Victoria Bolotina | Profiles RNS

Victoria Bolotina, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Vascular Biology

PhD, Moscow State University
BSc, Moscow State University

Websites

	Pharmacology & Experimental Therapeutics Faculty
	LinkedIn

ORCID : 0000-0001-5862-181X

Dr. Bolotina, Ph.D., is a leading expert in Calcium signaling and ion channels (with over 2000 citations of her work), who is well funded by NIH. The focus of her research is on the molecular mechanisms of Calcium entry and its role in physiological and pathological function.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Member
Boston University
Whitaker Cardiovascular Institute

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Multidisciplinary Training in Cardiovascular Research
07/01/1976 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
3T32HL007224-40S1

Structure-Function of PLA2g6
07/01/2019 - 06/30/2021 (PI)
National Institutes of Health/DHHS/NIH
1R21NS108724-01

The role of Bcl11b in dementia associated with Parkinson’s disease
09/01/2019 - 01/31/2021 (Subcontract PI)
PI: Victoria Bolotina, PhD
Trustees of Boston University, BUMC NIH NHLBI

PARK14/Calcium signaling as a novel biomarker for Parkinson disease
08/01/2019 - 07/31/2020 (PI)
National Institutes of Health/DHHS/NIH
5R21NS103142-02

Servier Contract Research Program
10/01/2014 - 06/30/2018 (PI)
Servier

Park14-dependent SOCE and sporadic PD
01/01/2017 - 12/31/2017 (PI)
Michael J. Fox Foundation

PARK-14-dependent SOCE and sporadic PD
01/01/2015 - 06/30/2016 (PI)
Michael J. Fox Foundation

Ion channels and calcium regulation in vascular SMC function
05/01/2010 - 04/30/2015 (PI)
NIH-NHLBI
5R01 HL054150-16

PARK 14: Validation of a mouse model of age-dependent PD
05/15/2013 - 05/14/2014 (PI)
Michael J. Fox Foundation

Store-operated Ca entry and iPLA2 in vascular SMC
01/01/2009 - 12/31/2013 (PI)
NIH-NHLBI
5R01 HL071793-08

Calcium Influx Factor
08/01/2009 - 07/31/2011 (PI)
NIH-NHLBI
5R21 HL097569-02

Showing 10 of 14 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Gene Therapy for Idiopathic Parkinson's Disease	1R43NS134446-01A1
2019	Structure-Function of PLA2g6	5R21NS108724-02	1
2019	The role of Bcl11b in dementia associated with Parkinsons disease	3R01HL136311-02S1	2
2018	Structure-Function of PLA2g6	1R21NS108724-01	1
2018	PARK14/Calcium signaling as a novel biomarker for Parkinson disease	5R21NS103142-02
2018	Multidisciplinary Training in Cardiovascular Research	5T32HL007224-43	195
2017	PARK14/Calcium signaling as a novel biomarker for Parkinson disease	1R21NS103142-01
2017	Multidisciplinary Training in Cardiovascular Research	3T32HL007224-41A1S1	195
2017	Multidisciplinary Training in Cardiovascular Research	3T32HL007224-40S1	195
2017	Multidisciplinary Training in Cardiovascular Research	5T32HL007224-42	195

Showing 10 of 44 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles.

Murdoch, Colin
Haeussler, Dagmar
Behring, Jessica
Han, Jingyan
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332.View Related Profiles.

Yen, Allen
Wolozin, Benjamin
Trengrove, Chelsea
Mostoslavsky, Gustavo
Asai, Hirohide
Kirber, Michael
Aziz, Nadine
Zhou, Qingde
Ikezu, Tsuneya
Bolotina, Victoria

PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;

Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 24920669; PMCID: PMC4106311; DOI: 10.1074/jbc.M114.554451;

Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 23089226; PMCID: PMC3568680; DOI: 10.1016/j.freeradbiomed.2012.10.546;

Schäfer C, Rymarczyk G, Ding L, Kirber MT, Bolotina VM. Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration. J Biol Chem. 2012 Nov 23; 287(48):40745-57.View Related Profiles.

