Keywords
Last Name

John Snyder, PhD

TitleProfessor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address590 Commonwealth Avenue
Boston MA 02215
Phone(617) 353-2621
Fax(617) 353-6466
Other Positions
TitleAssociate Chair
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry

 Research Expertise & Professional Interests
The Snyder Group focuses on both organic synthesis and the discovery of new synthetic methodology that allow for the synthesis of natural product type chemotypes that occupy new chemical space. These efforts explore novel applications of inverse electron demand Diels-Alder reactions, homo Diels-Alder reactions, and other chemistries in organic synthesis. They are also exploring the use of abundant natural products as scaffolds in the synthesis of small molecule libraries. The goal of this work is the discovery of completely novel compounds that have significant biological activities against disease targets. Our library synthesis work coordinates with the Boston University Center for Molecular Discovery (BU-CMD).

Techniques & Resources:

NMR Spectroscopy – The Chemistry Department as well as the BU-CMD have excellent spectroscopy facilities to aid synthetic organic chemists. Included are a 500 MHz, two 400 MHz and numerous 300 MHz NMR spectrometers.

Multimode Microwave Reactors Multimode - Microwave reactors have proven invaluable in both reaction condition optimization and in library synthesis.

LC-MS/UPLC – Reaction monitoring is rapidly achieved with LC-MS and UPLC spectrometers.

ISCO CombiFlash (CMD) – For rapid, automated purification.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Strom KR, Impastato AC, Moy KJ, Landreth AJ, Snyder JK. Gallium(III)-Promoted Halocyclizations of 1,6-Diynes. Org Lett. 2015 May 1; 17(9):2126-9. PMID: 25885017.
    View in: PubMed
  2. Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5. PMID: 24410175.
    View in: PubMed
  3. Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33. PMID: 23521799.
    View in: PubMed
  4. Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40. PMID: 23015831.
    View in: PubMed
  5. Kota S, Takahashi V, Ni F, Snyder JK, Strosberg AD. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS One. 2012; 7(2):e32207. PMID: 22389688.
    View in: PubMed
  6. Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73. PMID: 22213919.
    View in: PubMed
  7. Gibeau AL, Snyder JK. Indium(III)-catalyzed hydrative cyclization of 1,7-diynyl ethers. Org Lett. 2011 Aug 19; 13(16):4280-3. PMID: 21761825.
    View in: PubMed
  8. Ni F, Kota S, Takahashi V, Strosberg AD, Snyder JK. Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2198-202. PMID: 21440437.
    View in: PubMed
  9. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80. PMID: 21498685.
    View in: PubMed
  10. Strosberg AD, Kota S, Takahashi V, Snyder JK, Mousseau G. Core as a novel viral target for hepatitis C drugs. Viruses. 2010 Aug; 2(8):1734-51. PMID: 21994704.
    View in: PubMed
  11. Jones AL, Snyder JK. Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituted cyclohexadienes. Org Lett. 2010 Apr 2; 12(7):1592-5. PMID: 20210307.
    View in: PubMed
  12. Jones AL, Liu X, Snyder JK. Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary. Tetrahedron Lett. 2010 Feb 17; 51(7):1091-1094. PMID: 20305722.
    View in: PubMed
  13. Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay Drug Dev Technol. 2010 Feb; 8(1):96-105. PMID: 20035614.
    View in: PubMed
  14. Wei W, Cai C, Kota S, Takahashi V, Ni F, Strosberg AD, Snyder JK. New small molecule inhibitors of hepatitis C virus. Bioorg Med Chem Lett. 2009 Dec 15; 19(24):6926-30. PMID: 19896376.
    View in: PubMed
  15. Jones AL, Snyder JK. Intramolecular rhodium-catalyzed [2+2+2] cyclizations of diynes with enones. J Org Chem. 2009 Apr 3; 74(7):2907-10. PMID: 19281162.
    View in: PubMed
  16. Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK. Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds. J Comb Chem. 2008 Jul-Aug; 10(4):534-40. PMID: 18517255.
    View in: PubMed
  17. Liu X, Snyder JK. Anthracene cycloadducts as highly selective chiral auxiliaries. J Org Chem. 2008 Apr 4; 73(7):2935-8. PMID: 18321128.
    View in: PubMed
  18. Woo GH, Beeler AB, Snyder JK. 1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development. Tetrahedron. 2007 Jun 18; 63(25):5649-5655. PMID: 19112520.
    View in: PubMed
  19. Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Org Lett. 2007 Feb 1; 9(3):393-6. PMID: 17249770.
    View in: PubMed
  20. Burgess KL, Corbett MS, Eugenio P, Lajkiewicz NJ, Liu X, Sanyal A, Yan W, Yuan Q, Snyder JK. Chiral anthracene and anthrone templates as stereocontrolling elements in Diels-Alder/retro Diels-Alder sequences. Bioorg Med Chem. 2005 Sep 1; 13(17):5299-309. PMID: 16046136.
    View in: PubMed
  21. Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4. PMID: 15957938.
    View in: PubMed
  22. Burgess KL, Lajkiewicz NJ, Sanyal A, Yan W, Snyder JK. A new chiral anthracene for the asymmetric Diels-Alder/retro-Diels-Alder sequence. Org Lett. 2005 Jan 6; 7(1):31-4. PMID: 15624970.
    View in: PubMed
  23. Lahue BR, Lo SM, Wan ZK, Woo GH, Snyder JK. Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: a new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles. J Org Chem. 2004 Oct 15; 69(21):7171-82. PMID: 15471466.
    View in: PubMed
  24. Lahue BR, Wan ZK, Snyder JK. Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions. 4. Intermolecular reactions with 1,2,4-triazines. J Org Chem. 2003 May 30; 68(11):4345-54. PMID: 12762735.
    View in: PubMed
  25. Ma B, Snyder JK. A homo Diels-Alder approach to bicyclo[4.2.1]nonanes. Org Lett. 2002 Aug 8; 4(16):2731-4. PMID: 12153221.
    View in: PubMed
  26. Deng Y, Snyder JK. Preparation of a 24-nor-1,4-dien-3-one triterpene derivative from betulin: a new route to 24-nortriterpene analogues. J Org Chem. 2002 May 3; 67(9):2864-73. PMID: 11975539.
    View in: PubMed
  27. Chen Y, Kiattansakul R, Ma B, Snyder JK. Transition metal-catalyzed [4 + 2 + 2] cycloadditions of bicyclo[2.2.1]hepta-2,5-dienes (norbornadienes) and bicyclo[2.2.2]octa-2,5-dienes. J Org Chem. 2001 Oct 19; 66(21):6932-42. PMID: 11597212.
    View in: PubMed
  28. Chen Y, Snyder JK. Opening the [4 + 2 + 2] cycloadducts of bicyclo[2.2.1]hepta-2,5-dienes (norbornadienes) to cis-fused bicyclo[5.3.0]decanes. J Org Chem. 2001 Oct 19; 66(21):6943-57. PMID: 11597213.
    View in: PubMed
  29. Deng Y, Lee JP, Tianasoa-Ramamonjy M, Snyder JK, Des Etages SA, Kanada D, Snyder MP, Turner CJ. New antimicrobial flavanones from Physena madagascariensis. J Nat Prod. 2000 Aug; 63(8):1082-9. PMID: 10978202.
    View in: PubMed
  30. Deng Y, Jiang TY, Sheng S, Tianasoa-Ramamonjy M, Snyder JK. Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis. J Nat Prod. 1999 Mar; 62(3):471-6. PMID: 10096861.
    View in: PubMed
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