Keywords
Last Name

Satish K. Singh, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8330
ORCID ORCID Icon0000-0002-7664-3155
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine

InstitutionVA Boston Healthcare System

 Research Expertise & Professional Interests
Areas of expertise: Clinical gastroenterology, endoscopy, endoscopic research, advanced endoscopic imaging, confocal endomicroscopy, image processing, biomedical engineering, biophotonics, mucosal imaging, optical biopsy, computer-aided diagnosis, ion transport, intestinal glucose transport, incretin hormones

 Self-Described Keywords
  • diarrhea
  • Early Detection of Cancer
  • microscopy, confocal
  • obesity
  • Optics and Photonics
  • Sodium-Glucose Transport Proteins
  • spectrum analysis
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Di Leo M, Leandro G, Singh SK, Mariani A, Bianco M, Zuppardo RA, Goni E, Rogger TM, Di Mario F, Guslandi M, De Cobelli F, Del Maschio A, Testoni PA, Cavestro GM. Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis. Pancreas. 2017 Feb; 46(2):225-229. PMID: 27846144.
    View in: PubMed
  2. Atkinson C, Singh S, Fisichella PM. Volumetric laser endomicroscopy in the detection of neoplastic lesions of the esophagus. Dig Liver Dis. 2016 Jun; 48(6):692. PMID: 26976783.
    View in: PubMed
  3. Kumar S, Thangakani AM, Nagarajan R, Singh SK, Velmurugan D, Gromiha MM. Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions. Sci Rep. 2016 Feb 29; 6:22258. PMID: 26924748.
    View in: PubMed
  4. Tomar DS, Kumar S, Singh SK, Goswami S, Li L. Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development. MAbs. 2016; 8(2):216-28. PMID: 26736022.
    View in: PubMed
  5. Dubey SR, Singh SK, Singh RK. Local Wavelet Pattern: A New Feature Descriptor for Image Retrieval in Medical CT Databases. IEEE Trans Image Process. 2015 Dec; 24(12):5892-903. PMID: 26513789.
    View in: PubMed
  6. Rodriguez-Diaz E, Baffy G, Singh SK. Probe-based confocal laser endomicroscopy quantitative morphometric markers associated with portal hypertension in duodenal mucosa. Liver Int. 2016 Feb; 36(2):223-31. PMID: 26133980.
    View in: PubMed
  7. Wang KK, Carr-Locke DL, Singh SK, Neumann H, Bertani H, Galmiche JP, Arsenescu RI, Caillol F, Chang KJ, Chaussade S, Coron E, Costamagna G, Dlugosz A, Ian Gan S, Giovannini M, Gress FG, Haluszka O, Ho KY, Kahaleh M, Konda VJ, Prat F, Shah RJ, Sharma P, Slivka A, Wolfsen HC, Zfass A. Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence. United European Gastroenterol J. 2015 Jun; 3(3):230-54. PMID: 26137298.
    View in: PubMed
  8. Singh SK, Luisi DL, Pak RH. Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability. Pharm Res. 2015 Nov; 32(11):3541-71. PMID: 25986175.
    View in: PubMed
  9. Singh R, Allam BK, Singh N, Kumari K, Singh SK, Singh KN. A Direct Metal-Free Decarboxylative Sulfono Functionalization (DSF) of Cinnamic Acids to a,ß-Unsaturated Phenyl Sulfones. Org Lett. 2015 Jun 5; 17(11):2656-9. PMID: 25954832.
    View in: PubMed
  10. Narhi LO, Corvari V, Ripple DC, Afonina N, Cecchini I, Defelippis MR, Garidel P, Herre A, Koulov AV, Lubiniecki T, Mahler HC, Mangiagalli P, Nesta D, Perez-Ramirez B, Polozova A, Rossi M, Schmidt R, Simler R, Singh S, Spitznagel TM, Weiskopf A, Wuchner K. Subvisible (2-100 µm) Particle Analysis During Biotherapeutic Drug Product Development: Part 1, Considerations and Strategy. J Pharm Sci. 2015 Jun; 104(6):1899-908. PMID: 25832583.
