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BU Research
NIH RePORTER Research

Multidisciplinary Training in Cardiovascular Research
07/01/1976 - 06/30/2016 (PI of Sub-Project / SP)
PI: Victoria Bolotina, PhD
NIH/National Heart, Lung, and Blood Institute
3T32HL007224-40S1

Title

Yr	Title	Project-Sub Proj
2024	Vanderbilt University Cardiovascular Medicine Training Program	1T32HL170965-01
2024	ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing	5U24OD035523-02
2024	Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis	5R01HL164526-02
2023	ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing	1U24OD035523-01
2023	Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis	3R01HL164526-01A1S1
2023	Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis	1R01HL164526-01A1
2022	Long Non-coding RNA as Mediators of Metabolic Disease	5R01HL145721-05
2021	The Effect of Behavioral Weight Loss on Circulating Extracellular RNA	7R21HL147831-03
2021	The Effect of Behavioral Weight Loss on Circulating Extracellular RNA	5R21HL147831-02
2021	Long Non-coding RNA as Mediators of Metabolic Disease	5R01HL145721-03

Showing 10 of 65 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Freedman JE. Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease. Circ Res. 2014 Apr 25; 114(9):1372-3. PMID: 24763461; PMCID: PMC4029052; DOI: 10.1161/CIRCRESAHA.114.303976;

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1ß regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64.View Related Profiles.

Genco, Caroline
Kramer, Carolyn
Weinberg, Ellen
Benjamin, Emelia
Freedman, Jane
Beaulieu, Lea
Larson, Martin
Koupenova-Zamor, Milka

PMID: 24458711; PMCID: PMC4070375; DOI: 10.1161/ATVBAHA.113.302700;

McManus DD, Lin H, Tanriverdi K, Quercio M, Yin X, Larson MG, Ellinor PT, Levy D, Freedman JE, Benjamin EJ. Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study. Heart Rhythm. 2014 Apr; 11(4):663-9.View Related Profiles.

Benjamin, Emelia
Lin, Honghuang
Freedman, Jane
Larson, Martin

PMID: 24444445; PMCID: PMC4219255; DOI: 10.1016/j.hrthm.2014.01.018;

Clancy L, Freedman JE. New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. J Thromb Thrombolysis. 2014 Jan; 37(1):12-6. PMID: 24163053; DOI: 10.1007/s11239-013-1001-1;

Yao C, Joehanes R, Johnson AD, Huan T, Esko T, Ying S, Freedman JE, Murabito J, Lunetta KL, Metspalu A, Munson PJ, Levy D. Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet. 2014 Apr 1; 23(7):1947-56.View Related Profiles.

Freedman, Jane
Murabito, Joanne
Lunetta, Kathryn

PMID: 24242183; PMCID: PMC3943525; DOI: 10.1093/hmg/ddt582;

Li C, Chen P, Vadasz B, Ma L, Zhou H, Lang S, Freedman J, Ni H. Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia. Thromb Haemost. 2013 Dec; 110(6):1250-8. PMID: 24067944; DOI: 10.1160/TH13-04-0354;

Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet. 2014 Feb 1; 23(3):782-95.View Related Profiles.

O'Donnell, Christopher
Freedman, Jane
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 24057673; PMCID: PMC3900869; DOI: 10.1093/hmg/ddt461;

McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73.View Related Profiles.

Benjamin, Emelia
Freedman, Jane
Beaulieu, Lea
Larson, Martin

PMID: 23968978; PMCID: PMC4289138; DOI: 10.1161/ATVBAHA.112.301112;

Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug 1; 123(8):3378-82. PMID: 23867623; PMCID: PMC3726159; DOI: 10.1172/JCI67383;

Freedman JE, Tanriverdi K. Defining miRNA targets: balancing simplicity with complexity. Circulation. 2013 May 28; 127(21):2075-7. PMID: 23625958; PMCID: PMC3752376; DOI: 10.1161/CIRCULATIONAHA.113.003058;

Showing 10 of 142 results. Show More

Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ. Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1418-26.View Related Profiles.

