Catherine M. Klapperich, PhD

Dr. Catherine Klapperich is the Associate Dean for Research and the Director of the NIBIB POCTRN Center for Future Technologies in Cancer Care (CFTCC) at BU.

She is a Kern Innovation Faculty Fellow and an Associate Professor of Biomedical Engineering at Boston University. She was named the Dorf-Ebner Distinguished Faculty Fellow in 2014. She also holds appointments in the Division of Materials Science and Engineering and the Department of Mechanical Engineering. She is the Director of the Laboratory for Diagnostics and Global Healthcare Technologies and a member of the Center for Nanoscience and Nanotechnology. In 2014, Dr. Klapperich was elected a Fellow of the American Institute for Medical and Biological Engineering. She is also a guest faculty member in the Global Health Delivery Project at Harvard University.

Before coming to Boston, Dr. Klapperich was a Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley with Drs. Lisa Pruitt and Kyriakos Komvopoulos; her M.S. in Engineering Sciences from Harvard University and her B.S. in Materials Science and Engineering from Northwestern University.

Dr. Klapperich’s research is focused on engineering medical devices for use in low resource settings and at the point of care. Current projects are focused on disposable microfluidic diagnostics that incorporate on-board sample preparation and on minimally instrumented devices to enable molecular diagnostics. Her work includes diagnostics for infectious diarrhea, respiratory infections, HIV and other sexually transmitted diseases. These devices have been tested in Nicaragua and Kenya. Other work in the lab is focused on the design and deployment of devices to enable systems biology approaches to studying complex diseases including TB.

Dr. Klapperich’s lab is funded by grants from the NIH, DOD, CIMIT and the Coulter Foundation. In 2010, she was an invited participant in the National Academies of Engineering Frontiers of Engineering conference held in Agra, India. She serves on the editorial board of Biomedical Microdevices and is an active participant in both national and international research conferences.

Associate Dean for Research and Technology Development
Boston University College of Engineering


Professor
Boston University College of Engineering
Mechanical Engineering




Paper Microfluidic Chip for Isothermal Amplification and Lateral Flow Detection of Human Papillomaviru (HPVs)
05/01/2017 - 06/30/2018 (PI)
General Hospital Corp d/b/a Massachusett NIH NIBIB
5U54EB015408-05

Center for Innovation in Point of Care Technologies for the Future of Cancer Care
07/01/2016 - 06/30/2018 (PI)
NIH/National Institute of Biomedical Ima
4U54EB015403-05

Rapid Molecular Diagnosts for Chlamydia and Gonorrhea at the Point-of-Care
04/01/2015 - 03/31/2018 (PI)
NIH/National Institute of Allergy & Infe
5R01AI113927-03

Organic Biosensors for Personal Physiologic Monitoring
04/11/2016 - 10/10/2017 (Co-PI)
PI: James E. Galagan, PhD
Department of Defense/DARPA

Paper Microfluidic Chip for Isothermal Amplification and Lateral Flow Detection of HPV DNA
04/15/2015 - 06/30/2017 (PI)
General Hospital Corp d/b/a Massachusett NIH NIBIB
4U54EB015408-05

Center for Innovation in Point of Care Technologies for the Future of Cancer Care
07/01/2012 - 06/30/2017 (PI)
NIH/National Institute of Biomedical Ima
5U54EB015403-04

Rapid paper-based diagnostics of CT/Trich
08/15/2016 - 01/31/2017 (PI)
Micro Analysis LLC NIH NIAID
1R43AI122497-01

A Portable, Self-Contained Nucleic Acid Extraction and Storage System for POC Tests
04/01/2014 - 12/31/2015 (PI)
AI Biosciences, Inc. NIH NIBIB
1R43EB018641-01

BACTERIAL DRUG SUSCEPTIBILITY IDENTIFICATION BY SURFACE ENHANCED RAMAN MICROSCOPY
07/01/2010 - 12/31/2015 (PI)
Fraunhofer USA NIH NIAID
5R01AI090815-04

Single Molecule Sequencing by Nanopore induced Photon Emission (SM-SNIPE)
07/20/2010 - 06/30/2015 (Co-PI)
NIH/National Human Genome Research Insti
5R01HG005871-04

