John Snyder, PhD
Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, University of Chicago



The Snyder Group focuses on both organic synthesis and the discovery of new synthetic methodology that allow for the synthesis of natural product type chemotypes that occupy new chemical space. These efforts explore novel applications of inverse electron demand Diels-Alder reactions, homo Diels-Alder reactions, and other chemistries in organic synthesis. They are also exploring the use of abundant natural products as scaffolds in the synthesis of small molecule libraries. The goal of this work is the discovery of completely novel compounds that have significant biological activities against disease targets. Our library synthesis work coordinates with the Boston University Center for Molecular Discovery (BU-CMD).

Techniques & Resources:

NMR Spectroscopy – The Chemistry Department as well as the BU-CMD have excellent spectroscopy facilities to aid synthetic organic chemists. Included are a 500 MHz, two 400 MHz and numerous 300 MHz NMR spectrometers.

Multimode Microwave Reactors Multimode - Microwave reactors have proven invaluable in both reaction condition optimization and in library synthesis.

LC-MS/UPLC – Reaction monitoring is rapidly achieved with LC-MS and UPLC spectrometers.

ISCO CombiFlash (CMD) – For rapid, automated purification.

Associate Chair
Boston University College of Arts and Sciences
Department of Chemistry




Chemistry Research Addressing Biological Problems
05/01/2016 - 04/30/2019 (PI)
National Science Foundation
CHE-1560152

REU Site: Fundamental Research in Chemistry Addressing Biological Problems
08/01/2012 - 07/31/2015 (PI)
National Science Foundation
CHE-1156666




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles. PMID: 28490664.
  2. Strom KR, Impastato AC, Moy KJ, Landreth AJ, Snyder JK. Gallium(III)-Promoted Halocyclizations of 1,6-Diynes. Org Lett. 2015 May 1; 17(9):2126-9. PMID: 25885017; DOI: 10.1021/acs.orglett.5b00716;.
  3. Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5.View Related Profiles. PMID: 24410175; PMCID: PMC3927640; DOI: 10.1021/ol4035269;.
  4. Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33.View Related Profiles. PMID: 23521799; PMCID: PMC3712830; DOI: 10.1016/j.chembiol.2013.02.011;.
  5. Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40.View Related Profiles. PMID: 23015831; PMCID: PMC3388871.
  6. Kota S, Takahashi V, Ni F, Snyder JK, Strosberg AD. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS One. 2012; 7(2):e32207. PMID: 22389688; PMCID: PMC3289641; DOI: 10.1371/journal.pone.0032207;.
  7. Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73.View Related Profiles. PMID: 22213919; PMCID: PMC3254213.
  8. Gibeau AL, Snyder JK. Indium(III)-catalyzed hydrative cyclization of 1,7-diynyl ethers. Org Lett. 2011 Aug 19; 13(16):4280-3. PMID: 21761825; DOI: 10.1021/ol201624b;.
  9. Ni F, Kota S, Takahashi V, Strosberg AD, Snyder JK. Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2198-202. PMID: 21440437; PMCID: PMC3086078; DOI: 10.1016/j.bmcl.2011.03.014;.
  10. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80.View Related Profiles. PMID: 21498685; PMCID: PMC3084078; DOI: 10.1073/pnas.1017666108;.
Showing 10 of 31 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 31 publications over 17 distinct years, with a maximum of 4 publications in 2010 and 2011

YearPublications
19991
20001
20012
20022
20031
20041
20053
20072
20082
20092
20104
20114
20122
20131
20141
20151
20171
Contact for Mentoring:


590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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