Ian Francis
Pre-Doctoral Trainee
Boston University School of Medicine, Division of Graduate Medical Sciences
Dept of Microbiology




My interests lie in vaccine development. Specifically I am working on the human pathogen Neisseria gonorrhoeae (Ng). In 2012 there were greater than 330,000 new gonorrhea cases in the US and more than 100 million cases worldwide. Gonorrhea can present as urethritis in men and more seriously, pelvic inflammatory disease with infertility as a possible outcome in women. While this outcome is preventable with antibiotic treatment, the rapid development of resistance has led the CDC to identify Ng as an “immediate public health threat that requires urgent and aggressive action” towards new therapeutics and vaccines. This drive for innovation faces a significant challenge in the human-specific adaptations of Ng. We are working with our collaborators to develop a humanized transgenic mouse model of disease that will serve as the platform for our future testing of Neisseria gonorrhoeae vaccine antigen candidates.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Pendergrass SA, Lemaire R, Francis IP, Mahoney JM, Lafyatis R, Whitfield ML. Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol. 2012 May; 132(5):1363-73.View Related Profiles. PMID: 22318389; PMCID: PMC3326181; DOI: 10.1038/jid.2011.472;.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 1 publications over 1 distinct years, with a maximum of 1 publications in 2012

YearPublications
20121
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