Manish Sagar | Profiles RNS

Manish Sagar, MD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

MD, Johns Hopkins University School of Medicine
BS, Columbia University

Websites

	Infectious Diseases Faculty
	Boston Medical Center Provider Profile
	Linked In
	Twitter

ORCID : 0000-0001-9803-6594

Dr. Manish Sagar is a Professor of Medicine at the Chobanian and Avedisian School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission.

Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis.

Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Diversity, Equity, Inclusion and Accessibility

As an immigrant from India, I am acutely aware of the challenges encountered by foreign born students, physicians, and researchers. My experiences as a minority, albeit not one characterized or labeled as underrepresented minority in medicine, has raised my awareness for increasing diversity in medicine and science. To that end, I have actively promoted the training and careers of those underrepresented, such as women and minorities. I have consistently mentored foreign students and physicians in my laboratory and medical practice. I have also had number underrepresented minorities who have completed their PhD and other research training in my laboratory. I will continue to promote diversity and inclusion in scientific and medical education.
My childhood in India along with my education in the United States has heightened my awareness of the inequities in medicine. I have trained in and provided care to communities that house some of the most socio-economically disadvantaged populations in the United States. I pursued a career in Infectious Disease and specialization in HIV because of infectious diseases and HIV, specifically, overwhelmingly impact minority populations with limited economic and social means. Over my career and to this day, I am committed to providing medical care and conduct research that will help alleviate these structural inequities.

Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BMC Research
NIH RePORTER Research

Core H - The Providence/Boston Center for AIDS Research (CFAR) competitive renewal
07/01/2023 - 06/30/2028 (PI)
The Miriam Hospital National Institute o

Characterization of HIV-1 IgA bNAbs and ADCP function
09/01/2022 - 11/30/2025 (PI)
Trustees of Columbia University National Institute o

A MASTER PROTOCOL ASSESSING THE SAFETY, TOLERABILITY, AND EFFICACY OF ANTI-SPIKE (S) SARS-COV-2 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF HOSPITALIZED PATIENTS WITH COVID-19
08/19/2020 - 11/30/2024 (PI)
Regeneron Pharmaceuticals

Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission
09/19/2022 - 07/31/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R01AI172843-01A1

Persistent HIV expression induced type 1 IFN responses and inflammaging
05/01/2018 - 04/30/2024 (PI)
Trustees of Boston University, BUMC National Institute o

MassCPR Biospecimens; Biobank
03/01/2022 - 02/29/2024 (PI)
Harvard Medical School China Evergrande Gr

HIV-1 mucosal transmission and persistence
03/01/2020 - 02/29/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5K24AI145661-03

Providence Boston Center for AIDS Research (CFAR)
07/01/2019 - 06/30/2023 (Multi-PI)
PI: Manish Sagar, MD
The Miriam Hospital National Institute o
5P30AI042853-24

Sartorious Octet R8 System
06/17/2022 - 06/16/2023 (PI)
Office of the Director, National Institutes of Health/NIH/DHHS

Comparison of HIV and HCV viral loads in cell-free and enriched plasma
06/01/2022 - 05/31/2023 (PI)
Hermes Life Sciences, Inc. National Science Fdn

Showing 10 of 20 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2023	Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission	5R01AI172843-02
2023	HIV-1 mucosal transmission and persistence	5K24AI145661-05
2023	The effects of opioid use on HIV-1 reservoir dynamics	5R33DA047038-05
2022	Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission	1R01AI172843-01A1
2022	Sartorious Octet R8 System	1S10OD032333-01
2022	HIV-1 mucosal transmission and persistence	5K24AI145661-04
2022	The effects of opioid use on HIV-1 reservoir dynamics	4R33DA047038-04
2022	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-05
2022	Core H - Basic & Translational Sciences	5P30AI042853-24-7399
2021	HIV-1 mucosal transmission and persistence	5K24AI145661-03

Showing 10 of 37 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Heindel DW, Figueroa Acosta DM, Goff M, Yengo CK, Jan M, Liu X, Wang XH, Petrova MI, Zhang M, Sagar M, Barnette P, Pandey S, Hessell AJ, Chan KW, Kong XP, Chen BK, Mahal LK, Bensing BA, Hioe CE. HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralization by antibodies. Res Sq. 2024 Jan 03. PMID: 36824869; PMCID: PMC9949255; DOI: 10.21203/rs.3.rs-2596269/v2;

Bean DJ, Monroe J, Liang YM, Borberg E, Senussi Y, Swank Z, Chalise S, Walt D, Weinberg J, Sagar M. Heterotypic responses against nsp12/nsp13 from prior SARS-CoV-2 infection associates with lower subsequent endemic coronavirus incidence. bioRxiv. 2023 Oct 24.View Related Profiles.

