Catherine Klapperich | Profiles RNS

Catherine M. Klapperich, PhD

Professor

Boston University College of Engineering

Biomedical Engineering

PhD, University of California, Berkeley
MS, Harvard University
BS, Northwestern University

Websites

	Biomedical Engineering - Klapperich Laboratory
	Biomedical Engineering
	CFTCC
	Dorf-Ebner Distinguished
	BUnano
	Google Scholar
	LinkedIn
	Public Relations

ORCID : 0000-0001-6103-849X

Dr. Catherine Klapperich is the Associate Dean for Research and the Director of the NIBIB POCTRN Center for Future Technologies in Cancer Care (CFTCC) at BU.

She is a Kern Innovation Faculty Fellow and an Associate Professor of Biomedical Engineering at Boston University. She was named the Dorf-Ebner Distinguished Faculty Fellow in 2014. She also holds appointments in the Division of Materials Science and Engineering and the Department of Mechanical Engineering. She is the Director of the Laboratory for Diagnostics and Global Healthcare Technologies and a member of the Center for Nanoscience and Nanotechnology. In 2014, Dr. Klapperich was elected a Fellow of the American Institute for Medical and Biological Engineering. She is also a guest faculty member in the Global Health Delivery Project at Harvard University.

Before coming to Boston, Dr. Klapperich was a Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley with Drs. Lisa Pruitt and Kyriakos Komvopoulos; her M.S. in Engineering Sciences from Harvard University and her B.S. in Materials Science and Engineering from Northwestern University.

Dr. Klapperich’s research is focused on engineering medical devices for use in low resource settings and at the point of care. Current projects are focused on disposable microfluidic diagnostics that incorporate on-board sample preparation and on minimally instrumented devices to enable molecular diagnostics. Her work includes diagnostics for infectious diarrhea, respiratory infections, HIV and other sexually transmitted diseases. These devices have been tested in Nicaragua and Kenya. Other work in the lab is focused on the design and deployment of devices to enable systems biology approaches to studying complex diseases including TB.

Dr. Klapperich’s lab is funded by grants from the NIH, DOD, CIMIT and the Coulter Foundation. In 2010, she was an invited participant in the National Academies of Engineering Frontiers of Engineering conference held in Agra, India. She serves on the editorial board of Biomedical Microdevices and is an active participant in both national and international research conferences.

Associate Dean for Research and Technology Development
Boston University College of Engineering

Professor
Boston University College of Engineering
Mechanical Engineering

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

#N/A
07/01/2024 - 06/30/2027 (PI)
Massachusetts Life Sciences Center

Equipment: MRI: Track 1 Acquisition of an Illumina NextSeq 2000 Sequencing Instrument
09/01/2023 - 08/31/2026 (Multi-PI)
PI: Catherine M. Klapperich, PhD
National Science Foundation
CBET-2320685

Clare Boothe Luce Fellowship for Madison Fletcher
09/01/2023 - 08/31/2025 (Multi-PI)
PI: Catherine M. Klapperich, PhD
The Henry Luce Foundation, Inc.

Novel Biosensors based on Mining Bacterial Transcription Factors
07/01/2020 - 03/31/2025 (Multi-PI)
PI: Catherine M. Klapperich, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB029795-04

Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom
06/04/2018 - 03/31/2024 (Multi-PI)
PI: Catherine M. Klapperich, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R25EB025788-05

SARS-CoV-2 Variant Dynamics
10/01/2021 - 03/31/2023 (Subcontract PI)
Boston Medical Center Corporation China Evergrande Gr

Rapid Molecular Diagnosts for Chlamydia and Gonorrhea at the Point-of-Care
04/01/2015 - 03/31/2021 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113927-04

Portable Nucleic Acid Prep, Storage, and Shipping Device
11/01/2017 - 04/30/2019 (PI)
Bill and Melinda Gates Foundation

Paper Microfluidic Chip for Isothermal Amplification and Lateral Flow Detection of Human Papillomaviru (HPVs)
05/01/2017 - 06/30/2018 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIBIB
5U54EB015408-05

Center for Innovation in Point of Care Technologies for the Future of Cancer Care
07/01/2016 - 06/30/2018 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
4U54EB015403-05

Showing 10 of 24 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Novel Biosensors based on Mining Bacterial Transcription Factors	5R01EB029795-04
2023	Novel Biosensors based on Mining Bacterial Transcription Factors	5R01EB029795-03
2022	Novel Biosensors based on Mining Bacterial Transcription Factors	5R01EB029795-02
2022	Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom	5R25EB025788-05
2021	Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom	5R25EB025788-04
2020	Novel Biosensors based on Mining Bacterial Transcription Factors	1R01EB029795-01
2020	Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom	5R25EB025788-03
2018	Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care	5R01AI113927-04	5
2017	2017 Microfluidics, Physics and Chemistry of Gordon Research Conference and Gordon Research Seminar	1R13EB024404-01A1
2017	Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care	5R01AI113927-03	5

Showing 10 of 41 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Shiluli C, Kamath S, Kanoi BN, Kimani R, Maina M, Waweru H, Kamita M, Ndirangu I, Abkallo HM, Oduor B, Pamme N, Dupaty J, Klapperich CM, Lolabattu SR, Gitaka J. Improving gonorrhoea molecular diagnostics: Genome mining-based identification of identical multi-repeat sequences (IMRS) in Neisseria gonorrhoeae. Heliyon. 2024 Mar 30; 10(6):e27344. PMID: 38533083; PMCID: PMC10963193; DOI: 10.1016/j.heliyon.2024.e27344;