    View in: PubMed
  11. Robles LY, Singh S, Fisichella PM. Emerging enhanced imaging technologies of the esophagus: spectroscopy, confocal laser endomicroscopy, and optical coherence tomography. J Surg Res. 2015 May 15; 195(2):502-14. PMID: 25819772.
    View in: PubMed
  12. Nichols P, Li L, Kumar S, Buck PM, Singh SK, Goswami S, Balthazor B, Conley TR, Sek D, Allen MJ. Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions. MAbs. 2015; 7(1):212-30. PMID: 25559441.
    View in: PubMed
  13. Dubey SR, Singh SK, Singh RK. Rotation and illumination invariant interleaved intensity order-based local descriptor. IEEE Trans Image Process. 2014 Dec; 23(12):5323-33. PMID: 25248185.
    View in: PubMed
  14. Buck PM, Chaudhri A, Kumar S, Singh SK. Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: insights from coarse-grained simulations. Mol Pharm. 2015 Jan 5; 12(1):127-39. PMID: 25383990.
    View in: PubMed
  15. Cavestro GM, Leandro G, Di Leo M, Zuppardo RA, Morrow OB, Notaristefano C, Rossi G, Testoni SG, Mazzoleni G, Alessandri M, Goni E, Singh SK, Giliberti A, Bianco M, Fanti L, Viale E, Arcidiacono PG, Mariani A, Petrone MC, Testoni PA. A single-centre prospective, cohort study of the natural history of acute pancreatitis. Dig Liver Dis. 2015 Mar; 47(3):205-10. PMID: 25475611.
    View in: PubMed
  16. Coon SD, Rajendran VM, Schwartz JH, Singh SK. Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1; 308(1):G56-62. PMID: 25377315.
    View in: PubMed
  17. Rodriguez-Diaz E, Huang Q, Cerda SR, O'Brien MJ, Bigio IJ, Singh SK. Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointest Endosc. 2015 Mar; 81(3):539-47. PMID: 25257128.
    View in: PubMed
  18. Kumar B, Verma VK, Singh SK, Kumar S, Sharma CS, Akolkar AB. Polychlorinated Biphenyls in Residential Soils and their Health Risk and Hazard in an Industrial City in India. J Public Health Res. 2014 Jul 2; 3(2):252. PMID: 25343135.
    View in: PubMed
  19. Li L, Kumar S, Buck PM, Burns C, Lavoie J, Singh SK, Warne NW, Nichols P, Luksha N, Boardman D. Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties. Pharm Res. 2014 Nov; 31(11):3161-78. PMID: 24906598.
    View in: PubMed
  20. Rodriguez-Diaz E, Atkinson C, Jepeal LI, Berg A, Huang CS, Cerda SR, O'Brien MJ, Bigio IJ, Farraye FA, Singh SK. Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes. Inflamm Bowel Dis. 2014 Jun; 20(6):1029-36. PMID: 24798637.
    View in: PubMed
  21. Guo J, Kumar S, Prashad A, Starkey J, Singh SK. Assessment of physical stability of an antibody drug conjugate by higher order structure analysis: impact of thiol- maleimide chemistry. Pharm Res. 2014 Jul; 31(7):1710-23. PMID: 24464270.
    View in: PubMed
  22. Buck PM, Kumar S, Singh SK. Consequences of glycan truncation on Fc structural integrity. MAbs. 2013 Nov-Dec; 5(6):904-16. PMID: 24492344.
    View in: PubMed
  23. Buck PM, Kumar S, Singh SK. On the role of aggregation prone regions in protein evolution, stability, and enzymatic catalysis: insights from diverse analyses. PLoS Comput Biol. 2013; 9(10):e1003291. PMID: 24146608.
    View in: PubMed
  24. Coon SD, Schwartz JH, Rajendran VM, Jepeal L, Singh SK. Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum. Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15; 305(10):G678-84. PMID: 24072682.
