Keywords
Last Name

Catherine M. Klapperich, PhD

TitleProfessor
InstitutionBoston University College of Engineering
DepartmentBiomedical Engineering
Address44 Cummington St.
Boston MA 02215
Phone(617) 358-0253
Other Positions
TitleAssociate Dean for Research and Technology Development
InstitutionBoston University College of Engineering

TitleProfessor
InstitutionBoston University College of Engineering
DepartmentMechanical Engineering

 Research Expertise & Professional Interests
Dr. Catherine Klapperich is the Associate Dean for Research and the Director of the NIBIB POCTRN Center for Future Technologies in Cancer Care (CFTCC) at BU.

She is a Kern Innovation Faculty Fellow and an Associate Professor of Biomedical Engineering at Boston University. She was named the Dorf-Ebner Distinguished Faculty Fellow in 2014. She also holds appointments in the Division of Materials Science and Engineering and the Department of Mechanical Engineering. She is the Director of the Laboratory for Diagnostics and Global Healthcare Technologies and a member of the Center for Nanoscience and Nanotechnology. In 2014, Dr. Klapperich was elected a Fellow of the American Institute for Medical and Biological Engineering. She is also a guest faculty member in the Global Health Delivery Project at Harvard University.

Before coming to Boston, Dr. Klapperich was a Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley with Drs. Lisa Pruitt and Kyriakos Komvopoulos; her M.S. in Engineering Sciences from Harvard University and her B.S. in Materials Science and Engineering from Northwestern University.

Dr. Klapperich’s research is focused on engineering medical devices for use in low resource settings and at the point of care. Current projects are focused on disposable microfluidic diagnostics that incorporate on-board sample preparation and on minimally instrumented devices to enable molecular diagnostics. Her work includes diagnostics for infectious diarrhea, respiratory infections, HIV and other sexually transmitted diseases. These devices have been tested in Nicaragua and Kenya. Other work in the lab is focused on the design and deployment of devices to enable systems biology approaches to studying complex diseases including TB.