Turcinovic J, Kuhfeldt K, Sullivan M, Landaverde L, Platt JT, Alekseyev YO, Doucette-Stamm L, Hamer DH, Klapperich C, Landsberg HE, Connor JH. Transmission Dynamics and Rare Clustered Transmission Within an Urban University Population Before Widespread Vaccination. J Infect Dis. 2024 Feb 14; 229(2):485-492.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Kuhfeldt, Kayla
Alekseyev, Yuriy

PMID: 37856283

Zamani M, Klapperich CM, Furst AL. Recent advances in gold electrode fabrication for low-resource setting biosensing. Lab Chip. 2023 Mar 01; 23(5):1410-1419. PMID: 36602146; PMCID: PMC9977368; DOI: 10.1039/d2lc00552b;

Bouton TC, Atarere J, Turcinovic J, Seitz S, Sher-Jan C, Gilbert M, White L, Zhou Z, Hossain MM, Overbeck V, Doucette-Stamm L, Platt J, Landsberg HE, Hamer DH, Klapperich C, Jacobson KR, Connor JH. Viral Dynamics of Omicron and Delta Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants With Implications for Timing of Release from Isolation: A Longitudinal Cohort Study. Clin Infect Dis. 2023 Feb 08; 76(3):e227-e233.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Seitz, Scott
Bouton, Tara

PMID: 35737948; PMCID: PMC9278204; DOI: 10.1093/cid/ciac510;

Petros BA, Turcinovic J, Welch NL, White LF, Kolaczyk ED, Bauer MR, Cleary M, Dobbins ST, Doucette-Stamm L, Gore M, Nair P, Nguyen TG, Rose S, Taylor BP, Tsang D, Wendlandt E, Hope M, Platt JT, Jacobson KR, Bouton T, Yune S, Auclair JR, Landaverde L, Klapperich CM, Hamer DH, Hanage WP, MacInnis BL, Sabeti PC, Connor JH, Springer M. Early Introduction and Rise of the Omicron Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant in Highly Vaccinated University Populations. Clin Infect Dis. 2023 Feb 08; 76(3):e400-e408.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 35616119; PMCID: PMC9213864; DOI: 10.1093/cid/ciac413;

Landaverde L, Turcinovic J, Doucette-Stamm L, Gonzales K, Platt J, Connor JH, Klapperich C. Comparison of BinaxNOW and SARS-CoV-2 qRT-PCR Detection of the Omicron Variant from Matched Anterior Nares Swabs. Microbiol Spectr. 2022 Dec 21; 10(6):e0130722.View Related Profiles.

Klapperich, Catherine
Connor, John

PMID: 36255297; PMCID: PMC9769721; DOI: 10.1128/spectrum.01307-22;

Turcinovic J, Kuhfeldt K, Sullivan M, Landaverde L, Platt JT, Doucette-Stamm L, Hanage WP, Hamer DH, Klapperich C, Landsberg HE, Connor JH. Linking contact tracing with genomic surveillance to deconvolute SARS-CoV-2 transmission on a university campus. iScience. 2022 Nov 18; 25(11):105337.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Kuhfeldt, Kayla

PMID: 36246573; PMCID: PMC9554197; DOI: 10.1016/j.isci.2022.105337;

Kuhfeldt K, Turcinovic J, Sullivan M, Landaverde L, Doucette-Stamm L, Hamer DH, Platt JT, Klapperich C, Landsberg HE, Connor JH. Examination of SARS-CoV-2 In-Class Transmission at a Large Urban University With Public Health Mandates Using Epidemiological and Genomic Methodology. JAMA Netw Open. 2022 Aug 01; 5(8):e2225430.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Kuhfeldt, Kayla

PMID: 35930286; PMCID: PMC9356317; DOI: 10.1001/jamanetworkopen.2022.25430;

Hall SM, Landaverde L, Gill CJ, Yee GM, Sullivan M, Doucette-Stamm L, Landsberg H, Platt JT, White L, Hamer DH, Klapperich CM. Comparison of anterior nares CT values in asymptomatic and symptomatic individuals diagnosed with SARS-CoV-2 in a university screening program. PLoS One. 2022; 17(7):e0270694.View Related Profiles.

Klapperich, Catherine
Gill, Christopher
Hamer, Davidson
Platt, Judy
White, Laura

PMID: 35830378; PMCID: PMC9278773; DOI: 10.1371/journal.pone.0270694;

Landaverde L, McIntyre D, Robson J, Fu D, Ortiz L, Chen R, Oliveira SMD, Fan A, Barrett A, Burgay SP, Choate S, Corbett D, Doucette-Stamm L, Gonzales K, Hamer DH, Huang L, Huval S, Knight C, Landa C, Lindquist D, Lockard K, Macdowell TL, Mauro E, McGinty C, Miller C, Monahan M, Moore R, Platt J, Rolles L, Roy J, Schroeder T, Tolan DR, Zaia A, Brown RA, Waters G, Densmore D, Klapperich CM. Buildout and integration of an automated high-throughput CLIA laboratory for SARS-CoV-2 testing on a large urban campus. SLAS Technol. 2022 Oct; 27(5):302-311.View Related Profiles.

