Keywords
Last Name

Bjorn Reinhard, Dr. rer. nat.

TitleProfessor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address8 St. Mary's Street
Boston MA 02215
Phone(617) 353-8669
Fax(617) 353-6466
Other Positions
TitleDirector
InstitutionBoston University College of Arts and Sciences
DepartmentNano-Bio Interface Laboratory

 Research Expertise & Professional Interests
Research in the Reinhard Lab focuses on new optical materials and their application to interrogate fundamental life processes. We are exploring the interface between nanotechnology and biological systems. For an overview of current research projects, please visit our group’s website. Recents techniques/materials developed in the Nano-Bio Interface Lab include:

Plasmon ruler RNase A cleavage assay: (A) The RNA plasmon rulers are bound to the surface of a glass flow chamber using a BSA (bovin serum albumin)-Biotin-NeutrAvidin surface chemistry. Upon addition of RNase A, the RNA tether is cleaved, and the dimer converted into a monomer. (B) Single RNA plasmon ruler cleavage trajectory (recorded at 96 Hz). (I) The plasmon ruler is first incubated in buffer containing spermidine at defined concentrations (0 -5 mM), (II) the buffer is exchanged with a 1 nM RNase A solution, causing (III) a strong drop in intensity upon RNA cleavage. Inset: Number of cleavage events for flushing with/without enzyme. ?tcl is defined as the time between enzyme addition and cleavage. For more information, refer to: L.R. Skewis & B.M. Reinhard, Nano Lett., 8, 214 (2008).

Plasmon Coupling Microscopy: Gold nanoparticle labeled surface receptors (left) and spectral signature (right) as function of interparticle distance. (a) For interparticle separations ? larger than the particle diameter D, the near-field interactions between the particles is small and the resonance wavelength ?res is that of an individual particle. (b) For interparticle separations ? < D the plasmons in the individual particles couple and the resonance wavelength ?res red-shifts with decreasing separation. This spectral shift is observable as an increase in the intensity ratio R = I580nm/I530nm.

Multiscale Nanoparticle Cluster Arrays (NCAs): SEM images from extracts of nanoparticle cluster arrays with varying diameters of e-beam defined binding size D = 50 nm (a), 80 nm (b), 100 nm (c), 130 nm (d), 200 nm (e). The SEM images confirm that through control of the diameter of the e-beam fabricated binding site the cluster size can be continuously varied. The enlargement of an individual cluster in (f) shows junctions and crevices between nearly touching particles constituting a high degree of roughness on the nanoscale.

The Reinhard group utilizes a variety of techniques including:
-Spectroscopy: Raman, SERS, Single Molecule Fluorescence, Plasmon
-Live Cell Imaging
-Nanofabrication
-Transmission Electron Microscopy
-Scanning Electron Microscopy
-Cell Culture Facility
-Fluorescence Plate Readers
-Nanoparticle Synthesis/Functionalization/Integration
-The Photonics Center
-Center of Nanoscience and Nanobiotechnology

