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Last Name

Christopher V. Gabel, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4390
ORCID ORCID Icon0000-0002-2763-3938
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Research Expertise & Professional Interests
Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

 Self-Described Keywords
  • C. elegans
  • Femtosecond laser ablation
  • neuronal damage
  • neuronal regeneration
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Sun L, Shay J, McLoed M, Roodhouse K, Chung SH, Clark CM, Pirri JK, Alkema MJ, Gabel CV. Neuronal Regeneration in C. elegans Requires Subcellular Calcium Release by Ryanodine Receptor Channels and Can Be Enhanced by Optogenetic Stimulation. J Neurosci. 2014 Nov 26; 34(48):15947-56.
    View in: PubMed
  2. Chung SH, Schmalz A, Ruiz RC, Gabel CV, Mazur E. Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development. Cell Rep. 2013 Jul 25; 4(2):316-26.
    View in: PubMed
  3. Chung SH, Sun L, Gabel CV. In vivo neuronal calcium imaging in C. elegans. J Vis Exp. 2013; (74).
    View in: PubMed
  4. Reina CP, Driscoll M, Gabel CV. Neuronal repair: Apoptotic proteins make good. Worm. 2013 Apr 1; 2(2):e22285.
    View in: PubMed
  5. Kim E, Sun L, Gabel CV, Fang-Yen C. Long-term imaging of Caenorhabditis elegans using nanoparticle-mediated immobilization. PLoS One. 2013; 8(1):e53419.
    View in: PubMed
  6. Pinan-Lucarre B, Gabel CV, Reina CP, Hulme SE, Shevkoplyas SS, Slone RD, Xue J, Qiao Y, Weisberg S, Roodhouse K, Sun L, Whitesides GM, Samuel A, Driscoll M. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS Biol. 2012; 10(5):e1001331.
    View in: PubMed
  7. Fang-Yen C, Gabel CV, Samuel AD, Bargmann CI, Avery L. Laser microsurgery in Caenorhabditis elegans. Methods Cell Biol. 2012; 107:177-206.
    View in: PubMed
  8. Wolozin B, Gabel C, Ferree A, Guillily M, Ebata A. Watching worms whither: modeling neurodegeneration in C. elegans. Prog Mol Biol Transl Sci. 2011; 100:499-514.
    View in: PubMed
  9. Ha HI, Hendricks M, Shen Y, Gabel CV, Fang-Yen C, Qin Y, Colón-Ramos D, Shen K, Samuel AD, Zhang Y. Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans. Neuron. 2010 Dec 22; 68(6):1173-86.
    View in: PubMed
  10. Gabel A, Krapivsky PL, Redner S. Facilitated asymmetric exclusion. Phys Rev Lett. 2010 Nov 19; 105(21):210603.
    View in: PubMed
  11. Luo L, Gabel CV, Ha HI, Zhang Y, Samuel AD. Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorants. J Neurophysiol. 2008 May; 99(5):2617-25.
    View in: PubMed
  12. Gabel CV, Antoine F, Antonie F, Chuang CF, Samuel AD, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008 Mar; 135(6):1129-36.
    View in: PubMed
  13. Chi CA, Clark DA, Lee S, Biron D, Luo L, Gabel CV, Brown J, Sengupta P, Samuel AD. Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans. J Exp Biol. 2007 Nov; 210(Pt 22):4043-52.
    View in: PubMed
  14. Gabel CV, Gabel H, Pavlichin D, Kao A, Clark DA, Samuel AD. Neural circuits mediate electrosensory behavior in Caenorhabditis elegans. J Neurosci. 2007 Jul 11; 27(28):7586-96.
    View in: PubMed
  15. Korta J, Clark DA, Gabel CV, Mahadevan L, Samuel AD. Mechanosensation and mechanical load modulate the locomotory gait of swimming C. elegans. J Exp Biol. 2007 Jul; 210(Pt 13):2383-9.
    View in: PubMed
  16. Clark DA, Gabel CV, Gabel H, Samuel AD. Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients. J Neurosci. 2007 Jun 6; 27(23):6083-90.
    View in: PubMed
  17. Clark DA, Gabel CV, Lee TM, Samuel AD. Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans. J Neurophysiol. 2007 Mar; 97(3):1903-10.
    View in: PubMed
  18. Biron D, Shibuya M, Gabel C, Wasserman SM, Clark DA, Brown A, Sengupta P, Samuel AD. A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans. Nat Neurosci. 2006 Dec; 9(12):1499-505.
    View in: PubMed
  19. Chung SH, Clark DA, Gabel CV, Mazur E, Samuel AD. The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation. BMC Neurosci. 2006; 7:30.
    View in: PubMed
  20. Colosimo ME, Brown A, Mukhopadhyay S, Gabel C, Lanjuin AE, Samuel AD, Sengupta P. Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Curr Biol. 2004 Dec 29; 14(24):2245-51.
    View in: PubMed
  21. Gabel CV, Berg HC. The speed of the flagellar rotary motor of Escherichia coli varies linearly with protonmotive force. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8748-51.
    View in: PubMed
  22. Gifford SC, Frank MG, Derganc J, Gabel C, Austin RH, Yoshida T, Bitensky MW. Parallel microchannel-based measurements of individual erythrocyte areas and volumes. Biophys J. 2003 Jan; 84(1):623-33.
    View in: PubMed
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