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PhD, Boston University

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Generation of IL-33 Deficient Mice
05/19/2010 - 04/30/2014 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R03AI090404-02

Core C - Role of Innate Immune System in Pathogen Induced Chronic Inflammation
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Role of the T1/ST2 Receptor in Myocardial Ischemia
04/01/2005 - 07/31/2007 (PI)
NIH-NHLBI
7 R01 HL69484-05

Title

Yr	Title	Project-Sub Proj	Pubs
2011	Generation of IL-33 Deficient Mice	5R03AI090404-02	1
2010	Generation of IL-33 Deficient Mice	1R03AI090404-01	1
2004	Role of the T1/ST2 receptor in myocardial ischemia/repe*	5R01HL069484-04	4
2004	Role of the T1/ST2 receptor in myocardial ischemia/repe*	7R01HL069484-05	4
2003	Role of the T1/ST2 receptor in myocardial ischemia/repe*	5R01HL069484-03	4
2002	Role of the T1/ST2 receptor in myocardial ischemia/repe*	5R01HL069484-02	4
2001	Role of the T1/ST2 receptor in myocardial ischemia/repe*	1R01HL069484-01	4

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles.

Gower, Adam
Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Gibson, Frank
Beaulieu, Lea
Wetzler, Lee
Ingalls, Robin
He, Xianbao
Alekseyev, Yuriy

PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;

Papadopoulos G, Kramer CD, Slocum CS, Weinberg EO, Hua N, Gudino CV, Hamilton JA, Genco CA. A mouse model for pathogen-induced chronic inflammation at local and systemic sites. J Vis Exp. 2014; (90):e51556.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Papadopoulos, George
Hamilton, James
Hua, Ning

PMID: 25146644; PMCID: PMC4758716; DOI: 10.3791/51556;

Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog. 2014 Jul; 10(7):e1004215.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Papadopoulos, George
Hamilton, James
Hua, Ning

PMID: 25010102; PMCID: PMC4092147; DOI: 10.1371/journal.ppat.1004215;

Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC. Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis. J Periodontal Res. 2015 Feb; 50(1):89-102.View Related Profiles.

Genco, Caroline
Weinberg, Ellen
Gibson, Frank
Shaik-Dasthagirisheb, Yazdani

PMID: 24862405; PMCID: PMC4242805; DOI: 10.1111/jre.12185;

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1ß regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Weinberg, Ellen
Benjamin, Emelia
Freedman, Jane
Beaulieu, Lea
Larson, Martin
Koupenova-Zamor, Milka

PMID: 24458711; PMCID: PMC4070375; DOI: 10.1161/ATVBAHA.113.302700;

Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57.View Related Profiles.

Genco, Caroline
Morgan, Elise
Weinberg, Ellen
Gibson, Frank
Papadopoulos, George
Wetzler, Lee
Massari, Paola

PMID: 23264656; PMCID: PMC3549226; DOI: 10.4049/jimmunol.1202511;

Weinberg EO, Genco CA. Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis. Circulation. 2012 Oct 2; 126(14):1678-80.View Related Profiles.

Genco, Caroline
Weinberg, Ellen

PMID: 23027810; PMCID: PMC3645373; DOI: 10.1161/CIRCULATIONAHA.112.134379;

Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.View Related Profiles.

Madrigal, Andres
Genco, Caroline
Hayashi, Chie
Weinberg, Ellen
Gibson, Frank
Papadopoulos, George
Hamilton, James
Barth, Kenneth
LaValley, Michael

PMID: 22956579; PMCID: PMC3448820; DOI: 10.4049/jimmunol.1201541;

Pradhan L, Genis C, Scone P, Weinberg EO, Kasahara H, Nam HJ. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry. 2012 Aug 14; 51(32):6312-9. PMID: 22849347; PMCID: PMC3448007

Warren SA, Terada R, Briggs LE, Cole-Jeffrey CT, Chien WM, Seki T, Weinberg EO, Yang TP, Chin MT, Bungert J, Kasahara H. Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart. Mol Cell Biol. 2011 Nov; 31(22):4633-45. PMID: 21930795; PMCID: PMC3209251; DOI: 10.1128/MCB.05940-11;

Showing 10 of 55 results. Show More

Kuster GM, Lancel S, Zhang J, Communal C, Trucillo MP, Lim CC, Pfister O, Weinberg EO, Cohen RA, Liao R, Siwik DA, Colucci WS. Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med. 2010 May 1; 48(9):1182-7.View Related Profiles.

Siwik, Deborah
Weinberg, Ellen
Cohen, Richard
Colucci, Wilson

PMID: 20132882; PMCID: PMC2847633; DOI: 10.1016/j.freeradbiomed.2010.01.038;

Weinberg EO. ST2 protein in heart disease: from discovery to mechanisms and prognostic value. Biomark Med. 2009 Oct; 3(5):495-511. PMID: 20477519; DOI: 10.2217/bmm.09.56;

Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. PMID: 19546853; PMCID: PMC2733927; DOI: 10.1038/labinvest.2009.59;

Bartunek J, Delrue L, Van Durme F, Muller O, Casselman F, De Wiest B, Croes R, Verstreken S, Goethals M, de Raedt H, Sarma J, Joseph L, Vanderheyden M, Weinberg EO. Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load. J Am Coll Cardiol. 2008 Dec 16; 52(25):2166-74.View Related Profiles.