Klapperich, Catherine
Corbett, David
Hamer, Davidson
Oliveira, Samuel

PMID: 35718332; PMCID: PMC9212990; DOI: 10.1016/j.slast.2022.06.003;

Showing 10 of 96 results. Show More

Grazon C, Chern M, Lally P, Baer RC, Fan A, Lecommandoux S, Klapperich C, Dennis AM, Galagan JE, Grinstaff MW. The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose? Chem Sci. 2022 Jun 07; 13(22):6715-6731.View Related Profiles.

Dennis, Allison
Klapperich, Catherine
Galagan, James
Grinstaff, Mark

PMID: 35756504; PMCID: PMC9172442; DOI: 10.1039/d1sc06921g;

Sankar K, Baer R, Grazon C, Sabatelle RC, Lecommandoux S, Klapperich CM, Galagan JE, Grinstaff MW. An Allosteric Transcription Factor DNA-Binding Electrochemical Biosensor for Progesterone. ACS Sens. 2022 Apr 22; 7(4):1132-1137.View Related Profiles.

Klapperich, Catherine
Galagan, James
Grinstaff, Mark

PMID: 35412319; PMCID: PMC9985479; DOI: 10.1021/acssensors.2c00133;

Bouton TC, Atarere J, Turcinovic J, Seitz S, Sher-Jan C, Gilbert M, White L, Zhou Z, Hossain MM, Overbeck V, Doucette-Stamm L, Platt J, Landsberg HE, Hamer DH, Klapperich C, Jacobson KR, Connor JH. Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort study. medRxiv. 2022 Apr 05.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Seitz, Scott
Bouton, Tara

PMID: 35411341; PMCID: PMC8996632; DOI: 10.1101/2022.04.04.22273429;

Kuhfeldt K, Turcinovic J, Sullivan M, Landaverde L, Doucette-Stamm L, Hamer DH, Platt J, Klapperich C, Landsberg HE, Connor JH. Minimal SARS-CoV-2 classroom transmission at a large urban university experiencing repeated into campus introduction. medRxiv. 2022 Mar 16.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Kuhfeldt, Kayla

PMID: 35313596; PMCID: PMC8936094; DOI: 10.1101/2022.03.16.22271983;

Rosenbohm JM, Klapperich CM, Cabodi M. Tunable Duplex Semiquantitative Detection of Nucleic Acids with a Visual Lateral Flow Immunoassay Readout. Anal Chem. 2022 03 08; 94(9):3956-3962.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 35199994; PMCID: PMC10017168; DOI: 10.1021/acs.analchem.1c05039;

Zamani M, Dupaty J, Baer RC, Kuzmanovic U, Fan A, Grinstaff MW, Galagan JE, Klapperich CM. Paper-Based Progesterone Sensor Using an Allosteric Transcription Factor. ACS Omega. 2022 Feb 22; 7(7):5804-5808.View Related Profiles.

Klapperich, Catherine
Galagan, James
Grinstaff, Mark

PMID: 35224340; PMCID: PMC8867790; DOI: 10.1021/acsomega.1c05737;

Zamani M, Yang V, Maziashvili L, Fan G, Klapperich CM, Furst AL. Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes. ACS Meas Sci Au. 2022 Apr 20; 2(2):91-95. PMID: 35479101; PMCID: PMC9026247; DOI: 10.1021/acsmeasuresciau.1c00042;

Zamani M, Furst AL, Klapperich CM. Strategies for Engineering Affordable Technologies for Point-of-Care Diagnostics of Infectious Diseases. Acc Chem Res. 2021 10 19; 54(20):3772-3779. PMID: 34612619; PMCID: PMC8996141; DOI: 10.1021/acs.accounts.1c00434;

Hamer DH, White LF, Jenkins HE, Gill CJ, Landsberg HE, Klapperich C, Bulekova K, Platt J, Decarie L, Gilmore W, Pilkington M, MacDowell TL, Faria MA, Densmore D, Landaverde L, Li W, Rose T, Burgay SP, Miller C, Doucette-Stamm L, Lockard K, Elmore K, Schroeder T, Zaia AM, Kolaczyk ED, Waters G, Brown RA. Assessment of a COVID-19 Control Plan on an Urban University Campus During a Second Wave of the Pandemic. JAMA Netw Open. 2021 06 01; 4(6):e2116425.View Related Profiles.