Rymarczyk, Grzegorz
Kirber, Michael
Bolotina, Victoria

PMID: 23043102; PMCID: PMC3504787; DOI: 10.1074/jbc.M112.407155;

Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 22472004; PMCID: PMC3423867; DOI: 10.1089/ars.2011.4022;

Bolotina VM. Orai1, STIM1, and iPLA2ß determine arterial vasoconstriction. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1066-7. PMID: 22517361; DOI: 10.1161/ATVBAHA.112.245449;

Gwozdz T, Dutko-Gwozdz J, Schafer C, Bolotina VM. Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators. J Biol Chem. 2012 Jun 29; 287(27):22865-72. PMID: 22549787; PMCID: PMC3391152; DOI: 10.1074/jbc.M112.356626;

Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Mar 1; 302(5):C748-56. PMID: 22094335; PMCID: PMC3774541; DOI: 10.1152/ajpcell.00312.2011;

Gwozdz T, Dutko-Gwozdz J, Zarayskiy V, Peter K, Bolotina VM. How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1133-40. PMID: 18768920; PMCID: PMC2584986; DOI: 10.1152/ajpcell.00306.2008;

Showing 10 of 40 results. Show More

Bolotina VM. Orai, STIM1 and iPLA2beta: a view from a different perspective. J Physiol. 2008 Jul 1; 586(13):3035-42. PMID: 18499724; PMCID: PMC2538780; DOI: 10.1113/jphysiol.2008.154997;

Smani T, Patel T, Bolotina VM. Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1499-508. PMID: 18434622; DOI: 10.1152/ajpcell.00365.2007;

Csutora P, Peter K, Kilic H, Park KM, Zarayskiy V, Gwozdz T, Bolotina VM. Novel role for STIM1 as a trigger for calcium influx factor production. J Biol Chem. 2008 May 23; 283(21):14524-31. PMID: 18337241; PMCID: PMC2386937; DOI: 10.1074/jbc.M709575200;

Park KM, Trucillo M, Serban N, Cohen RA, Bolotina VM. Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1183-7.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 18156193

Zarayskiy V, Monje F, Peter K, Csutora P, Khodorov BI, Bolotina VM. Store-operated Orai1 and IP3 receptor-operated TRPC1 channel. Channels (Austin). 2007 Jul-Aug; 1(4):246-52. PMID: 18711860

Csutora P, Zarayskiy V, Peter K, Monje F, Smani T, Zakharov SI, Litvinov D, Bolotina VM. Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway. J Biol Chem. 2006 Nov 17; 281(46):34926-35. PMID: 17003039

Bolotina VM, Csutora P. CIF and other mysteries of the store-operated Ca2+-entry pathway. Trends Biochem Sci. 2005 Jul; 30(7):378-87. PMID: 15951181

Zakharov SI, Smani T, Dobrydneva Y, Monje F, Fichandler C, Blackmore PF, Bolotina VM. Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca(2+) influx. Mol Pharmacol. 2004 Sep; 66(3):702-7. PMID: 15322263

Gwanyanya A, Amuzescu B, Zakharov SI, Macianskiene R, Sipido KR, Bolotina VM, Vereecke J, Mubagwa K. Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation. J Physiol. 2004 Sep 15; 559(Pt 3):761-76. PMID: 15272039; PMCID: PMC1665187

Bolotina VM. Store-operated channels: diversity and activation mechanisms. Sci STKE. 2004 Jul 27; 2004(243):pe34. PMID: 15280576

Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, Bolotina VM. A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol. 2004 Feb; 6(2):113-20. PMID: 14730314

Smani T, Zakharov SI, Leno E, Csutora P, Trepakova ES, Bolotina VM. Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry. J Biol Chem. 2003 Apr 4; 278(14):11909-15. PMID: 12547829

Zakharov SI, Smani T, Leno E, Macianskiene R, Mubagwa K, Bolotina VM. Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ and inhibition by polycations. Br J Pharmacol. 2003 Jan; 138(1):234-44. PMID: 12522095; PMCID: PMC1573659

Birk AV, Leno E, Robertson HD, Bolotina VM, Szeto HH. Interaction between ATP and catecholamines in stimulation of platelet aggregation. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H619-25. PMID: 12388296

Li Y, Adachi T, Bolotina VM, Knowles C, Ault KA, Cohen RA. Abnormal platelet function and calcium handling in Dahl salt-hypertensive rats. Hypertension. 2001 Apr; 37(4):1129-35.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Li, Yu

