Keywords
Last Name

David J. Salant, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7330
ORCID ORCID Icon0000-0002-3866-3120
Other Positions
TitleSection Chief of Medicine in Nephrology
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionNephrology

 Research Expertise & Professional Interests
Experimental models of immunological glomerular diseases and autoimmunity resembling those seen in man are used to obtain a fundamental understanding of the immunopathogenetic mechanisms of injury.

Antibody-mediated podocyte injury

The primary focus of the Salant laboratory is on the immune basis of glomerular diseases with particular regard to the humoral mechanisms of glomerular cell injury. Current work will elucidate the mechanisms by which antibodies alter the function and morphology of glomerular visceral epithelial cells (podocytes).

1. We have identified the target antigen in human membranous nephropathy as the phospholipase A2 receptor (PLA2R) and shown that about 75% of patients have circulating ant-PLA2R autoantibodies. Current work is directed at defining the mechanisms of podocyte injury induced by anti-PLA2R using a combination of in vitro, in vivo and human genetic techniques. Additional studies will explore the role of anti-PLA2R in the development of recurrent membranous nephropathy post renal transplantation.

2. Ongoing interests include the role of podocyte-specific antibodies, and the effects of complement-mediated injury on podocyte structure, composition of the filtration slit diaphragm and its attachment to the cytoskeleton, and on cell-matrix adhesion using animal models, cell biological and immunochemical methodologies.

Mechanisms of post-inflammatory renal fibrogenesis

We have also developed a murine model of antibody-dependent rapidly progressive glomerulonephritis in which necrotizing and crescentic glomerulonephritis is associated with the activation of chemokine and interstitial-type collagen genes, followed by the development of interstitial fibrosis and renal failure. Since interstitial fibrosis and tubular atrophy are common to all forms of chronic progressive renal diseases and are the most reliable pathological indicators of an adverse long-term prognosis in humans, this mouse model in which the onset of immune injury is rapidly followed (within 5 days) by the induction and proliferation of interstitial cells expressing high levels of mRNA for type I collagen affords a unique opportunity to study the mechanisms of post-inflammatory renal fibrogenesis

 Self-Described Keywords
  • Complement Membrane Attack Complex [D12.776.124.486.274.930]
  • Glomerulonephritis, Membranous [C12.777.419.570.363.625]
  • Podocytes [A05.810.453.324.359.720]
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W. SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 Nov 17; 1(19):e86934. PMID: 27882344.
    View in: PubMed
  2. Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W. Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016 Dec; 90(6):1262-1273. PMID: 27591083.
    View in: PubMed
  3. Hoxha E, Beck LH, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA. An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. J Am Soc Nephrol. 2017 Feb; 28(2):520-531. PMID: 27436855.
    View in: PubMed
  4. Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 05; 134(1):61-72. PMID: 27358438.
    View in: PubMed
  5. Francis JM, Beck LH, Salant DJ. Membranous Nephropathy: A Journey From Bench to Bedside. Am J Kidney Dis. 2016 Jul; 68(1):138-47. PMID: 27085376.
    View in: PubMed
  6. Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH. Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis. 2016 May; 67(5):775-8. PMID: 26744127.
    View in: PubMed
  7. Verma R, Venkatareddy M, Kalinowski A, Patel SR, Salant DJ, Garg P. Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury. Mol Cell Biol. 2016 Feb; 36(4):596-614. PMID: 26644409.
    View in: PubMed
  8. Salant DJ. Podocyte Expression of B7-1/CD80: Is it a Reliable Biomarker for the Treatment of Proteinuric Kidney Diseases with Abatacept? J Am Soc Nephrol. 2016 Apr; 27(4):963-5. PMID: 26400567.
    View in: PubMed
  9. Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J. IL-6 Trans-Signaling Drives Murine Crescentic GN. J Am Soc Nephrol. 2016 Jan; 27(1):132-42. PMID: 26041841.
    View in: PubMed
  10. Kattah A, Ayalon R, Beck LH, Sethi S, Sandor DG, Cosio FG, Gandhi MJ, Lorenz EC, Salant DJ, Fervenza FC. Anti-phospholipase A2 receptor antibodies in recurrent membranous nephropathy. Am J Transplant. 2015 May; 15(5):1349-59. PMID: 25766759.
    View in: PubMed
  11. Tomas NM, Beck LH, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11; 371(24):2277-87. PMID: 25394321.
    View in: PubMed
  12. Timmermans SA, Damoiseaux JG, Heerings-Rewinkel PT, Ayalon R, Beck LH, Schlumberger W, Salant DJ, van Paassen P, Tervaert JW. Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. Am J Clin Pathol. 2014 Jul; 142(1):29-34. PMID: 24926082.
