Keywords
Last Name

Lee M. Wetzler, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Diseases
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 414-4394
ORCID ORCID Icon0000-0002-6596-2986
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionInfectious Diseases

 Research Expertise & Professional Interests
Expertise includes: Immunology, Inflammation and Host Pathogen Interaction basic research; Infectious Diseases Specialists; Neisserial infections and meningitis; STDS; and Travel Medicine.

 Self-Described Keywords
  • Adjuvants
  • Francisella
  • Infections Diseases
  • Innate Immunity
  • Neisseria
  • Vaccines
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD. Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward". Clin Vaccine Immunol. 2016 Aug; 23(8):656-63. PMID: 27335384.
    View in: PubMed
  2. Toussi DN, Wetzler LM, Liu X, Massari P. Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation. Microbes Infect. 2016 Oct; 18(10):627-638. PMID: 27373686.
    View in: PubMed
  3. Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200. PMID: 26720275.
    View in: PubMed
  4. Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD. The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice. Mucosal Immunol. 2016 Jul; 9(4):1051-64. PMID: 26693700.
    View in: PubMed
  5. Massari P, Gunawardana J, Liu X, Wetzler LM. Correction for Massari et al., meningococcal porin PorB prevents cellular apoptosis in a Toll-like receptor 2- and NF-?B-independent manner. Infect Immun. 2015 Aug; 83(8):3339. PMID: 26157088.
    View in: PubMed
  6. Barlam TF, Morgan JR, Wetzler LM, Christiansen CL, Drainoni ML. Antibiotics for respiratory tract infections: a comparison of prescribing in an outpatient setting. Infect Control Hosp Epidemiol. 2015 Feb; 36(2):153-9. PMID: 25632997.
    View in: PubMed
  7. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176. PMID: 25540039.
    View in: PubMed
  8. Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition. J Struct Biol. 2014 Mar; 185(3):440-7. PMID: 24361688.
    View in: PubMed
  9. Platt A, MacLeod H, Massari P, Liu X, Wetzler L. In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. PLoS One. 2013; 8(12):e82171. PMID: 24349212.
    View in: PubMed
  10. Platt A, Wetzler L. Innate immunity and vaccines. Curr Top Med Chem. 2013; 13(20):2597-608. PMID: 24066890.
    View in: PubMed
  11. Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57. PMID: 23264656.
    View in: PubMed
  12. Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P. The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation. Infect Immun. 2012 Oct; 80(10):3417-28. PMID: 22825445.
    View in: PubMed
  13. Oliveira-Nascimento L, Massari P, Wetzler LM. The Role of TLR2 in Infection and Immunity. Front Immunol. 2012; 3:79. PMID: 22566960.
    View in: PubMed
  14. Massari P, Wetzler LM. Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins. Methods Mol Biol. 2012; 799:319-41. PMID: 21993654.
    View in: PubMed
  15. Arjunaraja S, Massari P, Wetzler LM, Lees A, Colino J, Snapper CM. The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain. J Immunol. 2012 Jan 15; 188(2):569-77. PMID: 22156342.
    View in: PubMed
  16. Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM. Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells. Clin Immunol. 2011 Jan; 138(1):33-40. PMID: 20947433.
    View in: PubMed
  17. Liu X, Wetzler LM, Nascimento LO, Massari P. Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling. Infect Immun. 2010 Dec; 78(12):5314-23. PMID: 20937766.
    View in: PubMed
  18. Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, Weir S, Alroy J, Randall TD, Wetzler LM. Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia. PLoS One. 2010; 5(6):e11156. PMID: 20585390.
    View in: PubMed
  19. Wetzler LM. Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity. Future Microbiol. 2010 May; 5(5):749-58. PMID: 20441547.
    View in: PubMed
  20. Massari P, Gunawardana J, Liu X, Wetzler LM. Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner. Infect Immun. 2010 Mar; 78(3):994-1003. PMID: 20028813.
    View in: PubMed
  21. Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun. 2009 Sep; 77(9):3602-10. PMID: 19546192.
    View in: PubMed
  22. Chiavolini D, Weir S, Murphy JR, Wetzler LM. Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin Vaccine Immunol. 2008 Sep; 15(9):1322-9. PMID: 18614668.
    View in: PubMed
  23. MacLeod H, Bhasin N, Wetzler LM. Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin. Clin Vaccine Immunol. 2008 Apr; 15(4):630-7. PMID: 18287580.
    View in: PubMed
  24. Liu X, Wetzler LM, Massari P. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6; 26(6):786-96. PMID: 18191311.
    View in: PubMed
  25. Chiavolini D, Alroy J, King CA, Jorth P, Weir S, Madico G, Murphy JR, Wetzler LM. Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Infect Immun. 2008 Feb; 76(2):486-96. PMID: 18025095.
    View in: PubMed
  26. MacLeod H, Wetzler LM. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE. 2007 Sep 4; 2007(402):pe48. PMID: 17785715.
    View in: PubMed
  27. Burke JM, Ganley-Leal LM, Khatri A, Wetzler LM. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol. 2007 Sep 1; 179(5):3222-30. PMID: 17709538.