    View in: PubMed
  25. Bakhru MR, Sethi A, Jamidar PA, Singh SK, Kwon RS, Siddiqui UD, Sawhney M, Talreja JP, Kline P, Malik U, Gaidhane M, Sauer BG, Kahaleh M. Interobserver agreement for confocal imaging of ampullary lesions: a multicenter single-blinded study. J Clin Gastroenterol. 2013 May-Jun; 47(5):440-2. PMID: 23340063.
    View in: PubMed
  26. Huang S, Do J, Mahalanabis M, Fan A, Zhao L, Jepeal L, Singh SK, Klapperich CM. Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis. PLoS One. 2013; 8(3):e60059. PMID: 23555883.
    View in: PubMed
  27. Miller MA, Rodrigues MA, Glass MA, Singh SK, Johnston KP, Maynard JA. Frozen-state storage stability of a monoclonal antibody: aggregation is impacted by freezing rate and solute distribution. J Pharm Sci. 2013 Apr; 102(4):1194-208. PMID: 23400717.
    View in: PubMed
  28. Tewary K, Singh VK, Singh SK, Tiwary P, Garg A, Joshi KK. Epidemiology of diabetes mellitus in young population in rural districts of northern Bihar. J Indian Med Assoc. 2013 Feb; 111(2):103-6. PMID: 24003567.
    View in: PubMed
  29. Buck PM, Kumar S, Singh SK. Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics. Protein Eng Des Sel. 2013 Mar; 26(3):195-205. PMID: 23188804.
    View in: PubMed
  30. Wang X, Kumar S, Buck PM, Singh SK. Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations. Proteins. 2013 Mar; 81(3):443-60. PMID: 23065923.
    View in: PubMed
  31. Talreja JP, Sethi A, Jamidar PA, Singh SK, Kwon RS, Siddiqui UD, Sawhney M, Bakhru MR, Gaidhane M, Kline P, Sauer BG, Kahaleh M. Interpretation of probe-based confocal laser endomicroscopy of indeterminate biliary strictures: is there any interobserver agreement? Dig Dis Sci. 2012 Dec; 57(12):3299-302. PMID: 22875310.
    View in: PubMed
  32. Barbosa MD, Kumar S, Loughrey H, Singh SK. Biosimilars and biobetters as tools for understanding and mitigating the immunogenicity of biotherapeutics. Drug Discov Today. 2012 Dec; 17(23-24):1282-8. PMID: 22796124.
    View in: PubMed
  33. Singh SK, Cousens LP, Alvarez D, Mahajan PB. Determinants of immunogenic response to protein therapeutics. Biologicals. 2012 Sep; 40(5):364-8. PMID: 22770604.
    View in: PubMed
  34. Cavestro GM, Mariani A, Singh SK, Arcidiacono PG, Testoni PA. Study design biases in pancreatic inflammatory diseases. Gut. 2012 Dec; 61(12):1778-9; author reply 1779. PMID: 22661459.
    View in: PubMed
  35. Li N, Osborne B, Singh SK, Wang W. Metal-leachate-induced conjugate protein instability. J Pharm Sci. 2012 Aug; 101(8):2733-43. PMID: 22644953.
    View in: PubMed
  36. Kumar S, Mitchell MA, Rup B, Singh SK. Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies. J Pharm Sci. 2012 Aug; 101(8):2686-701. PMID: 22619033.
    View in: PubMed
  37. Wang W, Singh SK, Li N, Toler MR, King KR, Nema S. Immunogenicity of protein aggregates--concerns and realities. Int J Pharm. 2012 Jul 15; 431(1-2):1-11. PMID: 22546296.
    View in: PubMed
  38. Singh SK, O'Hara B, Talukder JR, Rajendran VM. Aldosterone induces active K? secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon. Am J Physiol Cell Physiol. 2012 May 1; 302(9):C1353-60. PMID: 22322970.
    View in: PubMed
  39. Zhou S, Evans B, Schöneich C, Singh SK. Biotherapeutic formulation factors affecting metal leachables from stainless steel studied by design of experiments. AAPS PharmSciTech. 2012 Mar; 13(1):284-94. PMID: 22246735.
