Keywords
Last Name

Paola Massari, PhD

TitleAdjunct Research Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Diseases
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 414-4807
ORCID ORCID Icon0000-0003-3106-0711
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise includes: Protein biochemistry and purification; Structure-function characterization; Cellular biology; Immunology; Apoptosis; Airways biology and immunology.

 Self-Described Keywords
  • airway biology and immunology
  • airway epithelial cells
  • cytokines
  • innate immunity
  • ligand/receptor studies
  • Neisseriae
  • oral pathogens
  • outer membrane proteins
  • pathogenic and commensal organisms interplay
  • sexually transmitted diseases
  • Toll-like receptors
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Toussi DN, Wetzler LM, Liu X, Massari P. Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation. Microbes Infect. 2016 Oct; 18(10):627-638. PMID: 27373686.
    View in: PubMed
  2. Stefanelli P, Neri A, Tanabe M, Fazio C, Massari P. Typing and surface charges of the variable loop regions of PorB from Neisseria meningitidis. IUBMB Life. 2016 Jun; 68(6):488-95. PMID: 27156582.
    View in: PubMed
  3. McClure R, Nudel K, Massari P, Tjaden B, Su X, Rice PA, Genco CA. The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women. PLoS One. 2015; 10(8):e0133982. PMID: 26244506.
    View in: PubMed
  4. Massari P, Gunawardana J, Liu X, Wetzler LM. Correction for Massari et al., meningococcal porin PorB prevents cellular apoptosis in a Toll-like receptor 2- and NF-?B-independent manner. Infect Immun. 2015 Aug; 83(8):3339. PMID: 26157088.
    View in: PubMed
  5. Nudel K, Massari P, Genco CA. Neisseria gonorrhoeae Modulates Cell Death in Human Endocervical Epithelial Cells through Export of Exosome-Associated cIAP2. Infect Immun. 2015 Sep; 83(9):3410-7. PMID: 26077759.
    View in: PubMed
  6. Kattner C, Pfennig S, Massari P, Tanabe M. One-step purification and porin transport activity of the major outer membrane proteins P2 from Haemophilus influenzae, FomA from Fusobacterium nucleatum and PorB from Neisseria meningitidis. Appl Biochem Biotechnol. 2015 Mar; 175(6):2907-15. PMID: 25575589.
    View in: PubMed
  7. McClure R, Massari P. TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens. Front Immunol. 2014; 5:386. PMID: 25161655.
    View in: PubMed
  8. Toussi DN, Massari P. Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor Ligands. Vaccines (Basel). 2014; 2(2):323-53. PMID: 26344622.
    View in: PubMed
  9. Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition. J Struct Biol. 2014 Mar; 185(3):440-7. PMID: 24361688.
    View in: PubMed
  10. Platt A, MacLeod H, Massari P, Liu X, Wetzler L. In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. PLoS One. 2013; 8(12):e82171. PMID: 24349212.
    View in: PubMed
  11. Tifrea DF, Pal S, Toussi DN, Massari P, de la Maza LM. Vaccination with major outer membrane protein proteosomes elicits protection in mice against a Chlamydia respiratory challenge. Microbes Infect. 2013 Nov; 15(13):920-7. PMID: 23999313.
    View in: PubMed
  12. Ahn S, Freedman DS, Massari P, Cabodi M, Ünlü MS. A mass-tagging approach for enhanced sensitivity of dynamic cytokine detection using a label-free biosensor. Langmuir. 2013 Apr 30; 29(17):5369-76. PMID: 23547938.
    View in: PubMed
  13. Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57. PMID: 23264656.
    View in: PubMed
  14. Massari P, Toussi DN, Tifrea DF, de la Maza LM. Toll-like receptor 2-dependent activity of native major outer membrane protein proteosomes of Chlamydia trachomatis. Infect Immun. 2013 Jan; 81(1):303-10. PMID: 23132491.
    View in: PubMed
  15. Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P. The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation. Infect Immun. 2012 Oct; 80(10):3417-28. PMID: 22825445.
    View in: PubMed
  16. Toussi DN, Liu X, Massari P. The FomA porin from Fusobacterium nucleatum is a Toll-like receptor 2 agonist with immune adjuvant activity. Clin Vaccine Immunol. 2012 Jul; 19(7):1093-101. PMID: 22623652.
    View in: PubMed
  17. Oliveira-Nascimento L, Massari P, Wetzler LM. The Role of TLR2 in Infection and Immunity. Front Immunol. 2012; 3:79. PMID: 22566960.
    View in: PubMed
  18. Massari P, Wetzler LM. Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins. Methods Mol Biol. 2012; 799:319-41. PMID: 21993654.
    View in: PubMed
  19. Arjunaraja S, Massari P, Wetzler LM, Lees A, Colino J, Snapper CM. The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain. J Immunol. 2012 Jan 15; 188(2):569-77. PMID: 22156342.
    View in: PubMed
