Vijaya Kolachalama, PhD
Adjunct Assistant Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

PhD, University of Southampton

The Kolachalama Laboratory's work is focused on three areas:

1. Machine learning and computer vision for prognosis

Data analytics is poised to help deliver precision medicine, yet achieving this goal is nontrivial. Machine learning and image processing techniques along with developments in software and hardware technologies allow us to consider questions across scales. We leverage these tools for pattern recognition and understanding pathophysiological mechanisms that would pave way towards developing biomedical technologies that are of prognostic relevance.

2. Machine learning and cardiovascular simulation

Cardiovascular applications are among the most important and widely studied cases of medical simulation. Devices such as stents and balloon catheters are used millions of times each year to help manage coronary heart disease, the leading cause of global mortality. Disease progression as well as the success and failure of such devices depend on local physical and biochemical processes coupled within complex physiological environments. Designing and achieving optimal device performance requires that we understand the confluence of fluid flow, drug transport and tissue reactivity coupled within relevant, often patient-specific environments. Recognizing this need, we utilize the theory and practice the application of machine learning to study a range of physiologic factors and their variations on several outputs of interest within the cardiovascular domain.

3. Mechanisms of endovascular therapies

Computational modeling approaches quantify aspects of device-based therapies at a resolution that is not possible to achieve using bench-top investigation or in vivo models alone. The models that we developed have explained the role of physiologic factors in determining maps of spatiotemporal arterial distribution patterns for drug-eluting devices as a function of intrinsic device design, relative device position and pulsatile nature of blood flow. We have extended models simulating idealized settings of physiology to real world issues and further examine and predict arterial tissue response that varies due to procedural settings, device composition, arterial wall ultrastructure and disease, physiologic changes within complex vascular anatomies, vascular injury and the mode of drug delivery. Understanding the mechanisms of endovascular therapies and developing new technologies is one of the core research themes of our laboratory.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150.View Related Profiles. PMID: 27661103; DOI: 10.18632/oncotarget.12107;.
  2. Mandal PK, Sarifuddin, Kolachalama VB. Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition. Cardiovasc Eng Technol. 2016 Dec; 7(4):406-419. PMID: 27443840.
  3. O'Brien CC, Kolandaivelu K, Brown J, Lopes AC, Kunio M, Kolachalama VB, Edelman ER. Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants. PLoS One. 2016; 11(2):e0149178. PMID: 26906566; PMCID: PMC4764338; DOI: 10.1371/journal.pone.0149178;.
  4. O''Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Ann Biomed Eng. 2016 Jul; 44(7):2251-60. PMID: 26732391; PMCID: PMC4893976; DOI: 10.1007/s10439-015-1518-x;.
  5. Ferdous J, Kolachalama VB, Kolandaivelu K, Shazly T. Degree of bioresorbable vascular scaffold expansion modulates loss of essential function. Acta Biomater. 2015 Oct; 26:195-204. PMID: 26277377; PMCID: PMC4584207; DOI: 10.1016/j.actbio.2015.08.009;.
  6. Kolandaivelu K, O'Brien CC, Shazly T, Edelman ER, Kolachalama VB. Enhancing physiologic simulations using supervised learning on coarse mesh solutions. J R Soc Interface. 2015 Mar 6; 12(104):20141073. PMID: 25652458; PMCID: PMC4345474; DOI: 10.1098/rsif.2014.1073;.
  7. Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama VB, Shazly T. Effect of spinal cord compression on local vascular blood flow and perfusion capacity. PLoS One. 2014; 9(9):e108820. PMID: 25268384; PMCID: PMC4182502; DOI: 10.1371/journal.pone.0108820;.
  8. Martorell J, Santomá P, Kolandaivelu K, Kolachalama VB, Melgar-Lesmes P, Molins JJ, Garcia L, Edelman ER, Balcells M. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Cardiovasc Res. 2014 Jul 1; 103(1):37-46. PMID: 24841070; PMCID: PMC4670884; DOI: 10.1093/cvr/cvu124;.
  9. Kolachalama VB, Pacetti SD, Franses JW, Stankus JJ, Zhao HQ, Shazly T, Nikanorov A, Schwartz LB, Tzafriri AR, Edelman ER. Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy. Circulation. 2013 May 21; 127(20):2047-55. PMID: 23584359; PMCID: PMC3748613; DOI: 10.1161/CIRCULATIONAHA.113.002051;.
  10. O'Brien CC, Kolachalama VB, Barber TJ, Simmons A, Edelman ER. Impact of flow pulsatility on arterial drug distribution in stent-based therapy. J Control Release. 2013 Jun 10; 168(2):115-24. PMID: 23541929; PMCID: PMC3697861; DOI: 10.1016/j.jconrel.2013.03.014;.
Showing 10 of 21 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 21 publications over 9 distinct years, with a maximum of 4 publications in 2016

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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