Dr. Klapperich’s lab is funded by grants from the NIH, DOD, CIMIT and the Coulter Foundation. In 2010, she was an invited participant in the National Academies of Engineering Frontiers of Engineering conference held in Agra, India. She serves on the editorial board of Biomedical Microdevices and is an active participant in both national and international research conferences.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ford Carleton P, Schachter S, Parrish JA, Collins JM, Crocker JB, Dixon RF, Edgman-Levitan S, Lewandrowski KB, Stahl JE, Klapperich C, Cabodi M, Gaydos CA, Rompalo AM, Manabe Y, Wang TH, Rothman R, Geddes CD, Widdice L, Jackman J, Mathura RA, Lash TB. National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine. IEEE J Transl Eng Health Med. 2016; 4:2800614. PMID: 27730014.
    View in: PubMed
  2. Boardman AK, Wong WS, Premasiri WR, Ziegler LD, Lee JC, Miljkovic M, Klapperich CM, Sharon A, Sauer-Budge AF. Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy. Anal Chem. 2016 Aug 16; 88(16):8026-35. PMID: 27429301.
    View in: PubMed
  3. Linnes JC, Rodriguez NM, Liu L, Klapperich CM. Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics. Biomed Microdevices. 2016 Apr; 18(2):30. PMID: 26906904.
    View in: PubMed
  4. Rodriguez NM, Wong WS, Liu L, Dewar R, Klapperich CM. A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples. Lab Chip. 2016 Feb 21; 16(4):753-63. PMID: 26785636.
    View in: PubMed
  5. Kim CS, Vanture S, Cho M, Klapperich CM, Wang C, Huang FW. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology. PLoS One. 2016; 11(1):e0145215. PMID: 26771309.
    View in: PubMed
  6. Rodriguez NM, Linnes JC, Fan A, Ellenson CK, Pollock NR, Klapperich CM. Paper-Based RNA Extraction, in Situ Isothermal Amplification, and Lateral Flow Detection for Low-Cost, Rapid Diagnosis of Influenza A (H1N1) from Clinical Specimens. Anal Chem. 2015 Aug 4; 87(15):7872-9. PMID: 26125635.
    View in: PubMed
  7. Derda R, Gitaka J, Klapperich CM, Mace CR, Kumar AA, Lieberman M, Linnes JC, Jores J, Nasimolo J, Ndung'u J, Taracha E, Weaver A, Weibel DB, Kariuki TM, Yager P. Enabling the Development and Deployment of Next Generation Point-of-Care Diagnostics. PLoS Negl Trop Dis. 2015 May; 9(5):e0003676. PMID: 25973602.
    View in: PubMed
  8. Pratt GW, Fan A, Klapperich CM. Colorimetric Detection of Azidothymidine Using an Alkyne-Modified Dextran Substrate. ACS Biomaterials Science & Engineering. 2015; 1(5):314-319.
    View in: External Website
  9. Bhattacharyya A, Klapperich CM. Encyclopedia of Microfluidics and Nanofluidics. On-Chip Cell Lysis. Springer. New York. 2015; 2481-2483.
    View in: External Website
  10. Wong S, Drain PK, Klapperich CM. Annals of Global Health. A point-of-care device for the rapid diagnosis of tuberculosis. Elsevier. 2015; 81(1):85-86.
    View in: External Website
  11. Wong SY, Cabodi M, Rolland J, Klapperich CM. Evaporative concentration on a paper-based device to concentrate analytes in a biological fluid. Anal Chem. 2014 Dec 16; 86(24):11981-5. PMID: 25419873.
    View in: PubMed
  12. Huang S, Sharma S, Liu L, Fan A, Klapperich CM, Rosen J. Cancer Research. Abstract 3494: Microfluidic platform for a protein-based thyroid cancer diagnostics. American Association for Cancer Research. 2014; 74(19 Suppl):3494-3494.
    View in: External Website
  13. Linnes JC, Fan A, Rodriguez NM, Lemieux B, Kong H, Klapperich CM. Paper-based molecular diagnostic for Chlamydia trachomatis. RSC Adv. 2014 Jan 01; 4(80):42245-42251. PMID: 25309740.
    View in: PubMed
  14. Byrnes S, Fan A, Trueb J, Jareczek F, Mazzochette M, Sharon A, Sauer-Budge AF, Klapperich CM. A Portable, Pressure Driven, Room Temperature Nucleic Acid Extraction and Storage System for Point of Care Molecular Diagnostics. Anal Methods. 2013 Jul 7; 5(13):3177-3184. PMID: 23914255.
    View in: PubMed
  15. Huang S, Do J, Mahalanabis M, Fan A, Zhao L, Jepeal L, Singh SK, Klapperich CM. Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis. PLoS One. 2013; 8(3):e60059. PMID: 23555883.
    View in: PubMed
  16. Cao Q, Fan A, Klapperich C. Microfluidic chip fabrication and method to detect influenza. J Vis Exp. 2013; (73). PMID: 23567317.
    View in: PubMed
  17. Zhang JY, Mahalanabis M, Liu L, Chang J, Pollock NR, Klapperich CM. A Disposable Microfluidic Virus Concentration Device Based on Evaporation and Interfacial Tension. Diagnostics (Basel). 2013 Mar; 3(1):155-69. PMID: 26617991.
    View in: PubMed
  18. Pratt GW, Fan A, Minocha S, Orozco E, Gomez-Marquez JF, Klapperich CM. Point-of-Care Healthcare Technologies (PHT), 2013 IEEE. Monitoring HIV drug adherence with a paper-based assay. IEEE. 2013; 69-71.
    View in: External Website
