Manish Sagar, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine



Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. He was recruited to the Boston University Medical Campus from Brigham and Women’s Hospital in 2012. Dr. Sagar’s research focuses on the pathogenesis of human immunodeficiency virus type 1 heterosexual transmission. He has been a member of the AIDS Clinical Trials Group (ACTG) since 2005. Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Associate Professor
Boston University School of Medicine
Microbiology


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


Active Staff Privileges
Boston Medical Center
Medicine Infectious Diseases



2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year



CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/17/2016 - 04/30/2020 (PI)
NIH-NIAID
3R01AI122209-02S1

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/15/2015 - 04/30/2020 (PI)
NIH-NIAID
5R01AI122209-02

A study to look at the experimental use of telavancin for the treatment of S. aureus blood infection
03/01/2017 - 03/01/2020 (PI)
Theravance Biopharma Antibiotics

NBS GeneRadar Evaluation
01/07/2015 - 01/06/2018 (PI)
Nanobiosym Advisory Services, LLC.

Neutralizing and Non-neutralizing Antibodies Protection from Breast Milk HIV-1
08/01/2013 - 07/31/2014 (PI)
NIH-NIAID
5R21 AI102774-02



Yr Title Project-Sub Proj Pubs
2018 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-04 1
2017 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-03 1
2016 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-02 1
2016 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 3R01AI122209-02S1 1
2013 Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1 5R21AI102774-02
2012 Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1 1R21AI102774-01
2011 Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1 5R01AI077473-04 8
2010 Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1 5R01AI077473-03 8
2009 Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1 5R01AI077473-02 8
2008 Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1 1R01AI077473-01A2 8
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M. HIV-1 replicates and persists in vaginal epithelial dendritic cells. J Clin Invest. 2018 Jul 09.View Related Profiles. PMID: 29723162.
     
  2. Ghulam-Smith M, Olson A, White LF, Chasela CS, Ellington SR, Kourtis AP, Jamieson DJ, Tegha G, van der Horst CM, Sagar M. Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity. MBio. 2017 10 24; 8(5).View Related Profiles. PMID: 29066544.
     
  3. Gonzalez OA, Sagar M. Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis. J Infect Dis. 2016 Oct 15; 214(8):1221-4. PMID: 27493237; PMCID: PMC5034959; DOI: 10.1093/infdis/jiw354;.
     
  4. Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles. PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;.
     
  5. Ofotokun I, Na LH, Landovitz RJ, Ribaudo HJ, McComsey GA, Godfrey C, Aweeka F, Cohn SE, Sagar M, Kuritzkes DR, Brown TT, Patterson KB, Para MF, Leavitt RY, Villasis-Keever A, Baugh BP, Lennox JL, Currier JS. Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257. Clin Infect Dis. 2015 Jun 15; 60(12):1842-51. PMID: 25767256; PMCID: PMC4660025; DOI: 10.1093/cid/civ193;.
     
  6. Etemad B, Ghulam-Smith M, Gonzalez O, White LF, Sagar M. Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics. J Virol Methods. 2015 Mar; 214:46-53.View Related Profiles. PMID: 25681527; PMCID: PMC4394631; DOI: 10.1016/j.jviromet.2015.01.006;.
     
  7. Sagar M. Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus. J Infect Dis. 2014 Dec 15; 210 Suppl 3:S667-73. PMID: 25414422; PMCID: PMC4303076; DOI: 10.1093/infdis/jiu369;.
     
  8. Etemad B, Gonzalez OA, White L, Laeyendecker O, Kirk GD, Mehta S, Sagar M. Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users. Retrovirology. 2014; 11:106.View Related Profiles. PMID: 25430652; PMCID: PMC4253609; DOI: 10.1186/s12977-014-0106-8;.
     
  9. Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, Kuritzkes DR, Sagar M, Brown TT, Cohn SE, McComsey GA, Aweeka F, Fichtenbaum CJ, Presti RM, Koletar SL, Haas DW, Patterson KB, Benson CA, Baugh BP, Leavitt RY, Rooney JF, Seekins D, Currier JS. Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial. Ann Intern Med. 2014 Oct 7; 161(7):461-71. PMID: 25285539; PMCID: PMC4412467; DOI: 10.7326/M14-1084;.
     
  10. Pena-Cruz V, Etemad B, Chatziandreou N, Nyein PH, Stock S, Reynolds SJ, Laeyendecker O, Gray RH, Serwadda D, Lee SJ, Quinn TC, Sagar M. HIV-1 envelope replication and a4ß7 utilization among newly infected subjects and their corresponding heterosexual partners. Retrovirology. 2013; 10:162.View Related Profiles. PMID: 24369910; PMCID: PMC3883469; DOI: 10.1186/1742-4690-10-162;.
     
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 18 distinct years, with a maximum of 4 publications in 2012

YearPublications
19961
19981
19991
20001
20031
20042
20053
20062
20082
20093
20102
20124
20133
20143
20152
20162
20171
20181

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