29871921

Showing 10 of 102 results. Show More

Schultz MJ, Tan AL, Gray CN, Isern S, Michael SF, Frydman HM, Connor JH. Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication. MBio. 2018 05 22; 9(3).View Related Profiles.

Frydman, Horacio
Connor, John

PMID: 29789369

Schultz MJ, Frydman HM, Connor JH. Dual Insect specific virus infection limits Arbovirus replication in Aedes mosquito cells. Virology. 2018 05; 518:406-413.View Related Profiles.

Frydman, Horacio
Connor, John

PMID: 29625404

Speranza E, Bixler SL, Altamura LA, Arnold CE, Pratt WD, Taylor-Howell C, Burrows C, Aguilar W, Rossi F, Shamblin JD, Wollen SE, Zelko JM, Minogue T, Nagle E, Palacios G, Goff AJ, Connor JH. A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever. Sci Transl Med. 2018 03 28; 10(434). PMID: 29593102

Lo J, Zhang D, Speranza E, Negron JA, Connor JH. HoTResDB: host transcriptional response database for viral hemorrhagic fevers. Bioinformatics. 2018 Jan 15; 34(2):321-322. PMID: 29028885

Schultz MJ, Connor JH, Frydman HM. Group B Wolbachia Strain-Dependent Inhibition of Arboviruses. DNA Cell Biol. 2018 Jan; 37(1):2-6.View Related Profiles.

Frydman, Horacio
Connor, John

PMID: 29297702

Speranza E, Altamura LA, Kulcsar K, Bixler SL, Rossi CA, Schoepp RJ, Nagle E, Aguilar W, Douglas CE, Delp KL, Minogue TD, Palacios G, Goff AJ, Connor JH. Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques. Sci Rep. 2017 11 07; 7(1):14756. PMID: 29116224

Speranza E, Connor JH. Host Transcriptional Response to Ebola Virus Infection. Vaccines (Basel). 2017 Sep 20; 5(3). PMID: 28930167

Mounce BC, Olsen ME, Vignuzzi M, Connor JH. Polyamines and Their Role in Virus Infection. Microbiol Mol Biol Rev. 2017 Dec; 81(4). PMID: 28904024

Nelson EV, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Ruedas JB, Connor JH, Ebihara H, Mühlberger E. An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening. Antiviral Res. 2017 Oct; 146:21-27.View Related Profiles.

Hume, Adam
Muhlberger, Elke
Nelson, Emily
Connor, John
Deflube, Laure

PMID: 28807685

Ruedas JB, Ladner JT, Ettinger CR, Gummuluru S, Palacios G, Connor JH. Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture. J Virol. 2017 Aug 01; 91(15).View Related Profiles.

Connor, John
Gummuluru, Suryaram

PMID: 28539437

Schultz MJ, Isern S, Michael SF, Corley RB, Connor JH, Frydman HM. Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J Virol. 2017 Jul 15; 91(14).View Related Profiles.

Frydman, Horacio
Connor, John
Corley, Ronald

PMID: 28446677

Daaboul GG, Freedman DS, Scherr SM, Carter E, Rosca A, Bernstein D, Mire CE, Agans KN, Hoenen T, Geisbert TW, Ünlü MS, Connor JH. Enhanced light microscopy visualization of virus particles from Zika virus to filamentous ebolaviruses. PLoS One. 2017; 12(6):e0179728.View Related Profiles.

Mire, Chad
Connor, John

PMID: 28651016

Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika virus induced cellular remodelling. Cell Microbiol. 2017 Aug; 19(8).View Related Profiles.

Bullitt, Esther
Rossignol, Evan
Connor, John

PMID: 28318141; DOI: 10.1111/cmi.12740;

Scherr SM, Freedman DS, Agans KN, Rosca A, Carter E, Kuroda M, Fawcett HE, Mire CE, Geisbert TW, Ünlü MS, Connor JH. Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses. Lab Chip. 2017 02 28; 17(5):917-925.View Related Profiles.

