Vijaya Kolachalama | Profiles RNS

Vijaya Kolachalama, PhD

Assistant Professor

Boston University School of Medicine

Dept of Medicine

Computational Biomedicine

BS, Indian Institute of Technology, Kharagpur, India
PhD, University of Southampton, UK

Websites

	Kolachalama Laboratory
	Google Scholar
	LinkedIn
	ORCID ID

Kolachalama laboratory research areas:

1) Machine learning and computer vision for precision medicine:

Artificial intelligence is poised to help deliver precision medicine, yet achieving this goal is nontrivial. Machine learning and image processing techniques along with developments in software and hardware technologies allow us to consider questions across scales. We leverage these tools for pattern recognition and understanding pathophysiological mechanisms that would pave way towards developing biomedical technologies that are of diagnostic and prognostic relevance. Current focus areas include computational pathology, cardiovascular diseases and Alzheimer’s disease.

2) Device-artery interactions, interfacial mechanics and drug delivery:

We use a multidisciplinary approach to quantify device-artery interactions and the interfacial mechanisms driving the performance of these devices. Our main focus has been on endovascular devices. Previous studies by us and our collaborators have explained the role of physiologic factors in modulating spatiotemporal arterial distribution patterns for drug-eluting devices as a function of intrinsic device design, relative device position and pulsatile nature of blood flow. We have extended models simulating idealized settings of physiology to real world issues and further examine arterial tissue response that varies due to procedural settings, device composition, arterial wall ultrastructure and disease, physiologic changes within complex vascular anatomies, vascular injury and the mode of drug delivery.

2018 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Junior Faculty Fellow

2018-2020 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Digital Health Initiative Research Incubation Award

2018-2018 Boston University: CTSI Pilot Award

2017-2017 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Hariri Research Award

2017-2020 American Heart Association: Scientist Development Grant

2008-2010 US Food and Drug Administration: ORISE Fellowship

2005 Massachusetts Institute of Technology: Young Researcher Fellowship

BU Sponsored Research

MECHANISMS OF DRUG-COATED BALLOON THERAPY
07/01/2017 - 06/30/2020 (PI)
American Heart Association

NOVEL ANTIBODY DESIGN USING DEEP LEARNING
01/01/2018 - 01/01/2019 (PI)
Visterra, Inc.

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Kumaradevan S, Lee SY, Richards S, Lyle C, Zhao Q, Tapan U, Jiangliu Y, Ghumman S, Walker J, Belghasem M, Arinze N, Kuhnen A, Weinberg J, Francis J, Hartshorn K, Kolachalama VB, Cifuentes D, Rahimi N, Chitalia VC. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ß-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Am J Pathol. 2018 Aug; 188(8):1921-1933.View Related Profiles.
Kuhnen, Angela
Cifuentes, Daniel
Weinberg, Janice
Francis, Jean
Hartshorn, Kevan
Belghasem, Mostafa
Rahimi, Nader
Zhao, Qing
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 30029779; DOI: 10.1016/j.ajpath.2018.05.007;.
Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 Mar; 29(3):1063-1072.View Related Profiles.
Francis, Jean
Ravid, Katya
Belghasem, Mostafa
Matsuura, Shinobu
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 29343519; DOI: 10.1681/ASN.2017080929;.
Kolachalama VB, Singh P, Lin CQ, Mun D, Belghasem ME, Henderson JM, Francis JM, Salant DJ, Chitalia VC. Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks. Kidney Int Rep. 2018 Mar; 3(2):464-475.View Related Profiles.
Salant, David
Francis, Jean
Henderson, Joel
Belghasem, Mostafa
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 29725651.
Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort. J Alzheimers Dis. 2018; 63(3):1119-1127.View Related Profiles.
Lin, Honghuang
Au, Rhoda
Kolachalama, Vijaya
PMID: 29710704.
Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles.
Gautam, Amitabh
Sherr, David
Francis, Jean
Henderson, Joel
Ravid, Katya
Belghasem, Mostafa
Rushmore, Richard
Matsuura, Shinobu
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 29167396; DOI: 10.1126/scitranslmed.aam8475;.
Tapan U, Lee SY, Weinberg J, Kolachalama VB, Francis J, Charlot M, Hartshorn K, Chitalia V. Racial differences in colorectal cancer survival at a safety net hospital. Cancer Epidemiol. 2017 08; 49:30-37.View Related Profiles.
Weinberg, Janice
Francis, Jean
Hartshorn, Kevan
Charlot, Marjory
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 28538169.
Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150.View Related Profiles.
Francis, Jean
Tan, Josenia
Hartshorn, Kevan
Rahimi, Nader
Zhao, Qing
Kolachalama, Vijaya
Chitalia, Vipul
PMID: 27661103; DOI: 10.18632/oncotarget.12107;.
Mandal PK, Sarifuddin, Kolachalama VB. Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition. Cardiovasc Eng Technol. 2016 Dec; 7(4):406-419. PMID: 27443840.
O'Brien CC, Kolandaivelu K, Brown J, Lopes AC, Kunio M, Kolachalama VB, Edelman ER. Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants. PLoS One. 2016; 11(2):e0149178. PMID: 26906566; PMCID: PMC4764338; DOI: 10.1371/journal.pone.0149178;.
O'Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Ann Biomed Eng. 2016 Jul; 44(7):2251-60. PMID: 26732391; PMCID: PMC4893976; DOI: 10.1007/s10439-015-1518-x;.