O'Donnell, Christopher
Freedman, Jane

PMID: 23539218; PMCID: PMC3684247; DOI: 10.1161/ATVBAHA.112.301169;

Johnson AD, Hwang SJ, Voorman A, Morrison A, Peloso GM, Hsu YH, Thanassoulis G, Newton-Cheh C, Rogers IS, Hoffmann U, Freedman JE, Fox CS, Psaty BM, Boerwinkle E, Cupples LA, O'Donnell CJ. Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation. 2013 Feb 19; 127(7):799-810.View Related Profiles.

O'Donnell, Christopher
Peloso, Gina
Freedman, Jane
Cupples, L
Hwang, Shih-Jen

PMID: 23315372; PMCID: PMC3686634; DOI: 10.1161/CIRCULATIONAHA.112.111559;

Freedman JE, Ercan B, Morin KM, Liu CT, Tamer L, Ayaz L, Kanadasi M, Cicek D, Seyhan AI, Akilli RE, Camci C, Cengiz B, Oztuzcu S, Tanriverdi K. The distribution of circulating microRNA and their relation to coronary disease. F1000Res. 2012; 1.View Related Profiles.

Ercan, Bahadir
Liu, Ching-Ti
Freedman, Jane

PMID: 24358814; PMCID: PMC3752638; DOI: 10.12688/f1000research.1-50.v1;

Risitano A, Beaulieu LM, Vitseva O, Freedman JE. Platelets and platelet-like particles mediate intercellular RNA transfer. Blood. 2012 Jun 28; 119(26):6288-95.View Related Profiles.

Risitano, Antonina
Freedman, Jane
Beaulieu, Lea
Vitseva, Olga

PMID: 22596260; PMCID: PMC3383198; DOI: 10.1182/blood-2011-12-396440;

Freedman JE. Appreciating and mitigating bleeding risk. Circulation. 2012 Apr 10; 125(14):e548-50. PMID: 22492953; DOI: 10.1161/CIRCULATIONAHA.112.104224;

Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ Cardiovasc Interv. 2012 Apr; 5(2):296-304. PMID: 22511738; PMCID: PMC3605036; DOI: 10.1161/CIRCINTERVENTIONS.111.965426;

Freedman JE. A platelet transcriptome revolution. Blood. 2011 Oct 6; 118(14):3760-1. PMID: 21980048; DOI: 10.1182/blood-2011-05-356600;

Beaulieu LM, Freedman JE. Inflammation & the platelet histone trap. Blood. 2011 Aug 18; 118(7):1714-5.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 21852442; DOI: 10.1182/blood-2011-06-362764;

Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE, Joseph L, Hess DT, Apovian CM, Vita JA, Gokce N. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol. 2011 Jul 12; 58(3):232-7.View Related Profiles.

Apovian, Caroline
Hess, Donald
Freedman, Jane
Vita, Joseph
Joseph, Lija
Mott, Melanie
Farb, Melissa
Gokce, Noyan

PMID: 21737012; PMCID: PMC3132399; DOI: 10.1016/j.jacc.2011.01.051;

Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011 Jun 2; 117(22):5963-74.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 21454454; PMCID: PMC3112041; DOI: 10.1182/blood-2010-09-304949;

Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Stone JH, Freedman JE, Merkel PA. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011 Jun; 38(6):1048-54.View Related Profiles.

Freedman, Jane
LaValley, Michael
Merkel, Peter

PMID: 21411717; PMCID: PMC3653633; DOI: 10.3899/jrheum.100735;

Gersh BJ, Freedman JE, Granger CB. Antiplatelet and anticoagulant therapy for stroke prevention in patients with non-valvular atrial fibrillation: evidence based strategies and new developments. Rev Esp Cardiol (Engl Ed). 2011 Apr; 64(4):260-8. PMID: 24775187; DOI: 10.1016/j.rec.2011.01.001;

Gersh BJ, Freedman JE, Granger CB. [Antiplatelet and anticoagulant therapy for stroke prevention in patients with non-valvular atrial fibrillation: evidence based strategies and new developments]. Rev Esp Cardiol. 2011 Apr; 64(4):260-8. PMID: 21411211; DOI: 10.1016/j.recesp.2011.01.001;

Freedman JE, Vitseva O, Tanriverdi K. The role of the blood transcriptome in innate inflammation and stroke. Ann N Y Acad Sci. 2010 Oct; 1207:41-5.View Related Profiles.