    View in: PubMed
  13. Beck LH, Salant DJ. Membranous nephropathy: from models to man. J Clin Invest. 2014 Jun 2; 124(6):2307-14. PMID: 24892704.
    View in: PubMed
  14. Wiggins RC, Alpers CE, Holzman LB, He JC, Salant DJ, Chugh SS, Natarajan R, Trachtman H, Brasile L, Star RA, Rys-Sikora KE, Moxey-Mims MM, Flessner MF. Glomerular disease: looking beyond pathology. Clin J Am Soc Nephrol. 2014 Jun 6; 9(6):1138-40. PMID: 24700796.
    View in: PubMed
  15. Salant DJ. Introduction: Complement-mediated kidney diseases. Semin Nephrol. 2013 Nov; 33(6):477-8. PMID: 24161034.
    View in: PubMed
  16. Timmermans SA, Ayalon R, van Paassen P, Beck LH, van Rie H, Wirtz JJ, Verseput GH, Frenken LA, Salant DJ, Cohen Tervaert JW. Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy. Am J Kidney Dis. 2013 Dec; 62(6):1223-5. PMID: 24021909.
    View in: PubMed
  17. Dai Y, Gu L, Yuan W, Yu Q, Ni Z, Ross MJ, Kaufman L, Xiong H, Salant DJ, He JC, Chuang PY. Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis. Kidney Int. 2013 Nov; 84(5):950-61. PMID: 23842188.
    View in: PubMed
  18. Salant DJ. Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy? J Am Soc Nephrol. 2013 Mar; 24(4):525-8. PMID: 23492731.
    View in: PubMed
  19. Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W. Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26; 2(1):52-61. PMID: 22840396.
    View in: PubMed
  20. Khosroshahi A, Ayalon R, Beck LH, Salant DJ, Bloch DB, Stone JH. IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor. Int J Rheumatol. 2012; 2012:139409. PMID: 22654915.
    View in: PubMed
  21. Surindran S, Ayalon R, Hasan N, Beck LH, Salant DJ, Barisoni L, Skolnik EY, Beara-Lasic L. Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy. Clin Kidney J. 2012 Apr; 5(2):162-165. PMID: 22833809.
    View in: PubMed
  22. George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb 1; 122(2):674-92. PMID: 22251701.
    View in: PubMed
  23. Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011 Oct; 17(10):1242-50. PMID: 21946538.
    View in: PubMed
  24. Wang H, Li Q, Liu J, Mendelsohn C, Salant DJ, Lu W. Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism. PLoS One. 2011; 6(9):e24763. PMID: 21949750.
    View in: PubMed
  25. Beck LH, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011 Aug; 22(8):1543-50. PMID: 21784898.
    View in: PubMed
  26. Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E, Marasà M, Beck LH, Salant DJ, Benigni A, D'Agati V, Remuzzi G. Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis. 2011 Aug; 58(2):272-5. PMID: 21658826.
    View in: PubMed
  27. Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol. 2011 Jun; 22(6):1137-43. PMID: 21566055.
    View in: PubMed
  28. Hofstra JM, Beck LH, Beck DM, Wetzels JF, Salant DJ. Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011 Jun; 6(6):1286-91. PMID: 21474589.
    View in: PubMed
  29. Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May; 79(10):1099-112. PMID: 21270765.
    View in: PubMed
  30. Salant DJ. Targeting complement C5 in atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2011 Jan; 22(1):7-9. PMID: 21127140.
    View in: PubMed
  31. Salant DJ. Goodpasture's disease--new secrets revealed. N Engl J Med. 2010 Jul 22; 363(4):388-91. PMID: 20660408.
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  32. Klein J, Gonzalez J, Decramer S, Bandin F, Neau E, Salant DJ, Heeringa P, Pesquero JB, Schanstra JP, Bascands JL. Blockade of the kinin B1 receptor ameloriates glomerulonephritis. J Am Soc Nephrol. 2010 Jul; 21(7):1157-64. PMID: 20448019.
    View in: PubMed
  33. Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010 May; 16(5):544-50. PMID: 20418885.
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  34. Beck LH, Salant DJ. Membranous nephropathy: recent travels and new roads ahead. Kidney Int. 2010 May; 77(9):765-70. PMID: 20182413.
    View in: PubMed
  35. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2; 361(1):11-21. PMID: 19571279.
    View in: PubMed
  36. Salant DJ. In search of the elusive membranous nephropathy antigen. Nephron Physiol. 2009; 112(1):p11-2. PMID: 19451724.
