James E. Galagan, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Massachusetts Institute of Technology




Dr. Galagan’s research is focused on Systems Biology of microbial organisms, specficially Mycobacterium tuberculosis – the causative agent of tuberculosis – and the fungus Neurospora crassa. The Galagan Lab is an interdisciplinary group that combines computational biology, genomics, and experimental lab work. Specific interests and projects include:

• Using a genomics, computational modeling, and experimental systems-identification techniques to reconstruct the gene regulatory network of M. tuberculosis.
• Developing and experimentally validating computational models of microbial metabolism for M. tuberculosis and N. crassa.
• Using high-throughput sequencing and comparative sequence analysis to study the functional evolution of M. tuberculosis.
• Developing computational methods for genomic data analysis (including gene prediction, gene expression analysis, and polymorphism discovery)
• Developing experimental methods for microbial systems identification and analysis, drawing on electrical and mechanical systems identification methods

Associate Professor
Boston University School of Medicine
Microbiology


Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Associate Director of Systems Biology
Boston University School of Medicine
National Emerging Infectious Disease Lab


Associate Director of Microbial Genome Analysis
Broad Institute


Member
Boston University
Genome Science Institute




Novel Biosensors based on Mining Bacterial Transcription Factors
07/01/2020 - 03/31/2025 (Multi-PI)
PI: James E. Galagan, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB029795-02

Biosensors for Physiological Monitoring from Bacterial Mining
05/01/2021 - 04/30/2024 (PI)
Department of Defense/ONR


Development of a Wearable Physiological Status Monitor
09/25/2018 - 09/30/2022 (Multi-PI)
PI: James E. Galagan, PhD
Uniformed Services University of the Health Sciences Federal Medical School


Biosensor Engineering from Metagenomic Screening
09/14/2021 - 09/13/2022 (PI)
Department of Defense/ONR


Global Mapping and Analysis of Bacterial Transcriptional Regulatory Network
06/01/2015 - 05/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R01GM114812-04

Development of a Wearable Physiological Status Monitor
09/25/2018 - 09/24/2021 (Subcontract PI)
Uniformed Services University Health Sciences HJF AdvOfMilitaryMed


Chemical and biochemical determinants of phosphorothioate stability and location in bacterial genomes
08/01/2017 - 07/31/2020 (Subcontract PI)
Massachusetts Institute of Technology National Science Fdn
CHE-1709364

Identifying Molecular Signatures of Drug Susceptibility in Enterococcus faecium
12/15/2015 - 12/31/2019 (PI)
Philips Healthcare


Systems Biology of the Circadian Clock Output Network
01/15/2015 - 06/30/2019 (Subcontract PI)
Texas A&M University NIH NIGMS
5R01GM113673-04

Predictive modeling of the Mycobacterium tuberculosis regulatory and metabolic networks
08/20/2016 - 01/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI119491-01A1

Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Novel Biosensors based on Mining Bacterial Transcription Factors 5R01EB029795-02
2020 Novel Biosensors based on Mining Bacterial Transcription Factors 1R01EB029795-01
2018 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-04 4
2018 Systems Biology of the Circadian Clock Output Network 5R01GM113673-04 3
2017 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-03 4
2017 Systems Biology of the Circadian Clock Output Network 5R01GM113673-03 3
2016 Predictive modeling of the Mycobacterium tuberculosis regulatory and metabolic networks 1R56AI119491-01A1
2016 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-02 4
2016 Systems Biology of the Circadian Clock Output Network 5R01GM113673-02 3
2016 Systems Biology of the Circadian Clock Output Network 3R01GM113673-02S1 3
Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Grazon C, Chern M, Lally P, Baer RC, Fan A, Lecommandoux S, Klapperich C, Dennis AM, Galagan JE, Grinstaff MW. The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose? Chem Sci. 2022 Jun 07; 13(22):6715-6731.View Related Profiles. PMID: 35756504; PMCID: PMC9172442; DOI: 10.1039/d1sc06921g;
     