Freedman, Jane
Vitseva, Olga

PMID: 20955424; PMCID: PMC2958681; DOI: 10.1111/j.1749-6632.2010.05731.x;

Freedman JE, Iafrati HF. Use of genetics and transcriptomics in the diagnosis and treatment of coronary artery disease. Rev Esp Cardiol. 2010 Oct; 63(10):1123-6. PMID: 20875351

Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation. 2010 Jul 13; 122(2):119-29.View Related Profiles.

O'Donnell, Christopher
Benjamin, Emelia
Freedman, Jane
Larson, Martin
Ramachandran, Vasan

PMID: 20606121; PMCID: PMC2910759; DOI: 10.1161/CIRCULATIONAHA.109.928192;

Chakrabarti S, Freedman JE. Review: Nutriceuticals as antithrombotic agents. Cardiovasc Ther. 2010 Aug; 28(4):227-35. PMID: 20553290; DOI: 10.1111/j.1755-5922.2010.00161.x;

Chakrabarti S, Rizvi M, Morin K, Garg R, Freedman JE. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):130-7. PMID: 20546942; DOI: 10.1016/j.vph.2010.05.003;

Beaulieu LM, Freedman JE. p38: signaling improved platelet storage? Blood. 2010 Mar 4; 115(9):1665-6.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 20203272; DOI: 10.1182/blood-2009-12-259259;

Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27.View Related Profiles.

Freedman, Jane
Ravid, Katya
Koupenova-Zamor, Milka
Toselli, Paul

PMID: 20102488; DOI: 10.1111/j.1538-7836.2010.03769.x;

Freedman JE, Iafrati HF. Use of genetics and transcriptomics in the diagnosis and treatment of coronary artery disease. Rev Esp Cardiol (Engl Ed). 2010; 63(10):1123-6. PMID: 24774332; DOI: 10.1016/S1885-5857(10)70225-5;

Beaulieu LM, Freedman JE. The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes. Thromb Res. 2010 Mar; 125(3):205-9.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 19945154; PMCID: PMC2830335; DOI: 10.1016/j.thromres.2009.11.004;

Chakrabarti S, Beaulieu LM, Reyelt LA, Iafrati MD, Freedman JE. M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice. J Thromb Thrombolysis. 2009 Nov; 28(4):394-400.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 19399370; PMCID: PMC2826881; DOI: 10.1007/s11239-009-0340-4;

Freedman JE, Gersh BJ. New therapies for stroke prevention in atrial fibrillation: the long road to enhanced efficacy. Circulation. 2009 Sep 22; 120(12):1024-6. PMID: 19738132; DOI: 10.1161/CIRCULATIONAHA.109.893362;

Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110.View Related Profiles.

Costello, Catherine
Freedman, Jane
Beaulieu, Lea
McComb, Mark
Vitseva, Olga

PMID: 19572074; PMCID: PMC2774228; DOI: 10.1160/TH08-08-0513;

Beaulieu LM, Freedman JE. NFkappaB regulation of platelet function: no nucleus, no genes, no problem? J Thromb Haemost. 2009 Aug; 7(8):1329-32.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 19500240; PMCID: PMC2826204; DOI: 10.1111/j.1538-7836.2009.03505.x;

Faxon DP, Freedman JE. Facts and controversies of aspirin and clopidogrel therapy. Am Heart J. 2009 Mar; 157(3):412-22. PMID: 19249409; DOI: 10.1016/j.ahj.2008.11.019;

Chakrabarti S, Rizvi M, Pathak D, Kirber MT, Freedman JE. Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. Immunol Lett. 2009 Feb 21; 122(2):170-84.View Related Profiles.

Freedman, Jane
Kirber, Michael

PMID: 19187784; DOI: 10.1016/j.imlet.2008.12.010;

Freedman JE, Hylek EM. Clopidogrel, genetics, and drug responsiveness. N Engl J Med. 2009 Jan 22; 360(4):411-3.View Related Profiles.

