James E. Galagan, PhD
Boston University College of Engineering
Biomedical Engineering

PhD, Massachusetts Institute of Technology
BS, University of California, Davis

Dr. Galagan’s research is focused on Systems Biology of microbial organisms, specficially Mycobacterium tuberculosis – the causative agent of tuberculosis – and the fungus Neurospora crassa. The Galagan Lab is an interdisciplinary group that combines computational biology, genomics, and experimental lab work. Specific interests and projects include:

• Using a genomics, computational modeling, and experimental systems-identification techniques to reconstruct the gene regulatory network of M. tuberculosis.
• Developing and experimentally validating computational models of microbial metabolism for M. tuberculosis and N. crassa.
• Using high-throughput sequencing and comparative sequence analysis to study the functional evolution of M. tuberculosis.
• Developing computational methods for genomic data analysis (including gene prediction, gene expression analysis, and polymorphism discovery)
• Developing experimental methods for microbial systems identification and analysis, drawing on electrical and mechanical systems identification methods

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Boston University
National Emerging Infectious Disease Lab

Boston University
Evans Center for Interdisciplinary Biomedical Research

Associate Director of Systems Biology
Boston University Chobanian & Avedisian School of Medicine
National Emerging Infectious Disease Lab

Associate Director of Microbial Genome Analysis
Broad Institute

Boston University
Genome Science Institute

Novel Biosensors based on Mining Bacterial Transcription Factors
07/01/2020 - 03/31/2025 (Multi-PI)
PI: James E. Galagan, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering

Continuous Multiplexed Sensing from Sweat and ISF with A Next Generation Wearable
05/10/2023 - 04/30/2024 (PI)
Defense and Security Accelerator

Biosensors for Physiological Monitoring from Bacterial Mining
05/01/2021 - 04/30/2024 (PI)
Department of Defense/ONR

Novel progesterone biosensor for monitoring fertility health
08/01/2021 - 12/29/2023 (Subcontract PI)
BioSens8 National Science Fdn

Biological and Physiological Monitoring and Modeling
08/01/2022 - 07/30/2023 (PI)
Department of Defense/ONR

Development of a Wearable Physiological Status Monitor
09/25/2018 - 03/31/2023 (Multi-PI)
PI: James E. Galagan, PhD
Uniformed Services University of the Health Sciences Federal Medical School

Biosensor Engineering from Metagenomic Screening
09/14/2021 - 09/13/2022 (PI)
Department of Defense/ONR

Global Mapping and Analysis of Bacterial Transcriptional Regulatory Network
06/01/2015 - 05/31/2022 (PI)
NIH/National Institute of General Medical Sciences

Development of a Wearable Physiological Status Monitor
09/25/2018 - 09/24/2021 (Subcontract PI)
Uniformed Services University Health Sciences HJF AdvOfMilitaryMed

Chemical and biochemical determinants of phosphorothioate stability and location in bacterial genomes
08/01/2017 - 07/31/2020 (Subcontract PI)
Massachusetts Institute of Technology National Science Fdn

