Keywords
Last Name

Manish Sagar, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Diseases
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 414-5239
ORCID ORCID Icon0000-0001-9803-6594
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine Infectious Diseases

 Awards and Honors

Start-EndDescription
1988Columbia University: Student Body Class Representative Junior Year
1989NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1991Columbia University: Graduated with highest honors (top 5%)
1991Columbia University: Gold Key Community Service Award
1995Howard Hughes Medical Institute: Research Training Award – Continued Support
1997Johns Hopkins Hospital: Osler Award – Best Intern
2001Infectious Diseases Society of America: Special Citation for Member in Training
2006Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006American Foundation for AIDS Research: Grant Recipient
2007Howard Hughes: Early Physician Scientist Award
2012Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2012University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
 Research Expertise & Professional Interests
Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. He was recruited to the Boston University Medical Campus from Brigham and Women’s Hospital in 2012. Dr. Sagar’s research focuses on the pathogenesis of human immunodeficiency virus type 1 heterosexual transmission. He has been a member of the AIDS Clinical Trials Group (ACTG) since 2005. Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Gonzalez OA, Sagar M. Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis. J Infect Dis. 2016 Oct 15; 214(8):1221-4. PMID: 27493237.
    View in: PubMed
  2. Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47. PMID: 27428434.
    View in: PubMed
  3. Ofotokun I, Na LH, Landovitz RJ, Ribaudo HJ, McComsey GA, Godfrey C, Aweeka F, Cohn SE, Sagar M, Kuritzkes DR, Brown TT, Patterson KB, Para MF, Leavitt RY, Villasis-Keever A, Baugh BP, Lennox JL, Currier JS. Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257. Clin Infect Dis. 2015 Jun 15; 60(12):1842-51. PMID: 25767256.
    View in: PubMed
  4. Etemad B, Ghulam-Smith M, Gonzalez O, White LF, Sagar M. Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics. J Virol Methods. 2015 Mar; 214:46-53. PMID: 25681527.
    View in: PubMed
  5. Sagar M. Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus. J Infect Dis. 2014 Dec 15; 210 Suppl 3:S667-73. PMID: 25414422.
    View in: PubMed
  6. Etemad B, Gonzalez OA, White L, Laeyendecker O, Kirk GD, Mehta S, Sagar M. Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users. Retrovirology. 2014; 11:106. PMID: 25430652.
    View in: PubMed
  7. Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, Kuritzkes DR, Sagar M, Brown TT, Cohn SE, McComsey GA, Aweeka F, Fichtenbaum CJ, Presti RM, Koletar SL, Haas DW, Patterson KB, Benson CA, Baugh BP, Leavitt RY, Rooney JF, Seekins D, Currier JS. Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial. Ann Intern Med. 2014 Oct 7; 161(7):461-71. PMID: 25285539.
    View in: PubMed
  8. Pena-Cruz V, Etemad B, Chatziandreou N, Nyein PH, Stock S, Reynolds SJ, Laeyendecker O, Gray RH, Serwadda D, Lee SJ, Quinn TC, Sagar M. HIV-1 envelope replication and a4ß7 utilization among newly infected subjects and their corresponding heterosexual partners. Retrovirology. 2013; 10:162. PMID: 24369910.
    View in: PubMed
  9. Etemad B, Gonzalez OA, McDonough S, Pena-Cruz V, Sagar M. Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of a4ß7 integrin. J Acquir Immune Defic Syndr. 2013 Nov 1; 64(3):249-53. PMID: 23797693.
    View in: PubMed
  10. Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 1; 207(11):1694-702. PMID: 23460751.
    View in: PubMed
  11. Redd AD, Collinson-Streng AN, Chatziandreou N, Mullis CE, Laeyendecker O, Martens C, Ricklefs S, Kiwanuka N, Nyein PH, Lutalo T, Grabowski MK, Kong X, Manucci J, Sewankambo N, Wawer MJ, Gray RH, Porcella SF, Fauci AS, Sagar M, Serwadda D, Quinn TC. Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions. J Infect Dis. 2012 Nov; 206(9):1433-42. PMID: 22997233.
    View in: PubMed
  12. Lin NH, Becerril C, Giguel F, Novitsky V, Moyo S, Makhema J, Essex M, Lockman S, Kuritzkes DR, Sagar M. Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C. Virology. 2012 Nov 25; 433(2):296-307. PMID: 22954962.
    View in: PubMed
  13. Chatziandreou N, Arauz AB, Freitas I, Nyein PH, Fenton G, Mehta SH, Kirk GD, Sagar M. Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers. AIDS Res Hum Retroviruses. 2012 Dec; 28(12):1584-93. PMID: 22650962.
    View in: PubMed
