Catherine M. Klapperich, PhD

Dr. Catherine Klapperich is the Associate Dean for Research and the Director of the NIBIB POCTRN Center for Future Technologies in Cancer Care (CFTCC) at BU.

She is a Kern Innovation Faculty Fellow and an Associate Professor of Biomedical Engineering at Boston University. She was named the Dorf-Ebner Distinguished Faculty Fellow in 2014. She also holds appointments in the Division of Materials Science and Engineering and the Department of Mechanical Engineering. She is the Director of the Laboratory for Diagnostics and Global Healthcare Technologies and a member of the Center for Nanoscience and Nanotechnology. In 2014, Dr. Klapperich was elected a Fellow of the American Institute for Medical and Biological Engineering. She is also a guest faculty member in the Global Health Delivery Project at Harvard University.

Before coming to Boston, Dr. Klapperich was a Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley with Drs. Lisa Pruitt and Kyriakos Komvopoulos; her M.S. in Engineering Sciences from Harvard University and her B.S. in Materials Science and Engineering from Northwestern University.

Dr. Klapperich’s research is focused on engineering medical devices for use in low resource settings and at the point of care. Current projects are focused on disposable microfluidic diagnostics that incorporate on-board sample preparation and on minimally instrumented devices to enable molecular diagnostics. Her work includes diagnostics for infectious diarrhea, respiratory infections, HIV and other sexually transmitted diseases. These devices have been tested in Nicaragua and Kenya. Other work in the lab is focused on the design and deployment of devices to enable systems biology approaches to studying complex diseases including TB.

Dr. Klapperich’s lab is funded by grants from the NIH, DOD, CIMIT and the Coulter Foundation. In 2010, she was an invited participant in the National Academies of Engineering Frontiers of Engineering conference held in Agra, India. She serves on the editorial board of Biomedical Microdevices and is an active participant in both national and international research conferences.

Associate Dean for Research and Technology Development
Boston University College of Engineering


Professor
Boston University College of Engineering
Mechanical Engineering


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom
06/04/2018 - 03/31/2023 (Multi-PI)
PI: Catherine M. Klapperich, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R25EB025788-02

Rapid Molecular Diagnosts for Chlamydia and Gonorrhea at the Point-of-Care
04/01/2015 - 03/31/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113927-04

Portable Nucleic Acid Prep, Storage, and Shipping Device
11/01/2017 - 04/30/2019 (PI)
Bill and Melinda Gates Foundation


Paper Microfluidic Chip for Isothermal Amplification and Lateral Flow Detection of Human Papillomaviru (HPVs)
05/01/2017 - 06/30/2018 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIBIB
5U54EB015408-05

Center for Innovation in Point of Care Technologies for the Future of Cancer Care
07/01/2016 - 06/30/2018 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
4U54EB015403-05

Rapid and multiplex diagnosis of maternal bacterial infections
11/15/2017 - 03/15/2018 (Subcontract PI)
Mount Kenya University AESA GrndChal Africa


Organic Biosensors for Personal Physiologic Monitoring
04/11/2016 - 10/10/2017 (Co-PI)
PI: James E. Galagan, PhD
Department of Defense/DARPA


Paper Microfluidic Chip for Isothermal Amplification and Lateral Flow Detection of HPV DNA
04/15/2015 - 06/30/2017 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIBIB
4U54EB015408-05

Center for Innovation in Point of Care Technologies for the Future of Cancer Care
07/01/2012 - 06/30/2017 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5U54EB015403-04

Rapid paper-based diagnostics of CT/Trich
08/15/2016 - 01/31/2017 (Subcontract PI)
Micro Analysis LLC NIH NIAID
1R43AI122497-01