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  37. Beck LH, Salant DJ. Treatment of membranous lupus nephritis: where are we now? J Am Soc Nephrol. 2009 Apr; 20(4):690-1. PMID: 19279123.
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  38. Beck LH, Salant DJ. Glomerular and tubulointerstitial diseases. Prim Care. 2008 Jun; 35(2):265-96, vi. PMID: 18486716.
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  39. Pradère JP, Gonzalez J, Klein J, Valet P, Grès S, Salant D, Bascands JL, Saulnier-Blache JS, Schanstra JP. Lysophosphatidic acid and renal fibrosis. Biochim Biophys Acta. 2008 Sep; 1781(9):582-7. PMID: 18455518.
    View in: PubMed
  40. Salant DJ. Intravenous methylprednisolone or plasma exchange for adjunctive therapy of severe renal vasculitis? Nat Clin Pract Nephrol. 2008 Jan; 4(1):14-5. PMID: 17955040.
    View in: PubMed
  41. Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56. PMID: 17675665.
    View in: PubMed
  42. Imai N, Hishikawa K, Marumo T, Hirahashi J, Inowa T, Matsuzaki Y, Okano H, Kitamura T, Salant D, Fujita T. Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. Stem Cells. 2007 Oct; 25(10):2469-75. PMID: 17641247.
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  43. Salant DJ, Sanchorawala V, D'Agati VD. A case of atypical light chain deposition disease--diagnosis and treatment. Clin J Am Soc Nephrol. 2007 Jul; 2(4):858-67. PMID: 17699503.
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  44. Sumi E, Iehara N, Akiyama H, Matsubara T, Mima A, Kanamori H, Fukatsu A, Salant DJ, Kita T, Arai H, Doi T. SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells. Am J Pathol. 2007 Jun; 170(6):1854-64. PMID: 17525254.
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  45. Meyers CM, Geanacopoulos M, Holzman LB, Salant DJ. Glomerular disease workshop. J Am Soc Nephrol. 2005 Dec; 16(12):3472-6. PMID: 16267152.
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  46. Cybulsky AV, Quigg RJ, Salant DJ. Experimental membranous nephropathy redux. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F660-71. PMID: 16159900.
    View in: PubMed
  47. Nakatsue T, Koike H, Han GD, Suzuki K, Miyauchi N, Yuan H, Salant DJ, Gejyo F, Shimizu F, Kawachi H. Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Kidney Int. 2005 Jun; 67(6):2239-53. PMID: 15882266.
    View in: PubMed
  48. Bonegio RG, Fuhro R, Wang Z, Valeri CR, Andry C, Salant DJ, Lieberthal W. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J Am Soc Nephrol. 2005 Jul; 16(7):2063-72. PMID: 15917339.
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  49. Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF. Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol. 2005 May; 16(5):1392-403. PMID: 15800116.
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  50. Trouw LA, Groeneveld TW, Seelen MA, Duijs JM, Bajema IM, Prins FA, Kishore U, Salant DJ, Verbeek JS, van Kooten C, Daha MR. Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest. 2004 Sep; 114(5):679-88. PMID: 15343386.
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  51. Lin F, Salant DJ, Meyerson H, Emancipator S, Morgan BP, Medof ME. Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis. J Immunol. 2004 Feb 15; 172(4):2636-42. PMID: 14764738.
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  52. Saran AM, Yuan H, Takeuchi E, McLaughlin M, Salant DJ. Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy. Kidney Int. 2003 Dec; 64(6):2072-8. PMID: 14633129.
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  53. Adler SG, Salant DJ. An outline of essential topics in glomerular pathophysiology, diagnosis, and treatment for nephrology trainees. Am J Kidney Dis. 2003 Aug; 42(2):395-418. PMID: 12900827.
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  54. Salant DJ, Topham PS. Role of nephrin in proteinuric renal diseases. Springer Semin Immunopathol. 2003 May; 24(4):423-39. PMID: 12778337.
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  55. Yanagita M, Ishimoto Y, Arai H, Nagai K, Ito T, Nakano T, Salant DJ, Fukatsu A, Doi T, Kita T. Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. J Clin Invest. 2002 Jul; 110(2):239-46. PMID: 12122116.
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  56. Lin F, Emancipator SN, Salant DJ, Medof ME. Decay-accelerating factor confers protection against complement-mediated podocyte injury in acute nephrotoxic nephritis. Lab Invest. 2002 May; 82(5):563-9. PMID: 12003997.
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  57. Yuan H, Takeuchi E, Salant DJ. Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F585-91. PMID: 11880318.