  14. Sagar M, Akiyama H, Etemad B, Ramirez N, Freitas I, Gummuluru S. Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection. J Infect Dis. 2012 Apr 15; 205(8):1248-57. PMID: 22396600.
    View in: PubMed
  15. Henrich TJ, Tsibris AM, Lewine NR, Konstantinidis I, Leopold KE, Sagar M, Kuritzkes DR. Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):420-7. PMID: 20856130.
    View in: PubMed
  16. Sagar M. HIV-1 transmission biology: selection and characteristics of infecting viruses. J Infect Dis. 2010 Oct 15; 202 Suppl 2:S289-96. PMID: 20846035.
    View in: PubMed
  17. Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M. Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection. J Virol. 2009 Oct; 83(19):9694-708. PMID: 19625411.
    View in: PubMed
  18. Sagar M. Clinical implications of new findings in HIV basic research. HIV Ther. 2009 Jul 01; 3(4):351-360. PMID: 20657756.
    View in: PubMed
  19. Sagar M, Laeyendecker O, Lee S, Gamiel J, Wawer MJ, Gray RH, Serwadda D, Sewankambo NK, Shepherd JC, Toma J, Huang W, Quinn TC. Selection of HIV variants with signature genotypic characteristics during heterosexual transmission. J Infect Dis. 2009 Feb 15; 199(4):580-9. PMID: 19143562.
    View in: PubMed
  20. Paredes R, Sagar M, Marconi VC, Hoh R, Martin JN, Parkin NT, Petropoulos CJ, Deeks SG, Kuritzkes DR. In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine. J Virol. 2009 Feb; 83(4):2038-43. PMID: 19019971.
    View in: PubMed
  21. Tsibris AM, Sagar M, Gulick RM, Su Z, Hughes M, Greaves W, Subramanian M, Flexner C, Giguel F, Leopold KE, Coakley E, Kuritzkes DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol. 2008 Aug; 82(16):8210-4. PMID: 18495779.
    View in: PubMed
  22. Sagar M, Wu X, Lee S, Overbaugh J. Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol. 2006 Oct; 80(19):9586-98. PMID: 16973562.
    View in: PubMed
  23. Sagar M, Kirkegaard E, Lavreys L, Overbaugh J. Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses. 2006 May; 22(5):430-7. PMID: 16706620.
    View in: PubMed
  24. Rainwater S, DeVange S, Sagar M, Ndinya-Achola J, Mandaliya K, Kreiss JK, Overbaugh J. No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate. AIDS Res Hum Retroviruses. 2005 Dec; 21(12):1060-5. PMID: 16379611.
    View in: PubMed
  25. Chohan B, Lang D, Sagar M, Korber B, Lavreys L, Richardson B, Overbaugh J. Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels. J Virol. 2005 May; 79(10):6528-31. PMID: 15858037.
    View in: PubMed
  26. Baeten JM, Lavreys L, Sagar M, Kreiss JK, Richardson BA, Chohan B, Panteleeff D, Mandaliya K, Ndinya-Achola JO, Overbaugh J, Farley T, Mwachari C, Cohen C, Chipato T, Jaisamrarn U, Kiriwat O, Duerr A. Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort. J Acquir Immune Defic Syndr. 2005 Mar; 38 Suppl 1:S18-21. PMID: 15867603.
    View in: PubMed
  27. Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J. Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes. J Virol. 2004 Jul; 78(13):7279-83. PMID: 15194805.
    View in: PubMed
  28. Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Ndinya-Achola JO, Kreiss JK, Overbaugh J. Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population. AIDS. 2004 Mar 5; 18(4):615-9. PMID: 15090766.
    View in: PubMed
  29. Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, Kreiss JK, Overbaugh J. Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression. J Virol. 2003 Dec; 77(23):12921-6. PMID: 14610215.
    View in: PubMed
  30. Limaye AP, Connolly PA, Sagar M, Fritsche TR, Cookson BT, Wheat LJ, Stamm WE. Transmission of Histoplasma capsulatum by organ transplantation. N Engl J Med. 2000 Oct 19; 343(16):1163-6. PMID: 11036122.
    View in: PubMed
  31. Fernández-Salas E, Sagar M, Cheng C, Yuspa SH, Weinberg WC. p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. J Biol Chem. 1999 Dec 17; 274(51):36488-97. PMID: 10593946.
    View in: PubMed
  32. Azzoli CG, Sagar M, Wu A, Lowry D, Hennings H, Morgan DL, Weinberg WC. Cooperation of p53 loss of function and v-Ha-ras in transformation of mouse keratinocyte cell lines. Mol Carcinog. 1998 Jan; 21(1):50-61. PMID: 9473771.
    View in: PubMed
  33. Goldschmidt-Clermont PJ, Schulman SP, Bray PF, Chandra NC, Grigoryev D, Dise KR, Sagar M, Fox RJ, Coleman LD, Richardson C, Dorsey FC, du Mee C, Kitt MM, Ouyang P, Baughman KL, Gerstenblith G. Refining the treatment of women with unstable angina--a randomized, double-blind, comparative safety and efficacy evaluation of Integrelin versus aspirin in the management of unstable angina. Clin Cardiol. 1996 Nov; 19(11):869-74. PMID: 8914780.
    View in: PubMed
Manish's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department