Klapperich, Catherine
Gill, Christopher
Hamer, Davidson
Jenkins, Helen
Platt, Judy
Bulekova, Katia
White, Laura

PMID: 34170303; PMCID: PMC8233704; DOI: 10.1001/jamanetworkopen.2021.16425;

Zamani M, Robson JM, Fan A, Bono MS, Furst AL, Klapperich CM. Electrochemical Strategy for Low-Cost Viral Detection. ACS Cent Sci. 2021 Jun 23; 7(6):963-972. PMID: 34235257; PMCID: PMC8227598; DOI: 10.1021/acscentsci.1c00186;

Davidi D, Fitzgerald S, Glaspell HL, Jalbert S, Klapperich CM, Landaverde L, Maheras S, Mattoon SE, Britto VM, Nguyen GT, Platt JT, Kuhfeldt K, Landsberg H, Stuopis CW, Turse JE, Hamer DH, Springer M. Amplicon residues in research laboratories masquerade as COVID-19 in surveillance tests. Cell Rep Methods. 2021 May 24; 1(1):100005.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Platt, Judy
Kuhfeldt, Kayla

PMID: 34235497; PMCID: PMC8017732; DOI: 10.1016/j.crmeth.2021.100005;

Kolluri N, Kamath S, Lally P, Zanna M, Galagan J, Gitaka J, Kamita M, Cabodi M, Lolabattu SR, Klapperich CM. Development and Clinical Validation of Iso-IMRS: A Novel Diagnostic Assay for P. falciparum Malaria. Anal Chem. 2021 02 02; 93(4):2097-2105.View Related Profiles.

Klapperich, Catherine
Galagan, James
Cabodi, Mario

PMID: 33464825; PMCID: PMC7859932; DOI: 10.1021/acs.analchem.0c03847;

Lee RA, Puig H, Nguyen PQ, Angenent-Mari NM, Donghia NM, McGee JP, Dvorin JD, Klapperich CM, Pollock NR, Collins JJ. Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25722-25731. PMID: 32958655; PMCID: PMC7568265; DOI: 10.1073/pnas.2010196117;

Chen M, Grazon C, Sensharma P, Nguyen TT, Feng Y, Chern M, Baer RC, Varongchayakul N, Cook K, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Hydrogel-Embedded Quantum Dot-Transcription Factor Sensors for Quantitative Progesterone Detection. ACS Appl Mater Interfaces. 2020 Sep 30; 12(39):43513-43521.View Related Profiles.

Dennis, Allison
Klapperich, Catherine
Galagan, James
Grinstaff, Mark
Baer, R

PMID: 32893612

Kolluri N, Albarran N, Fan A, Olson A, Sagar M, Young A, Gomez-Marquez J, Klapperich CM. SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood. Lab Chip. 2020 09 21; 20(18):3386-3398.View Related Profiles.

Klapperich, Catherine
Sagar, Manish

PMID: 32766666

Chen M, Nguyen TT, Varongchayakul N, Grazon C, Chern M, Baer RC, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Surface Immobilized Nucleic Acid-Transcription Factor Quantum Dots for Biosensing. Adv Healthc Mater. 2020 09; 9(17):e2000403.View Related Profiles.

Dennis, Allison
Klapperich, Catherine
Galagan, James
Grinstaff, Mark
Baer, R

PMID: 32691962

Landaverde L, Wong W, Hernandez G, Fan A, Klapperich C. Method for the elucidation of LAMP products captured on lateral flow strips in a point of care test for HPV 16. Anal Bioanal Chem. 2020 Sep; 412(24):6199-6209. PMID: 32488390; PMCID: PMC7266737; DOI: 10.1007/s00216-020-02702-9;

Grazon C, Baer RC, Kuzmanovic U, Nguyen T, Chen M, Zamani M, Chern M, Aquino P, Zhang X, Lecommandoux S, Fan A, Cabodi M, Klapperich C, Grinstaff MW, Dennis AM, Galagan JE. A progesterone biosensor derived from microbial screening. Nat Commun. 2020 03 09; 11(1):1276.View Related Profiles.

Dennis, Allison
Klapperich, Catherine
Galagan, James
Cabodi, Mario
Grinstaff, Mark
Baer, R

PMID: 32152281; PMCID: PMC7062782; DOI: 10.1038/s41467-020-14942-5;

Rosenbohm JM, Robson JM, Singh R, Lee R, Zhang JY, Klapperich CM, Pollock NR, Cabodi M. Rapid electrostatic DNA enrichment for sensitive detection of Trichomonas vaginalis in clinical urinary samples. Anal Methods. 2020 Feb 28; 12(8):1085-1093.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 35154421; PMCID: PMC8837197; DOI: 10.1039/c9ay02478f;

Claure I, Anderson D, Klapperich CM, Kuohung W, Wong JY. Biomaterials and Contraception: Promises and Pitfalls. Ann Biomed Eng. 2020 Jul; 48(7):2113-2131.View Related Profiles.

Klapperich, Catherine
Wong, Joyce
Kuohung, Wendy

PMID: 31701311; PMCID: PMC7202983; DOI: 10.1007/s10439-019-02402-1;

Raju LS, Kamath S, Shetty MC, Satpathi S, Mohanty AK, Ghosh SK, Kolluri N, Klapperich CM, Cabodi M, Padmanaban G, Nagaraj VA. Genome Mining-Based Identification of Identical Multirepeat Sequences in Plasmodium falciparum Genome for Highly Sensitive Real-Time Quantitative PCR Assay and Its Application in Malaria Diagnosis. J Mol Diagn. 2019 09; 21(5):824-838.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 31158524

Horst AL, Rosenbohm JM, Kolluri N, Hardick J, Gaydos CA, Cabodi M, Klapperich CM, Linnes JC. A paperfluidic platform to detect Neisseria gonorrhoeae in clinical samples. Biomed Microdevices. 2018 04 11; 20(2):35.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 29644437; PMCID: PMC6154386; DOI: 10.1007/s10544-018-0280-x;