Hylek, Elaine
Freedman, Jane

PMID: 19164193; DOI: 10.1056/NEJMe0810513;

Lin E, Freedman JE, Beaulieu LM. Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases. Cardiovasc Ther. 2009; 27(2):117-23.View Related Profiles.

Freedman, Jane
Beaulieu, Lea

PMID: 19426249; PMCID: PMC2832843; DOI: 10.1111/j.1755-5922.2009.00077.x;

Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54.View Related Profiles.

Genco, Caroline
Hayashi, Chie
Freedman, Jane
Tanriverdi, Kahraman
Beaulieu, Lea
Vitseva, Olga

PMID: 19106411; PMCID: PMC2732983; DOI: 10.1161/CIRCRESAHA.108.185785;

Rizvi M, Pathak D, Freedman JE, Chakrabarti S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med. 2008 Dec; 14(12):530-8. PMID: 18977174; DOI: 10.1016/j.molmed.2008.09.006;

Keaney JF, Lipinska I, Larson MG, Dupuis J, Freedman JE, Hamburg NM, Massaro JM, Rong J, Sutherland P, Vita JA, Vasan RS, Benjamin EJ. Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J. 2008 Nov; 156(5):1003-1009.e1.View Related Profiles.

Benjamin, Emelia
Freedman, Jane
Rong, Jian
Dupuis, Josee
Vita, Joseph
Massaro, Joseph
Larson, Martin
Hamburg, Naomi
Ramachandran, Vasan

PMID: 19061720; PMCID: PMC2613323; DOI: 10.1016/j.ahj.2008.06.041;

Tanriverdi K, Freedman JE. Blood and cardiovascular disease: the promise and limitations of gene expression analysis. Circ Cardiovasc Genet. 2008 Oct; 1(1):7-9.View Related Profiles.

Freedman, Jane
Tanriverdi, Kahraman

PMID: 20031537; DOI: 10.1161/CIRCGENETICS.108.814186;

Kleiman NS, Freedman JE, Tracy PB, Furie BC, Bray PF, Rao SV, Phillips DR, Storey RF, Rusconi CP, French PA, Steinhubl SR, Becker RC. Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development. Platelets. 2008 Jun; 19(4):239-51. PMID: 18569859; DOI: 10.1080/09537100801947442;

Ector H, Lancellotti P, Roberts WC, Wenger NK, Moss AJ, Smith ER, Borer JS, Eagle KA, Freedman J, Krum H, Lang C, Remme WJ, Piper HM, White CJ, Loscalzo J, Marbán E, Sobel BE, Roberts R, Rahimtoola SH, Camm AJ, Van de Werf F, Swedberg K, Timmis AD, Stone KS, Zipes DP, Iosselani DG, Taylor AJ, Rosen MR, Grines CL, DeMaria AN, Narula J, King SB, Wagner GS, Saksena S, Pearlman AS, Bodnar E, Emery RW, Cohn LH, van der Wall EE, Abdulla RI, Lesch M, Alfonso F, Ekroth R. A statement on ethics from the HEART Group. JACC Cardiovasc Imaging. 2008 May; 1(3):410-2. PMID: 19356460; DOI: 10.1016/j.jcmg.2008.02.001;

Blair P, Freedman JE. Aspirin resistance in atherosclerosis. Curr Atheroscler Rep. 2008 Apr; 10(2):149-57. PMID: 18417070

Vanichakarn P, Blair P, Wu C, Freedman JE, Chakrabarti S. Neutrophil CD40 enhances platelet-mediated inflammation. Thromb Res. 2008; 122(3):346-58. PMID: 18289643; DOI: 10.1016/j.thromres.2007.12.019;

Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring). 2008 May; 16(5):932-7.View Related Profiles.