Weinberg, Janice
Sagar, Manish

PMID: 37961343; PMCID: PMC10634759; DOI: 10.1101/2023.10.23.563621;

Esmaeilzadeh E, Etemad B, Lavine CL, Garneau L, Li Y, Regan J, Wong C, Sharaf R, Connick E, Volberding P, Sagar M, Seaman MS, Li JZ. Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption. Sci Transl Med. 2023 May 10; 15(695):eabq4490.View Related Profiles.

Etemad, Behzad
Sagar, Manish

PMID: 37163616; PMCID: PMC10576978; DOI: 10.1126/scitranslmed.abq4490;

Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M. Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses. iScience. 2023 May 19; 26(5):106631.View Related Profiles.

Olson, Alex
Jacobson, Karen
Sagar, Manish

PMID: 37168567; PMCID: PMC10165194; DOI: 10.1016/j.isci.2023.106631;

Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2).View Related Profiles.

Henderson, Andrew
So-Armah, Kaku
Sagar, Manish

PMID: 36851631; PMCID: PMC9961149; DOI: 10.3390/v15020415;

Bean DJ, Monroe J, Turcinovic J, Moreau Y, Connor JH, Sagar M. Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Associates With Unstable Housing and Occurs in the Presence of Antibodies. Clin Infect Dis. 2022 Aug 24; 75(1):e208-e215.View Related Profiles.

Connor, John
Sagar, Manish

PMID: 34755830; PMCID: PMC8689949; DOI: 10.1093/cid/ciab940;

Tu JJ, Kumar A, Giorgi EE, Eudailey J, LaBranche CC, Martinez DR, Fouda GG, Moreau Y, Thomas A, Montefiori D, Gao F, Sagar M, Permar SR. Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses. J Virol. 2022 Jun 08; 96(11):e0023122.View Related Profiles.

Thomas, Allison
Sagar, Manish

PMID: 35536018; PMCID: PMC9175633; DOI: 10.1128/jvi.00231-22;

Thomas AS, Coote C, Moreau Y, Isaac JE, Ewing AC, Kourtis AP, Sagar M. Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission. JCI Insight. 2022 May 09; 7(9).View Related Profiles.

Thomas, Allison
Sagar, Manish

PMID: 35324477; PMCID: PMC9090239; DOI: 10.1172/jci.insight.159435;

Asundi A, Olson A, Jiang W, Varshney SP, White LF, Sagar M, Lin NH. Integrase Inhibitor Use Associated with Weight Gain in Women and Incident Diabetes Mellitus. AIDS Res Hum Retroviruses. 2022 03; 38(3):208-215.View Related Profiles.

Olson, Alex
Asundi, Archana
White, Laura
Sagar, Manish
Lin, Nina

PMID: 34877881; PMCID: PMC8968841; DOI: 10.1089/aid.2021.0091;

Bean DJ, Sagar M. Family matters for coronavirus disease and vaccines. J Clin Invest. 2021 12 15; 131(24). PMID: 34752421; PMCID: PMC8670830; DOI: 10.1172/JCI155615;

Showing 10 of 60 results. Show More

Thomas AS, Moreau Y, Jiang W, Isaac JE, Ewing A, White LF, Kourtis AP, Sagar M. Pre-existing infant antibody-dependent cellular cytotoxicity associates with reduced HIV-1 acquisition and lower morbidity. Cell Rep Med. 2021 Oct 19; 2(10):100412.View Related Profiles.

Thomas, Allison
White, Laura
Sagar, Manish

PMID: 34755132; PMCID: PMC8561235; DOI: 10.1016/j.xcrm.2021.100412;

Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation. J Infect Dis. 2021 06 04; 223(11):1934-1942.View Related Profiles.

Olson, Alex
Snyder-Cappione , Jennifer
Sagar, Manish
Lin, Nina

PMID: 33075121; PMCID: PMC8176637; DOI: 10.1093/infdis/jiaa657;

Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles.