Pratt GW, Fan A, Melakeberhan B, Klapperich CM. A competitive lateral flow assay for the detection of tenofovir. Anal Chim Acta. 2018 Aug 09; 1017:34-40. PMID: 29534793; PMCID: PMC5877480; DOI: 10.1016/j.aca.2018.02.039;

Kolluri N, Klapperich CM, Cabodi M. Towards lab-on-a-chip diagnostics for malaria elimination. Lab Chip. 2017 12 19; 18(1):75-94.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 29125615

Katevatis C, Fan A, Klapperich CM. Low concentration DNA extraction and recovery using a silica solid phase. PLoS One. 2017; 12(5):e0176848. PMID: 28475611; PMCID: PMC5419563; DOI: 10.1371/journal.pone.0176848;

Cristillo AD, Bristow CC, Peeling R, Van Der Pol B, de Cortina SH, Dimov IK, Pai NP, Jin Shin D, Chiu RY, Klapperich C, Madhivanan P, Morris SR, Klausner JD. Point-of-Care Sexually Transmitted Infection Diagnostics: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2017 Apr; 44(4):211-218. PMID: 28282646; PMCID: PMC5347466; DOI: 10.1097/OLQ.0000000000000572;

Ford Carleton P, Schachter S, Parrish JA, Collins JM, Crocker JB, Dixon RF, Edgman-Levitan S, Lewandrowski KB, Stahl JE, Klapperich C, Cabodi M, Gaydos CA, Rompalo AM, Manabe Y, Wang TH, Rothman R, Geddes CD, Widdice L, Jackman J, Mathura RA, Lash TB. National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine. IEEE J Transl Eng Health Med. 2016; 4:2800614.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 27730014; PMCID: PMC5052024; DOI: 10.1109/JTEHM.2016.2598837;

Boardman AK, Wong WS, Premasiri WR, Ziegler LD, Lee JC, Miljkovic M, Klapperich CM, Sharon A, Sauer-Budge AF. Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy. Anal Chem. 2016 08 16; 88(16):8026-35.View Related Profiles.

Boardman, Anna
Klapperich, Catherine
Ziegler, Lawrence

PMID: 27429301; PMCID: PMC4988670; DOI: 10.1021/acs.analchem.6b01273;

Linnes JC, Rodriguez NM, Liu L, Klapperich CM. Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics. Biomed Microdevices. 2016 Apr; 18(2):30. PMID: 26906904; PMCID: PMC4855516; DOI: 10.1007/s10544-016-0057-z;

Rodriguez NM, Wong WS, Liu L, Dewar R, Klapperich CM. A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples. Lab Chip. 2016 Feb 21; 16(4):753-63. PMID: 26785636; PMCID: PMC4747825; DOI: 10.1039/c5lc01392e;

Kim CS, Vanture S, Cho M, Klapperich CM, Wang C, Huang FW. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology. PLoS One. 2016; 11(1):e0145215.View Related Profiles.

Wang, Catharine
Klapperich, Catherine

PMID: 26771309; PMCID: PMC4714834; DOI: 10.1371/journal.pone.0145215;

Rodriguez NM, Linnes JC, Fan A, Ellenson CK, Pollock NR, Klapperich CM. Paper-Based RNA Extraction, in Situ Isothermal Amplification, and Lateral Flow Detection for Low-Cost, Rapid Diagnosis of Influenza A (H1N1) from Clinical Specimens. Anal Chem. 2015 Aug 4; 87(15):7872-9. PMID: 26125635; PMCID: PMC4878390; DOI: 10.1021/acs.analchem.5b01594;

Derda R, Gitaka J, Klapperich CM, Mace CR, Kumar AA, Lieberman M, Linnes JC, Jores J, Nasimolo J, Ndung'u J, Taracha E, Weaver A, Weibel DB, Kariuki TM, Yager P. Enabling the Development and Deployment of Next Generation Point-of-Care Diagnostics. PLoS Negl Trop Dis. 2015 May; 9(5):e0003676. PMID: 25973602; PMCID: PMC4431858; DOI: 10.1371/journal.pntd.0003676;

Pratt GW, Fan A, Klapperich CM. Colorimetric Detection of Azidothymidine Using an Alkyne-Modified Dextran Substrate. ACS Biomater Sci Eng. 2015 May 11; 1(5):314-319. PMID: 33429574

Pratt GW, Fan A, Klapperich CM. Colorimetric Detection of Azidothymidine Using an Alkyne-Modified Dextran Substrate. ACS Biomaterials Science & Engineering. 2015; 1(5):314-319. View Publication

Stahl JE, McGowan H, DiResta E, Gaydos CA, Klapperich C, Parrish J, Korte B. Systems Engineering and Point of Care Testing: Report from the NIBIB POCT/Systems Engineering Workshop. Point Care. 2015 Mar; 14(1):12-24. PMID: 25750593; PMCID: PMC4349191; DOI: 10.1097/POC.0000000000000046;

Wong S, Drain PK, Klapperich CM. Annals of Global Health. A point-of-care device for the rapid diagnosis of tuberculosis. Elsevier. 2015; 81(1):85-86. View Publication
Bhattacharyya A, Klapperich CM. Encyclopedia of Microfluidics and Nanofluidics. On-Chip Cell Lysis. Springer. New York. 2015; 2481-2483. View Publication

