Xue Han, PhD
Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of Wisconsin-Madison



Dr. Han’s research interests include neurotechnology, optical neural modulation, optogenetics, neural prosthetics, neural network dynamics, brain rhythms, neurological and psychiatric diseases, and cognition.

Current Research:

Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. Accordingly, we are discovering design principles for novel neuromodulation therapies. We invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As an example, we have pioneered several technologies for silencing specific cells in the brain using pulses of light. We have also recently participated the first pre-clinical testing of a novel neurotechnology, optical neural modulation. Using these novel neurotechnologies and classical ones such as deep brain stimulation (DBS), we modulate the function of neural circuits to establish causal links between neural dynamics and behavioral phenomena (e.g., movement, attention, memory, and decision making). One of our current interests is the investigation of how neural synchrony arises within and across brain regions, and how synchronous activity contributes to normal cognition and pathology.

Assistant Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics




NRT UtB: Neurophotonics
09/01/2016 - 08/31/2021 (Co-PI)
National Science Foundation
DGE-1633516

Charaterize functional connectivitiy of hippocampal adult born neurogenesis during critical period
04/15/2016 - 03/31/2018 (PI)
NIH/National Institute of Mental Health
5R21MH109941-02

New Tools and Principles for Understanding the Biophysical Mechanisms of Ultrasound Neuromodulation
09/15/2015 - 09/14/2017 (PI)
Department of Defense/DARPA

Causal Analysis of Electrically Connected Neural Networks
09/01/2016 - 08/31/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
4R01NS087950-04

Multiplexed Multiphoton Interrogation of Brain Connectomics
09/30/2015 - 08/31/2017 (PI)
NIH/National Eye Institute
5R21EY026410-02

Light Controllable Nanorobot for Uncaging Arbitrary Bioactive Molecules
09/30/2012 - 08/31/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1DP2NS082126-01

Neural Circuit Mechanisms of Attention
08/01/2012 - 07/31/2017 (PI)
The Pew Charitable Trusts

Analysis and Bioengineering of Optogenetic Rhodopsins
07/01/2013 - 06/30/2017 (Co-PI)
PI: Kenneth J. Rothschild, PhD
National Science Foundation
CBET-1264434

Drive Principles of Brain Neural Network Architechture Using Novel Machine Learning Algorithms
04/01/2016 - 03/31/2017 (PI)
Northeastern University The Grainger Fdn Inc

Causal Analysis of Electrically Connected Neural Networks
09/30/2013 - 08/31/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS087950-03

Showing 10 of 18 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Characterize the functional connectivity of hippocampal adult neurogenesis during critical period 5R21MH109941-02
2016 Characterize the functional connectivity of hippocampal adult neurogenesis during critical period 1R21MH109941-01
2016 Multiplexed Multiphoton Interrogation of Brain Connectomics 5R21EY026410-02 1
2016 Causal Analysis of Electrically Connected Neural Networks 4R01NS087950-04 3
2015 Causal Analysis of Electrically Connected Neural Networks 5R01NS087950-03 3
2014 Causal Analysis of Electrically Connected Neural Networks 5R01NS087950-02 3
2013 Causal Analysis of Electrically Connected Neural Networks 1R01NS087950-01 3
2013 Striatal Origin of Pathological Beta Oscillations in Parkinson's Disease 5R21NS078660-02 2
2012 Light-Actuatable NanoRobots for Molecular Uncaging 1DP2NS082126-01 4
2012 Striatal Origin of Pathological Beta Oscillations in Parkinson's Disease 1R21NS078660-01A1 2
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kohman RE, Han X. Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers. Chem Commun (Camb). 2015 Apr 4; 51(26):5747-50. PMID: 25720373; PMCID: PMC4394657; DOI: 10.1039/c5cc00082c;.
  2. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767; DOI: 10.1002/alr.21436;.
  3. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685; DOI: 10.1002/alr.21361;.
  4. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014; (89).View Related Profiles. PMID: 25077554; DOI: 10.3791/51452;.
  5. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763; PMCID: PMC4184214; DOI: 10.1038/nn.3752;.
  6. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606; DOI: 10.1002/alr.21316;.
  7. Zhang XX, Lamanna CM, Kohman RE, McIntosh TJ, Han X, Grinstaff MW. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup. Soft Matter. 2013 May 05; 9(17).View Related Profiles. PMID: 24391676; DOI: 10.1039/C3SM27633C;.
  8. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694.View Related Profiles. PMID: 23637885; PMCID: PMC3634848; DOI: 10.1371/journal.pone.0061694;.
  9. Sun L, Li J, Zhou K, Zhang M, Yang J, Li Y, Ji B, Zhang Z, Zhu H, Yang L, He G, Gao L, Wei Z, Wang K, Han X, Liu W, Tan L, Yu Y, He L, Wan C. Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats. PLoS One. 2013; 8(4):e60598. PMID: 23577129; PMCID: PMC3618452; DOI: 10.1371/journal.pone.0060598;.
  10. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057; DOI: 10.1002/alr.21166;.
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 12 distinct years, with a maximum of 5 publications in 2014

YearPublications
20041
20051
20061
20071
20081
20092
20101
20112
20124
20134
20145
20151
Contact for Mentoring:


44 Cummington St
Boston MA 02215
Google Map


Han's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department