Our mission is to create methods to fit the science and not make science fit the methods.
Specifically, we are interested in the following questions that have clinical relevance:
-- Neurodegeneration: How can we develop software frameworks that can assist neurology practitioners in various real-world settings?
-- Digital pathology: How can we build clinical-grade software tools to complement the pathologist workflow?
We are also interested in the following frameworks that have computational relevance:
-- Multimodal machine learning: Efficient design of AI agents for multimodal data processing with incomplete information.
-- Representation learning: Construction of efficient neural networks on high resolution data to process local and contextual information.
Diversity, Equity, Inclusion and Accessibility
We value the importance of creating a diverse and equitable environment and take pride in maintaining a laboratory that has an equal number of trainees from both genders. The trainees are medical school students, graduate students from computer sciences, arts and engineering, undergraduate students, medical residents, and clinical fellows. Over 50 trainees have already been co-authors of journal papers and graduates from our laboratory are pursuing higher education, and accepted faculty appointments in research-intensive universities, as well as computer vision and machine learning intern and scientist roles in companies such as Microsoft and Bose.
We thrive on collaborative ideas and openly invite other faculty members to our group for discussions and forge new partnerships. For each project, we have a multidisciplinary team that brings together the needed perspectives to innovate and translate a computational framework to solve a clinically relevant problem. Our laboratory meetings are focused on mathematical concepts, coding hacks and algorithms, deeper dive on the clinical questions and overall translation of our findings.
Below are some specific contributions that reflect our DEIA initiatives:
2018 --- Faculty development and diversity committee, Boston University School of Medicine
2019-21 --- Mentor for Supporting Undergraduate Research Experience (SURE) Program (Grant# 55205494), American Heart Association; The focus of this program is to support undergraduate students from Historically Black Colleges and Universities and Hispanic Serving Institutions
2017-present --- Mentor to the following scholars.
• Shinobu Matsuura, PhD: K01 Grant Awardee (K01-OD025290), Project Title: The bone marrow extracellular matrix: scaffold of hematopoiesis
• Kathy Bacon, PhD: Rheumatology Research Foundation Career Development Awardee, Project Title: Machine learning analysis of longitudinal gait data in osteoarthritis
• Ileana De Anda-Duran, MD, MPH: AHA Postdoctoral Fellow (20SFRN35460031), Project Title: Integrated Digital Technology Platform for Optimization of Precision Brain Health
• Phillip Hwang, PhD: AHA Postdoctoral Fellow (20SFRN35460031), Project Title: Integrated Digital Technology Platform for Optimization of Precision Brain Health
• Huitong Ding, PhD: AHA Postdoctoral Fellow (20SFRN35460031), Project Title: Integrated Digital Technology Platform for Optimization of Precision Brain Health
• Kerry Costello, PhD: F32 Grant Awardee (F32-AR076907), Project Title: Machine learning for analysis of walking patterns and physical activity in knee osteoarthritis
• Claire Cordella, PhD: F32 Grant Awardee (F32-DC020342), Project Title: Detecting and classifying non-fluent speech in aphasia using machine learning
• Insa Schmidt, PhD: K01 Grant Awardee (F32-DK136973), Project Title: Deep learning approach for the assessment of arterial and arteriolar lesions in kidney biopsies and prediction of cardiovascular risk
Finally, we want to disseminate the value of data science education more broadly in the public domain. We have written articles about the value of machine learning education in medical (NPJ Digit Med. 2018 Sep 27;1:54. PMID: 31304333) as well as undergraduate (Artif Intell Med. 2022 Jul;129:102313. PMID: 35659392) institutions, and gave seminars to the scientific community on this topic. As a result, the curriculum that we designed for a graduate course in machine learning (MS650) is now being adapted by several researchers.
Member
Boston University
Whitaker Cardiovascular Institute
Member
Boston University
Evans Center for Interdisciplinary Biomedical Research
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Computing & Data Sciences Administration
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- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
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from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related Dementias08/01/2024 - 04/30/2029 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHANIH/National Institute on Aging1R01AG083735-01A1
Mechanisms of drug-coated balloon therapy09/01/2021 - 08/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL159620-03
Smartphone image analysis for real time adequacy assessment during kidney biopsy09/15/2022 - 08/31/2024 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHAArkana Laboratories NIH NIDDK1R43DK134273-01
PRISTINE: Pre-cancer histology identification of Endobronchial biopsies using deep learning09/01/2020 - 08/31/2024 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHANIH/National Cancer Institute1R21CA253498-01
Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults06/01/2023 - 07/31/2024 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHAThe Johns Hopkins University NIH NIA5P30AG073104-03
Integrated Digital Technology Platform for Optimization of Precision Brain Health07/01/2020 - 06/30/2024 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHAAmerican Heart Association
Using deep learning to advance lung cancer interception and early detection01/01/2022 - 12/31/2023 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHAJohnson & Johnson Enterprise Innovation, Inc.