    View in: PubMed
  28. Schnitzler AC, Burke JM, Wetzler LM. Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells. Infect Immun. 2007 Jun; 75(6):3150-9. PMID: 17353279.
    View in: PubMed
  29. Ganley-Leal LM, Liu X, Wetzler LM. Toll-like receptor 2-mediated human B cell differentiation. Clin Immunol. 2006 Sep; 120(3):272-84. PMID: 16766226.
    View in: PubMed
  30. Massari P, Visintin A, Gunawardana J, Halmen KA, King CA, Golenbock DT, Wetzler LM. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. J Immunol. 2006 Feb 15; 176(4):2373-80. PMID: 16455995.
    View in: PubMed
  31. Ayala P, Wilbur JS, Wetzler LM, Tainer JA, Snyder A, So M. The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells. Cell Microbiol. 2005 Dec; 7(12):1736-48. PMID: 16309460.
    View in: PubMed
  32. Laroux FS, Romero X, Wetzler L, Engel P, Terhorst C. Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria. J Immunol. 2005 Nov 1; 175(9):5596-600. PMID: 16237045.
    View in: PubMed
  33. Agarwal S, King CA, Klein EK, Soper DE, Rice PA, Wetzler LM, Genco CA. The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection. Infect Immun. 2005 Jul; 73(7):4281-7. PMID: 15972520.
    View in: PubMed
  34. Zhang J, Li G, Bafica A, Pantelic M, Zhang P, Broxmeyer H, Liu Y, Wetzler L, He JJ, Chen T. Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1. J Immunol. 2005 Jun 15; 174(12):7995-8002. PMID: 15944306.
    View in: PubMed
  35. Massari P, King CA, MacLeod H, Wetzler LM. Improved purification of native meningococcal porin PorB and studies on its structure/function. Protein Expr Purif. 2005 Dec; 44(2):136-46. PMID: 16027004.
    View in: PubMed
  36. Singleton TE, Massari P, Wetzler LM. Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent. J Immunol. 2005 Mar 15; 174(6):3545-50. PMID: 15749891.
    View in: PubMed
  37. Wetzler LM. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine. 2003 Jun 1; 21 Suppl 2:S55-60. PMID: 12763684.
    View in: PubMed
  38. Massari P, Ram S, Macleod H, Wetzler LM. The role of porins in neisserial pathogenesis and immunity. Trends Microbiol. 2003 Feb; 11(2):87-93. PMID: 12598131.
    View in: PubMed
  39. Massari P, King CA, Ho AY, Wetzler LM. Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis. Cell Microbiol. 2003 Feb; 5(2):99-109. PMID: 12580946.
    View in: PubMed
  40. Ayala P, Vasquez B, Wetzler L, So M. Neisseria gonorrhoeae porin P1.B induces endosome exocytosis and a redistribution of Lamp1 to the plasma membrane. Infect Immun. 2002 Nov; 70(11):5965-71. PMID: 12379671.
    View in: PubMed
  41. Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol. 2002 Feb 15; 168(4):1533-7. PMID: 11823477.
    View in: PubMed
  42. Bhasin N, Ho Y, Wetzler LM. Neisseria meningitidis lipopolysaccharide modulates the specific humoral immune response to neisserial porins but has no effect on porin-induced upregulation of costimulatory ligand B7-2. Infect Immun. 2001 Aug; 69(8):5031-6. PMID: 11447183.
    View in: PubMed
  43. Massari P, Wetzler LM. Studies on the effect of neisserial porins on apoptosis of Mammalian cells. Methods Mol Med. 2001; 67:587-97. PMID: 21337167.
    View in: PubMed
  44. Delvig AA, Robinson JH, Wetzler L. Testing meningococcal vaccines for mitogenicity and superantigenicity. Methods Mol Med. 2001; 66:199-221. PMID: 21336757.
    View in: PubMed
  45. Wedege E, Bolstad K, Wetzler LM, Guttormsen H. IgG antibody levels to meningococcal porins in patient sera: comparison of immunoblotting and ELISA measurements. J Immunol Methods. 2000 Oct 20; 244(1-2):9-15. PMID: 11033014.
    View in: PubMed
  46. Massari P, Ho Y, Wetzler LM. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9070-5. PMID: 10922061.
    View in: PubMed
  47. Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis. Mol Immunol. 1999 Sep-Oct; 36(13-14):915-28. PMID: 10698346.
    View in: PubMed
  48. Simpson SD, Ho Y, Rice PA, Wetzler LM. T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections. J Infect Dis. 1999 Sep; 180(3):762-73. PMID: 10438365.
    View in: PubMed
  49. Mackinnon FG, Ho Y, Blake MS, Michon F, Chandraker A, Sayegh MH, Wetzler LM. The role of B/T costimulatory signals in the immunopotentiating activity of neisserial porin. J Infect Dis. 1999 Sep; 180(3):755-61. PMID: 10438364.
    View in: PubMed
  50. Lehmann AK, Halstensen A, Aaberge IS, Holst J, Michaelsen TE, Sornes S, Wetzler LM, Guttormsen H. Human opsonins induced during meningococcal disease recognize outer membrane proteins PorA and PorB. Infect Immun. 1999 May; 67(5):2552-60. PMID: 10225920.