Mire, Chad
Connor, John

PMID: 28194457; DOI: 10.1039/c6lc01528j;

Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA. Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus. Genome Biol. 2017 Jan 19; 18(1):4. PMID: 28100256; DOI: 10.1186/s13059-016-1137-3;

Olsen ME, Connor JH. Hypusination of eIF5A as a Target for Antiviral Therapy. DNA Cell Biol. 2017 Mar; 36(3):198-201. PMID: 28080131; DOI: 10.1089/dna.2016.3611;

Ünlü NL, Kanik FE, Seymour E, Connor JH, Ünlü MS. DNA-Directed Antibody Immobilization for Robust Protein Microarrays: Application to Single Particle Detection 'DNA-Directed Antibody Immobilization. Methods Mol Biol. 2017; 1571:187-206. PMID: 28281257; DOI: 10.1007/978-1-4939-6848-0_12;

Carter EP, Seymour EÇ, Scherr SM, Daaboul GG, Freedman DS, Selim Ünlü M, Connor JH. Visualizing Ebolavirus Particles Using Single-Particle Interferometric Reflectance Imaging Sensor (SP-IRIS). Methods Mol Biol. 2017; 1628:259-270. PMID: 28573627

Connor J, Kobinger G, Olinger G. Therapeutics Against Filovirus Infection. Curr Top Microbiol Immunol. 2017; 411:263-290.View Related Profiles.

Olinger, Gene
Connor, John

PMID: 28653190

Ruedas JB, Connor JH. Generating Recombinant Vesicular Stomatitis Viruses for Use as Vaccine Platforms. Methods Mol Biol. 2017; 1581:203-222. PMID: 28374251; DOI: 10.1007/978-1-4939-6869-5_12;

Trueb J, Avci O, Sevenler D, Connor JH, Ünlü MS. Robust Visualization and Discrimination of Nanoparticles by Interferometric Imaging. IEEE J Sel Top Quantum Electron. 2017 Mar-Apr; 23(2). PMID: 28989270

Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH. In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genomics. 2016 Sep 05; 17:707.View Related Profiles.

Honko, Anna
Connor, John

PMID: 27595844; PMCID: PMC5011782; DOI: 10.1186/s12864-016-3060-0;

Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH. Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication. MBio. 2016 Jul 26; 7(4).View Related Profiles.

Mire, Chad
Filone, Claire Marie
Rozelle, Dan
Connor, John

PMID: 27460797; PMCID: PMC4981715; DOI: 10.1128/mBio.00882-16;

Wilson MR, Fedewa G, Stenglein MD, Olejnik J, Rennick LJ, Nambulli S, Feldmann F, Duprex WP, Connor JH, Mühlberger E, DeRisi JL. Multiplexed Metagenomic Deep Sequencing To Analyze the Composition of High-Priority Pathogen Reagents. mSystems. 2016 Jul-Aug; 1(4).View Related Profiles.

Muhlberger, Elke
Connor, John
Olejnik, Judith
Rennick, Linda
Nambulli, Shamkumar
Duprex, William

PMID: 27822544

Fawcett H, Ünlü MS, Connor JH. New Approaches for Virus Detection through Multidisciplinary Partnerships. ACS Infect Dis. 2016 Jun 10; 2(6):378-81. PMID: 27627625; DOI: 10.1021/acsinfecdis.6b00063;

Scherr SM, Daaboul GG, Trueb J, Sevenler D, Fawcett H, Goldberg B, Connor JH, Ünlü MS. Real-Time Capture and Visualization of Individual Viruses in Complex Media. ACS Nano. 2016 Feb 23; 10(2):2827-33. PMID: 26760677; PMCID: PMC5019356; DOI: 10.1021/acsnano.5b07948;

Seymour E, Daaboul GG, Zhang X, Scherr SM, Ünlü NL, Connor JH, Ünlü MS. DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens. Anal Chem. 2015 Oct 20; 87(20):10505-12. PMID: 26378807; DOI: 10.1021/acs.analchem.5b02702;

Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques. J Virol. 2015 Oct; 89(19):9875-85.View Related Profiles.

Honko, Anna
Connor, John

PMID: 26202230; PMCID: PMC4577920; DOI: 10.1128/JVI.01147-15;

Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ. Transcriptional Profiling of the Immune Response to Marburg Virus Infection. J Virol. 2015 Oct; 89(19):9865-74. PMID: 26202234; PMCID: PMC4577901; DOI: 10.1128/JVI.01142-15;

Mire CE, Geisbert JB, Versteeg KM, Mamaeva N, Agans KN, Geisbert TW, Connor JH. A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs. J Infect Dis. 2015 Oct 1; 212 Suppl 2:S384-8.View Related Profiles.