Olson, Alex
Belkina, Anna
Korkmaz, Filiz
Mostoslavsky, Gustavo
Rifkin, Ian
Snyder-Cappione , Jennifer
Quillen, Karen
Sagar, Manish
Bhadelia, Nahid
Lin, Nina
Pihl, Riley
Corley, Ronald
Gummuluru, Suryaram
Kataria, Yachana

PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;

Sinha P, Reifler K, Rossi M, Sagar M. Coronavirus Disease 2019 Mitigation Strategies Were Associated With Decreases in Other Respiratory Virus Infections. Open Forum Infect Dis. 2021 Jun; 8(6):ofab105.View Related Profiles.

Reifler, Katherine
Sagar, Manish
Sinha, Pranay

PMID: 34514014; PMCID: PMC8083776; DOI: 10.1093/ofid/ofab105;

Sinha P, Jafarzadeh SR, Assoumou SA, Bielick CG, Carpenter B, Garg S, Harleen S, Neogi T, Nishio MJ, Sagar M, Sharp V, Kissin EY. The Effect of IL-6 Inhibitors on Mortality Among Hospitalized COVID-19 Patients: A Multicenter Study. J Infect Dis. 2021 02 24; 223(4):581-588.View Related Profiles.

Bielick, Catherine
Kissin, Eugene
Sagar, Manish
Sinha, Pranay
Jafarzadeh, S. Reza
Assoumou, Sabrina
Neogi, Tuhina

PMID: 33216906; PMCID: PMC7717300; DOI: 10.1093/infdis/jiaa717;

Sagar M, Reifler K, Rossi M, Miller NS, Sinha P, White LF, Mizgerd JP. Recent endemic coronavirus infection is associated with less-severe COVID-19. J Clin Invest. 2021 01 04; 131(1).View Related Profiles.

Mizgerd, Joseph
Reifler, Katherine
White, Laura
Sagar, Manish
Miller, Nancy
Sinha, Pranay

PMID: 32997649; PMCID: PMC7773342; DOI: 10.1172/JCI143380;

Mostaghim A, Sinha P, Bielick C, Knudsen S, Beeram I, White LF, Apovian C, Sagar M, Hochberg NS. Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital. PLoS One. 2020; 15(12):e0243888.View Related Profiles.

Apovian, Caroline
Bielick, Catherine
White, Laura
Sagar, Manish
Hochberg, Natasha
Sinha, Pranay

PMID: 33326480; PMCID: PMC7744045; DOI: 10.1371/journal.pone.0243888;

Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, Horick NK, Healy BC, Shah R, Bensaci AM, Woolley AE, Nikiforow S, Lin N, Sagar M, Schrager H, Huckins DS, Axelrod M, Pincus MD, Fleisher J, Sacks CA, Dougan M, North CM, Halvorsen YD, Thurber TK, Dagher Z, Scherer A, Wallwork RS, Kim AY, Schoenfeld S, Sen P, Neilan TG, Perugino CA, Unizony SH, Collier DS, Matza MA, Yinh JM, Bowman KA, Meyerowitz E, Zafar A, Drobni ZD, Bolster MB, Kohler M, D'Silva KM, Dau J, Lockwood MM, Cubbison C, Weber BN, Mansour MK. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020 12 10; 383(24):2333-2344.View Related Profiles.

Moraco, Andrew
Tedrow, John
Fleisher, Jorge
Sagar, Manish
Lin, Nina
Lacamera, Peter

PMID: 33085857; PMCID: PMC7646626; DOI: 10.1056/NEJMoa2028836;

Kolluri N, Albarran N, Fan A, Olson A, Sagar M, Young A, Gomez-Marquez J, Klapperich CM. SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood. Lab Chip. 2020 09 21; 20(18):3386-3398.View Related Profiles.

Klapperich, Catherine
Sagar, Manish

PMID: 32766666

Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Oct; 99:28-33.View Related Profiles.

McLaughlin, Angela
Linas, Benjamin
Bielick, Catherine
Hamer, Davidson
Cooper, Ellen
White, Laura
Wetzler, Lee
Sagar, Manish
Fagan, Maura
Ieong, Michael
Bhadelia, Nahid
Lin, Nina
Sinha, Pranay
Assoumou, Sabrina
Barlam, Tamar

PMID: 32721528; PMCID: PMC7591937; DOI: 10.1016/j.ijid.2020.07.023;

Thomas AS, Ghulam-Smith M, Olson A, Coote C, Gonzales O, Sagar M. A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants. J Immunol Methods. 2020 05; 480:112766.View Related Profiles.

