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MD, State University of New York Upstate Medical University
BS, State University of New York at Binghamton

Websites

	Microbiology Faculty
	Boston Medical Center Provider Profile
	Wetzler Laboratory
	Immunology Training Program Faculty
	Google Scholar
	LinkedIn
	BMC Physician Lee Wetzler awarded $2.35 million grant to develop gonorrhea vaccine
	Loop Frontiers
	ResearchGate

ORCID : 0000-0002-6596-2986

23rd International Pathogenic Neisseria Conference
05/05/2023 - 12/31/2023 (PI)
Bill and Melinda Gates Foundation

Boston University Inflammatory Disorders Training Grant
09/15/2011 - 08/31/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5T32AI089673-05

Role of the Innate Immune System in Pathogen-Induced Chronic Inflammation
08/01/2010 - 07/31/2017 (PI of Sub-Project / SP)
PI: Caroline A. Genco, PhD
NIH/National Institute of Allergy & Infectious Diseases
5P01AI078894-05

Novel vaccine antigens against N. gonorrhoeae
09/08/2022 - 08/31/2026 (Subcontract PI)
PI: Lee M. Wetzler, MD
Tufts University NIH NIAID

Gonococcal Vaccine Evaluation in a Humanized Mouse Model
08/01/2019 - 07/31/2022 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5R01AI103400-06

Neisserial porins and antigen presenting cells
09/01/2016 - 08/31/2021 (PI)
National Institutes of Health/DHHS/NIH
5R01AI040944-22

Gonococcal Vaccine Evaluation in a Humanized Mouse Model
07/17/2013 - 08/01/2017 (PI)
NIH-NIAID
4R01AI103400-04

Gonococcal Vaccine Evaluation in a Humanized Mouse Model
07/17/2013 - 08/01/2017 (PI)
NIH-NIAID
5R01AI103400-03

Neisserial porins and antigen presenting cells
09/01/2015 - 08/31/2016 (PI)
NIH-NIAID
2R56AI040944-19

Neisserial Porins and Antigen Presenting Cells
09/01/2010 - 08/31/2015 (PI)
NIH-NIAID
5R01 AI040944-18

Characterization of a cell free recombinant gonococcal porin
09/01/2014 - 06/30/2015 (PI)
SutroVax, Inc.

Core C - Role of Innate Immune System in Pathogen Induced Chronic Inflammation
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Neisserial Porins and Antigen Presenting Cells
09/01/2006 - 08/31/2010 (PI)
NIH-NIAID
5R01 AI040944-13

Showing 10 of 19 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2020	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	5R01AI103400-08	6
2019	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	5R01AI103400-07	6
2019	Neisserial porins and antigen presenting cells	5R01AI040944-22	25
2018	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	5R01AI103400-06	6
2018	Neisserial porins and antigen presenting cells	5R01AI040944-21	25
2017	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	2R01AI103400-05	6
2017	Neisserial porins and antigen presenting cells	5R01AI040944-20	25
2016	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	4R01AI103400-04	6
2016	Neisserial porins and antigen presenting cells	2R01AI040944-19A1	25
2015	Gonococcal Vaccine Evaluation in a Humanized Mouse Model	5R01AI103400-03	6

Showing 10 of 59 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Feng F, Yuen R, Wang Y, Hua A, Kepler TB, Wetzler LM. Characterizing adjuvants' effects at murine immunoglobulin repertoire level. iScience. 2024 Jan 19; 27(1):108749.View Related Profiles.

Wetzler, Lee
Kepler, Thomas

PMID: 38269092; PMCID: PMC10805652; DOI: 10.1016/j.isci.2023.108749;

Roe SK, Felter B, Zheng B, Ram S, Wetzler LM, Garges E, Zhu T, Genco CA, Massari P. In Vitro Pre-Clinical Evaluation of a Gonococcal Trivalent Candidate Vaccine Identified by Transcriptomics. Vaccines (Basel). 2023 Dec 13; 11(12).View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 38140249; PMCID: PMC10747275; DOI: 10.3390/vaccines11121846;

Tejeda M, Farrell J, Zhu C, Wetzler L, Lunetta KL, Bush WS, Martin ER, Wang LS, Schellenberg GD, Pericak-Vance MA, Haines JL, Farrer LA, Sherva R. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement. 2024 Jan; 20(1):253-265.View Related Profiles.

