Manish Sagar, MD
Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine




Dr. Manish Sagar is a Professor of Medicine at the Boston University School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission.

Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis.

Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Associate Professor
Boston University School of Medicine
Microbiology


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences





HIV-1 mucosal transmission and persistence
03/01/2019 - 02/29/2024 (PI)
NIH-NIAID
1K24AI145661-01

A MASTER PROTOCOL ASSESSING THE SAFETY, TOLERABILITY, AND EFFICACY OF ANTI-SPIKE…
08/19/2020 - 08/18/2023 (PI)
Regeneron Pharmaceuticals, Inc.

Providence/Boston Center for AIDS Research(CFAR):Core H-YR03
07/01/2018 - 06/30/2023 (PI)
The Miriam Hospital National Institute o
5P30AI042853-23

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/15/2015 - 04/30/2022 (PI)
NIH-NIAID
5R01AI122209-05

Identification and characterization of individuals with elite anti-HIV-1 ADCC
08/08/2018 - 07/31/2021 (PI)
NIH-NIAID
5R21AI137119-02

CFAR Administrative Supplement: Basic Sciences Core Equipment
08/04/2020 - 06/30/2021 (PI)
The Miriam Hospital National Institute o

Transcriptional comparison of epidermal Langerhans cells and vaginal mucosal CD1a+ …
07/01/2019 - 06/30/2021 (PI)
Brigham & Women's NIH-NIAMS

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/17/2016 - 04/30/2020 (PI)
NIH-NIAID
3R01AI122209-02S1

A study to look at the experimental use of telavancin for the treatment of S. aureus blood infection
03/01/2017 - 03/01/2020 (PI)
Theravance Biopharma Antibiotics

NBS GeneRadar Evaluation
01/07/2015 - 01/06/2018 (PI)
Nanobiosym Advisory Services, LLC.

Showing 10 of 11 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2021 HIV-1 mucosal transmission and persistence 5K24AI145661-03
2021 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-04 2
2021 Core H - Basic & Translational Sciences 5P30AI042853-23-7399 905
2020 HIV-1 mucosal transmission and persistence 5K24AI145661-02
2020 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-03 2
2020 Core H - Basic & Translational Sciences 5P30AI042853-22-7399 905
2019 HIV-1 mucosal transmission and persistence 1K24AI145661-01
2019 Identification and characterization of individuals with elite anti-HIV-1 ADCC 5R21AI137119-02
2019 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-02 2
2019 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-05 5
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tu JJ, Kumar A, Giorgi EE, Eudailey J, LaBranche CC, Martinez DR, Fouda GG, Moreau Y, Thomas A, Montefiori D, Gao F, Sagar M, Permar SR. Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses. J Virol. 2022 May 10; e0023122.View Related Profiles. PMID: 35536018
     
  2. Thomas AS, Coote C, Moreau Y, Isaac JE, Ewing AC, Kourtis AP, Sagar M. Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission. JCI Insight. 2022 May 09; 7(9).View Related Profiles. PMID: 35324477
     
  3. Asundi A, Olson A, Jiang W, Varshney SP, White LF, Sagar M, Lin NH. Integrase Inhibitor Use Associated with Weight Gain in Women and Incident Diabetes Mellitus. AIDS Res Hum Retroviruses. 2022 03; 38(3):208-215.View Related Profiles. PMID: 34877881; PMCID: PMC8968841; DOI: 10.1089/aid.2021.0091;
     
  4. Bean DJ, Sagar M. Family matters for coronavirus disease and vaccines. J Clin Invest. 2021 12 15; 131(24). PMID: 34752421; PMCID: PMC8670830; DOI: 10.1172/JCI155615;
     
  5. Bean DJ, Monroe J, Turcinovic J, Moreau Y, Connor JH, Sagar M. SARS-CoV-2 reinfection associates with unstable housing and occurs in the presence of antibodies. Clin Infect Dis. 2021 Nov 10.View Related Profiles. PMID: 34755830; PMCID: PMC8689949; DOI: 10.1093/cid/ciab940;
     
  6. Thomas AS, Moreau Y, Jiang W, Isaac JE, Ewing A, White LF, Kourtis AP, Sagar M. Pre-existing infant antibody-dependent cellular cytotoxicity associates with reduced HIV-1 acquisition and lower morbidity. Cell Rep Med. 2021 Oct 19; 2(10):100412.View Related Profiles. PMID: 34755132; PMCID: PMC8561235; DOI: 10.1016/j.xcrm.2021.100412;
     