Apovian, Caroline
Freedman, Jane
Tanriverdi, Kahraman
McDonnell, Marie
Gokce, Noyan
Vitseva, Olga

PMID: 18292749; PMCID: PMC3264059; DOI: 10.1038/oby.2008.25;

Chakrabarti S, Freedman JE. Dipyridamole, cerebrovascular disease, and the vasculature. Vascul Pharmacol. 2008 Apr-Jun; 48(4-6):143-9. PMID: 18342579; DOI: 10.1016/j.vph.2007.12.004;

Freedman JE. Oxidative stress and platelets. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s11-6. PMID: 18174453; DOI: 10.1161/ATVBAHA.107.159178;

Freedman JE. Promoting ethical conduct in the publication of research. Cardiovasc Ther. 2008; 26(2):89-90. PMID: 18485131; DOI: 10.1111/j.1527-3466.2008.00045.x;

Freedman JE. Transcriptomics: new targets for diagnosing and treating cardiovascular disease. Cardiovasc Ther. 2008; 26(3):179-81. PMID: 18786087; DOI: 10.1111/j.1755-5922.2008.00055.x;

Chakrabarti S, Blair P, Wu C, Freedman JE. Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects. J Cardiovasc Pharmacol. 2007 Oct; 50(4):449-57. PMID: 18049314

Gimbel R, Ziac V, Tackley L, Lehrman S, Freedman J. A continuum-based outcome approach to measuring performance in HIV/AIDS case management. AIDS Care. 2007 Jul; 19(6):767-74. PMID: 17573597

Freedman JE. Heritability, platelet function, and aspirin: a link established but cause unknown. Circulation. 2007 May 15; 115(19):2468-70. PMID: 17502587

Chakrabarti S, Blair P, Freedman JE. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007 Jun 22; 282(25):18307-17. PMID: 17459878

Leung R, Gwozdz AM, Wang H, Bang KW, Packham MA, Freedman J, Rand ML. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost. 2007 Mar; 5(3):560-70. PMID: 17155950

Schmugge M, Bang KW, Blanchette VS, Albisetti M, Connolly BL, Freedman J, Rand ML. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol. 2007; 117(3):145-8. PMID: 17159336

Tziros C, Freedman JE. The many antithrombotic actions of nitric oxide. Curr Drug Targets. 2006 Oct; 7(10):1243-51. PMID: 17073585

Leytin V, Allen DJ, Mykhaylov S, Lyubimov E, Freedman J. Thrombin-triggered platelet apoptosis. J Thromb Haemost. 2006 Dec; 4(12):2656-63. PMID: 16961585

Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006 Oct; 4(10):2230-7. PMID: 16824188

Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost. 2006 Jul; 4(7):1621-3. PMID: 16839364

Freedman JE. The aspirin resistance controversy: clinical entity or platelet heterogeneity? Circulation. 2006 Jun 27; 113(25):2865-7. PMID: 16801473

Freedman JE. Resistance training: does it alter lytic potential? J Cardiopulm Rehabil. 2006 Mar-Apr; 26(2):84-5. PMID: 16569975

Freedman JE. Molecular regulation of platelet-dependent thrombosis. Circulation. 2005 Oct 25; 112(17):2725-34. PMID: 16246969

Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005 Oct; 46(4):445-51.View Related Profiles.

Freedman, Jane
Vitseva, Olga

PMID: 16160595

Mason PJ, Jacobs AK, Freedman JE. Aspirin resistance and atherothrombotic disease. J Am Coll Cardiol. 2005 Sep 20; 46(6):986-93.View Related Profiles.

Jacobs, Alice
Freedman, Jane

PMID: 16168280

Mason PJ, Chakrabarti S, Albers AA, Rex S, Vitseva O, Varghese S, Freedman JE. Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease. Am J Cardiol. 2005 Nov 15; 96(10):1365-9.View Related Profiles.

Freedman, Jane
Vitseva, Olga

PMID: 16275179

Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE. CD40 ligand influences platelet release of reactive oxygen intermediates. Arterioscler Thromb Vasc Biol. 2005 Nov; 25(11):2428-34.View Related Profiles.

Freedman, Jane
Tanriverdi, Kahraman
Vitseva, Olga

PMID: 16141403

Chakrabarti S, Vitseva O, Iyu D, Varghese S, Freedman JE. The effect of dipyridamole on vascular cell-derived reactive oxygen species. J Pharmacol Exp Ther. 2005 Nov; 315(2):494-500.View Related Profiles.