  19. Fan A, Byrnes S, Klapperich C. Purification of DNA/RNA in a microfluidic device. Methods Mol Biol. 2013; 949:403-11. PMID: 23329456.
    View in: PubMed
  20. Robert D White, Robert Littrell, Karl Grosh, Morgan Hamon, Jong Wook Hong, Jithesh V Veetil, Sruthi Ravindranathan, Sha Jin, Kaiming Ye, Abhijit Majumder, Jyotsna Dhawan, Oren Levy, Jeffrey M Karp, Ufuk Olgac, Sau Yin Chin, Tassaneewan Laksanasopin, Curtis D Chin, Samuel K Sia, Jane Y Zhang, Qingqing Cao, Madhumita Mahalanabis, Catherine Klapperich, Yihong Zhan, Chang Lu, Vivian M Hernandez, P Hande Özdinler, Shan Gao, Erkin Seker, Martin L Yarmush, Sasha H Bakhru, Christopher Highley, Stefan Zappe, Edward Kang, Sau Fung Wong, Sang-Hoon Lee, Elodie Sollier, Dino Di Carlo, Yagmur Demircan, Gürkan Yilmaz, Haluk Külah, Puttachat Khuntontong, Min Gong, Zhiping Wang, A Rezzan Kose, Hur Koser, ZhengYuan Luo, ShuQi Wang, Utkan Demirci, TianJian Lu, Feng Xu, BoFeng Bai, Matin Esfahani, Dusan Sarenac, Bettina Cheung, Aishwarya Vasudevan, Fatih Inci, Ali Khademhosseini, Robert Langer, Jeffrey Blander. A Microscale Bioinspired Cochlear-like Sensor. Microfluidic Technologies for Human Health. World Scientific. 2012.
    View in: External Website
  21. Zhang JY, Cao Q, Mahalanabis M, Klapperich C. Integrated Microfluidic Sample Preparation for Chip-based Molecular Diagnostics. Microfluidic Technologies for Human Health. World Scientific. 2012; 135.
    View in: External Website
  22. Klapperich CM, Mahalanabis M, Patel SH, Sharma S, Rosen JE. A novel platform for nucleic acid biomarker-based diagnosis of thyroid cancer. Head Neck Oncology. 2012; 4(5):85.
    View in: External Website
  23. Premasiri WR, Sauer-Budge AF, Lee JC, Klapperich CM, Ziegler LD. Rapid bacterial diagnostics via surface enhanced Raman microscopy. Spectroscopy (Springf). 2012 Jun 1; 27(6):s8-31. PMID: 24371371.
    View in: PubMed
  24. Cao Q, Mahalanabis M, Chang J, Carey B, Hsieh C, Stanley A, Odell CA, Mitchell P, Feldman J, Pollock NR, Klapperich CM. Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens. PLoS One. 2012; 7(3):e33176. PMID: 22457740.
    View in: PubMed
  25. Plouffe BD, Mahalanabis M, Lewis LH, Klapperich CM, Murthy SK. Clinically relevant microfluidic magnetophoretic isolation of rare-cell populations for diagnostic and therapeutic monitoring applications. Anal Chem. 2012 Feb 7; 84(3):1336-44. PMID: 22240089.
    View in: PubMed
  26. Ho NT, Fan A, Klapperich CM, Cabodi M. Sample concentration and purification for point-of-care diagnostics. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:2396-9. PMID: 23366407.
    View in: PubMed
  27. Mahalanabis M, Do J, Almuayad H, Zhang JY, Klapperich CM. Erratum to: An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices. 2011 Jun; 13(3):599-602. PMID: 21369762.
    View in: PubMed
  28. Do J, Zhang JY, Klapperich CM. Maskless writing of microfluidics: Rapid prototyping of 3D microfluidics using scratch on a polymer substrate. Robotics and Computer-Integrated Manufacturing. 2011; 27(2):245–248.
    View in: External Website
  29. Kim MC, Isenberg BC, Sutin J, Meller A, Wong JY, Klapperich CM. Programmed trapping of individual bacteria using micrometre-size sieves. Lab Chip. 2011 Mar 21; 11(6):1089-95. PMID: 21293825.
    View in: PubMed
  30. Cao Q, Kim MC, Klapperich C. Plastic microfluidic chip for continuous-flow polymerase chain reaction: simulations and experiments. Biotechnol J. 2011 Feb; 6(2):177-84. PMID: 21298803.
    View in: PubMed
  31. Zhang JY, Do J, Premasiri WR, Ziegler LD, Klapperich CM. Rapid point-of-care concentration of bacteria in a disposable microfluidic device using meniscus dragging effect. Lab Chip. 2010 Dec 7; 10(23):3265-70. PMID: 20938505.
    View in: PubMed
  32. Basu A, Cheung KC, Eddington DT, Günther A, Hansen C, Huang TJ, Juncker D, Kaji H, Khademhosseini A, Khan SA, Klapperich C, Love JC, Munson M, Murthy S, Ozcan A, Ozinsky A, Spotts JM, Squires T, Takeuchi S, Wang W, Williams J. Contributors to the emerging investigators issue. Lab Chip. 2010 Sep 21; 10(18):2323-33. PMID: 20717627.
    View in: PubMed
  33. Kim MC, Klapperich C. A new method for simulating the motion of individual ellipsoidal bacteria in microfluidic devices. Lab Chip. 2010 Sep 21; 10(18):2464-71. PMID: 20532377.
    View in: PubMed
  34. Chatterjee A, Mirer PL, Zaldivar Santamaria E, Klapperich C, Sharon A, Sauer-Budge AF. RNA isolation from mammalian cells using porous polymer monoliths: an approach for high-throughput automation. Anal Chem. 2010 Jun 1; 82(11):4344-56. PMID: 20443545.
    View in: PubMed
  35. Mahalanabis M, Do J, ALMuayad H, Zhang JY, Klapperich CM. An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices. 2010 Apr; 12(2):353-9. PMID: 20066496.
    View in: PubMed