Lunetta, Kathryn
Wetzler, Lee
Farrer, Lindsay
Sherva, Richard

PMID: 37578203; PMCID: PMC10840621; DOI: 10.1002/alz.13414;

Lisk C, Yuen R, Kuniholm J, Antos D, Reiser ML, Wetzler LM. CD169+ Subcapsular Macrophage Role in Antigen Adjuvant Activity. Front Immunol. 2021; 12:624197.View Related Profiles.

Lisk, Christina
Wetzler, Lee
Reiser, Michael

PMID: 33815376; PMCID: PMC8012505; DOI: 10.3389/fimmu.2021.624197;

Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Oct; 99:28-33.View Related Profiles.

McLaughlin, Angela
Linas, Benjamin
Bielick, Catherine
Hamer, Davidson
Cooper, Ellen
White, Laura
Wetzler, Lee
Sagar, Manish
Fagan, Maura
Ieong, Michael
Bhadelia, Nahid
Lin, Nina
Sinha, Pranay
Assoumou, Sabrina
Barlam, Tamar

PMID: 32721528; PMCID: PMC7591937; DOI: 10.1016/j.ijid.2020.07.023;

Lisk C, Yuen R, Kuniholm J, Antos D, Reiser ML, Wetzler LM. Toll-Like Receptor Ligand Based Adjuvant, PorB, Increases Antigen Deposition on Germinal Center Follicular Dendritic Cells While Enhancing the Follicular Dendritic Cells Network. Front Immunol. 2020; 11:1254.View Related Profiles.

Lisk, Christina
Wetzler, Lee
Reiser, Michael

PMID: 32636846; PMCID: PMC7318107; DOI: 10.3389/fimmu.2020.01254;

Yuen R, Kuniholm J, Lisk C, Wetzler LM. Neisserial PorB immune enhancing activity and use as a vaccine adjuvant. Hum Vaccin Immunother. 2019; 15(11):2778-2781.View Related Profiles.

Lisk, Christina
Wetzler, Lee

PMID: 31112447; PMCID: PMC6930065; DOI: 10.1080/21645515.2019.1609852;

Francis IP, Lui X, Wetzler LM. Isolation of Naturally Released Gonococcal Outer Membrane Vesicles as Vaccine Antigens. Methods Mol Biol. 2019; 1997:121-141.View Related Profiles.

Francis, Ian
Wetzler, Lee

PMID: 31119622

Mosaheb M, Wetzler LM. Meningococcal PorB induces a robust and diverse antigen specific T cell response as a vaccine adjuvant. Vaccine. 2018 11 29; 36(50):7689-7699.View Related Profiles.

Wetzler, Lee
Mosaheb, Munir

PMID: 30381152; PMCID: PMC6279244; DOI: 10.1016/j.vaccine.2018.10.074;

Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM. Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases. BMC Genomics. 2018 Aug 22; 19(1):627.View Related Profiles.

Gower, Adam
Francis, Ian
Wetzler, Lee
Shaik-Dasthagirisheb, Yazdani

PMID: 30134832; PMCID: PMC6106831; DOI: 10.1186/s12864-018-5000-7;

Showing 10 of 84 results. Show More

Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD. Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract. Infect Immun. 2018 08; 86(8).View Related Profiles.

Wetzler, Lee
Shaik-Dasthagirisheb, Yazdani

PMID: 29760215; PMCID: PMC6056862; DOI: 10.1128/IAI.00092-18;

Reiser ML, Mosaheb MM, Lisk C, Platt A, Wetzler LM. The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation. Sci Rep. 2017 04 07; 7(1):736.View Related Profiles.

Platt, Andrew
Lisk, Christina
Wetzler, Lee
Reiser, Michael
Mosaheb, Munir

PMID: 28389664; PMCID: PMC5428659; DOI: 10.1038/s41598-017-00555-4;

Mosaheb MM, Reiser ML, Wetzler LM. Toll-Like Receptor Ligand-Based Vaccine Adjuvants Require Intact MyD88 Signaling in Antigen-Presenting Cells for Germinal Center Formation and Antibody Production. Front Immunol. 2017; 8:225.View Related Profiles.