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Kijewski SD, Akiyama H, Feizpour A, Miller CM, Ramirez NG, Reinhard BM, Gummuluru S. Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated. Virology. 2016 Oct; 497:328-36. PMID: 27521724.
    View in: PubMed
  2. Wu L, Xu F, Reinhard BM. Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis. Nanoscale. 2016 Jul 14; 8(28):13755-68. PMID: 27378391.
    View in: PubMed
  3. Alizadeh MH, Reinhard BM. Emergence of transverse spin in optical modes of semiconductor nanowires. Opt Express. 2016 Apr 18; 24(8):8471-9. PMID: 27137285.
    View in: PubMed
  4. Chen T, Reinhard BM. Assembling Color on the Nanoscale: Multichromatic Switchable Pixels from Plasmonic Atoms and Molecules. Adv Mater. 2016 May; 28(18):3522-7. PMID: 26990416.
    View in: PubMed
  5. Ahn W, Zhao X, Hong Y, Reinhard BM. Low-Power Light Guiding and Localization in Optoplasmonic Chains Obtained by Directed Self-Assembly. Sci Rep. 2016 Mar 02; 6:22621. PMID: 26931149.
    View in: PubMed
  6. Zhao X, Alizadeh MH, Reinhard BM. Harnessing Leaky Modes for Fluorescence Enhancement in Gold-Tipped Silicon Nanowires. J Phys Chem C Nanomater Interfaces. 2016 Sep 22; 120(37):20555-20562. PMID: 27795751.
    View in: PubMed
  7. Lerch S, Reinhard BM. Quantum Plasmonics: Optical Monitoring of DNA-Mediated Charge Transfer in Plasmon Rulers. Adv Mater. 2016 Mar 09; 28(10):2030-6. PMID: 26789736.
    View in: PubMed
  8. Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200. PMID: 26720275.
    View in: PubMed
  9. Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13. PMID: 26507575.
    View in: PubMed
  10. Chen T, Hong Y, Reinhard BM. Probing DNA Stiffness through Optical Fluctuation Analysis of Plasmon Rulers. Nano Lett. 2015 Aug 12; 15(8):5349-57. PMID: 26121062.
    View in: PubMed
  11. Hong Y, Ahn W, Boriskina SV, Zhao X, Reinhard BM. Directed Assembly of Optoplasmonic Hybrid Materials with Tunable Photonic-Plasmonic Properties. J Phys Chem Lett. 2015 Jun 04; 6(11):2056-64. PMID: 26266502.
    View in: PubMed
  12. Yu X, Xu F, Ramirez NG, Kijewski SD, Akiyama H, Gummuluru S, Reinhard BM. Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse. ACS Nano. 2015; 9(4):4182-92. PMID: 25853367.
    View in: PubMed
  13. Burgmeier J, Feizpour A, Schade W, Reinhard BM. Plasmonic nanoshell functionalized etched fiber Bragg gratings for highly sensitive refractive index measurements. Opt Lett. 2015 Feb 15; 40(4):546-9. PMID: 25680146.
    View in: PubMed
  14. Feizpour A, Yu X, Akiyama H, Miller CM, Edmans E, Gummuluru S, Reinhard BM. Quantifying lipid contents in enveloped virus particles with plasmonic nanoparticles. Small. 2015 Apr; 11(13):1592-602. PMID: 25382201.
    View in: PubMed
  15. Yu X, Feizpour A, Ramirez NG, Wu L, Akiyama H, Xu F, Gummuluru S, Reinhard BM. Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells. Nat Commun. 2014; 5:4136. PMID: 24947940.
    View in: PubMed
  16. Wu L, Yu X, Feizpour A, Reinhard BM. Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis. Biomater Sci. 2014 Feb 1; 2(2):156-166. PMID: 24683470.
    View in: PubMed
  17. Wu L, Reinhard BM. Probing subdiffraction limit separations with plasmon coupling microscopy: concepts and applications. Chem Soc Rev. 2014 Jun 7; 43(11):3884-97. PMID: 24390574.
    View in: PubMed
  18. Chen T, Pourmand M, Feizpour A, Cushman B, Reinhard BM. Tailoring Plasmon Coupling in Self-Assembled One-Dimensional Au Nanoparticle Chains through Simultaneous Control of Size and Gap Separation. J Phys Chem Lett. 2013 Jun 13; 4(13):2147-2152. PMID: 24027605.
    View in: PubMed
  19. Ahn W, Hong Y, Boriskina SV, Reinhard BM. Demonstration of efficient on-chip photon transfer in self-assembled optoplasmonic networks. ACS Nano. 2013 May 28; 7(5):4470-8. PMID: 23600526.
    View in: PubMed
  20. Puryear WB, Akiyama H, Geer SD, Ramirez NP, Yu X, Reinhard BM, Gummuluru S. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. PLoS Pathog. 2013; 9(4):e1003291. PMID: 23593001.
    View in: PubMed
  21. Yu X, Wang J, Feizpour A, Reinhard BM. Illuminating the lateral organization of cell-surface CD24 and CD44 through plasmon coupling between Au nanoparticle immunolabels. Anal Chem. 2013 Feb 05; 85(3):1290-4. PMID: 23320416.
    View in: PubMed
