Manish Sagar, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine




Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission.

Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis.

Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Associate Professor
Boston University School of Medicine
Microbiology


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2015 Infection; Plos One: Editor
2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year



HIV-1 mucosal transmission and persistence
03/01/2019 - 02/29/2024 (PI)
NIH-NIAID
1K24AI145661-01

Identification and characterization of individuals with elite anti-HIV-1 ADCC
08/08/2018 - 07/31/2020 (PI)
NIH-NIAID
5R21AI137119-02

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/17/2016 - 04/30/2020 (PI)
NIH-NIAID
3R01AI122209-02S1

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/15/2015 - 04/30/2020 (PI)
NIH-NIAID
5R01AI122209-05

A study to look at the experimental use of telavancin for the treatment of S. aureus blood infection
03/01/2017 - 03/01/2020 (PI)
Theravance Biopharma Antibiotics

NBS GeneRadar Evaluation
01/07/2015 - 01/06/2018 (PI)
Nanobiosym Advisory Services, LLC.

Neutralizing and Non-neutralizing Antibodies Protection from Breast Milk HIV-1
08/01/2013 - 07/31/2014 (PI)
NIH-NIAID
5R21 AI102774-02


Title


Yr Title Project-Sub Proj Pubs
2020 HIV-1 mucosal transmission and persistence 5K24AI145661-02
2020 HIV-1 mucosal transmission and persistence 5K24AI145661-02
2020 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-03 2
2019 HIV-1 mucosal transmission and persistence 1K24AI145661-01
2019 Identification and characterization of individuals with elite anti-HIV-1 ADCC 5R21AI137119-02
2019 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-02 2
2019 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-05 5
2018 Identification and characterization of individuals with elite anti-HIV-1 ADCC 1R21AI137119-01A1
2018 Persistent HIV expression induced type I IFN responses and inflammaging 1R01AG060890-01 2
2018 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-04 5
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kolluri N, Albarran N, Fan A, Olson A, Sagar M, Young A, Gomez-Marquez J, Klapperich CM. SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood. Lab Chip. 2020 09 21; 20(18):3386-3398.View Related Profiles. PMID: 32766666
     
  2. Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Jul 25; 99:28-33.View Related Profiles. PMID: 32721528
     
  3. Thomas AS, Ghulam-Smith M, Olson A, Coote C, Gonzales O, Sagar M. A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants. J Immunol Methods. 2020 May; 480:112766.View Related Profiles. PMID: 32135162
     
  4. Registre L, Moreau Y, Ataca ST, Pulukuri S, Henrich TJ, Lin N, Sagar M. HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility. J Virol. 2020 01 06; 94(2).View Related Profiles. PMID: 31694950
     
  5. Pudney J, Wangu Z, Panther L, Fugelso D, Marathe JG, Sagar M, Politch JA, Anderson DJ. Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission. J Infect Dis. 2019 01 07; 219(2):275-283.View Related Profiles. PMID: 30137482
     
  6. Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles. PMID: 30063648
     
  7. Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M. HIV-1 replicates and persists in vaginal epithelial dendritic cells. J Clin Invest. 2018 08 01; 128(8):3439-3444.View Related Profiles. PMID: 29723162
     
  8. Thomas AS, Ghulam-Smith M, Sagar M. Neutralization and beyond: Antibodies and HIV-1 acquisition. Curr Top Virol. 2018; 15:73-86.View Related Profiles. PMID: 31787808
     
  9. Ghulam-Smith M, Olson A, White LF, Chasela CS, Ellington SR, Kourtis AP, Jamieson DJ, Tegha G, van der Horst CM, Sagar M. Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity. MBio. 2017 10 24; 8(5).View Related Profiles. PMID: 29066544
     
  10. Gonzalez OA, Sagar M. Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis. J Infect Dis. 2016 Oct 15; 214(8):1221-4. PMID: 27493237; PMCID: PMC5034959; DOI: 10.1093/infdis/jiw354;
     
Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 20 distinct years, with a maximum of 4 publications in 2012 and 2020

YearPublications
19961
19981
19991
20001
20031
20042
20053
20062
20082
20093
20102
20124
20133
20143
20152
20162
20171
20183
20191
20204

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