Victoria Bolotina, PhD
Boston University Chobanian & Avedisian School of Medicine
Vascular Biology

PhD, Moscow State University
BSc, Moscow State University

Dr. Bolotina, Ph.D., is a leading expert in Calcium signaling and ion channels (with over 2000 citations of her work), who is well funded by NIH. The focus of her research is on the molecular mechanisms of Calcium entry and its role in physiological and pathological function.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Boston University
Whitaker Cardiovascular Institute

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Multidisciplinary Training in Cardiovascular Research
07/01/1976 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute

Structure-Function of PLA2g6
07/01/2019 - 06/30/2021 (PI)
National Institutes of Health/DHHS/NIH

The role of Bcl11b in dementia associated with Parkinson’s disease
09/01/2019 - 01/31/2021 (PI)
Trustees of Boston University, BUMC National Heart, Lung

PARK14/Calcium signaling as a novel biomarker for Parkinson disease
08/01/2019 - 07/31/2020 (PI)
National Institutes of Health/DHHS/NIH

Servier Contract Research Program
10/01/2014 - 06/30/2018 (PI)

Park14-dependent SOCE and sporadic PD
01/01/2017 - 12/31/2017 (PI)
Michael J. Fox Foundation

PARK-14-dependent SOCE and sporadic PD
01/01/2015 - 06/30/2016 (PI)
Michael J. Fox Foundation

Ion channels and calcium regulation in vascular SMC function
05/01/2010 - 04/30/2015 (PI)
5R01 HL054150-16

PARK 14: Validation of a mouse model of age-dependent PD
05/15/2013 - 05/14/2014 (PI)
Michael J. Fox Foundation

Store-operated Ca entry and iPLA2 in vascular SMC
01/01/2009 - 12/31/2013 (PI)
5R01 HL071793-08

Calcium Influx Factor
08/01/2009 - 07/31/2011 (PI)
5R21 HL097569-02

Showing 10 of 14 results. Show All Results


Yr Title Project-Sub Proj Pubs
2019 Structure-Function of PLA2g6 5R21NS108724-02 1
2019 The role of Bcl11b in dementia associated with Parkinsons disease 3R01HL136311-02S1 2
2018 Structure-Function of PLA2g6 1R21NS108724-01 1
2018 PARK14/Calcium signaling as a novel biomarker for Parkinson disease 5R21NS103142-02
2018 Multidisciplinary Training in Cardiovascular Research 5T32HL007224-43 195
2017 PARK14/Calcium signaling as a novel biomarker for Parkinson disease 1R21NS103142-01
2017 Multidisciplinary Training in Cardiovascular Research 3T32HL007224-41A1S1 195
2017 Multidisciplinary Training in Cardiovascular Research 5T32HL007224-42 195
2017 Multidisciplinary Training in Cardiovascular Research 3T32HL007224-40S1 195
2016 Multidisciplinary Training in Cardiovascular Research 2T32HL007224-41A1 195
Showing 10 of 43 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;
  2. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332.View Related Profiles. PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;
  3. Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16.View Related Profiles. PMID: 24920669; PMCID: PMC4106311; DOI: 10.1074/jbc.M114.554451;
  4. Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34.View Related Profiles. PMID: 23089226; PMCID: PMC3568680; DOI: 10.1016/j.freeradbiomed.2012.10.546;
  5. Schäfer C, Rymarczyk G, Ding L, Kirber MT, Bolotina VM. Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration. J Biol Chem. 2012 Nov 23; 287(48):40745-57.View Related Profiles. PMID: 23043102; PMCID: PMC3504787; DOI: 10.1074/jbc.M112.407155;
  6. Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108.View Related Profiles. PMID: 22472004; PMCID: PMC3423867; DOI: 10.1089/ars.2011.4022;
  7. Gwozdz T, Dutko-Gwozdz J, Schafer C, Bolotina VM. Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators. J Biol Chem. 2012 Jun 29; 287(27):22865-72. PMID: 22549787; PMCID: PMC3391152; DOI: 10.1074/jbc.M112.356626;
  8. Bolotina VM. Orai1, STIM1, and iPLA2ß determine arterial vasoconstriction. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1066-7. PMID: 22517361; DOI: 10.1161/ATVBAHA.112.245449;
  9. Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Mar 1; 302(5):C748-56. PMID: 22094335; PMCID: PMC3774541; DOI: 10.1152/ajpcell.00312.2011;
  10. Gwozdz T, Dutko-Gwozdz J, Zarayskiy V, Peter K, Bolotina VM. How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1133-40. PMID: 18768920; PMCID: PMC2584986; DOI: 10.1152/ajpcell.00306.2008;
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 22 distinct years, with a maximum of 5 publications in 2012


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

calcium homeostasis
ion channels
Vascular smooth muscle
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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