Robin R. Ingalls, MD
Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases Section

MD, Harvard University



The ability of innate immune system to sense invasion by a pathogenic organism and respond appropriately in order to control infection is paramount to survival. To that end, an array of receptors and binding proteins has evolved as part of the innate immune system to detect invading microorganisms. My laboratory is interested in Toll-like receptors and the intracellular signaling pathways that contribute to the innate recognition of Gram-negative bacteria, with a particular focus on mucosal immunity. We have a variety of in vitro and in vivo models in the laboratory to address the interaction of Neisseria and Chlamydia species with epithelial cells and macrophages.

One major focus of the laboratory is exploring the role of TLR2 in host defense against C. trachomatis. Previous work in our laboratory established a role for TLR2 in cellular responses to chlamydia species. In our recent in vivo work we have observed that TLR2 plays a protective role in the lung but a detrimental role in the genital tract during infected of mice with the mouse pathogen, C. muridarum. The goal of this project is to determine the specific cell types that are responsible for this difference. As part of this project, we are also trying to identify the specific ligands in chlamydia that are important for TLR2-dependent and independent cell activation, and characterize TLR2 signaling mutant strains of chlamydia that lack the cryptic plasmid.

A second focus of the laboratory is exploring the role TLRs and NLRs in host defense against N. gonorrhoeae. Previous work in our laboratory established a role for TLR4 and TLR2 in cellular responses to Neisseria species in vitro and we have recently completed in vitro studies that also demonstrate that gonorrhea can activate Nod receptors. Our ongoing in vivo studies in TLR4 mutant mice demonstrate that TLR4 is important for early bacterial clearance and neutrophil function, and we plan to complete studies in TLR2 and Nod1/2 mutant mice when back breeding is complete.

The third focus of the laboratory relates to the role of innate immunity on regulating acute and chronic inflammation associated with the respiratory pathogen Chlamydophila pneumoniae. We are in the process of defining the specific receptors and ligands that are responsible for IL-1b activation during infection, and will investigate the role of IL-1b in C. pneumoniae-induced atherosclerosis.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Microbiology


Active Staff Privileges
Boston Medical Center
Medicine
Infectious Diseases Section



Role of the Innate Immune System in Pathogen-Induced Chronic Inflammation
08/01/2010 - 07/31/2017 (PI of Sub-Project / SP)
PI: Caroline A. Genco, PhD
NIH/National Institute of Allergy & Infectious Diseases
5P01AI078894-05


Role of complement activation in the development of HIV-associated metabolic syndrome
07/01/2016 - 06/30/2017 (PI)
Miriam Hospital NIH-NIAID

Role of Chlamydia Species in Pre-term Birth & Placental Dysfunction
07/01/2012 - 06/30/2017 (PI)
NIH-NIAID
4R01 AI101088-05

Role of Chlamydia Species in Pre-term Birth & Placental Dysfunction
07/01/2012 - 06/30/2017 (PI)
NIH-NIAID
5R01 AI101088-04

Role of Chlamydia Species in Preterm Birth and Placental Dysfunction (Supplement)
07/01/2012 - 06/30/2017 (PI)
NIH-NIAID
3R01AI101088-04

Project 2 - Innate Immune Defenses Against Acute and Chronic Infection with C. Penumoniae
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Innate and Adaptive Immunity in Experimental and Human Gonoccocal Infection
09/25/2009 - 08/31/2014 (PI)
UMASS Worcester NIH-NIAID

Interaction of Chalmydia with Innate Immune Receptors
03/15/2005 - 12/31/2012 (PI)
NIH-NIAID
5 R01 AI64749-05

Innate Immune Receptors in Host Responses to Neisseria
08/01/2005 - 01/31/2011 (PI)
NIH-NIAID
5R01 AI046613-10

R344 5R01Dk48236-03 7/31/
08/01/2005 - 01/31/2010 (PI)
NIH
5 R01DK48236-03

Role of Los And Its Receptors
01/15/2000 - 01/31/2006 (PI)
NIH-NIAID
5 R01 AI046613-03 (A)