    View in: PubMed
  51. Oftung F, Naess LM, Wetzler LM, Korsvold GE, Aase A, Høiby EA, Dalseg R, Holst J, Michaelsen TE, Haneberg B. Antigen-specific T-cell responses in humans after intranasal immunization with a meningococcal serogroup B outer membrane vesicle vaccine. Infect Immun. 1999 Feb; 67(2):921-7. PMID: 9916109.
    View in: PubMed
  52. Henriksen AZ, Maeland JA, Wetzler LM. An epitope shared by enterobacterial and neisserial porin proteins. APMIS. 1998 Aug; 106(8):818-24. PMID: 9744768.
    View in: PubMed
  53. Guttormsen HK, Wetzler LM, Finberg RW, Kasper DL. Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model. Infect Immun. 1998 May; 66(5):2026-32. PMID: 9573085.
    View in: PubMed
  54. Naess LM, Oftung F, Aase A, Wetzler LM, Sandin R, Michaelsen TE. Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine. Infect Immun. 1998 Mar; 66(3):959-65. PMID: 9488382.
    View in: PubMed
  55. Snapper CM, Rosas FR, Kehry MR, Mond JJ, Wetzler LM. Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion. Infect Immun. 1997 Aug; 65(8):3203-8. PMID: 9234776.
    View in: PubMed
  56. Gill MJ, McQuillen DP, van Putten JP, Wetzler LM, Bramley J, Crooke H, Parsons NJ, Cole JA, Smith H. Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae. Infect Immun. 1996 Aug; 64(8):3374-8. PMID: 8757878.
    View in: PubMed
  57. Wetzler LM, Ho Y, Reiser H, Wetzler LW. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J Exp Med. 1996 Mar 1; 183(3):1151-9. PMID: 8642257.
    View in: PubMed
  58. Blake MS, Wetzler LM. Vaccines for gonorrhea: where are we on the curve? Trends Microbiol. 1995 Dec; 3(12):469-74. PMID: 8800838.
    View in: PubMed
  59. Bjerknes R, Guttormsen HK, Solberg CO, Wetzler LM. Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst. Infect Immun. 1995 Jan; 63(1):160-7. PMID: 7806353.
    View in: PubMed
  60. Wetzler LM. Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines. Ann N Y Acad Sci. 1994 Aug 15; 730:367-70. PMID: 8080211.
    View in: PubMed
  61. Rice PA, McQuillen DP, Gulati S, Jani DB, Wetzler LM, Blake MS, Gotschlich EC. Serum resistance of Neisseria gonorrhoeae. Does it thwart the inflammatory response and facilitate the transmission of infection? Ann N Y Acad Sci. 1994 Aug 15; 730:7-14. PMID: 8080215.
    View in: PubMed
  62. Guttormsen HK, Wetzler LM, Solberg CO. Humoral immune response to class 1 outer membrane protein during the course of meningococcal disease. Infect Immun. 1994 Apr; 62(4):1437-43. PMID: 8132350.
    View in: PubMed
  63. Guttormsen HK, Wetzler LM, Naess A. Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease. Infect Immun. 1993 Nov; 61(11):4734-42. PMID: 8406872.
    View in: PubMed
  64. Wetzler LM, Blake MS, Barry K, Gotschlich EC. Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants. J Infect Dis. 1992 Sep; 166(3):551-5. PMID: 1323620.
    View in: PubMed
  65. Wetzler LM, Barry K, Blake MS, Gotschlich EC. Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera. Infect Immun. 1992 Jan; 60(1):39-43. PMID: 1729195.
    View in: PubMed
  66. Wetzler LM, Gotschlich EC, Blake MS, Koomey JM. The construction and characterization of Neisseria gonorrhoeae lacking protein III in its outer membrane. J Exp Med. 1989 Jun 1; 169(6):2199-209. PMID: 2499656.
    View in: PubMed
  67. Blake MS, Wetzler LM, Gotschlich EC, Rice PA. Protein III: structure, function, and genetics. Clin Microbiol Rev. 1989 Apr; 2 Suppl:S60-3. PMID: 2497964.
    View in: PubMed
  68. Wetzler LM, Blake MS, Gotschlich EC. Protein I (Por) of Neisseria gonorrhoeae as an immunogen: liposomes, proteosomes, and the lack of blocking antibodies. Trans Assoc Am Physicians. 1989; 102:78-90. PMID: 2561644.
    View in: PubMed
  69. Blake MS, Wetzler LM, Gotschlich EC, Rice PA. Developing a gonococcal protein I vaccine. Adv Exp Med Biol. 1989; 251:315-27. PMID: 2514585.
    View in: PubMed
  70. Wetzler LM, Blake MS, Gotschlich EC. Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations. J Exp Med. 1988 Nov 1; 168(5):1883-97. PMID: 3141555.
    View in: PubMed
  71. Wetzler L, Seiff ME. AIDS vaccine and the private sector. N Engl J Med. 1986 Jun 5; 314(23):1511-2. PMID: 3010117.
    View in: PubMed
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