Mire, Chad
Connor, John

PMID: 25957964; PMCID: PMC4564539; DOI: 10.1093/infdis/jiv126;

Griffith Q, Liang Y, Whitworth P, Rodriguez-Russo C, Gul A, Siddiqui AA, Connor J, Mwinzi P, Ganley-Leal L. Immuno-evasive tactics by schistosomes identify an effective allergy preventative. Exp Parasitol. 2015 Jun; 153:139-50. PMID: 25819297

Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH. Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA. Assay Drug Dev Technol. 2015 Jan-Feb; 13(1):34-43.View Related Profiles.

Filone, Claire Marie
Connor, John
Dower, Ken W

PMID: 25646658; PMCID: PMC4340469; DOI: 10.1089/adt.2014.613;

Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014; 15:960.View Related Profiles.

Honko, Anna
Connor, John

PMID: 25377889; PMCID: PMC4232721; DOI: 10.1186/1471-2164-15-960;

Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH. Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus. PLoS Negl Trop Dis. 2014; 8(7):e3061.View Related Profiles.

Honko, Anna
Connor, John

PMID: 25079789; PMCID: PMC4117489; DOI: 10.1371/journal.pntd.0003061;

Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA. Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. PLoS Pathog. 2014 Jun; 10(6):e1004213.View Related Profiles.

Filone, Claire Marie
Connor, John
Davey, Robert

PMID: 24967809; PMCID: PMC4072787; DOI: 10.1371/journal.ppat.1004213;

Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014; 3.View Related Profiles.

Rozelle, Dan
Connor, John

PMID: 24966209; PMCID: PMC4112549; DOI: 10.7554/eLife.02910;

Daaboul GG, Lopez CA, Chinnala J, Goldberg BB, Connor JH, Unlü MS. Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: a model for Ebola and Marburg detection. ACS Nano. 2014 Jun 24; 8(6):6047-55. PMID: 24840765; PMCID: PMC4466106; DOI: 10.1021/nn501312q;

Rozelle DK, Filone CM, Dower K, Connor JH. Vaccinia reporter viruses for quantifying viral function at all stages of gene expression. J Vis Exp. 2014; (87).View Related Profiles.

Filone, Claire Marie
Rozelle, Dan
Connor, John
Dower, Ken W

PMID: 24894622; DOI: 10.3791/51522;

Rozelle DK, Filone CM, Kedersha N, Connor JH. Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication. Mol Cell Biol. 2014 Jun; 34(11):2003-16.View Related Profiles.

Filone, Claire Marie
Rozelle, Dan
Connor, John

PMID: 24662051; PMCID: PMC4019067; DOI: 10.1128/MCB.01630-13;

Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog. 2014 Feb; 10(2):e1003904.View Related Profiles.

Filone, Claire Marie
Rozelle, Dan
Connor, John
Dower, Ken W

PMID: 24516381; PMCID: PMC3916389; DOI: 10.1371/journal.ppat.1003904;

Reddington AP, Trueb JT, Freedman DS, Tuysuzoglu A, Daaboul GG, Lopez CA, Karl WC, Connor JH, Fawcett H, Ünlu MS. An interferometric reflectance imaging sensor for point of care viral diagnostics. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3276-83. PMID: 24271115; PMCID: PMC4041624; DOI: 10.1109/TBME.2013.2272666;

Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLoS Negl Trop Dis. 2013; 7(4):e2171.View Related Profiles.

Honko, Anna
Connor, John

PMID: 23638192; PMCID: PMC3636129; DOI: 10.1371/journal.pntd.0002171;

Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33.View Related Profiles.

Filone, Claire Marie
Bushkin, Gary
Connor, John
Snyder, John

PMID: 23521799; PMCID: PMC3712830; DOI: 10.1016/j.chembiol.2013.02.011;

Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. J Virol. 2013 Apr; 87(8):4445-60.View Related Profiles.