Wetzler, Lee
Reiser, Michael
Mosaheb, Munir

PMID: 28316602; PMCID: PMC5334362; DOI: 10.3389/fimmu.2017.00225;

Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD. Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward". Clin Vaccine Immunol. 2016 Aug; 23(8):656-63. PMID: 27335384; PMCID: PMC4979170; DOI: 10.1128/CVI.00230-16;

Toussi DN, Wetzler LM, Liu X, Massari P. Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation. Microbes Infect. 2016 Oct; 18(10):627-638.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 27373686; PMCID: PMC5050100; DOI: 10.1016/j.micinf.2016.06.001;

Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200.View Related Profiles.

Reinhard, Bjorn
Wetzler, Lee
Reiser, Michael
Gummuluru, Suryaram

PMID: 26720275; PMCID: PMC4842014; DOI: 10.1021/acsnano.5b06501;

Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD. The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice. Mucosal Immunol. 2016 Jul; 9(4):1051-64.View Related Profiles.

Wetzler, Lee
Shaik-Dasthagirisheb, Yazdani

PMID: 26693700; PMCID: PMC4915993; DOI: 10.1038/mi.2015.122;

Massari P, Gunawardana J, Liu X, Wetzler LM. Correction for Massari et al., meningococcal porin PorB prevents cellular apoptosis in a Toll-like receptor 2- and NF-?B-independent manner. Infect Immun. 2015 Aug; 83(8):3339.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 26157088; PMCID: PMC4496629; DOI: 10.1128/IAI.00627-15;

Barlam TF, Morgan JR, Wetzler LM, Christiansen CL, Drainoni ML. Antibiotics for respiratory tract infections: a comparison of prescribing in an outpatient setting. Infect Control Hosp Epidemiol. 2015 Feb; 36(2):153-9.View Related Profiles.

Christiansen, Cindy
Morgan, Jake
Wetzler, Lee
Drainoni, Mari-Lynn
Barlam, Tamar

PMID: 25632997; DOI: 10.1017/ice.2014.21;

Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles.

Gower, Adam
Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Gibson, Frank
Beaulieu, Lea
Wetzler, Lee
Ingalls, Robin
He, Xianbao
Alekseyev, Yuriy

PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;

Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition. J Struct Biol. 2014 Mar; 185(3):440-7.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 24361688; PMCID: PMC3943661; DOI: 10.1016/j.jsb.2013.12.006;

Platt A, MacLeod H, Massari P, Liu X, Wetzler L. In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. PLoS One. 2013; 8(12):e82171.View Related Profiles.

Platt, Andrew
Wetzler, Lee
Massari, Paola

PMID: 24349212; PMCID: PMC3859593; DOI: 10.1371/journal.pone.0082171;

Platt A, Wetzler L. Innate immunity and vaccines. Curr Top Med Chem. 2013; 13(20):2597-608.View Related Profiles.

Platt, Andrew
Wetzler, Lee

PMID: 24066890

Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57.View Related Profiles.

Genco, Caroline
Morgan, Elise
Weinberg, Ellen
Gibson, Frank
Papadopoulos, George
Wetzler, Lee
Massari, Paola

PMID: 23264656; PMCID: PMC3549226; DOI: 10.4049/jimmunol.1202511;

Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P. The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation. Infect Immun. 2012 Oct; 80(10):3417-28.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 22825445; PMCID: PMC3457564; DOI: 10.1128/IAI.00683-12;

Oliveira-Nascimento L, Massari P, Wetzler LM. The Role of TLR2 in Infection and Immunity. Front Immunol. 2012; 3:79.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 22566960; PMCID: PMC3342043; DOI: 10.3389/fimmu.2012.00079;

Massari P, Wetzler LM. Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins. Methods Mol Biol. 2012; 799:319-41.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 21993654; DOI: 10.1007/978-1-61779-346-2_19;

Arjunaraja S, Massari P, Wetzler LM, Lees A, Colino J, Snapper CM. The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain. J Immunol. 2012 Jan 15; 188(2):569-77.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 22156342; PMCID: PMC3253264; DOI: 10.4049/jimmunol.1101446;

Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM. Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells. Clin Immunol. 2011 Jan; 138(1):33-40.View Related Profiles.