Freedman, Jane
Vitseva, Olga

PMID: 16046616

Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, Freedman J, Ni H. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost. 2005 May; 3(5):875-83. PMID: 15733060

Iafrati MD, Vitseva O, Tanriverdi K, Blair P, Rex S, Chakrabarti S, Varghese S, Freedman JE. Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1627-32.View Related Profiles.

Freedman, Jane
Tanriverdi, Kahraman
Vitseva, Olga

PMID: 15563534

Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JE. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):e179-80.View Related Profiles.

Freedman, Jane
Vita, Joseph
Vitseva, Olga

PMID: 15528483

Vitseva O, Flockhart DA, Jin Y, Varghese S, Freedman JE. The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates. J Pharmacol Exp Ther. 2005 Mar; 312(3):1144-50.View Related Profiles.

Freedman, Jane
Vitseva, Olga

PMID: 15509721

Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting. Circulation. 2004 Jun 1; 109(21):2672-9. PMID: 15173050

Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 1: fundamentals of study design. Circulation. 2004 Jun 1; 109(21):e302-4. PMID: 15173052

Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 2: statistical concepts in study design and analysis. Circulation. 2004 Jun 1; 109(21):e305-7. PMID: 15173053

Rand ML, Wang H, Bang KW, Poon KS, Packham MA, Freedman J. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost. 2004 Apr; 2(4):651-9. PMID: 15102022

Mason PJ, Freedman JE, Jacobs AK. Aspirin resistance: current concepts. Rev Cardiovasc Med. 2004; 5(3):156-63.View Related Profiles.

Jacobs, Alice
Freedman, Jane

PMID: 15346099

Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther. 2004 Jan; 75(1):60-9. PMID: 14749692

Chakrabarti S, Clutton P, Varghese S, Cox D, Mascelli MA, Freedman JE. Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release. Thromb Res. 2004; 113(3-4):225-33. PMID: 15140587

Clutton P, Miermont A, Freedman JE. Regulation of endogenous reactive oxygen species in platelets can reverse aggregation. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):187-92. PMID: 14604832

Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost. 2003 Jun; 1(6):1183-8. PMID: 12871317

Freedman JE. High-fat diets and cardiovascular disease: are nutritional supplements useful? J Am Coll Cardiol. 2003 May 21; 41(10):1750-2. PMID: 12767659

Freedman JE. CD40-CD40L and platelet function: beyond hemostasis. Circ Res. 2003 May 16; 92(9):944-6. PMID: 12750303

Freedman JE. CD40 ligand--assessing risk instead of damage? N Engl J Med. 2003 Mar 20; 348(12):1163-5. PMID: 12646674

Song S, Mody M, Freedman J, Ellis J, Lazarus AH. von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function. J Thromb Haemost. 2003 Feb; 1(2):337-46. PMID: 12871509

Freedman JE, Becker RC, Adams JE, Borzak S, Jesse RL, Newby LK, O'Gara P, Pezzullo JC, Kerber R, Coleman B, Broderick J, Yasuda S, Cannon C. Medication errors in acute cardiac care: An American Heart Association scientific statement from the Council on Clinical Cardiology Subcommittee on Acute Cardiac Care, Council on Cardiopulmonary and Critical Care, Council on Cardiovascular Nursing, and Council on Stroke. Circulation. 2002 Nov 12; 106(20):2623-9. PMID: 12427661

Freedman JE. Nitrated lipids: defining their bioactivity. Circ Res. 2002 Sep 6; 91(5):371-2. PMID: 12215483

Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, Freedman JE. Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics. 2002 Jul; 12(5):407-13. PMID: 12142730

Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002 May 7; 105(18):2130-2. PMID: 11994242

Freedman J, Mody M, Lazarus AH, Dewar L, Song S, Blanchette VS, Garvey MB, Ofosu FA. Platelet activation and hypercoagulability following treatment with porcine factor VIII (HYATE:C). Am J Hematol. 2002 Mar; 69(3):192-9. PMID: 11891806

Abernethy DR, Pezzullo J, Mascelli MA, Frederick B, Kleiman NS, Freedman J. Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects. Clin Pharmacol Ther. 2002 Mar; 71(3):186-95. PMID: 11907493