Wong SY, Cabodi M, Rolland J, Klapperich CM. Evaporative concentration on a paper-based device to concentrate analytes in a biological fluid. Anal Chem. 2014 Dec 16; 86(24):11981-5.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 25419873; PMCID: PMC4852713; DOI: 10.1021/ac503751a;

Huang S, Sharma S, Liu L, Fan A, Klapperich CM, Rosen J. Cancer Research. Abstract 3494: Microfluidic platform for a protein-based thyroid cancer diagnostics. American Association for Cancer Research. 2014; 74(19 Suppl):3494-3494. View Publication

Linnes JC, Fan A, Rodriguez NM, Lemieux B, Kong H, Klapperich CM. Paper-based molecular diagnostic for Chlamydia trachomatis. RSC Adv. 2014 Jan 01; 4(80):42245-42251. PMID: 25309740; PMCID: PMC4188396; DOI: 10.1039/C4RA07911F;

Byrnes S, Fan A, Trueb J, Jareczek F, Mazzochette M, Sharon A, Sauer-Budge AF, Klapperich CM. A Portable, Pressure Driven, Room Temperature Nucleic Acid Extraction and Storage System for Point of Care Molecular Diagnostics. Anal Methods. 2013 Jul 07; 5(13):3177-3184. PMID: 23914255; PMCID: PMC3727300; DOI: 10.1039/C3AY40162F;

Huang S, Do J, Mahalanabis M, Fan A, Zhao L, Jepeal L, Singh SK, Klapperich CM. Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis. PLoS One. 2013; 8(3):e60059.View Related Profiles.

Klapperich, Catherine
Singh, Satish

PMID: 23555883; PMCID: PMC3610934; DOI: 10.1371/journal.pone.0060059;

Cao Q, Fan A, Klapperich C. Microfluidic chip fabrication and method to detect influenza. J Vis Exp. 2013; (73). PMID: 23567317; PMCID: PMC3671660; DOI: 10.3791/50325;

Zhang JY, Mahalanabis M, Liu L, Chang J, Pollock NR, Klapperich CM. A Disposable Microfluidic Virus Concentration Device Based on Evaporation and Interfacial Tension. Diagnostics (Basel). 2013 Mar; 3(1):155-69. PMID: 26617991; PMCID: PMC4662409; DOI: 10.3390/diagnostics3010155;

Pratt GW, Fan A, Minocha S, Orozco E, Gomez-Marquez JF, Klapperich CM. Point-of-Care Healthcare Technologies (PHT), 2013 IEEE. Monitoring HIV drug adherence with a paper-based assay. IEEE. 2013; 69-71. View Publication

Fan A, Byrnes S, Klapperich C. Purification of DNA/RNA in a microfluidic device. Methods Mol Biol. 2013; 949:403-11. PMID: 23329456; PMCID: PMC4451820; DOI: 10.1007/978-1-62703-134-9_25;

Zhang JY, Cao Q, Mahalanabis M, Klapperich C. Integrated Microfluidic Sample Preparation for Chip-based Molecular Diagnostics. Microfluidic Technologies for Human Health. World Scientific. 2012; 135. View Publication
Robert D White, Robert Littrell, Karl Grosh, Morgan Hamon, Jong Wook Hong, Jithesh V Veetil, Sruthi Ravindranathan, Sha Jin, Kaiming Ye, Abhijit Majumder, Jyotsna Dhawan, Oren Levy, Jeffrey M Karp, Ufuk Olgac, Sau Yin Chin, Tassaneewan Laksanasopin, Curtis D Chin, Samuel K Sia, Jane Y Zhang, Qingqing Cao, Madhumita Mahalanabis, Catherine Klapperich, Yihong Zhan, Chang Lu, Vivian M Hernandez, P Hande Özdinler, Shan Gao, Erkin Seker, Martin L Yarmush, Sasha H Bakhru, Christopher Highley, Stefan Zappe, Edward Kang, Sau Fung Wong, Sang-Hoon Lee, Elodie Sollier, Dino Di Carlo, Yagmur Demircan, Gürkan Yilmaz, Haluk Külah, Puttachat Khuntontong, Min Gong, Zhiping Wang, A Rezzan Kose, Hur Koser, ZhengYuan Luo, ShuQi Wang, Utkan Demirci, TianJian Lu, Feng Xu, BoFeng Bai, Matin Esfahani, Dusan Sarenac, Bettina Cheung, Aishwarya Vasudevan, Fatih Inci, Ali Khademhosseini, Robert Langer, Jeffrey Blander. A Microscale Bioinspired Cochlear-like Sensor. Microfluidic Technologies for Human Health. World Scientific. 2012. View Publication
Klapperich CM, Mahalanabis M, Patel SH, Sharma S, Rosen JE. A novel platform for nucleic acid biomarker-based diagnosis of thyroid cancer. Head Neck Oncology. 2012; 4(5):85. View Publication

Premasiri WR, Sauer-Budge AF, Lee JC, Klapperich CM, Ziegler LD. Rapid bacterial diagnostics via surface enhanced Raman microscopy. Spectroscopy (Springf). 2012 Jun 01; 27(6):s8-31.View Related Profiles.