Connor, John
Dower, Ken W

PMID: 23388707; PMCID: PMC3624393; DOI: 10.1128/JVI.03488-12;

Hodges EN, Connor JH. Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction. Methods. 2013 Feb; 59(2):180-7. PMID: 23009810; PMCID: PMC3775576; DOI: 10.1016/j.ymeth.2012.09.003;

Hodges EN, Heinrich BS, Connor JH. A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription. J Virol. 2012 Aug; 86(16):8884-9. PMID: 22674990; PMCID: PMC3421768; DOI: 10.1128/JVI.00358-12;

Johnston SC, Lin KL, Connor JH, Ruthel G, Goff A, Hensley LE. In vitro inhibition of monkeypox virus production and spread by Interferon-ß. Virol J. 2012; 9:5. PMID: 22225589; PMCID: PMC3284473; DOI: 10.1186/1743-422X-9-5;

Yurt A, Daaboul GG, Connor JH, Goldberg BB, Ünlü MS. Single nanoparticle detectors for biological applications. Nanoscale. 2012 Feb 7; 4(3):715-26. PMID: 22214976; PMCID: PMC3759154; DOI: 10.1039/c2nr11562j;

Dunn EF, Connor JH. HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis. Prog Mol Biol Transl Sci. 2012; 106:223-50.View Related Profiles.

Dunn, Ewan
Connor, John

PMID: 22340720; DOI: 10.1016/B978-0-12-396456-4.00002-X;

Scott C. Benson Lily Lee, Wanguo Wei, Feng Ni, Julian David Janna Olmos, Kyle R. Strom, Aaron B. Beeler, Ken Chih-Chien Cheng, James Inglese, Smitha Kota, Virginia Takahashi, A. Donny Strosberg, Connor JH, Bushkin GG, Snyder JK. Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds. Heterocycles 84 No. 1. 2012; 135–155.

Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40.View Related Profiles.

Filone, Claire Marie
Connor, John
Dower, Ken W
Schaus, Scott

PMID: 22205744; PMCID: PMC3302283; DOI: 10.1128/JVI.05416-11;

Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Honko A, Xia Y, Connor JH, Hensley LE. Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. J Infect Dis. 2011 Nov; 204 Suppl 3:S1043-52.View Related Profiles.

Honko, Anna
Connor, John

PMID: 21987740; DOI: 10.1093/infdis/jir345;

Yanik AA, Cetin AE, Huang M, Artar A, Mousavi SH, Khanikaev A, Connor JH, Shvets G, Altug H. Seeing protein monolayers with naked eye through plasmonic Fano resonances. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11784-9. PMID: 21715661; PMCID: PMC3141965; DOI: 10.1073/pnas.1101910108;

Dower K, Rubins KH, Hensley LE, Connor JH. Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. Antiviral Res. 2011 Jul; 91(1):72-80.View Related Profiles.

Connor, John
Dower, Ken W

PMID: 21569797; PMCID: PMC3177160; DOI: 10.1016/j.antiviral.2011.04.014;

Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). J Vis Exp. 2011; (51).View Related Profiles.

Genco, Caroline
Connor, John

PMID: 21587155; PMCID: PMC3197112; DOI: 10.3791/2694;

Lopez CA, Daaboul GG, Vedula RS, Ozkumur E, Bergstein DA, Geisbert TW, Fawcett HE, Goldberg BB, Connor JH, Unlü MS. Label-free multiplexed virus detection using spectral reflectance imaging. Biosens Bioelectron. 2011 Apr 15; 26(8):3432-7. PMID: 21342761; PMCID: PMC3065545; DOI: 10.1016/j.bios.2011.01.019;

Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. J Virol. 2011 Feb; 85(4):1581-93.View Related Profiles.

Connor, John
Dower, Ken W
Simpson-Holley, Martha R

PMID: 21147913; PMCID: PMC3028896; DOI: 10.1128/JVI.02247-10;

Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TW, Connor JH, Altug H. An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media. Nano Lett. 2010 Dec 8; 10(12):4962-9. PMID: 21053965; DOI: 10.1021/nl103025u;

Dunn EF, Connor JH. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. J Virol. 2011 Jan; 85(1):422-31.View Related Profiles.

Dunn, Ewan
Connor, John

PMID: 20980511; PMCID: PMC3014155; DOI: 10.1128/JVI.01671-10;

Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, Hensley LE, Connor JH. Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Res. 2010 Aug; 87(2):187-94.View Related Profiles.

Olinger, Gene
Connor, John

PMID: 20452380; PMCID: PMC2907434; DOI: 10.1016/j.antiviral.2010.04.015;

Ozkumur E, Lopez CA, Yalcin A, Connor JH, Chiari M, Unlu MS. Spectral Reflectance Imaging for a Multiplexed, High-Throughput, Label-Free, and Dynamic Biosensing Platform Journal of Selected Topics in Quantum Electronics. 2010; PP(99):1-12.

Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol. 2009 Nov; 83(22):11665-72.View Related Profiles.