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  58. Yuan H, Takeuchi E, Taylor GA, McLaughlin M, Brown D, Salant DJ. Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy. J Am Soc Nephrol. 2002 Apr; 13(4):946-56. PMID: 11912254.
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  59. Shinozaki M, Hirahashi J, Lebedeva T, Liew FY, Salant DJ, Maron R, Kelley VR. IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis. J Clin Invest. 2002 Apr; 109(7):951-60. PMID: 11927622.
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  60. Haskell CA, Hancock WW, Salant DJ, Gao W, Csizmadia V, Peters W, Faia K, Fituri O, Rottman JB, Charo IF. Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. J Clin Invest. 2001 Sep; 108(5):679-88. PMID: 11544273.
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  61. Chugh S, Yuan H, Topham PS, Haydar SA, Mittal V, Taylor GA, Kalluri R, Salant DJ. Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum. Kidney Int. 2001 Feb; 59(2):601-13. PMID: 11168941.
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  62. Kawachi H, Koike H, Kurihara H, Yaoita E, Orikasa M, Shia MA, Sakai T, Yamamoto T, Salant DJ, Shimizu F. Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states. Kidney Int. 2000 May; 57(5):1949-61. PMID: 10792613.
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  63. Topham PS, Csizmadia V, Soler D, Hines D, Gerard CJ, Salant DJ, Hancock WW. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J Clin Invest. 1999 Dec; 104(11):1549-57. PMID: 10587518.
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  64. Topham PS, Kawachi H, Haydar SA, Chugh S, Addona TA, Charron KB, Holzman LB, Shia M, Shimizu F, Salant DJ. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin. J Clin Invest. 1999 Dec; 104(11):1559-66. PMID: 10587519.
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  65. Topham PS, Haydar SA, Kuphal R, Lightfoot JD, Salant DJ. Complement-mediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions. Kidney Int. 1999 May; 55(5):1763-75. PMID: 10231439.
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  66. Salant DJ. ANCA: fuel for the fire or the spark that ignites the flame? Kidney Int. 1999 Mar; 55(3):1125-7. PMID: 10027954.
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  67. Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70. PMID: 9820486.
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  68. Reddy S, Salant DJ. Treatment of acute interstitial nephritis. Ren Fail. 1998 Nov; 20(6):829-38. PMID: 9834981.
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  69. Hébert MJ, Takano T, Papayianni A, Rennke HG, Minto A, Salant DJ, Carroll MC, Brady HR. Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria. Nephrol Dial Transplant. 1998 Nov; 13(11):2799-803. PMID: 9829481.
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  70. Schiller B, He C, Salant DJ, Lim A, Alexander JJ, Quigg RJ. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. J Exp Med. 1998 Oct 5; 188(7):1353-8. PMID: 9763614.
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  71. Bailey E, Harper SJ, Pringle JH, Baker F, Furness PN, Salant DJ, Feehally J. Visceral glomerular epithelial cell DNA synthesis in experimental and human membranous disease. Exp Nephrol. 1998 Jul-Aug; 6(4):352-8. PMID: 9690098.
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  72. Minto AW, Kalluri R, Togawa M, Bergijk EC, Killen PD, Salant DJ. Augmented expression of glomerular basement membrane specific type IV collagen isoforms (alpha3-alpha5) in experimental membranous nephropathy. Proc Assoc Am Physicians. 1998 May-Jun; 110(3):207-17. PMID: 9625527.
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  73. Lu CY, Salant DJ. Renal immunology and pathology. Curr Opin Nephrol Hypertens. 1998 May; 7(3):279-80. PMID: 9617558.
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  74. Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant DJ, Weinfeld A, Griffin P, Kremmer E, Holers VM. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. J Immunol. 1998 May 1; 160(9):4553-60. PMID: 9574562.
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  75. Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ. Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes. Am J Physiol. 1997 Dec; 273(6 Pt 2):F984-93. PMID: 9435688.
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  76. Lloyd CM, Dorf ME, Proudfoot A, Salant DJ, Gutierrez-Ramos JC. Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis. J Leukoc Biol. 1997 Nov; 62(5):676-80. PMID: 9365123.
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  77. Budde K, Neumayer HH, Salant DJ, Cybulsky AV, Coleman DL, Sterzel RB. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney Int. 1997 Sep; 52(3):733-41. PMID: 9291194.
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  78. Lloyd CM, Gonzalo JA, Salant DJ, Just J, Gutierrez-Ramos JC. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest. 1997 Sep 1; 100(5):963-71. PMID: 9276713.
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  79. Obrador GT, Price B, O'Meara Y, Salant DJ. Acute renal failure due to lymphomatous infiltration of the kidneys. J Am Soc Nephrol. 1997 Aug; 8(8):1348-54. PMID: 9259365.
