Manish Sagar, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine
BS, Columbia University



Dr. Manish Sagar is a Professor of Medicine at the Chobanian and Avedisian School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission.

Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis.

Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Diversity, Equity, Inclusion and Accessibility

As an immigrant from India, I am acutely aware of the challenges encountered by foreign born students, physicians, and researchers. My experiences as a minority, albeit not one characterized or labeled as underrepresented minority in medicine, has raised my awareness for increasing diversity in medicine and science. To that end, I have actively promoted the training and careers of those underrepresented, such as women and minorities. I have consistently mentored foreign students and physicians in my laboratory and medical practice. I have also had number underrepresented minorities who have completed their PhD and other research training in my laboratory. I will continue to promote diversity and inclusion in scientific and medical education.
My childhood in India along with my education in the United States has heightened my awareness of the inequities in medicine. I have trained in and provided care to communities that house some of the most socio-economically disadvantaged populations in the United States. I pursued a career in Infectious Disease and specialization in HIV because of infectious diseases and HIV, specifically, overwhelmingly impact minority populations with limited economic and social means. Over my career and to this day, I am committed to providing medical care and conduct research that will help alleviate these structural inequities.

Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences





Core H - The Providence/Boston Center for AIDS Research (CFAR) competitive renewal
07/01/2023 - 06/30/2028 (PI)
The Miriam Hospital National Institute o

Pre-notification Spatially multiplexed biogel nanosensors with boron-doped diamond microelectrode arrays for HIV self-testing
02/23/2024 - 02/22/2027 (PI)
Fraunhofer USA - Center for Manufacturing Innovation (CMI) National Institutes

Characterization of HIV-1 IgA bNAbs and ADCP function
09/01/2022 - 11/30/2025 (PI)
Trustees of Columbia University National Institute o

A MASTER PROTOCOL ASSESSING THE SAFETY, TOLERABILITY, AND EFFICACY OF ANTI-SPIKE (S) SARS-COV-2 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF HOSPITALIZED PATIENTS WITH COVID-19
08/19/2020 - 11/30/2024 (PI)
Regeneron Pharmaceuticals

Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission
09/19/2022 - 07/31/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R01AI172843-01A1

MassCPR Biospecimen and Viral Variants: Biobank
07/01/2023 - 06/30/2024 (PI)
Harvard Medical School China Evergrande Gr

The Effects of Opioid Use on HIV-1 Reservoir Dynamics
06/01/2022 - 05/31/2024 (PI)
Brigham and Womens Hospital National Institute o
4R33DA047038-04

Persistent HIV expression induced type 1 IFN responses and inflammaging
05/01/2018 - 04/30/2024 (PI)
Trustees of Boston University, BUMC National Institute o

MassCPR Biospecimens; Biobank
03/01/2022 - 02/29/2024 (PI)
Harvard Medical School China Evergrande Gr

HIV-1 mucosal transmission and persistence
03/01/2020 - 02/29/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5K24AI145661-03

Showing 10 of 22 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2023 Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission 5R01AI172843-02
2023 HIV-1 mucosal transmission and persistence 5K24AI145661-05
2023 The effects of opioid use on HIV-1 reservoir dynamics 5R33DA047038-05
2022 Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission 1R01AI172843-01A1
2022 Sartorious Octet R8 System 1S10OD032333-01
2022 HIV-1 mucosal transmission and persistence 5K24AI145661-04
2022 The effects of opioid use on HIV-1 reservoir dynamics 4R33DA047038-04
2022 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-05
2022 Core H - Basic & Translational Sciences 5P30AI042853-24-7399
2021 HIV-1 mucosal transmission and persistence 5K24AI145661-03
Showing 10 of 37 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Heindel DW, Figueroa Acosta DM, Goff M, Yengo CK, Jan M, Liu X, Wang XH, Petrova MI, Zhang M, Sagar M, Barnette P, Pandey S, Hessell AJ, Chan KW, Kong XP, Chen BK, Mahal LK, Bensing BA, Hioe CE. HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralization by antibodies. Res Sq. 2024 Jan 03. PMID: 36824869; PMCID: PMC9949255; DOI: 10.21203/rs.3.rs-2596269/v2;
     
  2. Bean DJ, Monroe J, Liang YM, Borberg E, Senussi Y, Swank Z, Chalise S, Walt D, Weinberg J, Sagar M. Heterotypic responses against nsp12/nsp13 from prior SARS-CoV-2 infection associates with lower subsequent endemic coronavirus incidence. bioRxiv. 2023 Oct 24.View Related Profiles. PMID: 37961343; PMCID: PMC10634759; DOI: 10.1101/2023.10.23.563621;
     
  3. Esmaeilzadeh E, Etemad B, Lavine CL, Garneau L, Li Y, Regan J, Wong C, Sharaf R, Connick E, Volberding P, Sagar M, Seaman MS, Li JZ. Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption. Sci Transl Med. 2023 May 10; 15(695):eabq4490.View Related Profiles. PMID: 37163616; PMCID: PMC10576978; DOI: 10.1126/scitranslmed.abq4490;
     
  4. Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M. Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses. iScience. 2023 May 19; 26(5):106631.View Related Profiles. PMID: 37168567; PMCID: PMC10165194; DOI: 10.1016/j.isci.2023.106631;
     
  5. Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2).View Related Profiles. PMID: 36851631; PMCID: PMC9961149; DOI: 10.3390/v15020415;
     