  22. Chen T, Reinhard BM. Characterizing the lateral friction of nanoparticles on on-chip integrated black lipid membranes. Small. 2013 Mar 25; 9(6):876-84. PMID: 23180691.
    View in: PubMed
  23. Hong Y, Pourmand M, Boriskina SV, Reinhard BM. Enhanced light focusing in self-assembled optoplasmonic clusters with subwavelength dimensions. Adv Mater. 2013 Jan 04; 25(1):115-9. PMID: 23055393.
    View in: PubMed
  24. Wang H, Wu L, Reinhard BM. Scavenger receptor mediated endocytosis of silver nanoparticles into J774A.1 macrophages is heterogeneous. ACS Nano. 2012 Aug 28; 6(8):7122-32. PMID: 22799499.
    View in: PubMed
  25. Yan B, Hong Y, Chen T, Reinhard BM. Monitoring enzymatic degradation of pericellular matrices through SERS stamping. Nanoscale. 2012 Jul 7; 4(13):3917-25. PMID: 22659641.
    View in: PubMed
  26. Wang J, Yu X, Boriskina SV, Reinhard BM. Quantification of differential ErbB1 and ErbB2 cell surface expression and spatial nanoclustering through plasmon coupling. Nano Lett. 2012 Jun 13; 12(6):3231-7. PMID: 22587495.
    View in: PubMed
  27. Pasquale AJ, Reinhard BM, Dal Negro L. Concentric necklace nanolenses for optical near-field focusing and enhancement. ACS Nano. 2012 May 22; 6(5):4341-8. PMID: 22537221.
    View in: PubMed
  28. Puryear WB, Yu X, Ramirez NP, Reinhard BM, Gummuluru S. HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7475-80. PMID: 22529395.
    View in: PubMed
  29. Rong G, Reinhard BM. Monitoring the size and lateral dynamics of ErbB1 enriched membrane domains through live cell plasmon coupling microscopy. PLoS One. 2012; 7(3):e34175. PMID: 22470534.
    View in: PubMed
  30. Forestiere C, Pasquale AJ, Capretti A, Miano G, Tamburrino A, Lee SY, Reinhard BM, Dal Negro L. Genetically engineered plasmonic nanoarrays. Nano Lett. 2012 Apr 11; 12(4):2037-44. PMID: 22381056.
    View in: PubMed
  31. Ahn W, Boriskina SV, Hong Y, Reinhard BM. Electromagnetic field enhancement and spectrum shaping through plasmonically integrated optical vortices. Nano Lett. 2012 Jan 11; 12(1):219-27. PMID: 22171957.
    View in: PubMed
  32. Yan B, Boriskina SV, Reinhard BM. Design and Implementation of Noble Metal Nanoparticle Cluster Arrays for Plasmon Enhanced Biosensing. J Phys Chem C Nanomater Interfaces. 2011 Dec 20; 115(50):24437-24453. PMID: 22299057.
    View in: PubMed
  33. Ahn W, Boriskina SV, Hong Y, Reinhard BM. Photonic-plasmonic mode coupling in on-chip integrated optoplasmonic molecules. ACS Nano. 2012 Jan 24; 6(1):951-60. PMID: 22148502.
    View in: PubMed
  34. Boriskina SV, Reinhard BM. Molding the flow of light on the nanoscale: from vortex nanogears to phase-operated plasmonic machinery. Nanoscale. 2012 Jan 07; 4(1):76-90. PMID: 22127488.
    View in: PubMed
  35. Boriskina SV, Reinhard BM. Adaptive on-chip control of nano-optical fields with optoplasmonic vortex nanogates. Opt Express. 2011 Oct 24; 19(22):22305-15. PMID: 22109072.
    View in: PubMed
  36. Wang J, Boriskina SV, Wang H, Reinhard BM. Illuminating epidermal growth factor receptor densities on filopodia through plasmon coupling. ACS Nano. 2011 Aug 23; 5(8):6619-28. PMID: 21761914.
    View in: PubMed
  37. Pasquale AJ, Reinhard BM, Dal Negro L. Engineering photonic-plasmonic coupling in metal nanoparticle necklaces. ACS Nano. 2011 Aug 23; 5(8):6578-85. PMID: 21739951.
    View in: PubMed
  38. Yan B, Boriskina SV, Reinhard BM. Optimizing Gold Nanoparticle Cluster Configurations (n = 7) for Array Applications. J Phys Chem C Nanomater Interfaces. 2011 Mar 24; 115(11):4578-4583. PMID: 21603065.
    View in: PubMed
  39. Wang J, Yang L, Boriskina S, Yan B, Reinhard BM. Spectroscopic ultra-trace detection of nitroaromatic gas vapor on rationally designed two-dimensional nanoparticle cluster arrays. Anal Chem. 2011 Mar 15; 83(6):2243-9. PMID: 21332229.
    View in: PubMed
  40. Boriskina SV, Reinhard BM. Spectrally and spatially configurable superlenses for optoplasmonic nanocircuits. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3147-51. PMID: 21300898.
    View in: PubMed
  41. Wang H, Rong G, Yan B, Yang L, Reinhard BM. Optical sizing of immunolabel clusters through multispectral plasmon coupling microscopy. Nano Lett. 2011 Feb 09; 11(2):498-504. PMID: 21247191.
    View in: PubMed