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  80. Kumar R, Alpern R, Berl T, Blantz R, Chevalier R, Hostetter T, Madias N, Salant D, Wiggins R, Bennett W, Chapman A, Ekonyan G, Falk R, Gennari FJ, Helderman JH, Hruska K, Levey A, Lindheimer M, Miller R, Nissenson A, Schwab S, Schwab T, Schwartz R, Wilcox C. Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee. J Am Soc Nephrol. 1997 Jun; 8(6):1018-27. PMID: 9189871.
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  81. Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, Gutierrez-Ramos JC. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med. 1997 Apr 7; 185(7):1371-80. PMID: 9104823.
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  82. Goldstein DJ, Wheeler DC, Salant DJ. Effects of omega-3 fatty acids on complement-mediated glomerular epithelial cell injury. Kidney Int. 1996 Dec; 50(6):1863-71. PMID: 8943468.
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  83. Coers W, Reivinen J, Miettinen A, Huitema S, Vos JT, Salant DJ, Weening JJ. Characterization of a rat glomerular visceral epithelial cell line. Exp Nephrol. 1996 May-Jun; 4(3):184-92. PMID: 8773481.
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  84. Goldstein DJ, Wheeler DC, Sandstrom DJ, Kawachi H, Salant DJ. Fish oil ameliorates renal injury and hyperlipidemia in the Milan normotensive rat model of focal glomerulosclerosis. J Am Soc Nephrol. 1995 Nov; 6(5):1468-75. PMID: 8589325.
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  85. Kawachi H, Abrahamson DR, St John PL, Goldstein DJ, Shia MA, Matsui K, Shimizu F, Salant DJ. Developmental expression of the nephritogenic antigen of monoclonal antibody 5-1-6. Am J Pathol. 1995 Sep; 147(3):823-33. PMID: 7677194.
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  86. Panka DJ, Salant DJ, Jacobson BA, Minto AW, Marshak-Rothstein A. The effect of VH residues 6 and 23 on IgG3 cryoprecipitation and glomerular deposition. Eur J Immunol. 1995 Jan; 25(1):279-84. PMID: 7843244.
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  87. Salant DJ. The structural biology of glomerular epithelial cells in proteinuric diseases. Curr Opin Nephrol Hypertens. 1994 Nov; 3(6):569-74. PMID: 7881977.
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  88. O'Meara YM, Feehally J, Salant DJ. The nephritogenic immune response. Curr Opin Nephrol Hypertens. 1994 May; 3(3):318-28. PMID: 7922259.
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  89. Weise WJ, Natori Y, Levine JS, O'Meara YM, Minto AW, Manning EC, Goldstein DJ, Abrahamson DR, Salant DJ. Fish oil has protective and therapeutic effects on proteinuria in passive Heymann nephritis. Kidney Int. 1993 Feb; 43(2):359-68. PMID: 8441231.
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  90. Minto AW, Fogel MA, Natori Y, O'Meara YM, Abrahamson DR, Smith B, Salant DJ. Expression of type I collagen mRNA in glomeruli of rats with passive Heymann nephritis. Kidney Int. 1993 Jan; 43(1):121-7. PMID: 8433551.
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  91. O'Meara YM, Salant DJ. Management of glomerular diseases of primary and secondary origin. Curr Opin Nephrol Hypertens. 1992 Oct; 1(1):124-32. PMID: 1365824.
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  92. Coers W, Huitema S, Smeenk RJ, Salant DJ, Grond J, Weening JJ. Quantification of glomerular epithelial cell adhesion by using anti-DNA antibodies in ELISA. Hybridoma. 1992 Aug; 11(4):529-37. PMID: 1398686.
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  93. O'Meara YM, Natori Y, Minto AW, Goldstein DJ, Manning EC, Salant DJ. Nephrotoxic antiserum identifies a beta 1-integrin on rat glomerular epithelial cells. Am J Physiol. 1992 Jun; 262(6 Pt 2):F1083-91. PMID: 1377874.
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  94. Cybulsky AV, Salant DJ. Glomerular cell injury and proteinuria. Lab Invest. 1992 May; 66(5):652-3. PMID: 1573858.
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  95. Natori Y, O'Meara YM, Manning EC, Minto AW, Levine JS, Weise WJ, Salant DJ. Production and polarized secretion of basement membrane components by glomerular epithelial cells. Am J Physiol. 1992 Jan; 262(1 Pt 2):F131-7. PMID: 1733289.
