Manish Sagar, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine




Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission.

Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis.

Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Associate Professor
Boston University School of Medicine
Microbiology


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2015 Infection; Plos One: Editor
2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year



HIV-1 mucosal transmission and persistence
03/01/2019 - 02/29/2024 (PI)
NIH-NIAID
1K24AI145661-01

Dr. Sagar Discretionary
08/25/2020 - 08/24/2023 (PI)
Various

A MASTER PROTOCOL ASSESSING THE SAFETY, TOLERABILITY, AND EFFICACY OF ANTI-SPIKE…
08/19/2020 - 08/18/2023 (PI)
Regeneron Pharmaceuticals, Inc.

Providence/Boston Center for AIDS Research(CFAR): Core H-Basic Sciences
07/01/2018 - 06/30/2023 (PI)
Miriam Hospital NIH-NIAID

CFAR Administrative Supplement: Basic Sciences Core Equipment
08/04/2020 - 08/03/2021 (PI)
The Miriam Hospital National Institute o

Identification and characterization of individuals with elite anti-HIV-1 ADCC
08/08/2018 - 07/31/2021 (PI)
NIH-NIAID
5R21AI137119-02

Transcriptional comparison of epidermal Langerhans cells and vaginal mucosal CD1a+ …
07/01/2019 - 06/30/2021 (PI)
Brigham & Women's NIH-NIAMS

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/15/2015 - 04/30/2021 (PI)
NIH-NIAID
5R01AI122209-05

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/17/2016 - 04/30/2020 (PI)
NIH-NIAID
3R01AI122209-02S1

A study to look at the experimental use of telavancin for the treatment of S. aureus blood infection
03/01/2017 - 03/01/2020 (PI)
Theravance Biopharma Antibiotics

Showing 10 of 12 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2021 HIV-1 mucosal transmission and persistence 5K24AI145661-03
2021 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-04 2
2020 HIV-1 mucosal transmission and persistence 5K24AI145661-02
2020 HIV-1 mucosal transmission and persistence 5K24AI145661-02
2020 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-03 2
2020 Core H - Basic & Translational Sciences 5P30AI042853-22-7399 905
2019 HIV-1 mucosal transmission and persistence 1K24AI145661-01
2019 Identification and characterization of individuals with elite anti-HIV-1 ADCC 5R21AI137119-02
2019 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-02 2
2019 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-05 5
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation. J Infect Dis. 2021 Jun 04; 223(11):1934-1942.View Related Profiles. PMID: 33075121; PMCID: PMC8176637; DOI: 10.1093/infdis/jiaa657;
     
  2. Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles. PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;
     
  3. Sinha P, Jafarzadeh SR, Assoumou SA, Bielick CG, Carpenter B, Garg S, Harleen S, Neogi T, Nishio MJ, Sagar M, Sharp V, Kissin EY. The Effect of IL-6 Inhibitors on Mortality Among Hospitalized COVID-19 Patients: A Multicenter Study. J Infect Dis. 2021 02 24; 223(4):581-588.View Related Profiles. PMID: 33216906; PMCID: PMC7717300; DOI: 10.1093/infdis/jiaa717;
     
  4. Sagar M, Reifler K, Rossi M, Miller NS, Sinha P, White LF, Mizgerd JP. Recent endemic coronavirus infection is associated with less-severe COVID-19. J Clin Invest. 2021 01 04; 131(1).View Related Profiles. PMID: 32997649; PMCID: PMC7773342; DOI: 10.1172/JCI143380;
     
  5. Mostaghim A, Sinha P, Bielick C, Knudsen S, Beeram I, White LF, Apovian C, Sagar M, Hochberg NS. Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital. PLoS One. 2020; 15(12):e0243888.View Related Profiles. PMID: 33326480; PMCID: PMC7744045; DOI: 10.1371/journal.pone.0243888;
     
  6. Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, Horick NK, Healy BC, Shah R, Bensaci AM, Woolley AE, Nikiforow S, Lin N, Sagar M, Schrager H, Huckins DS, Axelrod M, Pincus MD, Fleisher J, Sacks CA, Dougan M, North CM, Halvorsen YD, Thurber TK, Dagher Z, Scherer A, Wallwork RS, Kim AY, Schoenfeld S, Sen P, Neilan TG, Perugino CA, Unizony SH, Collier DS, Matza MA, Yinh JM, Bowman KA, Meyerowitz E, Zafar A, Drobni ZD, Bolster MB, Kohler M, D'Silva KM, Dau J, Lockwood MM, Cubbison C, Weber BN, Mansour MK. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020 12 10; 383(24):2333-2344.View Related Profiles. PMID: 33085857; PMCID: PMC7646626; DOI: 10.1056/NEJMoa2028836;
     
  7. Kolluri N, Albarran N, Fan A, Olson A, Sagar M, Young A, Gomez-Marquez J, Klapperich CM. SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood. Lab Chip. 2020 09 21; 20(18):3386-3398.View Related Profiles. PMID: 32766666
     
  8. Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Oct; 99:28-33.View Related Profiles. PMID: 32721528; PMCID: PMC7591937; DOI: 10.1016/j.ijid.2020.07.023;
     
  9. Thomas AS, Ghulam-Smith M, Olson A, Coote C, Gonzales O, Sagar M. A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants. J Immunol Methods. 2020 05; 480:112766.View Related Profiles. PMID: 32135162; PMCID: PMC7188583; DOI: 10.1016/j.jim.2020.112766;
     
  10. Registre L, Moreau Y, Ataca ST, Pulukuri S, Henrich TJ, Lin N, Sagar M. HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility. J Virol. 2020 01 06; 94(2).View Related Profiles. PMID: 31694950; PMCID: PMC6955257; DOI: 10.1128/JVI.01604-19;
     
Showing 10 of 48 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 48 publications over 21 distinct years, with a maximum of 6 publications in 2020

YearPublications
19961
19981
19991
20001
20031
20042
20053
20062
20082
20093
20102
20124
20133
20143
20152
20162
20171
20183
20191
20206
20214


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Available to Mentor as: (Review Mentor Role Definitions):
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  • Career Mentor
  • Project Mentor
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Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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