  20. Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM. Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells. Clin Immunol. 2011 Jan; 138(1):33-40. PMID: 20947433.
    View in: PubMed
  21. Liu X, Wetzler LM, Nascimento LO, Massari P. Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling. Infect Immun. 2010 Dec; 78(12):5314-23. PMID: 20937766.
    View in: PubMed
  22. Vaughan AT, Brackenbury LS, Massari P, Davenport V, Gorringe A, Heyderman RS, Williams NA. Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig. J Immunol. 2010 Sep 15; 185(6):3652-60. PMID: 20709949.
    View in: PubMed
  23. Massari P, Gunawardana J, Liu X, Wetzler LM. Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner. Infect Immun. 2010 Mar; 78(3):994-1003. PMID: 20028813.
    View in: PubMed
  24. Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun. 2009 Sep; 77(9):3602-10. PMID: 19546192.
    View in: PubMed
  25. Liu X, Wetzler LM, Massari P. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6; 26(6):786-96. PMID: 18191311.
    View in: PubMed
  26. Massari P, Visintin A, Gunawardana J, Halmen KA, King CA, Golenbock DT, Wetzler LM. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. J Immunol. 2006 Feb 15; 176(4):2373-80. PMID: 16455995.
    View in: PubMed
  27. Massari P, King CA, MacLeod H, Wetzler LM. Improved purification of native meningococcal porin PorB and studies on its structure/function. Protein Expr Purif. 2005 Dec; 44(2):136-46. PMID: 16027004.
    View in: PubMed
  28. Singleton TE, Massari P, Wetzler LM. Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent. J Immunol. 2005 Mar 15; 174(6):3545-50. PMID: 15749891.
    View in: PubMed
  29. Massari P, King CA, Ho AY, Wetzler LM. Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis. Cell Microbiol. 2003 Feb; 5(2):99-109. PMID: 12580946.
    View in: PubMed
  30. Massari P, Ram S, Macleod H, Wetzler LM. The role of porins in neisserial pathogenesis and immunity. Trends Microbiol. 2003 Feb; 11(2):87-93. PMID: 12598131.
    View in: PubMed
  31. Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol. 2002 Feb 15; 168(4):1533-7. PMID: 11823477.
    View in: PubMed
  32. Massari P, Wetzler LM. Studies on the effect of neisserial porins on apoptosis of Mammalian cells. Methods Mol Med. 2001; 67:587-97. PMID: 21337167.
    View in: PubMed
  33. Massari P, Ho Y, Wetzler LM. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9070-5. PMID: 10922061.
    View in: PubMed
  34. Guarino A, Bisceglia M, Canani RB, Boccia MC, Mallardo G, Bruzzese E, Massari P, Rappuoli R, Telford J. Enterotoxic effect of the vacuolating toxin produced by Helicobacter pylori in Caco-2 cells. J Infect Dis. 1998 Nov; 178(5):1373-8. PMID: 9780258.
    View in: PubMed
  35. Massari P, Manetti R, Burroni D, Nuti S, Norais N, Rappuoli R, Telford JL. Binding of the Helicobacter pylori vacuolating cytotoxin to target cells. Infect Immun. 1998 Aug; 66(8):3981-4. PMID: 9673292.
    View in: PubMed
  36. Marchetti M, Rossi M, Giannelli V, Giuliani MM, Pizza M, Censini S, Covacci A, Massari P, Pagliaccia C, Manetti R, Telford JL, Douce G, Dougan G, Rappuoli R, Ghiara P. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine. 1998 Jan; 16(1):33-7. PMID: 9607006.
    View in: PubMed
  37. Manetti R, Massari P, Marchetti M, Magagnoli C, Nuti S, Lupetti P, Ghiara P, Rappuoli R, Telford JL. Detoxification of the Helicobacter pylori cytotoxin. Infect Immun. 1997 Nov; 65(11):4615-9. PMID: 9353041.
    View in: PubMed
  38. Papini E, Gottardi E, Satin B, de Bernard M, Massari P, Telford J, Rappuoli R, Sato SB, Montecucco C. The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori. J Med Microbiol. 1996 Aug; 45(2):84-9. PMID: 8683556.
    View in: PubMed
  39. Lupetti P, Heuser JE, Manetti R, Massari P, Lanzavecchia S, Bellon PL, Dallai R, Rappuoli R, Telford JL. Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J Cell Biol. 1996 May; 133(4):801-7. PMID: 8666665.
    View in: PubMed
  40. Manetti R, Massari P, Burroni D, de Bernard M, Marchini A, Olivieri R, Papini E, Montecucco C, Rappuoli R, Telford JL. Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies. Infect Immun. 1995 Nov; 63(11):4476-80. PMID: 7591088.
    View in: PubMed
  41. Marchini A, d'Apolito M, Massari P, Atzeni M, Copass M, Olivieri R. Cyclodextrins for growth of Helicobacter pylori and production of vacuolating cytotoxin. Arch Microbiol. 1995 Oct; 164(4):290-3. PMID: 7487335.
    View in: PubMed
  42. Marchini A, Massari P, Manetti R, Olivieri R. Optimized conditions for the fermentation of Helicobacter pylori and production of vacuolating cytotoxin. FEMS Microbiol Lett. 1994 Nov 15; 124(1):55-9. PMID: 8001770.
    View in: PubMed
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