John H. Connor, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, Duke University



My laboratory studies the virus-host interaction. We take a variety of approaches from genetic to systems biology to biochemistry and molecular biology. We are studying how viruses take over the cellular protein synthesis apparatus, how cells effectively fight virus infection, and how the host responds to infection with viruses that cause hemorrhagic fever.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Member
Boston University
Bioinformatics Graduate Program




GENETIC PROBING OF RESIDUES INVOLVED IN EBOLAVIRUS GLYCOPROTEIN ENTRY
07/01/2018 - 06/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R21AI135517-01

ROLE FOR POLYAMINES IN EBOLA VIRUS REPLICATION
02/01/2016 - 01/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI121933-02

ASSESSMENT OF INFECTION ROUTE AND VULNERABILITY OF NEURAL PRECURSOR CLASSES TO ZIKA VIRUS
09/30/2016 - 08/31/2018 (Co-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS101151-02

DEVELOPMENT OF NEAR REAL-TIME, MULTIPLEXED DIAGNOSTICS FOR VIRAL HEMORRHAGIC FEVER
08/01/2011 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI096159-05

ELIMINATION OF PATHOGENIC IGE IN CYSTIC FRIBROSIS
08/01/2016 - 05/01/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-05

INCLUSIVITY AND EXCLUSIVITY TESTING OF ADVANCED ASSAYS FOR FEVER OF UNKNOWN ORIGIN
04/13/2017 - 04/12/2018 (PI)
Becton, Dickinson and Company DOD Naval Res Lab

POINT-OF-CARE NANOTECHNOLOGY DIAGNOSTIC FOR DIFFERENTIAL FEVER DIAGNOSIS
10/01/2015 - 10/31/2017 (PI)
Becton, Dickinson and Company Paul G. Allen Fdn

BIOMARKER DISCOVERY
03/10/2015 - 02/28/2017 (PI)
Johns Hopkins University Applied Physics Laboratory LLC, The Ntl Intel - IARPA

I/UCRC COLLABORATIVE RESEARCH
07/01/2011 - 02/28/2017 (SP Co-PI of Sub-Project / SP)
I/UCRC: Industry Memberships

EVALUATION OF THE MECHANISM OF ACTION OF FDA-APPROVED COMPOUNDS THAT SHOW ACTIVITY AGAINST EBOLAVIRUS
08/18/2014 - 02/17/2017 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Showing 10 of 17 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Genetic probing of residues involved in ebolavirus glycoprotein entry 1R21AI135517-01
2017 Assessment of infection route and vulnerability of neural precursor classes to Zika virus 5R21NS101151-02
2017 Role for polyamines in Ebola Virus Replication 5R21AI121933-02 1
2016 Assessment of infection route and vulnerability of neural precursor classes to Zika virus 1R21NS101151-01
2016 Role for polyamines in Ebola Virus Replication 1R21AI121933-01 1
2015 Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve 5R01AI096159-05 9
2014 Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve 5R01AI096159-04 9
2013 Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve 5R01AI096159-03 9
2012 Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve 5R01AI096159-02 9
2012 Stage-Specific Inhibitors of Orthopoxviruses 5R03MH094169-02 2
Showing 10 of 18 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Olsen ME, Cressey TN, Mühlberger E, Connor JH. Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression. J Virol. 2018 Oct 15; 92(20).View Related Profiles. PMID: 30045993.
     
  2. Ruedas JB, Arnold CE, Palacios G, Connor JH. Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway. J Virol. 2018 10 01; 92(19). PMID: 30021890.
     
  3. Speranza E, Ruibal P, Port JR, Feng F, Burkhardt L, Grundhoff A, Günther S, Oestereich L, Hiscox JA, Connor JH, Muñoz-Fontela C. T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans. J Infect Dis. 2018 Jul 06.View Related Profiles. PMID: 29986035.
     
  4. Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH. Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication". MBio. 2018 Jun 05; 9(3).View Related Profiles. PMID: 29871921.
     
  5. Schultz MJ, Tan AL, Gray CN, Isern S, Michael SF, Frydman HM, Connor JH. Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication. MBio. 2018 May 22; 9(3). PMID: 29789369.
     
  6. Schultz MJ, Frydman HM, Connor JH. Dual Insect specific virus infection limits Arbovirus replication in Aedes mosquito cells. Virology. 2018 05; 518:406-413. PMID: 29625404.
     
  7. Speranza E, Bixler SL, Altamura LA, Arnold CE, Pratt WD, Taylor-Howell C, Burrows C, Aguilar W, Rossi F, Shamblin JD, Wollen SE, Zelko JM, Minogue T, Nagle E, Palacios G, Goff AJ, Connor JH. A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever. Sci Transl Med. 2018 Mar 28; 10(434). PMID: 29593102.
     
  8. Schultz MJ, Connor JH, Frydman HM. Group B Wolbachia Strain-Dependent Inhibition of Arboviruses. DNA Cell Biol. 2018 Jan; 37(1):2-6. PMID: 29297702.
     
  9. Speranza E, Altamura LA, Kulcsar K, Bixler SL, Rossi CA, Schoepp RJ, Nagle E, Aguilar W, Douglas CE, Delp KL, Minogue TD, Palacios G, Goff AJ, Connor JH. Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques. Sci Rep. 2017 Nov 07; 7(1):14756. PMID: 29116224.
     
  10. Lo J, Zhang D, Speranza E, Negron JA, Connor JH. HoTResDB: Host Transcriptional Response Database for Viral Hemorrhagic Fevers. Bioinformatics. 2017 Sep 22. PMID: 29028885.
     
Showing 10 of 96 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 96 publications over 23 distinct years, with a maximum of 16 publications in 2017

YearPublications
19961
19971
19983
19992
20004
20013
20022
20031
20042
20051
20064
20072
20083
20092
20105
20116
20126
20134
20148
20156
20166
201716
20188

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Co-Mentor or Peer Mentor
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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