Cognitive heterogeneity in those with high Alzheimer's Disease Risk05/01/2020 - 04/30/2023 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHANIH/National Institute on Aging1RF1AG062109-01A1
Predicting gene expression from pathology images in diabetic kidney disease07/01/2021 - 12/31/2022 (Subcontract PI)
Augusta University NIH NIDDK5U24DK115255-04
Biomarkers of lung squamous premalignant progression using deep learning on pathology images06/01/2020 - 12/31/2021 (Multi-PI)
PI:
Vijaya B. Kolachalama, PhD, FAHAJohnson & Johnson Enterprise Innovation, Inc.
Showing 10 of 12 results.
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Mechanisms of drug-coated balloon therapy07/01/2017 - 06/30/2021 (PI)
American Heart Association
Novel antibody design using deep learning01/01/2018 - 12/31/2019 (PI)
Visterra, Inc.
Predicting gene expression from pathology images in diabetic kidney disease07/01/2021 - 06/30/2022 (PI)
NIDDK - DIABETIC COMPLICATIONS CONSORTIUM (DiaComp)
Toffler Scholar in Neuroscience01/01/2021 - 12/31/2021 (PI)
The Karen Toffler Charitable Trust
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Ding H, Ho K, Searls E, Low S, Li Z, Rahman S, Madan S, Igwe A, Popp Z, Burk A, Wu H, Ding Y, Hwang PH, Anda-Duran I, Kolachalama VB, Gifford KA, Shih LC, Au R, Lin H. Assessment of Wearable Device Adherence for Monitoring Physical Activity in Older Adults: Pilot Cohort Study. JMIR Aging. 2024 Oct 25; 7:e60209.View Related Profiles. PMID: 39454101
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Jia S, Bit S, Searls E, Claus LA, Fan P, Jasodanand VH, Lauber MV, Veerapaneni D, Wang WM, Au R, Kolachalama VB. MedPodGPT: A multilingual audio-augmented large language model for medical research and education. medRxiv. 2024 Jul 12.View Related Profiles. PMID: 39040167; PMCID: PMC11261953; DOI: 10.1101/2024.07.11.24310304;
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Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Pham ST, Kaliaev A, Andreu-Arasa VC, Dwyer BC, Farris CW, Hao H, Kedar S, Mian AZ, Murman DL, O'Shea SA, Paul AB, Rohatgi S, Saint-Hilaire MH, Sartor EA, Setty BN, Small JE, Swaminathan A, Taraschenko O, Yuan J, Zhou Y, Zhu S, Karjadi C, Alvin Ang TF, Bargal SA, Plummer BA, Poston KL, Ahangaran M, Au R, Kolachalama VB. AI-based differential diagnosis of dementia etiologies on multimodal data. Nat Med. 2024 Oct; 30(10):2977-2989.View Related Profiles. PMID: 38965435; PMCID: PMC11485262; DOI: 10.1038/s41591-024-03118-z;
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Amini S, Hao B, Yang J, Karjadi C, Kolachalama VB, Au R, Paschalidis IC. Prediction of Alzheimer's disease progression within 6 years using speech: A novel approach leveraging language models. Alzheimers Dement. 2024 Aug; 20(8):5262-5270.View Related Profiles. PMID: 38924662; PMCID: PMC11350035; DOI: 10.1002/alz.13886;
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Ahangaran M, Sun E, Le K, Sun J, Wang WM, Tan TH, Yin L, Burdine LJ, Dvanajscak Z, Cassol CA, Sharma S, Kolachalama VB. Pilot Study of a Web-Based Tool for Real-Time Adequacy Assessment of Kidney Biopsies. Kidney Int Rep. 2024 Sep; 9(9):2809-2813.View Related Profiles. PMID: 39291211; PMCID: PMC11403039; DOI: 10.1016/j.ekir.2024.06.019;
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Laudon A, Zou A, Wang Z, Sharma R, Fan X, Ji J, Kim C, Qian Y, Ye Q, Chen H, Henderson JM, Zhang C, Kolachalama VB, Lu W. Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy. bioRxiv. 2024 Jun 17.View Related Profiles. PMID: 38948787; PMCID: PMC11212870; DOI: 10.1101/2024.06.14.599097;
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Lteif D, Sreerama S, Bargal SA, Plummer BA, Au R, Kolachalama VB. Disease-driven domain generalization for neuroimaging-based assessment of Alzheimer's disease. Hum Brain Mapp. 2024 Jun 01; 45(8):e26707.View Related Profiles. PMID: 38798082; PMCID: PMC11128757; DOI: 10.1002/hbm.26707;
Showing 10 of 99 results.