Noronha, Ansu
Farraye, Francis
Wetzler, Lee
Ganley-Leal, Lisa
Massari, Paola

PMID: 20947433; DOI: 10.1016/j.clim.2010.09.003;

Liu X, Wetzler LM, Nascimento LO, Massari P. Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling. Infect Immun. 2010 Dec; 78(12):5314-23.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 20937766; PMCID: PMC2981301; DOI: 10.1128/IAI.00681-10;

Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, Weir S, Alroy J, Randall TD, Wetzler LM. Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia. PLoS One. 2010; 5(6):e11156.View Related Profiles.

Wetzler, Lee
Weir, Susan

PMID: 20585390; PMCID: PMC2886834; DOI: 10.1371/journal.pone.0011156;

Wetzler LM. Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity. Future Microbiol. 2010 May; 5(5):749-58. PMID: 20441547; PMCID: PMC2907731; DOI: 10.2217/fmb.10.41;

Massari P, Gunawardana J, Liu X, Wetzler LM. Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner. Infect Immun. 2010 Mar; 78(3):994-1003.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 20028813; PMCID: PMC2825956; DOI: 10.1128/IAI.00156-09;

Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun. 2009 Sep; 77(9):3602-10.View Related Profiles.

Genco, Caroline
Wetzler, Lee
Massari, Paola

PMID: 19546192; PMCID: PMC2738021; DOI: 10.1128/IAI.01366-08;

Chiavolini D, Weir S, Murphy JR, Wetzler LM. Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin Vaccine Immunol. 2008 Sep; 15(9):1322-9.View Related Profiles.

Murphy, John
Wetzler, Lee
Weir, Susan

PMID: 18614668; PMCID: PMC2546688; DOI: 10.1128/CVI.00125-08;

MacLeod H, Bhasin N, Wetzler LM. Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin. Clin Vaccine Immunol. 2008 Apr; 15(4):630-7. PMID: 18287580; PMCID: PMC2292646; DOI: 10.1128/CVI.00435-07;

Liu X, Wetzler LM, Massari P. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6; 26(6):786-96.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 18191311; PMCID: PMC2259119; DOI: 10.1016/j.vaccine.2007.11.080;

Chiavolini D, Alroy J, King CA, Jorth P, Weir S, Madico G, Murphy JR, Wetzler LM. Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Infect Immun. 2008 Feb; 76(2):486-96.View Related Profiles.

Madico, Guillermo
Murphy, John
Wetzler, Lee
Weir, Susan

PMID: 18025095; PMCID: PMC2223482; DOI: 10.1128/IAI.00862-07;

MacLeod H, Wetzler LM. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE. 2007 Sep 4; 2007(402):pe48. PMID: 17785715

Burke JM, Ganley-Leal LM, Khatri A, Wetzler LM. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol. 2007 Sep 1; 179(5):3222-30. PMID: 17709538

Schnitzler AC, Burke JM, Wetzler LM. Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells. Infect Immun. 2007 Jun; 75(6):3150-9. PMID: 17353279; PMCID: PMC1932910; DOI: 10.1128/IAI.00581-06;

Ganley-Leal LM, Liu X, Wetzler LM. Toll-like receptor 2-mediated human B cell differentiation. Clin Immunol. 2006 Sep; 120(3):272-84. PMID: 16766226

Massari P, Visintin A, Gunawardana J, Halmen KA, King CA, Golenbock DT, Wetzler LM. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. J Immunol. 2006 Feb 15; 176(4):2373-80.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 16455995

Ayala P, Wilbur JS, Wetzler LM, Tainer JA, Snyder A, So M. The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells. Cell Microbiol. 2005 Dec; 7(12):1736-48. PMID: 16309460

Laroux FS, Romero X, Wetzler L, Engel P, Terhorst C. Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria. J Immunol. 2005 Nov 1; 175(9):5596-600. PMID: 16237045

Agarwal S, King CA, Klein EK, Soper DE, Rice PA, Wetzler LM, Genco CA. The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection. Infect Immun. 2005 Jul; 73(7):4281-7.View Related Profiles.