Klapperich, Catherine
Ziegler, Lawrence

PMID: 24371371; PMCID: PMC3872130

Cao Q, Mahalanabis M, Chang J, Carey B, Hsieh C, Stanley A, Odell CA, Mitchell P, Feldman J, Pollock NR, Klapperich CM. Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens. PLoS One. 2012; 7(3):e33176.View Related Profiles.

Klapperich, Catherine
Feldman, James

PMID: 22457740; PMCID: PMC3310856; DOI: 10.1371/journal.pone.0033176;

Plouffe BD, Mahalanabis M, Lewis LH, Klapperich CM, Murthy SK. Clinically relevant microfluidic magnetophoretic isolation of rare-cell populations for diagnostic and therapeutic monitoring applications. Anal Chem. 2012 Feb 7; 84(3):1336-44. PMID: 22240089; DOI: 10.1021/ac2022844;

Ho NT, Fan A, Klapperich CM, Cabodi M. Sample concentration and purification for point-of-care diagnostics. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:2396-9.View Related Profiles.

Klapperich, Catherine
Cabodi, Mario

PMID: 23366407; PMCID: PMC3650910; DOI: 10.1109/EMBC.2012.6346446;

Mahalanabis M, Do J, Almuayad H, Zhang JY, Klapperich CM. Erratum to: An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices. 2011 Jun; 13(3):599-602. PMID: 21369762; DOI: 10.1007/s10544-011-9518-6;

Do J, Zhang JY, Klapperich CM. Maskless writing of microfluidics: Rapid prototyping of 3D microfluidics using scratch on a polymer substrate. Robotics and Computer-Integrated Manufacturing. 2011; 27(2):245–248. View Publication

Kim MC, Isenberg BC, Sutin J, Meller A, Wong JY, Klapperich CM. Programmed trapping of individual bacteria using micrometre-size sieves. Lab Chip. 2011 Mar 21; 11(6):1089-95.View Related Profiles.

Klapperich, Catherine
Sutin, Jason
Wong, Joyce

PMID: 21293825; DOI: 10.1039/c0lc00362j;

Cao Q, Kim MC, Klapperich C. Plastic microfluidic chip for continuous-flow polymerase chain reaction: simulations and experiments. Biotechnol J. 2011 Feb; 6(2):177-84. PMID: 21298803; PMCID: PMC3049856; DOI: 10.1002/biot.201000100;

Zhang JY, Do J, Premasiri WR, Ziegler LD, Klapperich CM. Rapid point-of-care concentration of bacteria in a disposable microfluidic device using meniscus dragging effect. Lab Chip. 2010 Dec 7; 10(23):3265-70.View Related Profiles.

Klapperich, Catherine
Ziegler, Lawrence

PMID: 20938505; PMCID: PMC4452279; DOI: 10.1039/c0lc00051e;

Basu A, Cheung KC, Eddington DT, Günther A, Hansen C, Huang TJ, Juncker D, Kaji H, Khademhosseini A, Khan SA, Klapperich C, Love JC, Munson M, Murthy S, Ozcan A, Ozinsky A, Spotts JM, Squires T, Takeuchi S, Wang W, Williams J. Contributors to the emerging investigators issue. Lab Chip. 2010 Sep 21; 10(18):2323-33. PMID: 20717627; DOI: 10.1039/c0lc90044c;

Kim MC, Klapperich C. A new method for simulating the motion of individual ellipsoidal bacteria in microfluidic devices. Lab Chip. 2010 Sep 21; 10(18):2464-71. PMID: 20532377; DOI: 10.1039/c003627g;

Chatterjee A, Mirer PL, Zaldivar Santamaria E, Klapperich C, Sharon A, Sauer-Budge AF. RNA isolation from mammalian cells using porous polymer monoliths: an approach for high-throughput automation. Anal Chem. 2010 Jun 1; 82(11):4344-56. PMID: 20443545; DOI: 10.1021/ac100063f;

Mahalanabis M, Do J, ALMuayad H, Zhang JY, Klapperich CM. An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices. 2010 Apr; 12(2):353-9. PMID: 20066496; PMCID: PMC2998058; DOI: 10.1007/s10544-009-9391-8;

Klapperich CM, Noack CL, Kaufman JD, Zhu L, Bonnaillie L, Wool RP. A novel biocompatible adhesive incorporating plant-derived monomers. J Biomed Mater Res A. 2009 Nov; 91(2):378-84. PMID: 18980208; DOI: 10.1002/jbm.a.32250;

Sauer-Budge AF, Mirer P, Chatterjee A, Klapperich CM, Chargin D, Sharon A. Low cost and manufacturable complete microTAS for detecting bacteria. Lab Chip. 2009 Oct 7; 9(19):2803-10. PMID: 19967117; DOI: 10.1039/b904854e;

Mahalanabis M, Al-Muayad H, Kulinski MD, Altman D, Klapperich CM. Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip. Lab Chip. 2009 Oct 7; 9(19):2811-7. PMID: 19967118; DOI: 10.1039/b905065p;

Gillers S, Atkinson CD, Bartoo AC, Mahalanabis M, Boylan MO, Schwartz JH, Klapperich C, Singh SK. Microscale sample preparation for PCR of C. difficile infected stool. J Microbiol Methods. 2009 Aug; 78(2):203-7.View Related Profiles.