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  96. Quigg RJ, Cybulsky AV, Salant DJ. Effect of nephritogenic antibody on complement regulation in cultured rat glomerular epithelial cells. J Immunol. 1991 Aug 1; 147(3):838-45. PMID: 1861077.
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  97. Fogel MA, Boyd CD, Leardkamolkarn V, Abrahamson DR, Minto AW, Salant DJ. Glomerular basement membrane expansion in passive Heymann nephritis. Absence of increased synthesis of type IV collagen, laminin, or fibronectin. Am J Pathol. 1991 Feb; 138(2):465-75. PMID: 1992771.
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  98. Cybulsky AV, Bonventre JV, Quigg RJ, Lieberthal W, Salant DJ. Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury. Kidney Int. 1990 Nov; 38(5):803-11. PMID: 2266662.
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  99. Cybulsky AV, Bonventre JV, Quigg RJ, Wolfe LS, Salant DJ. Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells. Am J Physiol. 1990 Aug; 259(2 Pt 2):F326-37. PMID: 2386208.
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  100. Leardkamolkarn V, Salant DJ, Abrahamson DR. Loss and rearrangement of glomerular basement membrane laminin during acute nephrotoxic nephritis in the rat. Am J Pathol. 1990 Jul; 137(1):187-98. PMID: 2196815.
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  101. Cybulsky AV, Salant DJ, Quigg RJ, Badalamenti J, Bonventre JV. Complement C5b-9 complex activates phospholipases in glomerular epithelial cells. Am J Physiol. 1989 Nov; 257(5 Pt 2):F826-36. PMID: 2511764.
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  102. Quigg RJ, Abrahamson DR, Cybulsky AV, Badalamenti J, Minto AW, Salant DJ. Studies with antibodies to cultured rat glomerular epithelial cells. Subepithelial immune deposit formation after in vivo injection. Am J Pathol. 1989 May; 134(5):1125-33. PMID: 2655461.
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  103. Salant DJ, Quigg RJ, Cybulsky AV. Heymann nephritis: mechanisms of renal injury. Kidney Int. 1989 Apr; 35(4):976-84. PMID: 2651774.
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  104. Quigg RJ, Nicholson-Weller A, Cybulsky AV, Badalamenti J, Salant DJ. Decay accelerating factor regulates complement activation on glomerular epithelial cells. J Immunol. 1989 Feb 1; 142(3):877-82. PMID: 2464030.
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  105. Quigg RJ, Cybulsky AV, Jacobs JB, Salant DJ. Anti-Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells. Kidney Int. 1988 Jul; 34(1):43-52. PMID: 3172636.
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  106. Yared A, Miyazawa H, Purkerson ML, Klahr S, Salant DJ, Ichikawa I. Effect of diet, age and sex on the renal response to immune injury in the rat. Kidney Int. 1988 Feb; 33(2):561-70. PMID: 3361756.
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  107. Salant DJ, Cybulsky AV. Experimental glomerulonephritis. Methods Enzymol. 1988; 162:421-61. PMID: 3265756.
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  108. Cybulsky AV, Quigg RJ, Badalamenti J, Salant DJ. Anti-Fx1A induces association of Heymann nephritis antigens with microfilaments of cultured glomerular visceral epithelial cells. Am J Pathol. 1987 Nov; 129(2):373-84. PMID: 3674205.
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  109. Yoshioka T, Rennke HG, Salant DJ, Deen WM, Ichikawa I. Role of abnormally high transmural pressure in the permselectivity defect of glomerular capillary wall: a study in early passive Heymann nephritis. Circ Res. 1987 Oct; 61(4):531-8. PMID: 2443267.
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  110. Salant DJ. Immunopathogenesis of crescentic glomerulonephritis and lung purpura. Kidney Int. 1987 Sep; 32(3):408-25. PMID: 3312762.
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  111. Cybulsky AV, Lieberthal W, Quigg RJ, Rennke HG, Salant DJ. A role for thromboxane in complement-mediated glomerular injury. Am J Pathol. 1987 Jul; 128(1):45-51. PMID: 3111267.
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  112. Cybulsky AV, Quigg RJ, Salant DJ. The membrane attack complex in complement-mediated glomerular epithelial cell injury: formation and stability of C5b-9 and C5b-7 in rat membranous nephropathy. J Immunol. 1986 Sep 1; 137(5):1511-6. PMID: 3745914.
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  113. Salant DJ, Cybulsky AV, Feintzeig ID. Quantitation of exogenous and endogenous components of glomerular immune deposits. Kidney Int. 1986 Aug; 30(2):255-63. PMID: 3531679.