Genco, Caroline
Wetzler, Lee

PMID: 15972520; PMCID: PMC1168583; DOI: 10.1128/IAI.73.7.4281-4287.2005;

Zhang J, Li G, Bafica A, Pantelic M, Zhang P, Broxmeyer H, Liu Y, Wetzler L, He JJ, Chen T. Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1. J Immunol. 2005 Jun 15; 174(12):7995-8002. PMID: 15944306

Massari P, King CA, MacLeod H, Wetzler LM. Improved purification of native meningococcal porin PorB and studies on its structure/function. Protein Expr Purif. 2005 Dec; 44(2):136-46.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 16027004

Singleton TE, Massari P, Wetzler LM. Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent. J Immunol. 2005 Mar 15; 174(6):3545-50.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 15749891

Wetzler LM. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine. 2003 Jun 1; 21 Suppl 2:S55-60. PMID: 12763684

Massari P, Ram S, Macleod H, Wetzler LM. The role of porins in neisserial pathogenesis and immunity. Trends Microbiol. 2003 Feb; 11(2):87-93.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 12598131

Massari P, King CA, Ho AY, Wetzler LM. Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis. Cell Microbiol. 2003 Feb; 5(2):99-109.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 12580946

Ayala P, Vasquez B, Wetzler L, So M. Neisseria gonorrhoeae porin P1.B induces endosome exocytosis and a redistribution of Lamp1 to the plasma membrane. Infect Immun. 2002 Nov; 70(11):5965-71. PMID: 12379671; PMCID: PMC130337

Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol. 2002 Feb 15; 168(4):1533-7.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 11823477

Bhasin N, Ho Y, Wetzler LM. Neisseria meningitidis lipopolysaccharide modulates the specific humoral immune response to neisserial porins but has no effect on porin-induced upregulation of costimulatory ligand B7-2. Infect Immun. 2001 Aug; 69(8):5031-6. PMID: 11447183; PMCID: PMC98597

Delvig AA, Robinson JH, Wetzler L. Testing meningococcal vaccines for mitogenicity and superantigenicity. Methods Mol Med. 2001; 66:199-221. PMID: 21336757; DOI: 10.1385/1-59259-148-5:199;

Massari P, Wetzler LM. Studies on the effect of neisserial porins on apoptosis of Mammalian cells. Methods Mol Med. 2001; 67:587-97.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 21337167; DOI: 10.1385/1-59259-149-3:587;

Wedege E, Bolstad K, Wetzler LM, Guttormsen H. IgG antibody levels to meningococcal porins in patient sera: comparison of immunoblotting and ELISA measurements. J Immunol Methods. 2000 Oct 20; 244(1-2):9-15. PMID: 11033014

Massari P, Ho Y, Wetzler LM. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9070-5.View Related Profiles.

Wetzler, Lee
Massari, Paola

PMID: 10922061; PMCID: PMC16823

Simpson SD, Ho Y, Rice PA, Wetzler LM. T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections. J Infect Dis. 1999 Sep; 180(3):762-73. PMID: 10438365

Mackinnon FG, Ho Y, Blake MS, Michon F, Chandraker A, Sayegh MH, Wetzler LM. The role of B/T costimulatory signals in the immunopotentiating activity of neisserial porin. J Infect Dis. 1999 Sep; 180(3):755-61. PMID: 10438364

Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis. Mol Immunol. 1999 Sep-Oct; 36(13-14):915-28. PMID: 10698346

Lehmann AK, Halstensen A, Aaberge IS, Holst J, Michaelsen TE, Sornes S, Wetzler LM, Guttormsen H. Human opsonins induced during meningococcal disease recognize outer membrane proteins PorA and PorB. Infect Immun. 1999 May; 67(5):2552-60. PMID: 10225920; PMCID: PMC116003

Oftung F, Naess LM, Wetzler LM, Korsvold GE, Aase A, Høiby EA, Dalseg R, Holst J, Michaelsen TE, Haneberg B. Antigen-specific T-cell responses in humans after intranasal immunization with a meningococcal serogroup B outer membrane vesicle vaccine. Infect Immun. 1999 Feb; 67(2):921-7. PMID: 9916109; PMCID: PMC96405