Rand ML, Wang H, Mody M, Chu I, Treutiger I, Nguyen A, Packham MA, Freedman J. Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin. Cytometry. 2002 Feb 1; 47(2):111-7. PMID: 11813201

Freedman J, Mascelli MA, Pezzullo JC, Barnathan ES, Frederick B, Jordan RE, Abernethy DR. Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects. Am Heart J. 2002 Jan; 143(1):87-94. PMID: 11773917

Freedman JE. Antioxidant versus lipid-altering therapy--some answers, more questions. N Engl J Med. 2001 Nov 29; 345(22):1636-7. PMID: 11757512

Clutton P, Folts JD, Freedman JE. Pharmacological control of platelet function. Pharmacol Res. 2001 Oct; 44(4):255-64. PMID: 11592859

Freedman JE, Parker C, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001 Jun 12; 103(23):2792-8. PMID: 11401934

Parker C, Vita JA, Freedman JE. Soluble adhesion molecules and unstable coronary artery disease. Atherosclerosis. 2001 Jun; 156(2):417-24.View Related Profiles.

Freedman, Jane
Vita, Joseph

PMID: 11395039

Freedman JE. Thrombin, thrombomodulin, and extracellular signal-regulated kinases regulating cellular proliferation. Circ Res. 2001 Apr 13; 88(7):651-3. PMID: 11304485

Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide. J Cardiovasc Pharmacol Ther. 2001 Apr; 6(2):163-73.View Related Profiles.

Costello, Catherine
Freedman, Jane

PMID: 11509923

Freedman JE, Keaney JF. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J Nutr. 2001 Feb; 131(2):374S-7S. PMID: 11160564

Freedman JE, Li L, Sauter R, Keaney JF JR. alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J. 2000 Dec; 14(15):2377-9. PMID: 11024007

Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Quantification of platelet activation status by analyzing P-selectin expression. Biochem Biophys Res Commun. 2000 Jul 5; 273(2):565-70. PMID: 10873646

Song S, Freedman J, Mody M, Lazarus AH. Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets. Br J Haematol. 2000 Jun; 109(4):851-6. PMID: 10929041

Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations. Biochem Biophys Res Commun. 2000 Mar 5; 269(1):85-90. PMID: 10694482

Bang KW, Speck ER, Blanchette VS, Freedman J, Semple JW. Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens. Blood. 2000 Mar 1; 95(5):1735-42. PMID: 10688832

Lazarus AH, Ellis J, Semple JW, Mody M, Crow AR, Freedman J. Comparison of platelet immunity in patients with SLE and with ITP. Transfus Sci. 2000 Feb-Apr; 22(1-2):19-27. PMID: 10771375

Loscalzo J, Freedman J, Inbal A, Keaney JF, Michelson AD, Vita JA. Nitric oxide insufficiency and arterial thrombosis. Trans Am Clin Climatol Assoc. 2000; 111:158-63.View Related Profiles.

Freedman, Jane
Vita, Joseph

PMID: 10881340; PMCID: PMC2194373

Song S, Freedman J, Mody M, Lazarus AH. p38 MAPK is activated but not necessary in porcine von Willebrand factor-dependent platelet activation. Br J Haematol. 1999 Dec; 107(3):532-8. PMID: 10583254

Kenet G, Freedman J, Shenkman B, Regina E, Brok-Simoni F, Holzman F, Vavva F, Brand N, Michelson A, Trolliet M, Loscalzo J, Inbal A. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):2017-23. PMID: 10446087

Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res. 1999 Jun 25; 84(12):1416-21. PMID: 10381894

Mody M, Lazarus AH, Semple JW, Freedman J. Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant. Transfus Med. 1999 Jun; 9(2):147-54. PMID: 10354385

Keaney JF, Simon DI, Freedman JE. Vitamin E and vascular homeostasis: implications for atherosclerosis. FASEB J. 1999 Jun; 13(9):965-75. PMID: 10336880

Lieberthal W, Fuhro R, Freedman JE, Toolan G, Loscalzo J, Valeri CR. O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J Pharmacol Exp Ther. 1999 Mar; 288(3):1278-87. PMID: 10027869

Semple JW, Speck ER, Cosgrave D, Lazarus AH, Blanchette VS, Freedman J. Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity. Blood. 1999 Jan 15; 93(2):713-20. PMID: 9885234

Freedman JE, Keaney JF. Nitric oxide and superoxide detection in human platelets. Methods Enzymol. 1999; 301:61-70. PMID: 9919554

Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 1998 Oct 13; 98(15):1481-6.View Related Profiles.