    View in: PubMed
  40. Singh SK, Toler MR. Monitoring of subvisible particles in therapeutic proteins. Methods Mol Biol. 2012; 899:379-401. PMID: 22735966.
    View in: PubMed
  41. Buck PM, Kumar S, Wang X, Agrawal NJ, Trout BL, Singh SK. Computational methods to predict therapeutic protein aggregation. Methods Mol Biol. 2012; 899:425-51. PMID: 22735968.
    View in: PubMed
  42. Agrawal NJ, Kumar S, Wang X, Helk B, Singh SK, Trout BL. Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions. J Pharm Sci. 2011 Dec; 100(12):5081-95. PMID: 21789769.
    View in: PubMed
  43. Huang M, Horwitz TS, Zweiben C, Singh SK. Impact of extractables/leachables from filters on stability of protein formulations. J Pharm Sci. 2011 Nov; 100(11):4617-30. PMID: 21695696.
    View in: PubMed
  44. Wang X, Kumar S, Singh SK. Disulfide scrambling in IgG2 monoclonal antibodies: insights from molecular dynamics simulations. Pharm Res. 2011 Dec; 28(12):3128-44. PMID: 21671135.
    View in: PubMed
  45. Rodriguez-Diaz E, Castanon DA, Singh SK, Bigio IJ. Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia. J Biomed Opt. 2011 Jun; 16(6):067009. PMID: 21721830.
    View in: PubMed
  46. Rodriguez-Diaz E, Bigio IJ, Singh SK. INTEGRATED OPTICAL TOOLS FOR MINIMALLY INVASIVE DIAGNOSIS AND TREATMENT AT GASTROINTESTINAL ENDOSCOPY. Robot Comput Integr Manuf. 2011 Apr 1; 27(2):249-256. PMID: 21152112.
    View in: PubMed
  47. Kumar S, Singh SK, Wang X, Rup B, Gill D. Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions. Pharm Res. 2011 May; 28(5):949-61. PMID: 21437790.
    View in: PubMed
  48. Zhou S, Schöneich C, Singh SK. Biologics formulation factors affecting metal leachables from stainless steel. AAPS PharmSciTech. 2011 Mar; 12(1):411-21. PMID: 21360314.
    View in: PubMed
  49. Rodrigues MA, Miller MA, Glass MA, Singh SK, Johnston KP. Effect of freezing rate and dendritic ice formation on concentration profiles of proteins frozen in cylindrical vessels. J Pharm Sci. 2011 Apr; 100(4):1316-29. PMID: 24081467.
    View in: PubMed
  50. Zhou S, Zhang B, Sturm E, Teagarden DL, Schöneich C, Kolhe P, Lewis LM, Muralidhara BK, Singh SK. Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody. J Pharm Sci. 2010 Oct; 99(10):4239-50. PMID: 20737631.
    View in: PubMed
  51. Barnard JG, Singh S, Randolph TW, Carpenter JF. Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway. J Pharm Sci. 2011 Feb; 100(2):492-503. PMID: 20803602.
    View in: PubMed
  52. Singh SK. Impact of product-related factors on immunogenicity of biotherapeutics. J Pharm Sci. 2011 Feb; 100(2):354-87. PMID: 20740683.
    View in: PubMed
  53. Singh SK, Afonina N, Awwad M, Bechtold-Peters K, Blue JT, Chou D, Cromwell M, Krause HJ, Mahler HC, Meyer BK, Narhi L, Nesta DP, Spitznagel T. An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics. J Pharm Sci. 2010 Aug; 99(8):3302-21. PMID: 20310025.
    View in: PubMed
  54. Nanda Kumar NS, Singh SK, Rajendran VM. Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G707-14. PMID: 20616305.
    View in: PubMed
  55. Kolhe P, Amend E, Singh SK. Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation. Biotechnol Prog. 2010 May-Jun; 26(3):727-33. PMID: 20039442.
