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PhD, University of Rochester
MS, University of Rochester

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Boston University Inflammatory Disorders Training Grant
09/15/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Lee M. Wetzler, MD
NIH/National Institute of Allergy & Infectious Diseases
5T32AI089673-05

Role of the Innate Immune System in Pathogen-Induced Chronic Inflammation
08/01/2010 - 07/31/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5P01AI078894-05

Billing agreement for Jessica Ritter
07/01/2015 - 06/30/2016 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIAID
1R56AI107821-01A1

Billing Agreement for Kathleen Nudel (Goodmon)
07/01/2015 - 11/30/2015 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIAID
1R56AI107821-01A1

Innate and Adaptive Immunity in Experimental and Human Gonococal Infection
09/25/2009 - 08/31/2014 (Subcontract PI)
University of Massachusetts, Worcester NIH NIAID
5U19AI084048-05

The Gonococcal Fur Regulon: Link to Pathogenesis
04/01/2008 - 03/31/2014 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI048611-10

TLR4 evasion, bacterial persistence and chronic inflammation
09/24/2014 - 06/30/2015 (PI)
NIH-NIDCR
1R56DE024350-01

Global transcriptome analysis of mucosal gonococcal infection
08/15/2014 - 06/30/2015 (PI)
NIH-NIAID
1R56AI107821-01A1

P. gingivalis Mediated Evasion Strategies
05/05/2013 - 06/30/2015 (PI)
NIH-NIDCR
5R01DE023501-03

P.Gingavalis Lipid A Phosphate: Contribution to Virulence
06/01/2012 - 05/31/2015 (PI)
UNIV OF WASHING NIH-NIDCR

Invasive Bacteria Accelerate Atherosclerosis through TLRs
02/01/2006 - 01/31/2008 (PI)
NIH-NHLBI
5 R01 HL080387-02 (A)

Inhibition of Gingipains in vitro and in vivo
12/02/2005 - 01/31/2008 (PI)
ECI Biotech ECI Biotech

Hemin Utilization By P. Gingiv
12/01/1997 - 06/30/2007 (PI)
NIH-NIDCR
5 R01 DE009161-17 (E)

The Gonococcal Fur-Regulon: Li
07/15/2001 - 05/31/2007 (PI)
NIH-NIAID
5 R01 AI48611-04

MMP In Systemic Diseases (Genco)
03/31/2003 - 04/30/2006 (PI)
NIH-NIDCR
5P01DE13191-05

MMP In Systemic Diseases (Admin Core)
04/01/2003 - 03/31/2006 (PI)
NIH-NIDCR
5P01DE13191-05 (A)

Showing 10 of 18 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2022	Microbial Disruption of Dendritic Cell Maturation and Function	5R01AI142628-05
2021	Microbial Disruption of Dendritic Cell Maturation and Function	5R01AI142628-04
2020	Microbial Disruption of Dendritic Cell Maturation and Function	5R01AI142628-03
2020	The Gonococcal Fur Regulon Link to Pathogenesis	5R01AI130946-04	2
2019	Microbial Disruption of Dendritic Cell Maturation and Function	5R01AI142628-02
2019	Porphyromonas gingivalis and Pancreatic Carcinogenesis in Mouse Models	5R03CA228007-02
2019	The Gonococcal Fur Regulon Link to Pathogenesis	5R01AI130946-03	2
2019	Global Transcriptome Analysis of Mucosal Gonoccal Infection	5R01AI116969-04	5
2018	Microbial Disruption of Dendritic Cell Maturation and Function	1R01AI142628-01
2018	Porphyromonas gingivalis and Pancreatic Carcinogenesis in Mouse Models	1R03CA228007-01

Showing 10 of 114 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Slocum C, Kramer C, Genco CA. Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis. J Intern Med. 2016 Jul; 280(1):114-28.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Slocum, Connie

PMID: 26791914; DOI: 10.1111/joim.12476;

McClure R, Nudel K, Massari P, Tjaden B, Su X, Rice PA, Genco CA. The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women. PLoS One. 2015; 10(8):e0133982.View Related Profiles.

Genco, Caroline
Massari, Paola

PMID: 26244506; PMCID: PMC4526530; DOI: 10.1371/journal.pone.0133982;

Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One. 2015; 10(7):e0131688.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Benjamin, Emelia
Beaulieu, Lea
Ingalls, Robin
He, Xianbao

PMID: 26148065; PMCID: PMC4493099; DOI: 10.1371/journal.pone.0131688;

Nudel K, Massari P, Genco CA. Neisseria gonorrhoeae Modulates Cell Death in Human Endocervical Epithelial Cells through Export of Exosome-Associated cIAP2. Infect Immun. 2015 Sep; 83(9):3410-7.View Related Profiles.