Showing 10 of 16 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 5R01AI113927-03
2016 Rapid Paper-based Diagnostics of CT / Trich 1R43AI122497-01
2016 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 5R01AI113927-02
2016 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 4U54EB015403-05 14
2015 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 1R01AI113927-01A1
2014 Rapid Molecular Diagnostic for Chlamydia and Gonorrhea at the Point-of-Care 1R56AI113927-01
2014 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 5U54EB015403-03 14
2014 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 3U54EB015403-03S1 14
2013 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 5U54EB015403-02 14
2013 Single Molecule Sequencing by Nanopore induced Photon Emission (SM-SNIPE) 5R01HG005871-04 8
Showing 10 of 29 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cristillo AD, Bristow CC, Peeling R, Van Der Pol B, de Cortina SH, Dimov IK, Pai NP, Jin Shin D, Chiu RY, Klapperich C, Madhivanan P, Morris SR, Klausner JD. Point-of-Care Sexually Transmitted Infection Diagnostics: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2017 Apr; 44(4):211-218. PMID: 28282646; DOI: 10.1097/OLQ.0000000000000572;.
  2. Ford Carleton P, Schachter S, Parrish JA, Collins JM, Crocker JB, Dixon RF, Edgman-Levitan S, Lewandrowski KB, Stahl JE, Klapperich C, Cabodi M, Gaydos CA, Rompalo AM, Manabe Y, Wang TH, Rothman R, Geddes CD, Widdice L, Jackman J, Mathura RA, Lash TB. National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine. IEEE J Transl Eng Health Med. 2016; 4:2800614. PMID: 27730014.
  3. Boardman AK, Wong WS, Premasiri WR, Ziegler LD, Lee JC, Miljkovic M, Klapperich CM, Sharon A, Sauer-Budge AF. Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy. Anal Chem. 2016 Aug 16; 88(16):8026-35.View Related Profiles. PMID: 27429301; PMCID: PMC4988670; DOI: 10.1021/acs.analchem.6b01273;.
  4. Linnes JC, Rodriguez NM, Liu L, Klapperich CM. Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics. Biomed Microdevices. 2016 Apr; 18(2):30. PMID: 26906904; PMCID: PMC4855516; DOI: 10.1007/s10544-016-0057-z;.
  5. Rodriguez NM, Wong WS, Liu L, Dewar R, Klapperich CM. A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples. Lab Chip. 2016 Feb 21; 16(4):753-63. PMID: 26785636; PMCID: PMC4747825; DOI: 10.1039/c5lc01392e;.
  6. Kim CS, Vanture S, Cho M, Klapperich CM, Wang C, Huang FW. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology. PLoS One. 2016; 11(1):e0145215.View Related Profiles. PMID: 26771309; PMCID: PMC4714834; DOI: 10.1371/journal.pone.0145215;.
  7. Rodriguez NM, Linnes JC, Fan A, Ellenson CK, Pollock NR, Klapperich CM. Paper-Based RNA Extraction, in Situ Isothermal Amplification, and Lateral Flow Detection for Low-Cost, Rapid Diagnosis of Influenza A (H1N1) from Clinical Specimens. Anal Chem. 2015 Aug 4; 87(15):7872-9. PMID: 26125635; PMCID: PMC4878390; DOI: 10.1021/acs.analchem.5b01594;.
  8. Derda R, Gitaka J, Klapperich CM, Mace CR, Kumar AA, Lieberman M, Linnes JC, Jores J, Nasimolo J, Ndung'u J, Taracha E, Weaver A, Weibel DB, Kariuki TM, Yager P. Enabling the Development and Deployment of Next Generation Point-of-Care Diagnostics. PLoS Negl Trop Dis. 2015 May; 9(5):e0003676. PMID: 25973602; PMCID: PMC4431858; DOI: 10.1371/journal.pntd.0003676;.
  9. Pratt GW, Fan A, Klapperich CM. Colorimetric Detection of Azidothymidine Using an Alkyne-Modified Dextran Substrate. ACS Biomaterials Science & Engineering. 2015; 1(5):314-319. View Publication
  10. Stahl JE, McGowan H, DiResta E, Gaydos CA, Klapperich C, Parrish J, Korte B. Systems Engineering and Point of Care Testing: Report from the NIBIB POCT/Systems Engineering Workshop. Point Care. 2015 Mar; 14(1):12-24. PMID: 25750593.
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 16 distinct years, with a maximum of 8 publications in 2009

YearPublications
19991
20001
20012
20041
20062
20074
20084
20098
20106
20113
20127
20136
20143
20156
20165
20171
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