    View in: PubMed
  56. Wang X, Singh SK, Kumar S. Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis. Pharm Res. 2010 Aug; 27(8):1512-29. PMID: 20422267.
    View in: PubMed
  57. Cavestro GM, Zuppardo RA, Bertolini S, Sereni G, Frulloni L, Okolicsanyi S, Calzolari C, Singh SK, Sianesi M, Del Rio P, Leandro G, Franzè A, Di Mario F. Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. Am J Gastroenterol. 2010 Jan; 105(1):199-206. PMID: 19844201.
    View in: PubMed
  58. Gillers S, Atkinson CD, Bartoo AC, Mahalanabis M, Boylan MO, Schwartz JH, Klapperich C, Singh SK. Microscale sample preparation for PCR of C. difficile infected stool. J Microbiol Methods. 2009 Aug; 78(2):203-7. PMID: 19505511.
    View in: PubMed
  59. Kulinski MD, Mahalanabis M, Gillers S, Zhang JY, Singh S, Klapperich CM. Sample preparation module for bacterial lysis and isolation of DNA from human urine. Biomed Microdevices. 2009 Jun; 11(3):671-8. PMID: 19130239.
    View in: PubMed
  60. Wang X, Das TK, Singh SK, Kumar S. Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs. 2009 May-Jun; 1(3):254-67. PMID: 20065649.
    View in: PubMed
  61. Santos S, Chu KK, Lim D, Bozinovic N, Ford TN, Hourtoule C, Bartoo AC, Singh SK, Mertz J. Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle. J Biomed Opt. 2009 May-Jun; 14(3):030502. PMID: 19566286.
    View in: PubMed
  62. Singh SK, Bartoo AC, Krishnan S, Boylan MO, Schwartz JH, Michael Wolfe M. Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport. Obesity (Silver Spring). 2008 Nov; 16(11):2412-6. PMID: 18719661.
    View in: PubMed
  63. Reif R, Amorosino MS, Calabro KW, A'Amar O, Singh SK, Bigio IJ. Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures. J Biomed Opt. 2008 Jan-Feb; 13(1):010502. PMID: 18315347.
    View in: PubMed
  64. Bigio IJ, Singh SK. Gastrointestinal cancer surveillance by optical sensing. Clin Cancer Res. 2007 Aug 1; 13(15 Pt 1):4315-6. PMID: 17671109.
    View in: PubMed
  65. Wang W, Singh S, Zeng DL, King K, Nema S. Antibody structure, instability, and formulation. J Pharm Sci. 2007 Jan; 96(1):1-26. PMID: 16998873.
    View in: PubMed
  66. Goyal PK, Singh SK, Sharma MK, Rupert E. Giant left anterior descending artery aneurysm. Ann Card Anaesth. 2006 Jul; 9(2):155. PMID: 17699899.
    View in: PubMed
  67. Yang Q, Li G, Singh SK, Alexander EA, Schwartz JH. Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells. J Am Soc Nephrol. 2006 Jul; 17(7):1858-66. PMID: 16769747.
    View in: PubMed
  68. Moore TC, Jepeal LI, Boylan MO, Singh SK, Boyd N, Beer DG, Chang AJ, Wolfe MM. Gastrin stimulates receptor-mediated proliferation of human esophageal adenocarcinoma cells. Regul Pept. 2004 Aug 15; 120(1-3):195-203. PMID: 15177938.
    View in: PubMed
  69. Toivola DM, Krishnan S, Binder HJ, Singh SK, Omary MB. Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol. 2004 Mar 15; 164(6):911-21. PMID: 15007064.
    View in: PubMed
  70. Ruchalski K, Mao H, Singh SK, Wang Y, Mosser DD, Li F, Schwartz JH, Borkan SC. HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1483-93. PMID: 12930708.
    View in: PubMed
  71. Singh SK, Mennone A, Gigliozzi A, Fraioli F, Boyer JL. Cl(-)-dependent secretory mechanisms in isolated rat bile duct epithelial units. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G438-46. PMID: 11447024.
    View in: PubMed
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