Olson, Alex
Thomas, Allison
Sagar, Manish
Ghulam-Smith, Melissa

PMID: 32135162; PMCID: PMC7188583; DOI: 10.1016/j.jim.2020.112766;

Registre L, Moreau Y, Ataca ST, Pulukuri S, Henrich TJ, Lin N, Sagar M. HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility. J Virol. 2020 01 06; 94(2).View Related Profiles.

Registre, Ludy
Sagar, Manish
Lin, Nina
Ataca, Sila

PMID: 31694950; PMCID: PMC6955257; DOI: 10.1128/JVI.01604-19;

Pudney J, Wangu Z, Panther L, Fugelso D, Marathe JG, Sagar M, Politch JA, Anderson DJ. Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission. J Infect Dis. 2019 01 07; 219(2):275-283.View Related Profiles.

Anderson, Deborah
Marathe, Jai
Pudney, Jeffrey
Politch, Joseph
Sagar, Manish

PMID: 30137482; PMCID: PMC6306021; DOI: 10.1093/infdis/jiy505;

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles.

Olson, Alex
Ellner, Jerrold
Jacobson, Karen
Sagar, Manish
Lin, Nina

PMID: 30063648; PMCID: PMC6506856; DOI: 10.1097/QAI.0000000000001823;

Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M. HIV-1 replicates and persists in vaginal epithelial dendritic cells. J Clin Invest. 2018 08 01; 128(8):3439-3444.View Related Profiles.

Olson, Alex
Henderson, Andrew
Akiyama, Hisashi
Larrieux, Jean-Robert
Agosto Vazquez, Luis
Sagar, Manish
Gummuluru, Suryaram

PMID: 29723162; PMCID: PMC6063466; DOI: 10.1172/JCI98943;

Thomas AS, Ghulam-Smith M, Sagar M. Neutralization and beyond: Antibodies and HIV-1 acquisition. Curr Top Virol. 2018; 15:73-86.View Related Profiles.

Sagar, Manish
Ghulam-Smith, Melissa

PMID: 31787808; PMCID: PMC6884343

Ghulam-Smith M, Olson A, White LF, Chasela CS, Ellington SR, Kourtis AP, Jamieson DJ, Tegha G, van der Horst CM, Sagar M. Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity. MBio. 2017 10 24; 8(5).View Related Profiles.

Olson, Alex
White, Laura
Sagar, Manish
Ghulam-Smith, Melissa

PMID: 29066544; PMCID: PMC5654929; DOI: 10.1128/mBio.01373-17;

Gonzalez OA, Sagar M. Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis. J Infect Dis. 2016 Oct 15; 214(8):1221-4. PMID: 27493237; PMCID: PMC5034959; DOI: 10.1093/infdis/jiw354;

Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles.

Etemad, Behzad
Registre, Ludy
Sagar, Manish
Lin, Nina

PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;

Ofotokun I, Na LH, Landovitz RJ, Ribaudo HJ, McComsey GA, Godfrey C, Aweeka F, Cohn SE, Sagar M, Kuritzkes DR, Brown TT, Patterson KB, Para MF, Leavitt RY, Villasis-Keever A, Baugh BP, Lennox JL, Currier JS. Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257. Clin Infect Dis. 2015 Jun 15; 60(12):1842-51. PMID: 25767256; PMCID: PMC4660025; DOI: 10.1093/cid/civ193;

Etemad B, Ghulam-Smith M, Gonzalez O, White LF, Sagar M. Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics. J Virol Methods. 2015 Mar; 214:46-53.View Related Profiles.

Etemad, Behzad
White, Laura
Sagar, Manish
Ghulam-Smith, Melissa

PMID: 25681527; PMCID: PMC4394631; DOI: 10.1016/j.jviromet.2015.01.006;

Sagar M. Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus. J Infect Dis. 2014 Dec 15; 210 Suppl 3:S667-73. PMID: 25414422; PMCID: PMC4303076; DOI: 10.1093/infdis/jiu369;

Etemad B, Gonzalez OA, White L, Laeyendecker O, Kirk GD, Mehta S, Sagar M. Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users. Retrovirology. 2014; 11:106.View Related Profiles.