Genco, Caroline
Massari, Paola

PMID: 26077759; PMCID: PMC4534674; DOI: 10.1128/IAI.00732-15;

El-Awady AR, Miles B, Scisci E, Kurago ZB, Palani CD, Arce RM, Waller JL, Genco CA, Slocum C, Manning M, Schoenlein PV, Cutler CW. Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk. PLoS Pathog. 2015 Feb; 10(2):e1004647.View Related Profiles.

Genco, Caroline
Slocum, Connie

PMID: 25679217; PMCID: PMC4352937; DOI: 10.1371/journal.ppat.1004647;

Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles.

Gower, Adam
Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Gibson, Frank
Beaulieu, Lea
Wetzler, Lee
Ingalls, Robin
He, Xianbao
Alekseyev, Yuriy

PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;

McClure R, Tjaden B, Genco C. Identification of sRNAs expressed by the human pathogen Neisseria gonorrhoeae under disparate growth conditions. Front Microbiol. 2014; 5:456. PMID: 25221548; DOI: 10.3389/fmicb.2014.00456;

Papadopoulos G, Kramer CD, Slocum CS, Weinberg EO, Hua N, Gudino CV, Hamilton JA, Genco CA. A mouse model for pathogen-induced chronic inflammation at local and systemic sites. J Vis Exp. 2014; (90):e51556.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Papadopoulos, George
Hamilton, James
Hua, Ning

PMID: 25146644; PMCID: PMC4758716; DOI: 10.3791/51556;

Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog. 2014 Jul; 10(7):e1004215.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Slocum, Connie
Weinberg, Ellen
Papadopoulos, George
Hamilton, James
Hua, Ning

PMID: 25010102; PMCID: PMC4092147; DOI: 10.1371/journal.ppat.1004215;

Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC. Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis. J Periodontal Res. 2015 Feb; 50(1):89-102.View Related Profiles.

Genco, Caroline
Weinberg, Ellen
Gibson, Frank
Shaik-Dasthagirisheb, Yazdani

PMID: 24862405; PMCID: PMC4242805; DOI: 10.1111/jre.12185;

Showing 10 of 109 results. Show More

Yu C, Lopez CA, Hu H, Xia Y, Freedman DS, Reddington AP, Daaboul GG, Unlü MS, Genco CA. A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein fur. PLoS One. 2014; 9(5):e96832.View Related Profiles.

Genco, Caroline
Yu, Chunxiao
Ünlü, Selim

PMID: 24811061; PMCID: PMC4014563; DOI: 10.1371/journal.pone.0096832;

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1ß regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Weinberg, Ellen
Benjamin, Emelia
Freedman, Jane
Beaulieu, Lea
Larson, Martin
Koupenova-Zamor, Milka

PMID: 24458711; PMCID: PMC4070375; DOI: 10.1161/ATVBAHA.113.302700;

Daou N, Yu C, McClure R, Gudino C, Reed GW, Genco CA. Neisseria prophage repressor implicated in gonococcal pathogenesis. Infect Immun. 2013 Oct; 81(10):3652-61.View Related Profiles.

Genco, Caroline
Daou, Nadine

PMID: 23876804; PMCID: PMC3811788; DOI: 10.1128/IAI.00298-13;

Barth K, Remick DG, Genco CA. Disruption of immune regulation by microbial pathogens and resulting chronic inflammation. J Cell Physiol. 2013 Jul; 228(7):1413-22.View Related Profiles.

Genco, Caroline
Remick, Daniel
Barth, Kenneth

PMID: 23255141; PMCID: PMC3995356; DOI: 10.1002/jcp.24299;

Miles B, Scisci E, Carrion J, Sabino GJ, Genco CA, Cutler CW. Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen. J Leukoc Biol. 2013 Aug; 94(2):281-9. PMID: 23729500; PMCID: PMC3714568; DOI: 10.1189/jlb.0213108;

McClure R, Balasubramanian D, Sun Y, Bobrovskyy M, Sumby P, Genco CA, Vanderpool CK, Tjaden B. Computational analysis of bacterial RNA-Seq data. Nucleic Acids Res. 2013 Aug; 41(14):e140. PMID: 23716638; PMCID: PMC3737546

Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57.View Related Profiles.

Genco, Caroline
Morgan, Elise
Weinberg, Ellen
Gibson, Frank
Papadopoulos, George
Wetzler, Lee
Massari, Paola

PMID: 23264656; PMCID: PMC3549226; DOI: 10.4049/jimmunol.1202511;

Weinberg EO, Genco CA. Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis. Circulation. 2012 Oct 2; 126(14):1678-80.View Related Profiles.

