Keywords
Last Name

Xue Han, PhD

TitleAssistant Professor
InstitutionBoston University College of Engineering
DepartmentBiomedical Engineering
Address44 Cummington Street, Rm. 521
Boston MA 02215
Phone(617) 358-6189
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Research Expertise & Professional Interests
Dr. Han’s research interests include neurotechnology, optical neural modulation, optogenetics, neural prosthetics, neural network dynamics, brain rhythms, neurological and psychiatric diseases, and cognition.

Current Research:

Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. Accordingly, we are discovering design principles for novel neuromodulation therapies. We invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As an example, we have pioneered several technologies for silencing specific cells in the brain using pulses of light. We have also recently participated the first pre-clinical testing of a novel neurotechnology, optical neural modulation. Using these novel neurotechnologies and classical ones such as deep brain stimulation (DBS), we modulate the function of neural circuits to establish causal links between neural dynamics and behavioral phenomena (e.g., movement, attention, memory, and decision making). One of our current interests is the investigation of how neural synchrony arises within and across brain regions, and how synchronous activity contributes to normal cognition and pathology.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kohman RE, Han X. Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers. Chem Commun (Camb). 2015 Apr 4; 51(26):5747-50. PMID: 25720373.
    View in: PubMed
  2. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767.
    View in: PubMed
  3. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685.
    View in: PubMed
  4. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014; (89). PMID: 25077554.
    View in: PubMed
  5. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763.
    View in: PubMed
  6. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606.
    View in: PubMed
  7. Zhang XX, Lamanna CM, Kohman RE, McIntosh TJ, Han X, Grinstaff MW. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup. Soft Matter. 2013 May 5; 9(17). PMID: 24391676.
    View in: PubMed
  8. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694. PMID: 23637885.
    View in: PubMed
  9. Sun L, Li J, Zhou K, Zhang M, Yang J, Li Y, Ji B, Zhang Z, Zhu H, Yang L, He G, Gao L, Wei Z, Wang K, Han X, Liu W, Tan L, Yu Y, He L, Wan C. Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats. PLoS One. 2013; 8(4):e60598. PMID: 23577129.
    View in: PubMed
  10. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057.
    View in: PubMed
  11. Han X. In vivo application of optogenetics for neural circuit analysis. ACS Chem Neurosci. 2012 Aug 15; 3(8):577-84. PMID: 22896801.
    View in: PubMed
  12. Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 May; 15(5):793-802. PMID: 22446880.
    View in: PubMed
  13. Chow BY, Han X, Boyden ES. Genetically encoded molecular tools for light-driven silencing of targeted neurons. Prog Brain Res. 2012; 196:49-61. PMID: 22341320.
    View in: PubMed
  14. Han X. Optogenetics in the nonhuman primate. Prog Brain Res. 2012; 196:215-33. PMID: 22341328.
    View in: PubMed
  15. McCarthy MM, Moore-Kochlacs C, Gu X, Boyden ES, Han X, Kopell N. Striatal origin of the pathologic beta oscillations in Parkinson's disease. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11620-5. PMID: 21697509.
    View in: PubMed
  16. Han X, Chow BY, Zhou H, Klapoetke NC, Chuong A, Rajimehr R, Yang A, Baratta MV, Winkle J, Desimone R, Boyden ES. A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Front Syst Neurosci. 2011; 5:18. PMID: 21811444.
    View in: PubMed
  17. Chow BY, Han X, Dobry AS, Qian X, Chuong AS, Li M, Henninger MA, Belfort GM, Lin Y, Monahan PE, Boyden ES. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature. 2010 Jan 7; 463(7277):98-102. PMID: 20054397.
    View in: PubMed
  18. Han X, Qian X, Stern P, Chuong AS, Boyden ES. Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions. Front Mol Neurosci. 2009; 2:12. PMID: 19753326.
    View in: PubMed
  19. Han X, Qian X, Bernstein JG, Zhou HH, Franzesi GT, Stern P, Bronson RT, Graybiel AM, Desimone R, Boyden ES. Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron. 2009 Apr 30; 62(2):191-8. PMID: 19409264.
    View in: PubMed
  20. Bernstein JG, Han X, Henninger MA, Ko EY, Qian X, Franzesi GT, McConnell JP, Stern P, Desimone R, Boyden ES. Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons. Proc SPIE Int Soc Opt Eng. 2008; 6854:68540H. PMID: 18458792.
    View in: PubMed
  21. Han X, Boyden ES. Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One. 2007; 2(3):e299. PMID: 17375185.
    View in: PubMed
  22. Han X, Jackson MB. Structural transitions in the synaptic SNARE complex during Ca2+-triggered exocytosis. J Cell Biol. 2006 Jan 16; 172(2):281-93. PMID: 16418536.
    View in: PubMed
  23. Han X, Jackson MB. Electrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore. Biophys J. 2005 Mar; 88(3):L20-2. PMID: 15653732.
    View in: PubMed
  24. Han X, Wang CT, Bai J, Chapman ER, Jackson MB. Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis. Science. 2004 Apr 9; 304(5668):289-92. PMID: 15016962.
    View in: PubMed
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