Klapperich, Catherine
Schwartz, John
Singh, Satish

PMID: 19505511; PMCID: PMC4429880; DOI: 10.1016/j.mimet.2009.05.020;

Kulinski MD, Mahalanabis M, Gillers S, Zhang JY, Singh S, Klapperich CM. Sample preparation module for bacterial lysis and isolation of DNA from human urine. Biomed Microdevices. 2009 Jun; 11(3):671-8.View Related Profiles.

Klapperich, Catherine
Singh, Satish

PMID: 19130239; PMCID: PMC4442481; DOI: 10.1007/s10544-008-9277-1;

Klapperich CM. Microfluidic diagnostics: time for industry standards. Expert Rev Med Devices. 2009 May; 6(3):211-3. PMID: 19419277; DOI: 10.1586/erd.09.11;

Jardeleza MS, Daly MK, Kaufman JD, Klapperich C, Legutko PA. Effect of trypan blue staining on the elastic modulus of anterior lens capsules of diabetic and nondiabetic patients. J Cataract Refract Surg. 2009 Feb; 35(2):318-23.View Related Profiles.

Klapperich, Catherine
Daly, Mary

PMID: 19185249; DOI: 10.1016/j.jcrs.2008.10.040;

Bhattacharyya A, Klapperich CM. Differential gene expression using mRNA isolated on plastic microfluidic chips. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1067-70. PMID: 19965139; DOI: 10.1109/IEMBS.2009.5335124;

Kaufman JD, Klapperich CM. Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials. J Mech Behav Biomed Mater. 2009 Aug; 2(4):312-7. PMID: 19627837; DOI: 10.1016/j.jmbbm.2008.08.004;

Kaufman JD, Miller GJ, Morgan EF, Klapperich CM. Time-dependent mechanical characterization of poly(2-hydroxyethyl methacrylate) hydrogels using nanoindentation and unconfined compression. J Mater Res. 2008 May; 23(5):1472-1481.View Related Profiles.

Klapperich, Catherine
Morgan, Elise

PMID: 19081812; PMCID: PMC2600455; DOI: 10.1557/JMR.2008.0185;

Bhattacharyya A, Kulinski D, Klapperich C. Fabrication of the thermoplastic microfluidic channels. J Vis Exp. 2008; (12). PMID: 19066567; PMCID: PMC2582846; DOI: 10.3791/664;

Klapperich C. Microfluidic applications for disposable diagnostics. J Vis Exp. 2008; (12). PMID: 19066566; PMCID: PMC2582842; DOI: 10.3791/665;

Spencer NJ, Cotanche DA, Klapperich CM. Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. Biomaterials. 2008 Mar; 29(8):1028-42. PMID: 18037163; PMCID: PMC2424202; DOI: 10.1016/j.biomaterials.2007.11.006;

Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23. PMID: 17187400; DOI: 10.1002/jbm.a.30976;

Bhattacharyya A, Klapperich CM. Mechanical and chemical analysis of plasma and ultraviolet-ozone surface treatments for thermal bonding of polymeric microfluidic devices. Lab Chip. 2007 Jul; 7(7):876-82. PMID: 17594007; DOI: 10.1039/b700442g;

Bhattacharyya A, Klapperich CM. Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples. Biomed Microdevices. 2007 Apr; 9(2):245-51. PMID: 17165125; DOI: 10.1007/s10544-006-9026-2;

Jaworski J, Klapperich CM. Fibroblast remodeling activity at two- and three-dimensional collagen-glycosaminoglycan interfaces. Biomaterials. 2006 Aug; 27(23):4212-20. PMID: 16620959; DOI: 10.1016/j.biomaterials.2006.03.026;

Bhattacharyya A, Klapperich CM. Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics. Anal Chem. 2006 Feb 1; 78(3):788-92. PMID: 16448052; DOI: 10.1021/ac051449j;

Klapperich CM, Bertozzi CR. Global gene expression of cells attached to a tissue engineering scaffold. Biomaterials. 2004 Nov; 25(25):5631-41. PMID: 15159079; DOI: 10.1016/j.biomaterials.2004.01.025;

Niedzwiecki S, Klapperich C, Short J, Jani S, Ries M, Pruitt L. Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage. J Biomed Mater Res. 2001 Aug; 56(2):245-9. PMID: 11340595

Klapperich C, Pruitt L, Komvopoulos K. Chemical and biological characteristics of low-temperature plasma treated ultra-high molecular weight polyethylene for biomedical applications. J Mater Sci Mater Med. 2001 Jun; 12(6):549-56. PMID: 15348272

Klapperich C, Niedzwiecki S, Ries M, Pruitt L. Fluid sorption of orthopedic grade ultrahigh molecular weight polyethylene in a serum environment is affected by the surface area and sterilization method. J Biomed Mater Res. 2000; 53(1):73-5. PMID: 10634955

Klapperich C, Graham J, Pruitt L, Ries MD. Failure of a metal-on-metal total hip arthroplasty from progressive osteolysis. J Arthroplasty. 1999 Oct; 14(7):877-81. PMID: 10537267

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 96 publications over 23 distinct years, with a maximum of 11 publications in 2022