Manish Sagar, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine

Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. He was recruited to the Boston University Medical Campus from Brigham and Women’s Hospital in 2012. Dr. Sagar’s research focuses on the pathogenesis of human immunodeficiency virus type 1 heterosexual transmission. He has been a member of the AIDS Clinical Trials Group (ACTG) since 2005. Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Associate Professor
Boston University School of Medicine

Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Medicine Infectious Diseases

2012 University of North Carolina Infectious Diseases Grand Rounds: Invited Speaker
2012 Conference on Retroviruses and Opportunistic Infections 2012: Chair Host and Viral Factors in HIV-1 Transmission
2007 Howard Hughes: Early Physician Scientist Award
2006 Doris Duke Charitable Foundation: Clinical Scientist Development Award
2006 American Foundation for AIDS Research: Grant Recipient
2001 Infectious Diseases Society of America: Special Citation for Member in Training
1997 Johns Hopkins Hospital: Osler Award – Best Intern
1995 Howard Hughes Medical Institute: Research Training Award – Continued Support
1991 Columbia University: Graduated with highest honors (top 5%)
1991 Columbia University: Gold Key Community Service Award
1989 NY Alpha Chapter: Tau Beta Pi (Engineering Honor Society), President
1988 Columbia University: Student Body Class Representative Junior Year

Identification and characterization of individuals with elite anti-HIV-1 ADCC
08/08/2018 - 07/31/2020 (PI)

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/17/2016 - 04/30/2020 (PI)

CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
05/15/2015 - 04/30/2020 (PI)

A study to look at the experimental use of telavancin for the treatment of S. aureus blood infection
03/01/2017 - 03/01/2020 (PI)
Theravance Biopharma Antibiotics

NBS GeneRadar Evaluation
01/07/2015 - 01/06/2018 (PI)
Nanobiosym Advisory Services, LLC.

Neutralizing and Non-neutralizing Antibodies Protection from Breast Milk HIV-1
08/01/2013 - 07/31/2014 (PI)
5R21 AI102774-02

Yr Title Project-Sub Proj Pubs
2019 HIV-1 mucosal transmission and persistence 1K24AI145661-01
2019 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-05 4
2018 Identification and characterization of individuals with elite anti-HIV-1 ADCC 1R21AI137119-01A1
2018 Persistent HIV expression induced type I IFN responses and inflammaging 1R01AG060890-01
2018 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-04 4
2017 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-03 4
2016 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 5R01AI122209-02 4
2016 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 3R01AI122209-02S1 4
2015 CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract 1R01AI122209-01 4
2013 Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1 5R21AI102774-02 3
Showing 10 of 20 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Pudney J, Wangu Z, Panther L, Fugelso D, Marathe JG, Sagar M, Politch JA, Anderson DJ. Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission. J Infect Dis. 2019 Jan 07; 219(2):275-283.View Related Profiles. PMID: 30137482.
  2. Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 Nov 01; 79(3):407-411.View Related Profiles. PMID: 30063648.
  3. Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M. HIV-1 replicates and persists in vaginal epithelial dendritic cells. J Clin Invest. 2018 Aug 01; 128(8):3439-3444.View Related Profiles. PMID: 29723162.
  4. Ghulam-Smith M, Olson A, White LF, Chasela CS, Ellington SR, Kourtis AP, Jamieson DJ, Tegha G, van der Horst CM, Sagar M. Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity. MBio. 2017 10 24; 8(5).View Related Profiles. PMID: 29066544.
  5. Gonzalez OA, Sagar M. Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis. J Infect Dis. 2016 Oct 15; 214(8):1221-4. PMID: 27493237; PMCID: PMC5034959; DOI: 10.1093/infdis/jiw354;.
  6. Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles. PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;.
  7. Ofotokun I, Na LH, Landovitz RJ, Ribaudo HJ, McComsey GA, Godfrey C, Aweeka F, Cohn SE, Sagar M, Kuritzkes DR, Brown TT, Patterson KB, Para MF, Leavitt RY, Villasis-Keever A, Baugh BP, Lennox JL, Currier JS. Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257. Clin Infect Dis. 2015 Jun 15; 60(12):1842-51. PMID: 25767256; PMCID: PMC4660025; DOI: 10.1093/cid/civ193;.
  8. Etemad B, Ghulam-Smith M, Gonzalez O, White LF, Sagar M. Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics. J Virol Methods. 2015 Mar; 214:46-53.View Related Profiles. PMID: 25681527; PMCID: PMC4394631; DOI: 10.1016/j.jviromet.2015.01.006;.
  9. Sagar M. Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus. J Infect Dis. 2014 Dec 15; 210 Suppl 3:S667-73. PMID: 25414422; PMCID: PMC4303076; DOI: 10.1093/infdis/jiu369;.
  10. Etemad B, Gonzalez OA, White L, Laeyendecker O, Kirk GD, Mehta S, Sagar M. Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users. Retrovirology. 2014; 11:106.View Related Profiles. PMID: 25430652; PMCID: PMC4253609; DOI: 10.1186/s12977-014-0106-8;.
Showing 10 of 37 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 19 distinct years, with a maximum of 4 publications in 2012


Available to Mentor as: (Review Mentor Role Definitions):
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  • Career Mentor
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Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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