Keywords
Last Name

Victoria Bolotina, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionVascular Biology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7118
ORCID ORCID Icon0000-0001-5862-181X
Other Positions
TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
I am an expert in Calcium signaling and ion channels in a wide spectrum of cell types.

 Self-Described Keywords
  • calcium homeostasis
  • ion channels
  • signaling
  • Vascular smooth muscle
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.
    View in: PubMed
  2. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332. PMID: 26755131.
    View in: PubMed
  3. Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16. PMID: 24920669.
    View in: PubMed
  4. Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34. PMID: 23089226.
    View in: PubMed
  5. Schäfer C, Rymarczyk G, Ding L, Kirber MT, Bolotina VM. Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration. J Biol Chem. 2012 Nov 23; 287(48):40745-57. PMID: 23043102.
    View in: PubMed
  6. Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108. PMID: 22472004.
    View in: PubMed
  7. Bolotina VM. Orai1, STIM1, and iPLA2ß determine arterial vasoconstriction. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1066-7. PMID: 22517361.
    View in: PubMed
  8. Gwozdz T, Dutko-Gwozdz J, Schafer C, Bolotina VM. Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators. J Biol Chem. 2012 Jun 29; 287(27):22865-72. PMID: 22549787.
    View in: PubMed
  9. Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Mar 1; 302(5):C748-56. PMID: 22094335.
    View in: PubMed
  10. Gwozdz T, Dutko-Gwozdz J, Zarayskiy V, Peter K, Bolotina VM. How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1133-40. PMID: 18768920.
    View in: PubMed
  11. Bolotina VM. Orai, STIM1 and iPLA2beta: a view from a different perspective. J Physiol. 2008 Jul 1; 586(13):3035-42. PMID: 18499724.
    View in: PubMed
  12. Smani T, Patel T, Bolotina VM. Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1499-508. PMID: 18434622.
    View in: PubMed
  13. Csutora P, Peter K, Kilic H, Park KM, Zarayskiy V, Gwozdz T, Bolotina VM. Novel role for STIM1 as a trigger for calcium influx factor production. J Biol Chem. 2008 May 23; 283(21):14524-31. PMID: 18337241.
    View in: PubMed
  14. Park KM, Trucillo M, Serban N, Cohen RA, Bolotina VM. Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1183-7. PMID: 18156193.
    View in: PubMed
  15. Zarayskiy V, Monje F, Peter K, Csutora P, Khodorov BI, Bolotina VM. Store-operated Orai1 and IP3 receptor-operated TRPC1 channel. Channels (Austin). 2007 Jul-Aug; 1(4):246-52. PMID: 18711860.
    View in: PubMed
  16. Csutora P, Zarayskiy V, Peter K, Monje F, Smani T, Zakharov SI, Litvinov D, Bolotina VM. Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway. J Biol Chem. 2006 Nov 17; 281(46):34926-35. PMID: 17003039.
    View in: PubMed
  17. Bolotina VM, Csutora P. CIF and other mysteries of the store-operated Ca2+-entry pathway. Trends Biochem Sci. 2005 Jul; 30(7):378-87. PMID: 15951181.
    View in: PubMed
  18. Zakharov SI, Smani T, Dobrydneva Y, Monje F, Fichandler C, Blackmore PF, Bolotina VM. Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca(2+) influx. Mol Pharmacol. 2004 Sep; 66(3):702-7. PMID: 15322263.
    View in: PubMed
  19. Gwanyanya A, Amuzescu B, Zakharov SI, Macianskiene R, Sipido KR, Bolotina VM, Vereecke J, Mubagwa K. Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation. J Physiol. 2004 Sep 15; 559(Pt 3):761-76. PMID: 15272039.
    View in: PubMed
  20. Bolotina VM. Store-operated channels: diversity and activation mechanisms. Sci STKE. 2004 Jul 27; 2004(243):pe34. PMID: 15280576.
    View in: PubMed
  21. Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, Bolotina VM. A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol. 2004 Feb; 6(2):113-20. PMID: 14730314.
    View in: PubMed
  22. Smani T, Zakharov SI, Leno E, Csutora P, Trepakova ES, Bolotina VM. Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry. J Biol Chem. 2003 Apr 4; 278(14):11909-15. PMID: 12547829.
    View in: PubMed
  23. Zakharov SI, Smani T, Leno E, Macianskiene R, Mubagwa K, Bolotina VM. Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ and inhibition by polycations. Br J Pharmacol. 2003 Jan; 138(1):234-44. PMID: 12522095.
    View in: PubMed
  24. Birk AV, Leno E, Robertson HD, Bolotina VM, Szeto HH. Interaction between ATP and catecholamines in stimulation of platelet aggregation. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H619-25. PMID: 12388296.