Henriksen AZ, Maeland JA, Wetzler LM. An epitope shared by enterobacterial and neisserial porin proteins. APMIS. 1998 Aug; 106(8):818-24. PMID: 9744768

Guttormsen HK, Wetzler LM, Finberg RW, Kasper DL. Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model. Infect Immun. 1998 May; 66(5):2026-32. PMID: 9573085; PMCID: PMC108159

Naess LM, Oftung F, Aase A, Wetzler LM, Sandin R, Michaelsen TE. Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine. Infect Immun. 1998 Mar; 66(3):959-65. PMID: 9488382; PMCID: PMC108002

Snapper CM, Rosas FR, Kehry MR, Mond JJ, Wetzler LM. Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion. Infect Immun. 1997 Aug; 65(8):3203-8. PMID: 9234776; PMCID: PMC175453

Gill MJ, McQuillen DP, van Putten JP, Wetzler LM, Bramley J, Crooke H, Parsons NJ, Cole JA, Smith H. Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae. Infect Immun. 1996 Aug; 64(8):3374-8. PMID: 8757878; PMCID: PMC174232

Wetzler LM, Ho Y, Reiser H, Wetzler LW. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J Exp Med. 1996 Mar 1; 183(3):1151-9. PMID: 8642257; PMCID: PMC2192323

Blake MS, Wetzler LM. Vaccines for gonorrhea: where are we on the curve? Trends Microbiol. 1995 Dec; 3(12):469-74. PMID: 8800838

Bjerknes R, Guttormsen HK, Solberg CO, Wetzler LM. Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst. Infect Immun. 1995 Jan; 63(1):160-7. PMID: 7806353; PMCID: PMC172973

Rice PA, McQuillen DP, Gulati S, Jani DB, Wetzler LM, Blake MS, Gotschlich EC. Serum resistance of Neisseria gonorrhoeae. Does it thwart the inflammatory response and facilitate the transmission of infection? Ann N Y Acad Sci. 1994 Aug 15; 730:7-14. PMID: 8080215

Wetzler LM. Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines. Ann N Y Acad Sci. 1994 Aug 15; 730:367-70. PMID: 8080211

Guttormsen HK, Wetzler LM, Solberg CO. Humoral immune response to class 1 outer membrane protein during the course of meningococcal disease. Infect Immun. 1994 Apr; 62(4):1437-43. PMID: 8132350; PMCID: PMC186299

Guttormsen HK, Wetzler LM, Naess A. Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease. Infect Immun. 1993 Nov; 61(11):4734-42. PMID: 8406872; PMCID: PMC281228

Wetzler LM, Blake MS, Barry K, Gotschlich EC. Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants. J Infect Dis. 1992 Sep; 166(3):551-5. PMID: 1323620

Wetzler LM, Barry K, Blake MS, Gotschlich EC. Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera. Infect Immun. 1992 Jan; 60(1):39-43. PMID: 1729195; PMCID: PMC257500

Wetzler LM, Gotschlich EC, Blake MS, Koomey JM. The construction and characterization of Neisseria gonorrhoeae lacking protein III in its outer membrane. J Exp Med. 1989 Jun 1; 169(6):2199-209. PMID: 2499656; PMCID: PMC2189350

Blake MS, Wetzler LM, Gotschlich EC, Rice PA. Protein III: structure, function, and genetics. Clin Microbiol Rev. 1989 Apr; 2 Suppl:S60-3. PMID: 2497964; PMCID: PMC358079

Wetzler LM, Blake MS, Gotschlich EC. Protein I (Por) of Neisseria gonorrhoeae as an immunogen: liposomes, proteosomes, and the lack of blocking antibodies. Trans Assoc Am Physicians. 1989; 102:78-90. PMID: 2561644

Blake MS, Wetzler LM, Gotschlich EC, Rice PA. Developing a gonococcal protein I vaccine. Adv Exp Med Biol. 1989; 251:315-27. PMID: 2514585

Wetzler LM, Blake MS, Gotschlich EC. Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations. J Exp Med. 1988 Nov 1; 168(5):1883-97. PMID: 3141555; PMCID: PMC2189125

Wetzler L, Seiff ME. AIDS vaccine and the private sector. N Engl J Med. 1986 Jun 5; 314(23):1511-2. PMID: 3010117

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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