Freedman, Jane
Vita, Joseph

PMID: 9769300

Schimmer A, Mody M, Sager M, Garvey MB, Hogarth M, Freedman J. Platelet cold agglutinins: a flow cytometric analysis. Transfus Sci. 1998 Sep; 19(3):217-24. PMID: 10351132

Vita JA, Keaney JF, Raby KE, Morrow JD, Freedman JE, Lynch S, Koulouris SN, Hankin BR, Frei B. Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome. J Am Coll Cardiol. 1998 Apr; 31(5):980-6.View Related Profiles.

Freedman, Jane
Vita, Joseph
Raby, Khether

PMID: 9561997

Chang H, Mody M, Lazarus AH, Ofosu F, Garvey MB, Blanchette V, Teitel J, Freedman J. Platelet activation induced by porcine factor VIII (Hyate:C). Am J Hematol. 1998 Mar; 57(3):200-5. PMID: 9495369

Liu Z, Rudd MA, Freedman JE, Loscalzo J. S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther. 1998 Feb; 284(2):526-34. PMID: 9454793

Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997 Jul 15; 100(2):350-6. PMID: 9218511; PMCID: PMC508197

Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 Jul 4; 272(27):17012-7. PMID: 9202015

Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54. PMID: 9217172

Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21. PMID: 9133522

Freedman JE, Loscalzo J. Endothelial dysfunction and atherothrombotic occlusive disease. Drugs. 1997; 54 Suppl 3:41-9; discussion 49-50. PMID: 9360851

Kühne T, Ryan G, Blanchette V, Semple JW, Hornstein A, Mody M, Chang W, McWhirter L, Freedman J. Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants. Pediatr Res. 1996 Dec; 40(6):876-80. PMID: 8947966

Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40. PMID: 8921785

Bang A, Speck ER, Blanchette VS, Freedman J, Semple JW. Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase. Blood. 1996 Oct 15; 88(8):2959-66. PMID: 8874192

Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J Clin Invest. 1996 Feb 15; 97(4):979-87. PMID: 8613552; PMCID: PMC507144

Semple JW, Speck ER, Milev YP, Blanchette V, Freedman J. Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation. Blood. 1995 Jul 15; 86(2):805-12. PMID: 7606011

Freedman JE, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest. 1995 Jul; 96(1):394-400. PMID: 7615810; PMCID: PMC185212

Loscalzo J, Pasche B, Ouimet H, Freedman JE. Platelets and plasminogen activation. Thromb Haemost. 1995 Jul; 74(1):291-3. PMID: 8578474

Mazer CD, Hornstein A, Freedman J. Platelet activation in warm and cold heart surgery. Ann Thorac Surg. 1995 Jun; 59(6):1481-6. PMID: 7771828

Freedman JE, Fabian A, Loscalzo J. Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. Am J Physiol. 1995 Feb; 268(2 Pt 1):C520-6. PMID: 7532361

Liu L, Freedman J, Hornstein A, Fenton JW, Ofosu FA. Thrombin binding to platelets and their activation in plasma. Br J Haematol. 1994 Nov; 88(3):592-600. PMID: 7529534

Ouimet H, Freedman JE, Loscalzo J. Kinetics and mechanism of platelet-surface plasminogen activation by tissue-type plasminogen activator. Biochemistry. 1994 Mar 15; 33(10):2970-6. PMID: 8130211

Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991 Nov 15; 78(10):2619-25. PMID: 1840468

Loscalzo J, Freedman J, Rudd MA, Barsky-Vasserman I, Vaughan DE. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis. 1987 Sep-Oct; 7(5):450-5. PMID: 3675304

Loscalzo J, Freedman J. Purification and characterization of human platelet glutathione-S-transferase. Blood. 1986 Jun; 67(6):1595-9. PMID: 3085745

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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