Showing 10 of 16 results. Show All Results


Yr Title Project-Sub Proj Pubs
2023 Novel Biosensors based on Mining Bacterial Transcription Factors 5R01EB029795-03
2022 Novel Biosensors based on Mining Bacterial Transcription Factors 5R01EB029795-02
2020 Novel Biosensors based on Mining Bacterial Transcription Factors 1R01EB029795-01
2018 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-04 4
2018 Systems Biology of the Circadian Clock Output Network 5R01GM113673-04 3
2017 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-03 4
2017 Systems Biology of the Circadian Clock Output Network 5R01GM113673-03 3
2016 Predictive modeling of the Mycobacterium tuberculosis regulatory and metabolic networks 1R56AI119491-01A1
2016 Global mapping and analysis of a bacterial transcriptional regulatory network 5R01GM114812-02 4
2016 Systems Biology of the Circadian Clock Output Network 5R01GM113673-02 3
Showing 10 of 18 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Grazon C, Garanger E, Lalanne P, Ibarboure E, Galagan JE, Grinstaff MW, Lecommandoux S. Transcription-Factor-Induced Aggregation of Biomimetic Oligonucleotide-b-Protein Micelles. Biomacromolecules. 2023 Nov 13; 24(11):5027-5034.View Related Profiles. PMID: 37877162
  2. Muellers SN, Tararina MA, Kuzmanovic U, Galagan JE, Allen KN. Structural Insights into the Substrate Range of a Bacterial Monoamine Oxidase. Biochemistry. 2023 Feb 07; 62(3):851-862. PMID: 36662673
  3. Grazon C, Chern M, Lally P, Baer RC, Fan A, Lecommandoux S, Klapperich C, Dennis AM, Galagan JE, Grinstaff MW. The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose? Chem Sci. 2022 Jun 07; 13(22):6715-6731.View Related Profiles. PMID: 35756504; PMCID: PMC9172442; DOI: 10.1039/d1sc06921g;
  4. Tierrafría VH, Rioualen C, Salgado H, Lara P, Gama-Castro S, Lally P, Gómez-Romero L, Peña-Loredo P, López-Almazo AG, Alarcón-Carranza G, Betancourt-Figueroa F, Alquicira-Hernández S, Polanco-Morelos JE, García-Sotelo J, Gaytan-Nuñez E, Méndez-Cruz CF, Muñiz LJ, Bonavides-Martínez C, Moreno-Hagelsieb G, Galagan JE, Wade JT, Collado-Vides J. RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation in Escherichia coli K-12. Microb Genom. 2022 May; 8(5). PMID: 35584008; PMCID: PMC9465075; DOI: 10.1099/mgen.0.000833;
  5. Sankar K, Baer R, Grazon C, Sabatelle RC, Lecommandoux S, Klapperich CM, Galagan JE, Grinstaff MW. An Allosteric Transcription Factor DNA-Binding Electrochemical Biosensor for Progesterone. ACS Sens. 2022 Apr 22; 7(4):1132-1137.View Related Profiles. PMID: 35412319; PMCID: PMC9985479; DOI: 10.1021/acssensors.2c00133;
  6. Zamani M, Dupaty J, Baer RC, Kuzmanovic U, Fan A, Grinstaff MW, Galagan JE, Klapperich CM. Paper-Based Progesterone Sensor Using an Allosteric Transcription Factor. ACS Omega. 2022 Feb 22; 7(7):5804-5808.View Related Profiles. PMID: 35224340; PMCID: PMC8867790; DOI: 10.1021/acsomega.1c05737;
  7. Kolluri N, Kamath S, Lally P, Zanna M, Galagan J, Gitaka J, Kamita M, Cabodi M, Lolabattu SR, Klapperich CM. Development and Clinical Validation of Iso-IMRS: A Novel Diagnostic Assay for P. falciparum Malaria. Anal Chem. 2021 02 02; 93(4):2097-2105.View Related Profiles. PMID: 33464825; PMCID: PMC7859932; DOI: 10.1021/acs.analchem.0c03847;
  8. Chern M, Garden PM, Baer RC, Galagan JE, Dennis AM. Transcription Factor Based Small-Molecule Sensing with a Rapid Cell Phone Enabled Fluorescent Bead Assay. Angew Chem Int Ed Engl. 2020 11 23; 59(48):21597-21602.View Related Profiles. PMID: 32945589; PMCID: PMC8243852; DOI: 10.1002/anie.202007575;
  9. Chen M, Grazon C, Sensharma P, Nguyen TT, Feng Y, Chern M, Baer RC, Varongchayakul N, Cook K, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Hydrogel-Embedded Quantum Dot-Transcription Factor Sensors for Quantitative Progesterone Detection. ACS Appl Mater Interfaces. 2020 Sep 30; 12(39):43513-43521.View Related Profiles. PMID: 32893612
  10. Chen M, Nguyen TT, Varongchayakul N, Grazon C, Chern M, Baer RC, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Surface Immobilized Nucleic Acid-Transcription Factor Quantum Dots for Biosensing. Adv Healthc Mater. 2020 09; 9(17):e2000403.View Related Profiles. PMID: 32691962
Showing 10 of 92 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 25 distinct years, with a maximum of 8 publications in 2008


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Computational Biology
Infectious Diseases
Systems Biology
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24 Cummington St
Boston MA 02215
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