Weinberg, Ellen
Joseph, Lija

PMID: 19095135; PMCID: PMC2637465; DOI: 10.1016/j.jacc.2008.09.027;

Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. PMID: 18689573; PMCID: PMC2590500; DOI: 10.1161/CIRCRESAHA.108.171835;

Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circ Res. 2008 Mar 14; 102(5):571-80. PMID: 18202317; PMCID: PMC2504503; DOI: 10.1161/CIRCRESAHA.107.161687;

Mirotsou M, Dzau VJ, Pratt RE, Weinberg EO. Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy. Physiol Genomics. 2006 Oct 3; 27(1):86-94. PMID: 16835353

Weinberg EO, Scherrer-Crosbie M, Picard MH, Nasseri BA, MacGillivray C, Gannon J, Lian Q, Bloch KD, Lee RT. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1802-9. PMID: 15563531

Hendrickx J, Doggen K, Weinberg EO, Van Tongelen P, Fransen P, De Keulenaer GW. Molecular diversity of cardiac endothelial cells in vitro and in vivo. Physiol Genomics. 2004 Oct 4; 19(2):198-206. PMID: 15304623

Shimpo M, Morrow DA, Weinberg EO, Sabatine MS, Murphy SA, Antman EM, Lee RT. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004 May 11; 109(18):2186-90. PMID: 15117853

Weinberg EO, Shimpo M, Hurwitz S, Tominaga S, Rouleau JL, Lee RT. Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation. 2003 Feb 11; 107(5):721-6. PMID: 12578875

Weinberg EO, Mirotsou M, Gannon J, Dzau VJ, Lee RT, Pratt RE. Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics. 2003 Jan 15; 12(2):113-27. PMID: 12454204

Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, Rouleau JL, Lee RT. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002 Dec 3; 106(23):2961-6. PMID: 12460879; PMCID: PMC1460012

Wang Y, De Keulenaer GW, Weinberg EO, Muangman S, Gualberto A, Landschulz KT, Turi TG, Thompson JF, Lee RT. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H533-9. PMID: 12124198

Weinberg EO, Herzig JW. Management of hypertension and heart failure with AT1 receptor blockade. J Pak Med Assoc. 2001 Feb; 51(2):81-5. PMID: 11321878

Ding B, Price RL, Goldsmith EC, Borg TK, Yan X, Douglas PS, Weinberg EO, Bartunek J, Thielen T, Didenko VV, Lorell BH. Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. Circulation. 2000 Jun 20; 101(24):2854-62. PMID: 10859293

Bartunek J, Weinberg EO, Tajima M, Rohrbach S, Katz SE, Douglas PS, Lorell BH. Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy. Circulation. 2000 Feb 1; 101(4):423-9. PMID: 10653835

Rohrbach S, Yan X, Weinberg EO, Hasan F, Bartunek J, Marchionni MA, Lorell BH. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation. 1999 Jul 27; 100(4):407-12. PMID: 10421602

Weinberg EO, Thienelt CD, Katz SE, Bartunek J, Tajima M, Rohrbach S, Douglas PS, Lorell BH. Gender differences in molecular remodeling in pressure overload hypertrophy. J Am Coll Cardiol. 1999 Jul; 34(1):264-73. PMID: 10400020

Ding B, Price RL, Borg TK, Weinberg EO, Halloran PF, Lorell BH. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. Circ Res. 1999 Apr 2; 84(6):729-34. PMID: 10189361

Tajima M, Weinberg EO, Bartunek J, Jin H, Yang R, Paoni NF, Lorell BH. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure. Circulation. 1999 Jan 5-12; 99(1):127-34. PMID: 9884389

Bartunek J, Weinberg EO, Tajima M, Rohrbach S, Lorell BH. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation. 1999 Jan 5-12; 99(1):22-5. PMID: 9884374

Tajima M, Bartunek J, Weinberg EO, Ito N, Lorell BH. Atrial natriuretic peptide has different effects on contractility and intracellular pH in normal and hypertrophied myocytes from pressure-overloaded hearts. Circulation. 1998 Dec 15; 98(24):2760-4. PMID: 9851964

Douglas PS, Katz SE, Weinberg EO, Chen MH, Bishop SP, Lorell BH. Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol. 1998 Oct; 32(4):1118-25. PMID: 9768741

Bartunek J, Dempsey S, Weinberg EO, Ito N, Tajima M, Rohrbach S, Lorell BH. Chronic L-arginine treatment increases cardiac cyclic guanosine 5'-monophosphate in rats with aortic stenosis: effects on left ventricular mass and beta-adrenergic contractile reserve. J Am Coll Cardiol. 1998 Aug; 32(2):528-35. PMID: 9708487