Etemad, Behzad
White, Laura
Sagar, Manish

PMID: 25430652; PMCID: PMC4253609; DOI: 10.1186/s12977-014-0106-8;

Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, Kuritzkes DR, Sagar M, Brown TT, Cohn SE, McComsey GA, Aweeka F, Fichtenbaum CJ, Presti RM, Koletar SL, Haas DW, Patterson KB, Benson CA, Baugh BP, Leavitt RY, Rooney JF, Seekins D, Currier JS. Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial. Ann Intern Med. 2014 Oct 7; 161(7):461-71. PMID: 25285539; PMCID: PMC4412467; DOI: 10.7326/M14-1084;

Pena-Cruz V, Etemad B, Chatziandreou N, Nyein PH, Stock S, Reynolds SJ, Laeyendecker O, Gray RH, Serwadda D, Lee SJ, Quinn TC, Sagar M. HIV-1 envelope replication and a4ß7 utilization among newly infected subjects and their corresponding heterosexual partners. Retrovirology. 2013; 10:162.View Related Profiles.

Etemad, Behzad
Sagar, Manish

PMID: 24369910; PMCID: PMC3883469; DOI: 10.1186/1742-4690-10-162;

Etemad B, Gonzalez OA, McDonough S, Pena-Cruz V, Sagar M. Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of a4ß7 integrin. J Acquir Immune Defic Syndr. 2013 Nov 1; 64(3):249-53.View Related Profiles.

Etemad, Behzad
Sagar, Manish

PMID: 23797693; PMCID: PMC3800220; DOI: 10.1097/QAI.0b013e3182a06ddd;

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 1; 207(11):1694-702.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 23460751; PMCID: PMC3636784; DOI: 10.1093/infdis/jit086;

Redd AD, Collinson-Streng AN, Chatziandreou N, Mullis CE, Laeyendecker O, Martens C, Ricklefs S, Kiwanuka N, Nyein PH, Lutalo T, Grabowski MK, Kong X, Manucci J, Sewankambo N, Wawer MJ, Gray RH, Porcella SF, Fauci AS, Sagar M, Serwadda D, Quinn TC. Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions. J Infect Dis. 2012 Nov; 206(9):1433-42. PMID: 22997233; PMCID: PMC3466994; DOI: 10.1093/infdis/jis503;

Lin NH, Becerril C, Giguel F, Novitsky V, Moyo S, Makhema J, Essex M, Lockman S, Kuritzkes DR, Sagar M. Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C. Virology. 2012 Nov 25; 433(2):296-307.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 22954962; PMCID: PMC3616623; DOI: 10.1016/j.virol.2012.08.013;

Chatziandreou N, Arauz AB, Freitas I, Nyein PH, Fenton G, Mehta SH, Kirk GD, Sagar M. Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers. AIDS Res Hum Retroviruses. 2012 Dec; 28(12):1584-93. PMID: 22650962; PMCID: PMC3505054; DOI: 10.1089/AID.2011.0319;

Sagar M, Akiyama H, Etemad B, Ramirez N, Freitas I, Gummuluru S. Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection. J Infect Dis. 2012 Apr 15; 205(8):1248-57.View Related Profiles.

Etemad, Behzad
Akiyama, Hisashi
Sagar, Manish
Gummuluru, Suryaram

PMID: 22396600; PMCID: PMC3308909; DOI: 10.1093/infdis/jis183;

Henrich TJ, Tsibris AM, Lewine NR, Konstantinidis I, Leopold KE, Sagar M, Kuritzkes DR. Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):420-7. PMID: 20856130; PMCID: PMC3070184; DOI: 10.1097/QAI.0b013e3181f25574;

Sagar M. HIV-1 transmission biology: selection and characteristics of infecting viruses. J Infect Dis. 2010 Oct 15; 202 Suppl 2:S289-96. PMID: 20846035; PMCID: PMC2946383; DOI: 10.1086/655656;

Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M. Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection. J Virol. 2009 Oct; 83(19):9694-708.View Related Profiles.