  36. Klapperich CM, Noack CL, Kaufman JD, Zhu L, Bonnaillie L, Wool RP. A novel biocompatible adhesive incorporating plant-derived monomers. J Biomed Mater Res A. 2009 Nov; 91(2):378-84. PMID: 18980208.
    View in: PubMed
  37. Mahalanabis M, Al-Muayad H, Kulinski MD, Altman D, Klapperich CM. Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip. Lab Chip. 2009 Oct 7; 9(19):2811-7. PMID: 19967118.
    View in: PubMed
  38. Sauer-Budge AF, Mirer P, Chatterjee A, Klapperich CM, Chargin D, Sharon A. Low cost and manufacturable complete microTAS for detecting bacteria. Lab Chip. 2009 Oct 7; 9(19):2803-10. PMID: 19967117.
    View in: PubMed
  39. Gillers S, Atkinson CD, Bartoo AC, Mahalanabis M, Boylan MO, Schwartz JH, Klapperich C, Singh SK. Microscale sample preparation for PCR of C. difficile infected stool. J Microbiol Methods. 2009 Aug; 78(2):203-7. PMID: 19505511.
    View in: PubMed
  40. Kulinski MD, Mahalanabis M, Gillers S, Zhang JY, Singh S, Klapperich CM. Sample preparation module for bacterial lysis and isolation of DNA from human urine. Biomed Microdevices. 2009 Jun; 11(3):671-8. PMID: 19130239.
    View in: PubMed
  41. Klapperich CM. Microfluidic diagnostics: time for industry standards. Expert Rev Med Devices. 2009 May; 6(3):211-3. PMID: 19419277.
    View in: PubMed
  42. Jardeleza MS, Daly MK, Kaufman JD, Klapperich C, Legutko PA. Effect of trypan blue staining on the elastic modulus of anterior lens capsules of diabetic and nondiabetic patients. J Cataract Refract Surg. 2009 Feb; 35(2):318-23. PMID: 19185249.
    View in: PubMed
  43. Bhattacharyya A, Klapperich CM. Differential gene expression using mRNA isolated on plastic microfluidic chips. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1067-70. PMID: 19965139.
    View in: PubMed
  44. Kaufman JD, Klapperich CM. Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials. J Mech Behav Biomed Mater. 2009 Aug; 2(4):312-7. PMID: 19627837.
    View in: PubMed
  45. Kaufman JD, Miller GJ, Morgan EF, Klapperich CM. Time-dependent mechanical characterization of poly(2-hydroxyethyl methacrylate) hydrogels using nanoindentation and unconfined compression. J Mater Res. 2008 May; 23(5):1472-1481. PMID: 19081812.
    View in: PubMed
  46. Klapperich C. Microfluidic applications for disposable diagnostics. J Vis Exp. 2008; (12). PMID: 19066566.
    View in: PubMed
  47. Bhattacharyya A, Kulinski D, Klapperich C. Fabrication of the thermoplastic microfluidic channels. J Vis Exp. 2008; (12). PMID: 19066567.
    View in: PubMed
  48. Spencer NJ, Cotanche DA, Klapperich CM. Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. Biomaterials. 2008 Mar; 29(8):1028-42. PMID: 18037163.
    View in: PubMed
  49. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23. PMID: 17187400.
    View in: PubMed
  50. Bhattacharyya A, Klapperich CM. Mechanical and chemical analysis of plasma and ultraviolet-ozone surface treatments for thermal bonding of polymeric microfluidic devices. Lab Chip. 2007 Jul; 7(7):876-82. PMID: 17594007.
    View in: PubMed
  51. Bhattacharyya A, Klapperich CM. Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples. Biomed Microdevices. 2007 Apr; 9(2):245-51. PMID: 17165125.
    View in: PubMed
  52. Jaworski J, Klapperich CM. Fibroblast remodeling activity at two- and three-dimensional collagen-glycosaminoglycan interfaces. Biomaterials. 2006 Aug; 27(23):4212-20. PMID: 16620959.
    View in: PubMed
  53. Bhattacharyya A, Klapperich CM. Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics. Anal Chem. 2006 Feb 1; 78(3):788-92. PMID: 16448052.
    View in: PubMed
  54. Klapperich CM, Bertozzi CR. Global gene expression of cells attached to a tissue engineering scaffold. Biomaterials. 2004 Nov; 25(25):5631-41. PMID: 15159079.
    View in: PubMed
  55. Niedzwiecki S, Klapperich C, Short J, Jani S, Ries M, Pruitt L. Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage. J Biomed Mater Res. 2001 Aug; 56(2):245-9. PMID: 11340595.
    View in: PubMed
  56. Klapperich C, Pruitt L, Komvopoulos K. Chemical and biological characteristics of low-temperature plasma treated ultra-high molecular weight polyethylene for biomedical applications. J Mater Sci Mater Med. 2001 Jun; 12(6):549-56. PMID: 15348272.
    View in: PubMed
  57. Klapperich C, Niedzwiecki S, Ries M, Pruitt L. Fluid sorption of orthopedic grade ultrahigh molecular weight polyethylene in a serum environment is affected by the surface area and sterilization method. J Biomed Mater Res. 2000; 53(1):73-5. PMID: 10634955.
    View in: PubMed
  58. Klapperich C, Graham J, Pruitt L, Ries MD. Failure of a metal-on-metal total hip arthroplasty from progressive osteolysis. J Arthroplasty. 1999 Oct; 14(7):877-81. PMID: 10537267.
    View in: PubMed
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