  42. Thubagere A, Reinhard BM. Nanoparticle-induced apoptosis propagates through hydrogen-peroxide-mediated bystander killing: insights from a human intestinal epithelium in vitro model. ACS Nano. 2010 Jul 27; 4(7):3611-22. PMID: 20560658.
    View in: PubMed
  43. Mellin JR, McClure R, Lopez D, Green O, Reinhard B, Genco C. Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis. Microbiology. 2010 Aug; 156(Pt 8):2316-26. PMID: 20430815.
    View in: PubMed
  44. Yang L, Wang H, Yan B, Reinhard BM. Calibration of Silver Plasmon Rulers in the 1-25 nm Separation Range: Experimental Indications of Distinct Plasmon Coupling Regimes. J Phys Chem C Nanomater Interfaces. 2010 Mar 1; 114(11):4901-4908. PMID: 20606714.
    View in: PubMed
  45. Skewis LR, Reinhard BM. Control of colloid surface chemistry through matrix confinement: facile preparation of stable antibody functionalized silver nanoparticles. ACS Appl Mater Interfaces. 2010 Jan; 2(1):35-40. PMID: 20161660.
    View in: PubMed
  46. Rong G, Wang H, Reinhard BM. Insights from a nanoparticle minuet: two-dimensional membrane profiling through silver plasmon ruler tracking. Nano Lett. 2010 Jan; 10(1):230-8. PMID: 20017502.
    View in: PubMed
  47. Reinhard BM, Yassif JM, Vach P, Liphardt J. Plasmon rulers as dynamic molecular rulers in enzymology. Methods Enzymol. 2010; 475:175-98. PMID: 20627158.
    View in: PubMed
  48. Gopinath A, Boriskina SV, Premasiri WR, Ziegler L, Reinhard BM, Dal Negro L. Plasmonic nanogalaxies: multiscale aperiodic arrays for surface-enhanced Raman sensing. Nano Lett. 2009 Nov; 9(11):3922-9. PMID: 19754067.
    View in: PubMed
  49. Wang H, Reinhard BM. Monitoring Simultaneous Distance and Orientation Changes in Discrete Dimers of DNA Linked Gold Nanoparticles. J Phys Chem C Nanomater Interfaces. 2009 Jun 8; 113(26):11215-11222. PMID: 20160921.
    View in: PubMed
  50. Yan B, Thubagere A, Premasiri WR, Ziegler LD, Dal Negro L, Reinhard BM. Engineered SERS substrates with multiscale signal enhancement: nanoparticle cluster arrays. ACS Nano. 2009 May 26; 3(5):1190-202. PMID: 19354266.
    View in: PubMed
  51. Gopinath A, Boriskina SV, Reinhard BM, Dal Negro L. Deterministic aperiodic arrays of metal nanoparticles for surface-enhanced Raman scattering (SERS). Opt Express. 2009 Mar 02; 17(5):3741-53. PMID: 19259215.
    View in: PubMed
  52. Yang L, Yan B, Reinhard BM. Correlated Optical Spectroscopy and Transmission Electron Microscopy of Individual Hollow Nanoparticles and their Dimers. J Phys Chem C Nanomater Interfaces. 2008 Sep 18; 112(41):15989-15996. PMID: 19768108.
    View in: PubMed
  53. Rong G, Wang H, Skewis LR, Reinhard BM. Resolving sub-diffraction limit encounters in nanoparticle tracking using live cell plasmon coupling microscopy. Nano Lett. 2008 Oct; 8(10):3386-93. PMID: 18788826.
    View in: PubMed
  54. Gopinath A, Boriskina SV, Feng NN, Reinhard BM, Dal Negro L. Photonic-plasmonic scattering resonances in deterministic aperiodic structures. Nano Lett. 2008 Aug; 8(8):2423-31. PMID: 18646833.
    View in: PubMed
  55. Cabot A, Smith RK, Yin Y, Zheng H, Reinhard BM, Liu H, Alivisatos AP. Sulfidation of cadmium at the nanoscale. ACS Nano. 2008 Jul; 2(7):1452-8. PMID: 19206314.
    View in: PubMed
  56. Skewis LR, Reinhard BM. Spermidine modulated ribonuclease activity probed by RNA plasmon rulers. Nano Lett. 2008 Jan; 8(1):214-20. PMID: 18052230.
    View in: PubMed
  57. Reinhard BM, Sheikholeslami S, Mastroianni A, Alivisatos AP, Liphardt J. Use of plasmon coupling to reveal the dynamics of DNA bending and cleavage by single EcoRV restriction enzymes. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2667-72. PMID: 17307879.
    View in: PubMed
  58. Reinhard BM, Siu M, Agarwal H, Alivisatos AP, Liphardt J. Calibration of dynamic molecular rulers based on plasmon coupling between gold nanoparticles. Nano Lett. 2005 Nov; 5(11):2246-52. PMID: 16277462.
    View in: PubMed
  59. Shroff H, Reinhard BM, Siu M, Agarwal H, Spakowitz A, Liphardt J. Biocompatible force sensor with optical readout and dimensions of 6 nm3. Nano Lett. 2005 Jul; 5(7):1509-14. PMID: 16178266.
    View in: PubMed
  60. Sönnichsen C, Reinhard BM, Liphardt J, Alivisatos AP. A molecular ruler based on plasmon coupling of single gold and silver nanoparticles. Nat Biotechnol. 2005 Jun; 23(6):741-5. PMID: 15908940.
    View in: PubMed
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