Thienelt CD, Weinberg EO, Bartunek J, Lorell BH. Load-induced growth responses in isolated adult rat hearts. Role of the AT1 receptor. Circulation. 1997 Jun 17; 95(12):2677-83. PMID: 9193437

Weinberg EO, Lee MA, Weigner M, Lindpaintner K, Bishop SP, Benedict CR, Ho KK, Douglas PS, Chafizadeh E, Lorell BH. Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. Circulation. 1997 Mar 18; 95(6):1592-600. PMID: 9118530

Ito N, Kagaya Y, Weinberg EO, Barry WH, Lorell BH. Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy. J Clin Invest. 1997 Jan 1; 99(1):125-35. PMID: 9011566; PMCID: PMC507776

Schunkert H, Weinberg EO, Bruckschlegel G, Riegger AJ, Lorell BH. Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding. J Clin Invest. 1995 Dec; 96(6):2768-74. PMID: 8675646; PMCID: PMC185986

Kagaya Y, Weinberg EO, Ito N, Mochizuki T, Barry WH, Lorell BH. Glycolytic inhibition: effects on diastolic relaxation and intracellular calcium handling in hypertrophied rat ventricular myocytes. J Clin Invest. 1995 Jun; 95(6):2766-76. PMID: 7769117; PMCID: PMC295961

Litwin SE, Katz SE, Weinberg EO, Lorell BH, Aurigemma GP, Douglas PS. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation. 1995 May 15; 91(10):2642-54. PMID: 7743628

Schunkert H, Sadoshima J, Cornelius T, Kagaya Y, Weinberg EO, Izumo S, Riegger G, Lorell BH. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res. 1995 Mar; 76(3):489-97. PMID: 7859394

Ikenouchi H, Barry WH, Bridge JH, Weinberg EO, Apstein CS, Lorell BH. Effects of angiotensin II on intracellular Ca2+ and pH in isolated beating rabbit hearts and myocytes loaded with the indicator indo-1. J Physiol. 1994 Oct 15; 480 ( Pt 2):203-15. PMID: 7869240; PMCID: PMC1155839

Weinberg EO, Schoen FJ, George D, Kagaya Y, Douglas PS, Litwin SE, Schunkert H, Benedict CR, Lorell BH. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Circulation. 1994 Sep; 90(3):1410-22. PMID: 8087951

Lopez JJ, Lorell BH, Ingelfinger JR, Weinberg EO, Schunkert H, Diamant D, Tang SS. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 1994 Aug; 267(2 Pt 2):H844-52. PMID: 8067441

Feldman AM, Weinberg EO, Ray PE, Lorell BH. Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res. 1993 Jul; 73(1):184-92. PMID: 8508529

Eberli FR, Weinberg EO, Grice WN, Horowitz GL, Apstein CS. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ Res. 1991 Feb; 68(2):466-81. PMID: 1991351

Lorell BH, Apstein CS, Weinberg EO, Cunningham MJ. Diastolic function in left ventricular hypertrophy: clinical and experimental relationships. Eur Heart J. 1990 Nov; 11 Suppl G:54-64. PMID: 2150037

Lorell BH, Apstein CS, Cunningham MJ, Schoen FJ, Weinberg EO, Peeters GA, Barry WH. Contribution of endothelial cells to calcium-dependent fluorescence transients in rabbit hearts loaded with indo 1. Circ Res. 1990 Aug; 67(2):415-25. PMID: 2376080

Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990 May; 81(5):1644-53. PMID: 2139593

Cunningham MJ, Apstein CS, Weinberg EO, Vogel WM, Lorell BH. Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia. Circ Res. 1990 Feb; 66(2):406-15. PMID: 2137038

Cunningham MJ, Apstein CS, Weinberg EO, Lorell BH. Deleterious effect of ouabain on myocardial function during hypoxia. Am J Physiol. 1989 Mar; 256(3 Pt 2):H681-7. PMID: 2923234

Lorell BH, Isoyama S, Grice WN, Weinberg EO, Apstein CS. Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts. Circ Res. 1988 Aug; 63(2):457-67. PMID: 3396161

Wexler LF, Lorell BH, Momomura S, Weinberg EO, Ingwall JS, Apstein CS. Enhanced sensitivity to hypoxia-induced diastolic dysfunction in pressure-overload left ventricular hypertrophy in the rat: role of high-energy phosphate depletion. Circ Res. 1988 Apr; 62(4):766-75. PMID: 2964946

Wexler LF, Weinberg EO, Ingwall JS, Apstein CS. Acute alterations in diastolic left ventricular chamber distensibility: mechanistic differences between hypoxemia and ischemia in isolated perfused rabbit and rat hearts. Circ Res. 1986 Nov; 59(5):515-28. PMID: 3802427

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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