Genco, Caroline
Weinberg, Ellen

PMID: 23027810; PMCID: PMC3645373; DOI: 10.1161/CIRCULATIONAHA.112.134379;

Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.View Related Profiles.

Madrigal, Andres
Genco, Caroline
Hayashi, Chie
Weinberg, Ellen
Gibson, Frank
Papadopoulos, George
Hamilton, James
Barth, Kenneth
LaValley, Michael

PMID: 22956579; PMCID: PMC3448820; DOI: 10.4049/jimmunol.1201541;

Carrion J, Scisci E, Miles B, Sabino GJ, Zeituni AE, Gu Y, Bear A, Genco CA, Brown DL, Cutler CW. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J Immunol. 2012 Sep 15; 189(6):3178-87. PMID: 22891282; PMCID: PMC3459682; DOI: 10.4049/jimmunol.1201053;

Yu C, Genco CA. Fur-mediated global regulatory circuits in pathogenic Neisseria species. J Bacteriol. 2012 Dec; 194(23):6372-81.View Related Profiles.

Genco, Caroline
Yu, Chunxiao

PMID: 22885296; PMCID: PMC3497530; DOI: 10.1128/JB.00262-12;

Madrigal AG, Barth K, Papadopoulos G, Genco CA. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012; 8(6):e1002723.View Related Profiles.

Madrigal, Andres
Genco, Caroline
Papadopoulos, George
Barth, Kenneth

PMID: 22685397; PMCID: PMC3369954; DOI: 10.1371/journal.ppat.1002723;

Yu C, Genco CA. Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae. J Bacteriol. 2012 Apr; 194(7):1730-42.View Related Profiles.

Genco, Caroline
Yu, Chunxiao

PMID: 22287521; PMCID: PMC3302472; DOI: 10.1128/JB.06176-11;

Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). J Vis Exp. 2011; (51).View Related Profiles.

Genco, Caroline
Connor, John

PMID: 21587155; PMCID: PMC3197112; DOI: 10.3791/2694;

Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC, Hamilton JA, Genco CA. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 2011 Mar; 215(1):52-9.View Related Profiles.

Phinikaridou, Alkystis
Madrigal, Andres
Genco, Caroline
Hayashi, Chie
Gibson, Frank
Hamilton, James
Hua, Ning

PMID: 21251656; PMCID: PMC3057233; DOI: 10.1016/j.atherosclerosis.2010.12.009;

Hayashi C, Gudino CV, Gibson FC, Genco CA. Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010 Oct; 25(5):305-16.View Related Profiles.

Genco, Caroline
Hayashi, Chie
Gibson, Frank

PMID: 20883220; PMCID: PMC2951292; DOI: 10.1111/j.2041-1014.2010.00582.x;

Hayashi C, Madrigal AG, Liu X, Ukai T, Goswami S, Gudino CV, Gibson FC, Genco CA. Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun. 2010; 2(4):334-43.View Related Profiles.

Madrigal, Andres
Genco, Caroline
Hayashi, Chie
Gibson, Frank

PMID: 20505314; PMCID: PMC2895755; DOI: 10.1159/000314686;

Mellin JR, McClure R, Lopez D, Green O, Reinhard B, Genco C. Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis. Microbiology. 2010 Aug; 156(Pt 8):2316-26.View Related Profiles.

Reinhard, Bjorn
Genco, Caroline
Lopez, Delia

PMID: 20430815; PMCID: PMC3068672; DOI: 10.1099/mic.0.039040-0;

Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun. 2009 Sep; 77(9):3602-10.View Related Profiles.

Genco, Caroline
Wetzler, Lee
Massari, Paola

PMID: 19546192; PMCID: PMC2738021; DOI: 10.1128/IAI.01366-08;

Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54.View Related Profiles.

Genco, Caroline
Hayashi, Chie
Freedman, Jane
Tanriverdi, Kahraman
Beaulieu, Lea
Vitseva, Olga

PMID: 19106411; PMCID: PMC2732983; DOI: 10.1161/CIRCRESAHA.108.185785;

Agarwal S, Sebastian S, Szmigielski B, Rice PA, Genco CA. Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J Bacteriol. 2008 May; 190(9):3129-39. PMID: 18310343; PMCID: PMC2347397; DOI: 10.1128/JB.01830-07;

Davey M, Liu X, Ukai T, Jain V, Gudino C, Gibson FC, Golenbock D, Visintin A, Genco CA. Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs. J Immunol. 2008 Feb 15; 180(4):2187-95.View Related Profiles.