Showing 10 of 19 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Novel Biosensors based on Mining Bacterial Transcription Factors 1R01EB029795-01
2018 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 5R01AI113927-04 5
2017 2017 Microfluidics, Physics and Chemistry of Gordon Research Conference and Gordon Research Seminar 1R13EB024404-01A1
2017 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 5R01AI113927-03 5
2016 Rapid Paper-based Diagnostics of CT / Trich 1R43AI122497-01
2016 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 5R01AI113927-02 5
2016 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 4U54EB015403-05 43
2015 Rapid molecular diagnostic for chlamydia and gonorrhea at the point-of-care 1R01AI113927-01A1 5
2015 Center for Innovation in Point of Care Technologies for the Future of Cancer Care 5U54EB015403-04 43
2014 Rapid Molecular Diagnostic for Chlamydia and Gonorrhea at the Point-of-Care 1R56AI113927-01 1
Showing 10 of 35 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lee RA, Puig H, Nguyen PQ, Angenent-Mari NM, Donghia NM, McGee JP, Dvorin JD, Klapperich CM, Pollock NR, Collins JJ. Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria. Proc Natl Acad Sci U S A. 2020 Oct 13; 117(41):25722-25731. PMID: 32958655
     
  2. Chen M, Grazon C, Sensharma P, Nguyen TT, Feng Y, Chern M, Baer RC, Varongchayakul N, Cook K, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Hydrogel-Embedded Quantum Dot-Transcription Factor Sensors for Quantitative Progesterone Detection. ACS Appl Mater Interfaces. 2020 Sep 30; 12(39):43513-43521.View Related Profiles. PMID: 32893612
     
  3. Kolluri N, Albarran N, Fan A, Olson A, Sagar M, Young A, Gomez-Marquez J, Klapperich CM. SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood. Lab Chip. 2020 09 21; 20(18):3386-3398.View Related Profiles. PMID: 32766666
     
  4. Chen M, Nguyen TT, Varongchayakul N, Grazon C, Chern M, Baer RC, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Surface Immobilized Nucleic Acid-Transcription Factor Quantum Dots for Biosensing. Adv Healthc Mater. 2020 Jul 21; e2000403.View Related Profiles. PMID: 32691962
     
  5. Landaverde L, Wong W, Hernandez G, Fan A, Klapperich C. Method for the elucidation of LAMP products captured on lateral flow strips in a point of care test for HPV 16. Anal Bioanal Chem. 2020 Sep; 412(24):6199-6209. PMID: 32488390
     
  6. Grazon C, Baer RC, Kuzmanovic U, Nguyen T, Chen M, Zamani M, Chern M, Aquino P, Zhang X, Lecommandoux S, Fan A, Cabodi M, Klapperich C, Grinstaff MW, Dennis AM, Galagan JE. A progesterone biosensor derived from microbial screening. Nat Commun. 2020 03 09; 11(1):1276.View Related Profiles. PMID: 32152281
     
  7. Claure I, Anderson D, Klapperich CM, Kuohung W, Wong JY. Biomaterials and Contraception: Promises and Pitfalls. Ann Biomed Eng. 2020 Jul; 48(7):2113-2131.View Related Profiles. PMID: 31701311
     
  8. Raju LS, Kamath S, Shetty MC, Satpathi S, Mohanty AK, Ghosh SK, Kolluri N, Klapperich CM, Cabodi M, Padmanaban G, Nagaraj VA. Genome Mining-Based Identification of Identical Multirepeat Sequences in Plasmodium falciparum Genome for Highly Sensitive Real-Time Quantitative PCR Assay and Its Application in Malaria Diagnosis. J Mol Diagn. 2019 09; 21(5):824-838. PMID: 31158524
     
  9. Horst AL, Rosenbohm JM, Kolluri N, Hardick J, Gaydos CA, Cabodi M, Klapperich CM, Linnes JC. A paperfluidic platform to detect Neisseria gonorrhoeae in clinical samples. Biomed Microdevices. 2018 04 11; 20(2):35. PMID: 29644437
     
  10. Pratt GW, Fan A, Melakeberhan B, Klapperich CM. A competitive lateral flow assay for the detection of tenofovir. Anal Chim Acta. 2018 Aug 09; 1017:34-40. PMID: 29534793
     
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 19 distinct years, with a maximum of 8 publications in 2009

YearPublications
19991
20001
20012
20041
20062
20074
20084
20098
20106
20113
20127
20136
20143
20156
20165
20173
20182
20192
20206
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