PMID: 11304514

Trepakova ES, Gericke M, Hirakawa Y, Weisbrod RM, Cohen RA, Bolotina VM. Properties of a native cation channel activated by Ca2+ store depletion in vascular smooth muscle cells. J Biol Chem. 2001 Mar 16; 276(11):7782-90.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 11113149

Trepakova ES, Csutora P, Hunton DL, Marchase RB, Cohen RA, Bolotina VM. Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cells. J Biol Chem. 2000 Aug 25; 275(34):26158-63.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 10851243

Hirakawa Y, Gericke M, Cohen RA, Bolotina VM. Ca(2+)-dependent Cl(-) channels in mouse and rabbit aortic smooth muscle cells: regulation by intracellular Ca(2+) and NO. Am J Physiol. 1999 Nov; 277(5 Pt 2):H1732-44.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 10564126

Trepakova ES, Cohen RA, Bolotina VM. Nitric oxide inhibits capacitative cation influx in human platelets by promoting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase-dependent refilling of Ca2+ stores. Circ Res. 1999 Feb 5; 84(2):201-9.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 9933252

Cohen RA, Weisbrod RM, Gericke M, Yaghoubi M, Bierl C, Bolotina VM. Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx. Circ Res. 1999 Feb 5; 84(2):210-9.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 9933253

Zakharov SI, Mongayt DA, Cohen RA, Bolotina VM. Monovalent cation and L-type Ca2+ channels participate in calcium paradox-like phenomenon in rabbit aortic smooth muscle cells. J Physiol. 1999 Jan 1; 514 ( Pt 1):71-81.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 9831717; PMCID: PMC2269055

Weisbrod RM, Griswold MC, Du Y, Bolotina VM, Cohen RA. Reduced responsiveness of hypercholesterolemic rabbit aortic smooth muscle cells to nitric oxide. Arterioscler Thromb Vasc Biol. 1997 Feb; 17(2):394-402.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 9081696

Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature. 1994 Apr 28; 368(6474):850-3.View Related Profiles.

Cohen, Richard
Bolotina, Victoria

PMID: 7512692

Bolotina V, Courtney KR, Khodorov B. Gate-dependent blockade of sodium channels by phenothiazine derivatives: structure-activity relationships. Mol Pharmacol. 1992 Sep; 42(3):423-31. PMID: 1328843

Bolotina V, Gericke M, Bregestovski P. Kinetic differences between Ca(2+)-dependent K+ channels in smooth muscle cells isolated from normal and atherosclerotic human aorta. Proc Biol Sci. 1991 Apr 22; 244(1309):51-5. PMID: 1677196

Bolotina V, Omelyanenko V, Heyes B, Ryan U, Bregestovski P. Variations of membrane cholesterol alter the kinetics of Ca2(+)-dependent K+ channels and membrane fluidity in vascular smooth muscle cells. Pflugers Arch. 1989 Dec; 415(3):262-8. PMID: 2622758

Bregestovski PD, Bolotina VM, Serebryakov VN. Fatty acid modifies Ca2+-dependent potassium channel activity in smooth muscle cells from the human aorta. Proc R Soc Lond B Biol Sci. 1989 Aug 22; 237(1288):259-66. PMID: 2571153

Bolotina V, Borecký J, Vlachová V, Baudysová M, Vyskocil F. Voltage-dependent chloride channels with several substates in excised patches from mouse neuroblastoma cells. Neurosci Lett. 1987 Jun 26; 77(3):298-302. PMID: 2441328

Khodorov BI, Bolotina VM. Batrachotoxin decreases the sensitivity of sodium channels to the blocking action of phenobarbital. Gen Physiol Biophys. 1984 Feb; 3(1):85-7. PMID: 6086450

Bolotina VM, Revenko SV, Khodorov BI. [Stimulus-dependent blockade of node of Ranvier sodium channels by ethmozine]. Neirofiziologiia. 1981; 13(4):380-9. PMID: 6272135

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 22 distinct years, with a maximum of 5 publications in 2012

Bar chart showing 40 publications over 22 distinct years, with a maximum of 5 publications in 2012

Year	Publications
1981	1
1984	1
1987	1
1989	2
1991	1
1992	1
1994	1
1997	1
1999	4
2000	2
2001	1
2002	1
2003	2
2004	4
2005	1
2006	1
2007	2
2008	4
2011	1
2012	5
2014	1
2016	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

calcium homeostasis
ion channels
signaling
Vascular smooth muscle

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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617.638.7118

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