Dunn, Ewan
Connor, John
Fearns, Rachel

PMID: 19740993; PMCID: PMC2772702; DOI: 10.1128/JVI.01092-09;

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
van Seventer, Jean
Connor, John
Yasuda, Kei

PMID: 19587008; PMCID: PMC2929820; DOI: 10.4049/jimmunol.0803899;

Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009 Feb 13; 284(7):4500-9. PMID: 19088071; PMCID: PMC2640965; DOI: 10.1074/jbc.M808136200;

Pettit Kneller EL, Connor JH, Lyles DS. hnRNPs Relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009 Jan; 83(2):770-80. PMID: 19004954; PMCID: PMC2612367; DOI: 10.1128/JVI.01279-08;

Izquierdo-Useros N, Naranjo-Gómez M, Archer J, Hatch SC, Erkizia I, Blanco J, Borràs FE, Puertas MC, Connor JH, Fernández-Figueras MT, Moore L, Clotet B, Gummuluru S, Martinez-Picado J. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood. 2009 Mar 19; 113(12):2732-41.View Related Profiles.

Connor, John
Gummuluru, Suryaram

PMID: 18945959; PMCID: PMC2661860; DOI: 10.1182/blood-2008-05-158642;

Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008 Mar; 82(5):2286-94. PMID: 18094194; PMCID: PMC2258916

Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007 May 25; 362(1):109-19. PMID: 17258257; PMCID: PMC1995422

Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007 Mar; 5(3):542-50. PMID: 17166246

Whitlow ZW, Connor JH, Lyles DS. Preferential translation of vesicular stomatitis virus mRNAs is conferred by transcription from the viral genome. J Virol. 2006 Dec; 80(23):11733-42. PMID: 17005665; PMCID: PMC1642595

Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006 Aug; 15(8):1893-906. PMID: 16877710; PMCID: PMC2242588

Connor JH, McKenzie MO, Lyles DS. Role of residues 121 to 124 of vesicular stomatitis virus matrix protein in virus assembly and virus-host interaction. J Virol. 2006 Apr; 80(8):3701-11. PMID: 16571787; PMCID: PMC1440435

Connor JH, Lyles DS. Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation. J Biol Chem. 2005 Apr 8; 280(14):13512-9. PMID: 15705563

Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol. 2004 Oct 1; 342(5):1625-36. PMID: 15364586

Connor JH, Naczki C, Koumenis C, Lyles DS. Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo. J Virol. 2004 Sep; 78(17):8960-70. PMID: 15308693; PMCID: PMC506958

Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem. 2004 Feb 27; 279(9):7685-91. PMID: 14670976

Connor JH, Lyles DS. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J Virol. 2002 Oct; 76(20):10177-87. PMID: 12239292; PMCID: PMC136556

Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J Biol Chem. 2002 Aug 2; 277(31):27716-24. PMID: 12016225

Morishita W, Connor JH, Xia H, Quinlan EM, Shenolikar S, Malenka RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001 Dec 20; 32(6):1133-48. PMID: 11754843

Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 2001 Oct; 21(20):6841-50. PMID: 11564868; PMCID: PMC99861

Connor JH, Weiser DC, Li S, Hallenbeck J, Shenolikar S. Growth Arrest and DNA Damage-Induced Protein, GADD34, Assembles a Novel Signaling Complex Containing Protein Phosphatase-1 and Inhibitor-1. Mol. Cell. Biol. 2001; 21:6841-6850.

Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM. Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. J Neurosci. 2000 Nov 1; 20(21):7880-7. PMID: 11050107

Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nat Neurosci. 2000 Sep; 3(9):881-6. PMID: 10966618

Connor JH, Frederick D, Huang Hb, Yang J, Helps NR, Cohen PT, Nairn AC, DePaoli-Roach A, Tatchell K, Shenolikar S. Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. J Biol Chem. 2000 Jun 23; 275(25):18670-5. PMID: 10748125

Terry-Lorenzo RT, Inoue M, Connor JH, Haystead TA, Armbruster BN, Gupta RP, Oliver CJ, Shenolikar S. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J Biol Chem. 2000 Jan 28; 275(4):2439-46. PMID: 10644697

Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. J Biol Chem. 1999 Aug 6; 274(32):22366-72. PMID: 10428807

Beullens M, Van Eynde A, Vulsteke V, Connor J, Shenolikar S, Stalmans W, Bollen M. Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. J Biol Chem. 1999 May 14; 274(20):14053-61. PMID: 10318819