  7. Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation. J Infect Dis. 2021 06 04; 223(11):1934-1942.View Related Profiles. PMID: 33075121; PMCID: PMC8176637; DOI: 10.1093/infdis/jiaa657;
     
  8. Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles. PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;
     
  9. Sinha P, Reifler K, Rossi M, Sagar M. Coronavirus Disease 2019 Mitigation Strategies Were Associated With Decreases in Other Respiratory Virus Infections. Open Forum Infect Dis. 2021 Jun; 8(6):ofab105.View Related Profiles. PMID: 34514014; PMCID: PMC8083776; DOI: 10.1093/ofid/ofab105;
     
  10. Sinha P, Jafarzadeh SR, Assoumou SA, Bielick CG, Carpenter B, Garg S, Harleen S, Neogi T, Nishio MJ, Sagar M, Sharp V, Kissin EY. The Effect of IL-6 Inhibitors on Mortality Among Hospitalized COVID-19 Patients: A Multicenter Study. J Infect Dis. 2021 02 24; 223(4):581-588.View Related Profiles. PMID: 33216906; PMCID: PMC7717300; DOI: 10.1093/infdis/jiaa717;
     
Showing 10 of 55 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 55 publications over 22 distinct years, with a maximum of 8 publications in 2021

YearPublications
19961
19981
19991
20001
20031
20042
20053
20062
20082
20093
20102
20124
20133
20143
20152
20162
20171
20183
20191
20206
20218
20223


Why Does Homelessness Increase the Risk of COVID-19 Reinfection?

Health City 1/6/2022

Homelessness, SDOH Increase Risk of COVID-19 Re-Infection

Patient Engagement HIT 11/16/2021

Severe Acute Respiratory Syndrome Reinfection More Likely to Occur in Homeless People

The Science times 11/13/2021

Unstable housing, homelessness associated with COVID-19 re-infection: Study Read more At: https://www.aninews.in/news/health/unstable-housing-homelessness-associated-with-covid-19-re-infection-study20211112085128/

ANI 11/12/2021

New Findings Point to a Promising HIV Vaccine Research Path

HealthCity 11/9/2021

COVID-19 Precautions Cut Rates of Common Respiratory Illnesses

Pharmacy Times 6/8/2021

Are Face Masks Here To Stay Even After The Pandemic?

Tatler 4/15/2021

COVID-19 Precautions Also Decreased Rates of Common Respiratory Illnesses

Pharmacy Times 4/6/2021

Could Face Masks Be Here to Stay, Even after the Pandemic? Here's What Researchers Have to Say

Yahoo! News: 3/24/2021

COVID-19 prevention strategies may have led to a decrease in common respiratory infections

News Medical Life Sciences 3/21/2021

HIV tied to poorer COVID-19 outcomes in New York State

Medscape 2/10/2021

If You Get Covid-19, Here Are the Current Treatments Available

Elemental 2/8/2021

Learning About the New Strain of COVID-19

NECN 12/23/2020

Viral Reservoir’s Production of HIV RNA Tied to Harmful Inflammation

POZ 11/20/2020

Common cold coronaviruses linked to less severe COVID-19 cases

ZME Science 11/16/2020

Common Cold Coronaviruses Tied to Less Severe COVID-19 Cases

The Scientist 11/11/2020

Common Cold Could Protect Against COVID-19, Research Shows

Voice of America 10/21/2020

Previous infection with ‘common cold’ coronavirus may lessen COVID-19 severity: Report

Livemint 10/8/2020

Does catching the common cold make COVID-19 less severe

Digital Journal 10/7/2020

Coming in From the Cold: An Interview With Three Corona Experts on SARS-CoV-2 and Pneumonia

Biomedical Central 6/15/2020

Virus Characteristics Could Predict Efficacy of Antibody-Based Treatments in HIV

Pharmacy Times 12/18/2019

Viral Characteristics May Predict HIV Treatment Efficacy

Pharmacy Times 12/2/2019

Virus Characteristics Predict HIV Treatment Efficacy With Antibody Treatment

Outrage Magazine 11/8/2019

Is HIV Transmission Different for Women?

HIV Plus Magazine 12/19/2018

2015 Infection; Plos One: Editor
2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year

I have a established track record of mentoring post-doctoral fellows, pre-doctoral candidates, undergraduates, and high school students. I am also co-director of the BU Clinical and Translationall Science Institute (CTSI) Program for Early Research Career (PERC) Development Program. I am committed to developing the next wave of physicians and scientists that will conduct future patient oriented research.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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