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  114. Feintzeig ID, Abrahamson DR, Cybulsky AV, Dittmer JE, Salant DJ. Nephritogenic potential of sheep antibodies against glomerular basement membrane laminin in the rat. Lab Invest. 1986 May; 54(5):531-42. PMID: 3517487.
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  115. Cybulsky AV, Rennke HG, Feintzeig ID, Salant DJ. Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest. 1986 Apr; 77(4):1096-107. PMID: 3514672.
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  116. Madaio MP, Adler S, Groggel GC, Couser WG, Salant DJ. Charge selective properties of the glomerular capillary wall influence antibody binding in rat membranous nephropathy. Clin Immunol Immunopathol. 1986 Apr; 39(1):131-8. PMID: 3485021.
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  117. Feintzeig ID, Dittmer JE, Cybulsky AV, Salant DJ. Antibody, antigen, and glomerular capillary wall charge interactions: influence of antigen location on in situ immune complex formation. Kidney Int. 1986 Mar; 29(3):649-57. PMID: 3517458.
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  118. Couser WG, Darby C, Salant DJ, Adler S, Stilmant MM, Lowenstein LM. Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney. Am J Physiol. 1985 Aug; 249(2 Pt 2):F241-50. PMID: 3161341.
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  119. Salant DJ, Adler S, Darby C, Capparell NJ, Groggel GC, Feintzeig ID, Rennke HG, Dittmer JE. Influence of antigen distribution on the mediation of immunological glomerular injury. Kidney Int. 1985 Jun; 27(6):938-50. PMID: 3894765.
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  120. Groggel GC, Salant DJ, Darby C, Rennke HG, Couser WG. Role of terminal complement pathway in the heterologous phase of antiglomerular basement membrane nephritis. Kidney Int. 1985 Apr; 27(4):643-51. PMID: 4010151.
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  121. Weinberg MS, Quigg RJ, Salant DJ, Bernard DB. Anuric renal failure precipitated by indomethacin and triamterene. Nephron. 1985; 40(2):216-8. PMID: 4000350.
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  122. Madaio MP, Salant DJ, Adler S, Darby C, Couser WG. Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane. Kidney Int. 1984 Oct; 26(4):397-403. PMID: 6527470.
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  123. Groggel GC, Adler S, Rennke HG, Couser WG, Salant DJ. Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit. J Clin Invest. 1983 Dec; 72(6):1948-57. PMID: 6227634.
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  124. Adler S, Salant DJ, Dittmer JE, Rennke HG, Madaio MP, Couser WG. Mediation of proteinuria in membranous nephropathy due to a planted glomerular antigen. Kidney Int. 1983 Jun; 23(6):807-15. PMID: 6224959.
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  125. Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG. Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int. 1983 Mar; 23(3):498-505. PMID: 6221142.
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  126. Couser WG, Salant DJ, Adler S, Madaio MP. Studies of experimental membranous nephropathy. Transplant Proc. 1982 Sep; 14(3):474-81. PMID: 6217598.
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  127. Couser WG, Salant DJ, Madaio MP, Adler S, Groggel GC. Factors influencing glomerular and tubulointerstitial patterns of injury in SLE. Am J Kidney Dis. 1982 Jul; 2(1 Suppl 1):126-34. PMID: 6213148.
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  128. Neale TJ, Couser WG, Salant DJ, Lowenstein LM, Wilson CB. Specific uptake of Heymann's nephritic kidney eluate by rat kidney: studies in vivo and in isolated perfused kidneys. Lab Invest. 1982 Apr; 46(4):450-3. PMID: 7040800.
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  129. Salant DJ, Madaio MP, Adler S, Stilmant MM, Couser WG. Altered glomerular permeability induced by F(ab')2 and Fab' antibodies to rat renal tubular epithelial antigen. Kidney Int. 1982 Jan; 21(1):36-43. PMID: 7043051.
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  130. Salant DJ, Belok S, Madaio MP, Couser WG. A new role for complement in experimental membranous nephropathy in rats. J Clin Invest. 1980 Dec; 66(6):1339-50. PMID: 7440718.
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  131. Salant DJ, Darby C, Couser WG. Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J Clin Invest. 1980 Jul; 66(1):71-81. PMID: 7400310.
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  132. Couser WG, Salant DJ. In situ immune complex formation and glomerular injury. Kidney Int. 1980 Jan; 17(1):1-13. PMID: 6990087.
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  133. Couser WG, Salant DJ, Stilmant MM, Arbeit LA, Darby C, Sliogeris VG. The effects of aminonucleoside of puromycin and nephrotoxic serum on subepithelial immune-deposit formation in passive Heymann nephritis. J Lab Clin Med. 1979 Dec; 94(6):917-32. PMID: 501213.