  2. Tierrafría VH, Rioualen C, Salgado H, Lara P, Gama-Castro S, Lally P, Gómez-Romero L, Peña-Loredo P, López-Almazo AG, Alarcón-Carranza G, Betancourt-Figueroa F, Alquicira-Hernández S, Polanco-Morelos JE, García-Sotelo J, Gaytan-Nuñez E, Méndez-Cruz CF, Muñiz LJ, Bonavides-Martínez C, Moreno-Hagelsieb G, Galagan JE, Wade JT, Collado-Vides J. RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation in Escherichia coli K-12. Microb Genom. 2022 May; 8(5). PMID: 35584008; PMCID: PMC9465075; DOI: 10.1099/mgen.0.000833;
     
  3. Sankar K, Baer R, Grazon C, Sabatelle RC, Lecommandoux S, Klapperich CM, Galagan JE, Grinstaff MW. An Allosteric Transcription Factor DNA-Binding Electrochemical Biosensor for Progesterone. ACS Sens. 2022 Apr 22; 7(4):1132-1137.View Related Profiles. PMID: 35412319
     
  4. Zamani M, Dupaty J, Baer RC, Kuzmanovic U, Fan A, Grinstaff MW, Galagan JE, Klapperich CM. Paper-Based Progesterone Sensor Using an Allosteric Transcription Factor. ACS Omega. 2022 Feb 22; 7(7):5804-5808.View Related Profiles. PMID: 35224340; PMCID: PMC8867790; DOI: 10.1021/acsomega.1c05737;
     
  5. Kolluri N, Kamath S, Lally P, Zanna M, Galagan J, Gitaka J, Kamita M, Cabodi M, Lolabattu SR, Klapperich CM. Development and Clinical Validation of Iso-IMRS: A Novel Diagnostic Assay for P. falciparum Malaria. Anal Chem. 2021 02 02; 93(4):2097-2105.View Related Profiles. PMID: 33464825; PMCID: PMC7859932; DOI: 10.1021/acs.analchem.0c03847;
     
  6. Chern M, Garden PM, Baer RC, Galagan JE, Dennis AM. Transcription Factor Based Small-Molecule Sensing with a Rapid Cell Phone Enabled Fluorescent Bead Assay. Angew Chem Int Ed Engl. 2020 11 23; 59(48):21597-21602.View Related Profiles. PMID: 32945589; PMCID: PMC8243852; DOI: 10.1002/anie.202007575;
     
  7. Chen M, Grazon C, Sensharma P, Nguyen TT, Feng Y, Chern M, Baer RC, Varongchayakul N, Cook K, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Hydrogel-Embedded Quantum Dot-Transcription Factor Sensors for Quantitative Progesterone Detection. ACS Appl Mater Interfaces. 2020 Sep 30; 12(39):43513-43521.View Related Profiles. PMID: 32893612
     
  8. Chen M, Nguyen TT, Varongchayakul N, Grazon C, Chern M, Baer RC, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Surface Immobilized Nucleic Acid-Transcription Factor Quantum Dots for Biosensing. Adv Healthc Mater. 2020 09; 9(17):e2000403.View Related Profiles. PMID: 32691962
     
  9. Mejía-Almonte C, Busby SJW, Wade JT, van Helden J, Arkin AP, Stormo GD, Eilbeck K, Palsson BO, Galagan JE, Collado-Vides J. Redefining fundamental concepts of transcription initiation in bacteria. Nat Rev Genet. 2020 11; 21(11):699-714. PMID: 32665585; PMCID: PMC7990032; DOI: 10.1038/s41576-020-0254-8;
     
  10. Wu X, Cao B, Aquino P, Chiu TP, Chen C, Jiang S, Deng Z, Chen S, Rohs R, Wang L, Galagan JE, Dedon PC. Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14322-14330. PMID: 32518115; PMCID: PMC7322087; DOI: 10.1073/pnas.2002933117;
     
Showing 10 of 90 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 90 publications over 24 distinct years, with a maximum of 8 publications in 2008

YearPublications
19851
19861
20012
20021
20031
20044
20056
20063
20076
20088
20097
20103
20116
20124
20136
20145
20154
20163
20174
20182
20191
20207
20211
20224

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Computational Biology
Genomics
Infectious Diseases
Microbiology
Systems Biology
Tuberculosis
Contact for Mentoring:

24 Cummington St
Boston MA 02215
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