Christopher V. Gabel, PhD
Assistant Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Harvard University



Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Assistant Professor
Boston University School of Medicine
Department of Pharmacology & Experimental Therapeutics




Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage and Regeneration
05/01/2016 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS077929-05

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage
05/01/2013 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS077929-03

C. elegans model for mammalian lesion-conditioned axon regeneration
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS078580-02

Wedge-based approach for simultaneous multi-channel microscopy
10/01/2014 - 07/31/2015 (PI)
Physical Sciences, Inc. NIH NIGMS
1R43GM112403



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature. 2017 Feb 16; 542(7641):367-371. PMID: 28178240; DOI: 10.1038/nature21362;.
  2. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275; DOI: 10.1016/j.neuron.2016.10.060;.
  3. Chung SH, Awal MR, Shay J, McLoed MM, Mazur E, Gabel CV. Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):E2852-60.View Related Profiles. PMID: 27078101; PMCID: PMC4878464; DOI: 10.1073/pnas.1600564113;.
  4. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19.View Related Profiles. PMID: 26526391; DOI: 10.1016/j.neuron.2015.10.005;.
  5. He S, Philbrook A, McWhirter R, Gabel CV, Taub DG, Carter MH, Hanna IM, Francis MM, Miller DM. Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein. Curr Biol. 2015 Oct 5; 25(19):2541-8.View Related Profiles. PMID: 26387713; PMCID: PMC4596794; DOI: 10.1016/j.cub.2015.08.022;.
  6. Sun L, Shay J, McLoed M, Roodhouse K, Chung SH, Clark CM, Pirri JK, Alkema MJ, Gabel CV. Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation. J Neurosci. 2014 Nov 26; 34(48):15947-56.View Related Profiles. PMID: 25429136; PMCID: PMC4244466; DOI: 10.1523/JNEUROSCI.4238-13.2014;.
  7. Gruner M, Nelson D, Winbush A, Hintz R, Ryu L, Chung SH, Kim K, Gabel CV, van der Linden AM. Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. PLoS Genet. 2014 Oct; 10(10):e1004707.View Related Profiles. PMID: 25357003; PMCID: PMC4214617; DOI: 10.1371/journal.pgen.1004707;.
  8. Chung SH, Schmalz A, Ruiz RC, Gabel CV, Mazur E. Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development. Cell Rep. 2013 Jul 25; 4(2):316-26.View Related Profiles. PMID: 23871668; DOI: 10.1016/j.celrep.2013.06.027;.
  9. Chung SH, Sun L, Gabel CV. In vivo neuronal calcium imaging in C. elegans. J Vis Exp. 2013; (74).View Related Profiles. PMID: 23603812; DOI: 10.3791/50357;.
  10. Reina CP, Driscoll M, Gabel CV. Neuronal repair: Apoptotic proteins make good. Worm. 2013 Apr 1; 2(2):e22285. PMID: 24058867; PMCID: PMC3704441.
Showing 10 of 28 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 28 publications over 13 distinct years, with a maximum of 4 publications in 2007 and 2013

YearPublications
20032
20041
20063
20074
20082
20102
20111
20122
20134
20142
20152
20162
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

C. elegans
Femtosecond laser ablation
neuronal damage
neuronal regeneration
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