Showing 10 of 12 results. Show All Results


Yr Title Project-Sub Proj Pubs
2016 Role of Chlamydia Species in Preterm Birth and Placental Dysfunction 4R01AI101088-05 1
2015 Function-specific serotonergic neurons, discrete brain targets, and addiction 5R21DA036056-02
2014 Function-specific serotonergic neurons, discrete brain targets, and addiction 1R21DA036056-01A1
2014 Role of Chlamydia Species in Preterm Birth and Placental Dysfunction 5R01AI101088-03 1
2014 Defenses against Acute Chronic Infection with C pneumoniae 5P01AI078894-05-7795 22
2013 Role of Chlamydia Species in Preterm Birth and Placental Dysfunction 5R01AI101088-02 1
2013 Role of Chlamydia Species in Preterm Birth and Placental Dysfunction 3R01AI101088-02S1 1
2013 Cognitive Aspects of Addiction-Related Behavior 3R01DA011716-14S1 33
2013 Cognitive Aspects of Addiction-Related Behavior 5R01DA011716-15 33
2013 Genetic variations in the innate immune response to Neisseria 5U19AI084048-05-6543 31
Showing 10 of 73 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kramer CD, Simas AM, He X, Ingalls RR, Weinberg EO, Genco CA. Distinct roles for dietary lipids and Porphyromonas gingivalis infection on atherosclerosis progression and the gut microbiota. Anaerobe. 2017 Jun; 45:19-30.View Related Profiles. PMID: 28442421.
  2. Aqeel Y, Rodriguez R, Chatterjee A, Ingalls RR, Samuelson J. Killing of diverse eye pathogens (Acanthamoeba spp., Fusarium solani, and Chlamydia trachomatis) with alcohols. PLoS Negl Trop Dis. 2017 Feb; 11(2):e0005382.View Related Profiles. PMID: 28182670; DOI: 10.1371/journal.pntd.0005382;.
  3. Shaik-Dasthagirisaheb YB, Mekasha S, He X, Gibson FC, Ingalls RR. Signaling events in pathogen-induced macrophage foam cell formation. Pathog Dis. 2016 08; 74(6).View Related Profiles. PMID: 27481727; DOI: 10.1093/femspd/ftw074;.
  4. Pudney J, He X, Masheeb Z, Kindelberger DW, Kuohung W, Ingalls RR. Differential expression of toll-like receptors in the human placenta across early gestation. Placenta. 2016 Oct; 46:1-10.View Related Profiles. PMID: 27697215; DOI: 10.1016/j.placenta.2016.07.005;.
  5. He X, Liang Y, LaValley MP, Lai J, Ingalls RR. Comparative analysis of the growth and biological activity of a respiratory and atheroma isolate of Chlamydia pneumoniae reveals strain-dependent differences in inflammatory activity and innate immune evasion. BMC Microbiol. 2015; 15:228.View Related Profiles. PMID: 26494400; PMCID: PMC4619265; DOI: 10.1186/s12866-015-0569-3;.
  6. Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One. 2015; 10(7):e0131688.View Related Profiles. PMID: 26148065; PMCID: PMC4493099; DOI: 10.1371/journal.pone.0131688;.
  7. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles. PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;.
  8. He X, Berland R, Mekasha S, Christensen TG, Alroy J, Kramnik I, Ingalls RR. The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS Pathog. 2013; 9(8):e1003569.View Related Profiles. PMID: 24009502; PMCID: PMC3757055; DOI: 10.1371/journal.ppat.1003569;.
  9. Roseman DA, Kabbani D, Kwah J, Bird D, Ingalls R, Gautam A, Nuhn M, Francis JM. Strongyloides stercoralis transmission by kidney transplantation in two recipients from a common donor. Am J Transplant. 2013 Sep; 13(9):2483-6.View Related Profiles. PMID: 23919410; PMCID: PMC3785548; DOI: 10.1111/ajt.12390;.
  10. Mavrogiorgos N, Mekasha S, Yang Y, Kelliher MA, Ingalls RR. Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun. 2014 May; 20(4):377-89.View Related Profiles. PMID: 23884094; PMCID: PMC3880408; DOI: 10.1177/1753425913493453;.
Showing 10 of 46 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 21 distinct years, with a maximum of 4 publications in 1997 and 1998 and 1999 and 2000 and 2002

YearPublications
19952
19961
19974
19984
19994
20004
20012
20024
20031
20051
20061
20071
20092
20101
20112
20122
20133
20141
20152
20162
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Host-Pathogen Interactions
Infectious Diseases
Innate Immunity
Sepsis
Sexually Transmitted Infections
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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