Showing 10 of 27 results. Show More

Ferdous J, Kolachalama VB, Kolandaivelu K, Shazly T. Degree of bioresorbable vascular scaffold expansion modulates loss of essential function. Acta Biomater. 2015 Oct; 26:195-204. PMID: 26277377; PMCID: PMC4584207; DOI: 10.1016/j.actbio.2015.08.009;.
Kolandaivelu K, O'Brien CC, Shazly T, Edelman ER, Kolachalama VB. Enhancing physiologic simulations using supervised learning on coarse mesh solutions. J R Soc Interface. 2015 Mar 6; 12(104):20141073. PMID: 25652458; PMCID: PMC4345474; DOI: 10.1098/rsif.2014.1073;.
Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama VB, Shazly T. Effect of spinal cord compression on local vascular blood flow and perfusion capacity. PLoS One. 2014; 9(9):e108820. PMID: 25268384; PMCID: PMC4182502; DOI: 10.1371/journal.pone.0108820;.
Martorell J, Santomá P, Kolandaivelu K, Kolachalama VB, Melgar-Lesmes P, Molins JJ, Garcia L, Edelman ER, Balcells M. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Cardiovasc Res. 2014 Jul 1; 103(1):37-46. PMID: 24841070; PMCID: PMC4670884; DOI: 10.1093/cvr/cvu124;.
Kolachalama VB, Pacetti SD, Franses JW, Stankus JJ, Zhao HQ, Shazly T, Nikanorov A, Schwartz LB, Tzafriri AR, Edelman ER. Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy. Circulation. 2013 May 21; 127(20):2047-55. PMID: 23584359; PMCID: PMC3748613; DOI: 10.1161/CIRCULATIONAHA.113.002051;.
O'Brien CC, Kolachalama VB, Barber TJ, Simmons A, Edelman ER. Impact of flow pulsatility on arterial drug distribution in stent-based therapy. J Control Release. 2013 Jun 10; 168(2):115-24. PMID: 23541929; PMCID: PMC3697861; DOI: 10.1016/j.jconrel.2013.03.014;.
Ferdous J, Kolachalama VB, Shazly T. Impact of polymer structure and composition on fully resorbable endovascular scaffold performance. Acta Biomater. 2013 Apr; 9(4):6052-61. PMID: 23261926; PMCID: PMC4104616; DOI: 10.1016/j.actbio.2012.12.011;.
Baker AB, Gibson WJ, Kolachalama VB, Golomb M, Indolfi L, Spruell C, Zcharia E, Vlodavsky I, Edelman ER. Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance. J Am Coll Cardiol. 2012 Apr 24; 59(17):1551-60. PMID: 22516446; PMCID: PMC4191917; DOI: 10.1016/j.jacc.2011.11.057;.
Kniazeva T, Epshteyn AA, Hsiao JC, Kim ES, Kolachalama VB, Charest JL, Borenstein JT. Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device. Lab Chip. 2012 May 7; 12(9):1686-95. PMID: 22418858; PMCID: PMC3320667; DOI: 10.1039/c2lc21156d;.
Shazly T, Kolachalama VB, Ferdous J, Oberhauser JP, Hossainy S, Edelman ER. Assessment of material by-product fate from bioresorbable vascular scaffolds. Ann Biomed Eng. 2012 Apr; 40(4):955-65. PMID: 22042625; PMCID: PMC4616251; DOI: 10.1007/s10439-011-0445-8;.
Kolandaivelu K, Swaminathan R, Gibson WJ, Kolachalama VB, Nguyen-Ehrenreich KL, Giddings VL, Coleman L, Wong GK, Edelman ER. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Circulation. 2011 Apr 5; 123(13):1400-9. PMID: 21422389; PMCID: PMC3131199; DOI: 10.1161/CIRCULATIONAHA.110.003210;.
Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. PLoS One. 2009; 4(12):e8105. PMID: 19956555; PMCID: PMC2781163; DOI: 10.1371/journal.pone.0008105;.
Tzafriri AR, Vukmirovic N, Kolachalama VB, Astafieva I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. J Control Release. 2010 Mar 19; 142(3):332-8. PMID: 19925836; PMCID: PMC2994187; DOI: 10.1016/j.jconrel.2009.11.007;.
Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release. 2009 Jan 5; 133(1):24-30. PMID: 18926864; PMCID: PMC2836846; DOI: 10.1016/j.jconrel.2008.09.075;.
Kolachalama VB, Bressloff NW, Nair PB, Shearman CP. Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part II: Application to graft design. IEEE Trans Biomed Eng. 2008 Mar; 55(3):1176-84. PMID: 18334411; DOI: 10.1109/TBME.2007.912398;.
Kolachalama VB, Bressloff NW, Nair PB. Mining data from hemodynamic simulations via Bayesian emulation. Biomed Eng Online. 2007; 6:47. PMID: 18078522; PMCID: PMC2231366; DOI: 10.1186/1475-925X-6-47;.
Kolachalama VB, Bressloff NW, Nair PB, Shearman CP. Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part I: Application to stent design. IEEE Trans Biomed Eng. 2007 May; 54(5):802-12. PMID: 17518276; DOI: 10.1109/TBME.2006.889188;.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 11 distinct years, with a maximum of 4 publications in 2016 and 2018

Bar chart showing 27 publications over 11 distinct years, with a maximum of 4 publications in 2016 and 2018

Year	Publications
2007	2
2008	2
2009	2
2011	2
2012	3
2013	2
2014	2
2015	2
2016	4
2017	2
2018	4

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Machine learning
Image processing
Deep learning
Cardiovascular devices
Drug coated balloons
Vascular drug delivery
Computational pathology
Drug eluting stents
Deep neural networks
Adversarial learning

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72 East Concord Street, Evans 636
Boston MA 02118
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617.414.3371

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