  6. Bean DJ, Monroe J, Turcinovic J, Moreau Y, Connor JH, Sagar M. Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Associates With Unstable Housing and Occurs in the Presence of Antibodies. Clin Infect Dis. 2022 Aug 24; 75(1):e208-e215.View Related Profiles. PMID: 34755830; PMCID: PMC8689949; DOI: 10.1093/cid/ciab940;
     
  7. Tu JJ, Kumar A, Giorgi EE, Eudailey J, LaBranche CC, Martinez DR, Fouda GG, Moreau Y, Thomas A, Montefiori D, Gao F, Sagar M, Permar SR. Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses. J Virol. 2022 Jun 08; 96(11):e0023122.View Related Profiles. PMID: 35536018; PMCID: PMC9175633; DOI: 10.1128/jvi.00231-22;
     
  8. Thomas AS, Coote C, Moreau Y, Isaac JE, Ewing AC, Kourtis AP, Sagar M. Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission. JCI Insight. 2022 May 09; 7(9).View Related Profiles. PMID: 35324477; PMCID: PMC9090239; DOI: 10.1172/jci.insight.159435;
     
  9. Asundi A, Olson A, Jiang W, Varshney SP, White LF, Sagar M, Lin NH. Integrase Inhibitor Use Associated with Weight Gain in Women and Incident Diabetes Mellitus. AIDS Res Hum Retroviruses. 2022 03; 38(3):208-215.View Related Profiles. PMID: 34877881; PMCID: PMC8968841; DOI: 10.1089/aid.2021.0091;
     
  10. Bean DJ, Sagar M. Family matters for coronavirus disease and vaccines. J Clin Invest. 2021 12 15; 131(24). PMID: 34752421; PMCID: PMC8670830; DOI: 10.1172/JCI155615;
     
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 24 distinct years, with a maximum of 7 publications in 2021

YearPublications
19961
19981
19991
20001
20031
20042
20053
20062
20082
20093
20102
20124
20133
20143
20152
20162
20171
20183
20191
20206
20217
20224
20234
20241


COVID’S cold cousins

Science 1/11/2024

Tuberculosis Disease Improves Antibody Response in Patients Coinfected With HIV

Pharmacy Times 5/18/2023

HIV Antibody Response Intensified in Patients With Tuberculosis Disease

Technology Networks 5/9/2023

Why Does Homelessness Increase the Risk of COVID-19 Reinfection?

Health City 1/6/2022

Homelessness, SDOH Increase Risk of COVID-19 Re-Infection

Patient Engagement HIT 11/16/2021

Severe Acute Respiratory Syndrome Reinfection More Likely to Occur in Homeless People

The Science times 11/13/2021

Unstable housing, homelessness associated with COVID-19 re-infection: Study Read more At: https://www.aninews.in/news/health/unstable-housing-homelessness-associated-with-covid-19-re-infection-study20211112085128/

ANI 11/12/2021

New Findings Point to a Promising HIV Vaccine Research Path

HealthCity 11/9/2021

COVID-19 Precautions Cut Rates of Common Respiratory Illnesses

Pharmacy Times 6/8/2021

Are Face Masks Here To Stay Even After The Pandemic?

Tatler 4/15/2021

COVID-19 Precautions Also Decreased Rates of Common Respiratory Illnesses

Pharmacy Times 4/6/2021

Could Face Masks Be Here to Stay, Even after the Pandemic? Here's What Researchers Have to Say

Yahoo! News: 3/24/2021

COVID-19 prevention strategies may have led to a decrease in common respiratory infections

News Medical Life Sciences 3/21/2021

HIV tied to poorer COVID-19 outcomes in New York State

Medscape 2/10/2021

If You Get Covid-19, Here Are the Current Treatments Available

Elemental 2/8/2021

Learning About the New Strain of COVID-19

NECN 12/23/2020

Viral Reservoir’s Production of HIV RNA Tied to Harmful Inflammation

POZ 11/20/2020

Common cold coronaviruses linked to less severe COVID-19 cases

ZME Science 11/16/2020

Common Cold Coronaviruses Tied to Less Severe COVID-19 Cases

The Scientist 11/11/2020

Common Cold Could Protect Against COVID-19, Research Shows

Voice of America 10/21/2020

Previous infection with ‘common cold’ coronavirus may lessen COVID-19 severity: Report

Livemint 10/8/2020

Does catching the common cold make COVID-19 less severe

Digital Journal 10/7/2020

Coming in From the Cold: An Interview With Three Corona Experts on SARS-CoV-2 and Pneumonia

Biomedical Central 6/15/2020

Virus Characteristics Could Predict Efficacy of Antibody-Based Treatments in HIV

Pharmacy Times 12/18/2019

Viral Characteristics May Predict HIV Treatment Efficacy

Pharmacy Times 12/2/2019

Virus Characteristics Predict HIV Treatment Efficacy With Antibody Treatment

Outrage Magazine 11/8/2019

Is HIV Transmission Different for Women?

HIV Plus Magazine 12/19/2018

2015 Infection; Plos One: Editor
2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year

I have a established track record of mentoring post-doctoral fellows, pre-doctoral candidates, undergraduates, and high school students. I am also co-director of the BU Clinical and Translationall Science Institute (CTSI) Program for Early Research Career (PERC) Development Program. I am committed to developing the next wave of physicians and scientists that will conduct future patient oriented research.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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