    View in: PubMed
  25. Li Y, Adachi T, Bolotina VM, Knowles C, Ault KA, Cohen RA. Abnormal platelet function and calcium handling in Dahl salt-hypertensive rats. Hypertension. 2001 Apr; 37(4):1129-35. PMID: 11304514.
    View in: PubMed
  26. Trepakova ES, Gericke M, Hirakawa Y, Weisbrod RM, Cohen RA, Bolotina VM. Properties of a native cation channel activated by Ca2+ store depletion in vascular smooth muscle cells. J Biol Chem. 2001 Mar 16; 276(11):7782-90. PMID: 11113149.
    View in: PubMed
  27. Trepakova ES, Csutora P, Hunton DL, Marchase RB, Cohen RA, Bolotina VM. Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cells. J Biol Chem. 2000 Aug 25; 275(34):26158-63. PMID: 10851243.
    View in: PubMed
  28. Hirakawa Y, Gericke M, Cohen RA, Bolotina VM. Ca(2+)-dependent Cl(-) channels in mouse and rabbit aortic smooth muscle cells: regulation by intracellular Ca(2+) and NO. Am J Physiol. 1999 Nov; 277(5 Pt 2):H1732-44. PMID: 10564126.
    View in: PubMed
  29. Trepakova ES, Cohen RA, Bolotina VM. Nitric oxide inhibits capacitative cation influx in human platelets by promoting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase-dependent refilling of Ca2+ stores. Circ Res. 1999 Feb 5; 84(2):201-9. PMID: 9933252.
    View in: PubMed
  30. Cohen RA, Weisbrod RM, Gericke M, Yaghoubi M, Bierl C, Bolotina VM. Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx. Circ Res. 1999 Feb 5; 84(2):210-9. PMID: 9933253.
    View in: PubMed
  31. Zakharov SI, Mongayt DA, Cohen RA, Bolotina VM. Monovalent cation and L-type Ca2+ channels participate in calcium paradox-like phenomenon in rabbit aortic smooth muscle cells. J Physiol. 1999 Jan 1; 514 ( Pt 1):71-81. PMID: 9831717.
    View in: PubMed
  32. Weisbrod RM, Griswold MC, Du Y, Bolotina VM, Cohen RA. Reduced responsiveness of hypercholesterolemic rabbit aortic smooth muscle cells to nitric oxide. Arterioscler Thromb Vasc Biol. 1997 Feb; 17(2):394-402. PMID: 9081696.
    View in: PubMed
  33. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature. 1994 Apr 28; 368(6474):850-3. PMID: 7512692.
    View in: PubMed
  34. Bolotina V, Courtney KR, Khodorov B. Gate-dependent blockade of sodium channels by phenothiazine derivatives: structure-activity relationships. Mol Pharmacol. 1992 Sep; 42(3):423-31. PMID: 1328843.
    View in: PubMed
  35. Bolotina V, Gericke M, Bregestovski P. Kinetic differences between Ca(2+)-dependent K+ channels in smooth muscle cells isolated from normal and atherosclerotic human aorta. Proc Biol Sci. 1991 Apr 22; 244(1309):51-5. PMID: 1677196.
    View in: PubMed
  36. Bolotina V, Omelyanenko V, Heyes B, Ryan U, Bregestovski P. Variations of membrane cholesterol alter the kinetics of Ca2(+)-dependent K+ channels and membrane fluidity in vascular smooth muscle cells. Pflugers Arch. 1989 Dec; 415(3):262-8. PMID: 2622758.
    View in: PubMed
  37. Bregestovski PD, Bolotina VM, Serebryakov VN. Fatty acid modifies Ca2+-dependent potassium channel activity in smooth muscle cells from the human aorta. Proc R Soc Lond B Biol Sci. 1989 Aug 22; 237(1288):259-66. PMID: 2571153.
    View in: PubMed
  38. Bolotina V, Borecký J, Vlachová V, Baudysová M, Vyskocil F. Voltage-dependent chloride channels with several substates in excised patches from mouse neuroblastoma cells. Neurosci Lett. 1987 Jun 26; 77(3):298-302. PMID: 2441328.
    View in: PubMed
  39. Khodorov BI, Bolotina VM. Batrachotoxin decreases the sensitivity of sodium channels to the blocking action of phenobarbital. Gen Physiol Biophys. 1984 Feb; 3(1):85-7. PMID: 6086450.
    View in: PubMed
  40. Bolotina VM, Revenko SV, Khodorov BI. [Stimulus-dependent blockade of node of Ranvier sodium channels by ethmozine]. Neirofiziologiia. 1981; 13(4):380-9. PMID: 6272135.
    View in: PubMed
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