Etemad, Behzad
Sagar, Manish

PMID: 19625411; PMCID: PMC2748008; DOI: 10.1128/JVI.00925-09;

Sagar M. Clinical implications of new findings in HIV basic research. HIV Ther. 2009 Jul 01; 3(4):351-360. PMID: 20657756; PMCID: PMC2908407; DOI: 10.2217/hiv.09.20;

Sagar M, Laeyendecker O, Lee S, Gamiel J, Wawer MJ, Gray RH, Serwadda D, Sewankambo NK, Shepherd JC, Toma J, Huang W, Quinn TC. Selection of HIV variants with signature genotypic characteristics during heterosexual transmission. J Infect Dis. 2009 Feb 15; 199(4):580-9. PMID: 19143562; PMCID: PMC2755256; DOI: 10.1086/596557;

Paredes R, Sagar M, Marconi VC, Hoh R, Martin JN, Parkin NT, Petropoulos CJ, Deeks SG, Kuritzkes DR. In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine. J Virol. 2009 Feb; 83(4):2038-43. PMID: 19019971; PMCID: PMC2643770; DOI: 10.1128/JVI.02154-08;

Tsibris AM, Sagar M, Gulick RM, Su Z, Hughes M, Greaves W, Subramanian M, Flexner C, Giguel F, Leopold KE, Coakley E, Kuritzkes DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol. 2008 Aug; 82(16):8210-4. PMID: 18495779; PMCID: PMC2519584; DOI: 10.1128/JVI.00444-08;

Sagar M, Wu X, Lee S, Overbaugh J. Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol. 2006 Oct; 80(19):9586-98. PMID: 16973562; PMCID: PMC1617272; DOI: 10.1128/JVI.00141-06;

Sagar M, Kirkegaard E, Lavreys L, Overbaugh J. Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses. 2006 May; 22(5):430-7. PMID: 16706620

Rainwater S, DeVange S, Sagar M, Ndinya-Achola J, Mandaliya K, Kreiss JK, Overbaugh J. No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate. AIDS Res Hum Retroviruses. 2005 Dec; 21(12):1060-5. PMID: 16379611

Chohan B, Lang D, Sagar M, Korber B, Lavreys L, Richardson B, Overbaugh J. Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels. J Virol. 2005 May; 79(10):6528-31. PMID: 15858037; PMCID: PMC1091724; DOI: 10.1128/JVI.79.10.6528-6531.2005;

Baeten JM, Lavreys L, Sagar M, Kreiss JK, Richardson BA, Chohan B, Panteleeff D, Mandaliya K, Ndinya-Achola JO, Overbaugh J, Farley T, Mwachari C, Cohen C, Chipato T, Jaisamrarn U, Kiriwat O, Duerr A. Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort. J Acquir Immune Defic Syndr. 2005 Mar; 38 Suppl 1:S18-21. PMID: 15867603

Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J. Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes. J Virol. 2004 Jul; 78(13):7279-83. PMID: 15194805; PMCID: PMC421693

Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Ndinya-Achola JO, Kreiss JK, Overbaugh J. Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population. AIDS. 2004 Mar 5; 18(4):615-9. PMID: 15090766

Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, Kreiss JK, Overbaugh J. Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression. J Virol. 2003 Dec; 77(23):12921-6. PMID: 14610215; PMCID: PMC262567

Limaye AP, Connolly PA, Sagar M, Fritsche TR, Cookson BT, Wheat LJ, Stamm WE. Transmission of Histoplasma capsulatum by organ transplantation. N Engl J Med. 2000 Oct 19; 343(16):1163-6. PMID: 11036122

Fernández-Salas E, Sagar M, Cheng C, Yuspa SH, Weinberg WC. p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. J Biol Chem. 1999 Dec 17; 274(51):36488-97. PMID: 10593946

Azzoli CG, Sagar M, Wu A, Lowry D, Hennings H, Morgan DL, Weinberg WC. Cooperation of p53 loss of function and v-Ha-ras in transformation of mouse keratinocyte cell lines. Mol Carcinog. 1998 Jan; 21(1):50-61. PMID: 9473771

Goldschmidt-Clermont PJ, Schulman SP, Bray PF, Chandra NC, Grigoryev D, Dise KR, Sagar M, Fox RJ, Coleman LD, Richardson C, Dorsey FC, du Mee C, Kitt MM, Ouyang P, Baughman KL, Gerstenblith G. Refining the treatment of women with unstable angina--a randomized, double-blind, comparative safety and efficacy evaluation of Integrelin versus aspirin in the management of unstable angina. Clin Cardiol. 1996 Nov; 19(11):869-74. PMID: 8914780

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 24 distinct years, with a maximum of 7 publications in 2021