Connor JH, Quan HN, Ramaswamy NT, Zhang L, Barik S, Zheng J, Cannon JF, Lee EY, Shenolikar S. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. J Biol Chem. 1998 Oct 16; 273(42):27716-24. PMID: 9765309

Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science. 1998 Jun 19; 280(5371):1940-2. PMID: 9632393

Connor JH, Quan H, Oliver C, Shenolikar S. Inhibitor-1, a regulator of protein phosphatase 1 function. Methods Mol Biol. 1998; 93:41-58. PMID: 9664526

Endo S, Connor JH, Forney B, Zhang L, Ingebritsen TS, Lee EY, Shenolikar S. Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. Biochemistry. 1997 Jun 10; 36(23):6986-92. PMID: 9188695

Endo S, Xiaozhen Z, Connor JH, Wang B, Shenolikar S. Multiple Structural Elements Define the Specificity of Recombinant Human Inhibitor-1 as a Protein Phosphatase Inhibitor. Biochemistry. 1996; 35:5220-5228.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 102 publications over 24 distinct years, with a maximum of 15 publications in 2017

Bar chart showing 102 publications over 24 distinct years, with a maximum of 15 publications in 2017

Year	Publications
1996	1
1997	1
1998	3
1999	2
2000	4
2001	3
2002	2
2003	1
2004	2
2005	1
2006	4
2007	2
2008	3
2009	2
2010	5
2011	6
2012	6
2013	4
2014	8
2015	6
2016	6
2017	15
2018	11
2020	4

Media Mentions

Recent (within 3 months)

Recovered Holyoke Soldiers’ Home vet testing positive for coronavirus raises questions about reinfection

The Boston Herald 7/28/2020

Older

Coronavirus immunity studies ‘encouraging’ for short-term protection from reinfection, says BU immunologist

The Boston Herald 5/6/2020

Coronavirus Immunity Studies ‘Encouraging’ For Short-Term Protection From Reinfection, Says BU Immunologist

The Boston Herald 5/5/2020

Mass. Hospitals To Launch Trial Of Japanese Drug Aimed At Fighting COVID-19

WBUR 4/9/2020

Mass. Hospitals To Launch Trail Of Japanese Drug Aimed At Fighting COVID-19

WBUR 4/9/2020

Antibodies found in blood of recovered coronavirus patients could offer a path to treatment

The Boston Herald 3/31/2020

Boston University Researchers Work To Develop Quick Coronavirus Test For Doctors’ Offices

CBS Boston 3/12/2020

Coronavirus Declared a Pandemic, Cases in U.S. and Massachusetts Continue to Rise

The Boston Herald 3/11/2020

COVID-19: What You Should And Shouldn’t Do Now

Futurity 3/4/2020

Coronavirus Is Coming: Dos and Don’ts for Protecting Yourself

BU Today 2/27/2020

Coronavirus Declared a Global Health Emergency by World Health Organization

The Boston Herald 1/30/2020

Robots on the March

Bloomberg Baystate Business 1/24/2020

Why Doesn’t The Flu Freak Us Out More?

Futurity 12/3/2019

Should We Fear The Flu More Than EEE?

BU Today 12/2/2019

Boston Medical Center Pathogen Specialist Hails New Ebola Study Hinting at Possible Cure

Boston Globe 8/12/2019

Amid High-Profile Outbreaks, Benefit of Widespread Asymptomatic Screening Remains Low

Contagion Live 2/14/2019

Spotting Ebola in the Crowd

BU Today 1/28/2019

Rapid diagnostic test detects Ebola, malaria in the field

MedTech DIVE 12/14/2018

New Portable Diagnostic Test For Ebola And Malaria Has Big Public Health Implications

WBUR 12/13/2018

Point-of-care test differentiates Ebola from similar diseases in 30 minutes

Healio ITJ 12/13/2018

Researchers Develop Portable Diagnostic Test For Ebola And Malaria

AAAS 12/12/2018

New Field Test Discerns Between Ebola and Lookalike Fevers

MDDI 12/12/2018

BU Experts on New Ebola Outbreak in Democratic Republic of the Congo

BU Today 5/31/2018

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

antiviral drugs
hemorrhagic fever viruses
microarray analysis
molecular biology
orthopoxvirus
protein biochemistry
reverse genetics
rhabdovirus
signal transduction
virology
virus-host interaction

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