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  134. Salant DJ, Belok S, Stilmant MM, Darby C, Couser WG. Determinants of glomerular localization of subepithelial immune deposits: effects of altered antigen to antibody ratio, steroids, vasoactive amine antagonists, and aminonucleoside of puromycin on passive Heymann nephritis in rats. Lab Invest. 1979 Jul; 41(1):89-99. PMID: 376941.
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  135. Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM. Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest. 1978 Dec; 62(6):1275-87. PMID: 372233.
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  136. Abrahams C, Furman KI, Salant D. Dermal micro-angiopathy in patients with analgesic nephropathy. S Afr Med J. 1978 Sep 2; 54(10):393-6. PMID: 734548.
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  137. Abrahams C, Furman KI, Salant D. Analgesic abuse and microvascular changes. Am Heart J. 1978 Feb; 95(2):268-9. PMID: 622962.
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  138. Gomperts ED, Zucker M, Feesey M, Russel D, Salant D, Joffe BI, Mendelsohn D, Seftel H. Antithrombin functional activity after a fatty meal in normal subjects, familial hyperlipidemia, and nephrotic syndrome. J Lab Clin Med. 1977 Sep; 90(3):529-35. PMID: 578151.
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  139. Kaye V, Stark JH, Salant DJ, Katz J. Evaluation of 125I-DNA for detecting anti-DNA antibodies in the diagnosis of systemic lupus erythematosus. S Afr Med J. 1977 Apr 23; 51(17):577-80. PMID: 68546.
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  140. Salant DJ, Glover AM, Anderson R, Meyers AM, Rabkin R, Myburgh JA, Rabson AR. Depressed neutrophil chemotaxis in patients with chronic renal failure and after renal transplantation. J Lab Clin Med. 1976 Oct; 88(4):536-45. PMID: 787456.
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  141. Botha JR, Myburgh JA, Smit JA, Maier G, Shapiro M, Milne FJ, Salant DJ, Meyers AM. Cross-matching assays of cell-mediated immunity for transplant patients. S Afr Med J. 1976 Jul 31; 50(33):1275-8. PMID: 785619.
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  142. Gomperts ED, Judelman JJ, Hockley J, Mindel A, Goldberg RB, Meyers AM, Salant DJ, Joffe BI, Myburgh JA, Seftel HC. Coagulation studies in long-term survivors after renal allograft transplantation. S Afr Med J. 1976 Jul 31; 50(33):1284-7. PMID: 785621.
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  143. Salant DJ, Marcus RG, Milne FJ, Meyers AM, Botha JR, Myburgh JA. Pregnancy in renal transplant recipients. S Afr Med J. 1976 Jul 31; 50(33):1288-90. PMID: 785622.
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  144. Levine E, Meyers AM, Salant DJ, Myburgh JA, Milne FJ, Botha JR, Goldberg B. Angiography after renal homotransplantation. S Afr Med J. 1976 Jul 31; 50(33):1295-8. PMID: 785624.
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  145. Goldberg RB, Judelman JJ, Mindel A, Meyers AM, Salant DJ, Myburgh JA, Rabkin R, Joffe BI, Seftel HC. Hyperlipidaemia in renal transplant patients. S Afr Med J. 1976 Jul 31; 50(33):1291-4. PMID: 785623.
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  146. Salant DJ, Glover AM, Anderson R, Meyers AM, Rabkin R, Myburgh JA, Rabson AR. Polymorphonuclear leucocyte function in chronic renal failure and after renal transplantation. Proc Eur Dial Transplant Assoc. 1976; 12:370-9. PMID: 778831.
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  147. Meyers A, Salant D, Rabkin R, Milne J, Botha R, Myburgh J. Lymphocoeles in renal homograft recipients. Proc Eur Dial Transplant Assoc. 1976; 12:452-60. PMID: 778837.
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  148. Salant DJ, Rabkin R. An unusual hormonal cause of hypertension and hypokalaemia. S Afr Med J. 1975 Aug 30; 49(37):1525-6. PMID: 1162532.
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  149. Caro I, Salant DJ. Chronic meningococcaemia. Report of a case. S Afr Med J. 1974 Oct 19; 48(51):2154-6. PMID: 4428298.
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  150. Caro I and Salant DJ. Chronic meningococcaemia: Report of a case. S Afr Med J. 1974; 48:2154-2156.
  151. Bramwell-Jones DM, Pocock WA, Salant DJ, Barlow JB. Isolated tricuspid bacterial endocarditis resulting in severe tricuspid insufficiency. Chest. 1972 Dec; 62(6):749-52. PMID: 4635429.
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