Lee M. Wetzler, MD
Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases Section

MD, State University of New York Upstate Medical University



Expertise includes: Immunology, Inflammation and Host Pathogen Interaction basic research; Infectious Diseases Specialists; Neisserial infections and meningitis; STDS; and Travel Medicine.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Department of Microbiology


Active Staff Privileges
Boston Medical Center
Department of Medicine
Infectious Diseases Section



Boston University Inflammatory Disorders Training Grant
09/15/2011 - 08/31/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5T32AI089673-05

Role of the Innate Immune System in Pathogen-Induced Chronic Inflammation
08/01/2010 - 07/31/2017 (PI of Sub-Project / SP)
PI: Caroline A. Genco, PhD
NIH/National Institute of Allergy & Infectious Diseases
5P01AI078894-05


Neisserial porins and antigen presenting cells
09/01/2016 - 08/31/2020 (PI)
NIH-NIAID
2R01AI040944-19A1

Gonococcal Vaccine Evaluation in a Humanized Mouse Model
07/17/2013 - 06/30/2017 (PI)
NIH-NIAID
4R01AI103400-04

Gonococcal Vaccine Evaluation in a Humanized Mouse Model
07/17/2013 - 06/30/2017 (PI)
NIH-NIAID
5R01AI103400-03

Neisserial porins and antigen presenting cells
09/01/2015 - 08/31/2016 (PI)
NIH-NIAID
2R56AI040944-19

Neisserial Porins and Antigen Presenting Cells
09/01/2010 - 08/31/2015 (PI)
NIH-NIAID
5R01 AI040944-18

Characterization of a cell free recombinant gonococcal porin
09/01/2014 - 06/30/2015 (PI)
SutroVax, Inc.

Core C - Role of Innate Immune System in Pathogen Induced Chronic Inflammation
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Neisserial Porins and Antigen Presenting Cells
09/01/2006 - 08/31/2010 (PI)
NIH-NIAID
5R01 AI040944-13

Immuno - Prophylaxis - Core A: Animals (Tularemia - Murphy)
09/15/2003 - 02/28/2009 (PI)
NIH-NIAID
5 U19 AI056543-05 (A)

Immuno-Prophylaxis - Project 1: Vaccines (Tularemia - Murphy)
09/15/2003 - 02/28/2009 (PI)
NIH-NIAID
5 U19 AI056543-05 (A)

Showing 10 of 17 results. Show All Results


Yr Title Project-Sub Proj Pubs
2016 Gonococcal Vaccine Evaluation in a Humanized Mouse Model 4R01AI103400-04 1
2016 Neisserial porins and antigen presenting cells 2R01AI040944-19A1 20
2015 Boston University Inflammatory Disorders Training Grant 5T32AI089673-05 7
2015 Neisserial porins and antigen presenting cells 2R56AI040944-19
2014 Gonococcal Vaccine Evaluation in a Humanized Mouse Model 5R01AI103400-02 1
2014 Neisserial Porins and Antigen Presenting Cells 5R01AI040944-18 20
2014 Animal Core 5P01AI078894-05-7799 22
2013 Gonococcal Vaccine Evaluation in a Humanized Mouse Model 1R01AI103400-01A1 1
2013 Neisserial Porins and Antigen Presenting Cells 5R01AI040944-17 20
2013 Animal Core 5P01AI078894-04-7799 22
Showing 10 of 48 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Mosaheb MM, Reiser ML, Wetzler LM. Toll-Like Receptor Ligand-Based Vaccine Adjuvants Require Intact MyD88 Signaling in Antigen-Presenting Cells for Germinal Center Formation and Antibody Production. Front Immunol. 2017; 8:225.View Related Profiles. PMID: 28316602; DOI: 10.3389/fimmu.2017.00225;.
  2. Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD. Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward". Clin Vaccine Immunol. 2016 Aug; 23(8):656-63. PMID: 27335384; PMCID: PMC4979170; DOI: 10.1128/CVI.00230-16;.
  3. Toussi DN, Wetzler LM, Liu X, Massari P. Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation. Microbes Infect. 2016 Oct; 18(10):627-638.View Related Profiles. PMID: 27373686; DOI: 10.1016/j.micinf.2016.06.001;.
  4. Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200.View Related Profiles. PMID: 26720275; PMCID: PMC4842014; DOI: 10.1021/acsnano.5b06501;.
  5. Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD. The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice. Mucosal Immunol. 2016 Jul; 9(4):1051-64. PMID: 26693700; PMCID: PMC4915993; DOI: 10.1038/mi.2015.122;.
  6. Massari P, Gunawardana J, Liu X, Wetzler LM. Correction for Massari et al., meningococcal porin PorB prevents cellular apoptosis in a Toll-like receptor 2- and NF-?B-independent manner. Infect Immun. 2015 Aug; 83(8):3339.View Related Profiles. PMID: 26157088; PMCID: PMC4496629; DOI: 10.1128/IAI.00627-15;.
  7. Barlam TF, Morgan JR, Wetzler LM, Christiansen CL, Drainoni ML. Antibiotics for respiratory tract infections: a comparison of prescribing in an outpatient setting. Infect Control Hosp Epidemiol. 2015 Feb; 36(2):153-9.View Related Profiles. PMID: 25632997; DOI: 10.1017/ice.2014.21;.
  8. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles. PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;.
  9. Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition. J Struct Biol. 2014 Mar; 185(3):440-7.View Related Profiles. PMID: 24361688; PMCID: PMC3943661; DOI: 10.1016/j.jsb.2013.12.006;.
  10. Platt A, MacLeod H, Massari P, Liu X, Wetzler L. In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. PLoS One. 2013; 8(12):e82171.View Related Profiles. PMID: 24349212; PMCID: PMC3859593; DOI: 10.1371/journal.pone.0082171;.
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 28 distinct years, with a maximum of 6 publications in 2005

YearPublications
19861
19881
19894
19922
19931
19943
19952
19962
19971
19983
19995
20002
20013
20022
20033
20056
20062
20075
20082
20092
20104
20111
20124
20133
20141
20153
20163
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adjuvants
Francisella
Infections Diseases
Innate Immunity
Neisseria
Vaccines

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map


Wetzler's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department