Bar chart showing 60 publications over 24 distinct years, with a maximum of 7 publications in 2021

Year	Publications
1996	1
1998	1
1999	1
2000	1
2003	1
2004	2
2005	3
2006	2
2008	2
2009	3
2010	2
2012	4
2013	3
2014	3
2015	2
2016	2
2017	1
2018	3
2019	1
2020	6
2021	7
2022	4
2023	4
2024	1

Media Mentions

COVID’S cold cousins

Science 1/11/2024

Tuberculosis Disease Improves Antibody Response in Patients Coinfected With HIV

Pharmacy Times 5/18/2023

HIV Antibody Response Intensified in Patients With Tuberculosis Disease

Technology Networks 5/9/2023

Why Does Homelessness Increase the Risk of COVID-19 Reinfection?

Health City 1/6/2022

Homelessness, SDOH Increase Risk of COVID-19 Re-Infection

Patient Engagement HIT 11/16/2021

Severe Acute Respiratory Syndrome Reinfection More Likely to Occur in Homeless People

The Science times 11/13/2021

Unstable housing, homelessness associated with COVID-19 re-infection: Study Read more At: https://www.aninews.in/news/health/unstable-housing-homelessness-associated-with-covid-19-re-infection-study20211112085128/

ANI 11/12/2021

New Findings Point to a Promising HIV Vaccine Research Path

HealthCity 11/9/2021

COVID-19 Precautions Cut Rates of Common Respiratory Illnesses

Pharmacy Times 6/8/2021

Are Face Masks Here To Stay Even After The Pandemic?

Tatler 4/15/2021

COVID-19 Precautions Also Decreased Rates of Common Respiratory Illnesses

Pharmacy Times 4/6/2021

Could Face Masks Be Here to Stay, Even after the Pandemic? Here's What Researchers Have to Say

Yahoo! News: 3/24/2021

COVID-19 prevention strategies may have led to a decrease in common respiratory infections

News Medical Life Sciences 3/21/2021

HIV tied to poorer COVID-19 outcomes in New York State

Medscape 2/10/2021

If You Get Covid-19, Here Are the Current Treatments Available

Elemental 2/8/2021

Learning About the New Strain of COVID-19

NECN 12/23/2020

Viral Reservoir’s Production of HIV RNA Tied to Harmful Inflammation

POZ 11/20/2020

Common cold coronaviruses linked to less severe COVID-19 cases

ZME Science 11/16/2020

Common Cold Coronaviruses Tied to Less Severe COVID-19 Cases

The Scientist 11/11/2020

Common Cold Could Protect Against COVID-19, Research Shows

Voice of America 10/21/2020

Previous infection with ‘common cold’ coronavirus may lessen COVID-19 severity: Report

Livemint 10/8/2020

Does catching the common cold make COVID-19 less severe

Digital Journal 10/7/2020

Coming in From the Cold: An Interview With Three Corona Experts on SARS-CoV-2 and Pneumonia

Biomedical Central 6/15/2020

Virus Characteristics Could Predict Efficacy of Antibody-Based Treatments in HIV

Pharmacy Times 12/18/2019

Viral Characteristics May Predict HIV Treatment Efficacy

Pharmacy Times 12/2/2019

Virus Characteristics Predict HIV Treatment Efficacy With Antibody Treatment

Outrage Magazine 11/8/2019

Is HIV Transmission Different for Women?

HIV Plus Magazine 12/19/2018

2015 Infection; Plos One: Editor

2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker

2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission

2007 Howard Hughes: Early Physician Scientist Award

2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award

2006 American Foundation for AIDS Research: Grant Recipient

2001 Infectious Diseases Society of America: Special Citation for Member in Training

1997 Johns Hopkins Hospital: Osler Award – Best Intern

1995 Howard Hughes Medical Institute: Research Training Award – Continued Support

1991 Columbia University: Graduated with highest honors (top 5%)

1991 Columbia University: Gold Key Community Service Award

1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President

1988 Columbia University: Student Body Class Representative Junior Year

I have a established track record of mentoring post-doctoral fellows, pre-doctoral candidates, undergraduates, and high school students. I am also co-director of the BU Clinical and Translationall Science Institute (CTSI) Program for Early Research Career (PERC) Development Program. I am committed to developing the next wave of physicians and scientists that will conduct future patient oriented research.

Available to Mentor as: (Review Mentor Role Definitions):