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Ding H, Kim M, Searls E, Sunderaraman P, Anda-Duran I, Low S, Popp Z, Hwang PH, Li Z, Goyal K, Hathaway L, Monteverde J, Rahman S, Igwe A, Kolachalama VB, Au R, Lin H. Corrigendum: Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates. Front Neurol. 2024; 15:1433972.View Related Profiles. PMID: 38867888; PMCID: PMC11167070; DOI: 10.3389/fneur.2024.1433972;
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Shazly T, Eberth JF, Kostelnik CJ, Uline MJ, Chitalia VC, Spinale FG, Alshareef A, Kolachalama VB. Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy. ACS Appl Bio Mater. 2024 May 20; 7(5):3041-3049.View Related Profiles. PMID: 38661721; PMCID: PMC11366439; DOI: 10.1021/acsabm.4c00080;
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Cordella C, Di Filippo L, Kolachalama VB, Kiran S. Connected Speech Fluency in Poststroke and Progressive Aphasia: A Scoping Review of Quantitative Approaches and Features. Am J Speech Lang Pathol. 2024 Jul 03; 33(4):2091-2128. PMID: 38652820; PMCID: PMC11253646; DOI: 10.1044/2024_AJSLP-23-00208;
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Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Stefanik JJ, Corrigan P, Segal NA, Lewis CE, Nevitt MC, Kumar D. Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Jul; 76(7):984-992.View Related Profiles. PMID: 38523250; PMCID: PMC11209802; DOI: 10.1002/acr.25327;
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Gindra RH, Zheng Y, Green EJ, Reid ME, Mazzilli SA, Merrick DT, Burks EJ, Kolachalama VB, Beane JE. Graph Perceiver Network for Lung Tumor and Bronchial Premalignant Lesion Stratification from Histopathology. Am J Pathol. 2024 Jul; 194(7):1285-1293.View Related Profiles. PMID: 38588853; PMCID: PMC11220922; DOI: 10.1016/j.ajpath.2024.03.009;
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Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Pham ST, Kaliaev A, Andreu-Arasa VC, Dwyer BC, Farris CW, Hao H, Kedar S, Mian AZ, Murman DL, O'Shea SA, Paul AB, Rohatgi S, Saint-Hilaire MH, Sartor EA, Setty BN, Small JE, Swaminathan A, Taraschenko O, Yuan J, Zhou Y, Zhu S, Karjadi C, Ang TFA, Bargal SA, Plummer BA, Poston KL, Ahangaran M, Au R, Kolachalama VB. AI-based differential diagnosis of dementia etiologies on multimodal data. medRxiv. 2024 Mar 26.View Related Profiles. PMID: 38585870; PMCID: PMC10996713; DOI: 10.1101/2024.02.08.24302531;
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Ding H, Kim M, Searls E, Sunderaraman P, De Anda-Duran I, Low S, Popp Z, Hwang PH, Li Z, Goyal K, Hathaway L, Monteverde J, Rahman S, Igwe A, Kolachalama VB, Au R, Lin H. Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates. Front Neurol. 2024; 15:1340710.View Related Profiles. PMID: 38426173; PMCID: PMC10902432; DOI: 10.3389/fneur.2024.1340710;
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Ahangaran M, Sun E, Le K, Sun J, Wang WM, Tan TH, Burdine LJ, Dvanajscak Z, Cassol CA, Sharma S, Kolachalama VB. A web-based tool for real-time adequacy assessment of kidney biopsies. medRxiv. 2024 Feb 05.View Related Profiles. PMID: 38370740; PMCID: PMC10871452; DOI: 10.1101/2024.02.01.24302147;
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Popp Z, Low S, Igwe A, Rahman MS, Kim M, Khan R, Oh E, Kumar A, De Anda-Duran I, Ding H, Hwang PH, Sunderaraman P, Shih LC, Lin H, Kolachalama VB, Au R. Shifting From Active to Passive Monitoring of Alzheimer Disease: The State of the Research. J Am Heart Assoc. 2024 Jan 16; 13(2):e031247.View Related Profiles. PMID: 38226518; PMCID: PMC10926806; DOI: 10.1161/JAHA.123.031247;
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De Anda-Duran I, Sunderaraman P, Searls E, Moukaled S, Jin X, Popp Z, Karjadi C, Hwang PH, Ding H, Devine S, Shih LC, Low S, Lin H, Kolachalama VB, Bazzano L, Libon DJ, Au R. Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts. J Am Heart Assoc. 2024 Jan 16; 13(2):e032733.View Related Profiles. PMID: 38226519; PMCID: PMC10926794; DOI: 10.1161/JAHA.123.032733;
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Sunderaraman P, De Anda-Duran I, Karjadi C, Peterson J, Ding H, Devine SA, Shih LC, Popp Z, Low S, Hwang PH, Goyal K, Hathaway L, Monteverde J, Lin H, Kolachalama VB, Au R. Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study. J Am Heart Assoc. 2024 Jan 16; 13(2):e031348.View Related Profiles. PMID: 38226510; PMCID: PMC10926817; DOI: 10.1161/JAHA.123.031348;
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Shazly T, Uline M, Webb C, Pederson B, Eberth JF, Kolachalama VB. Novel Payloads to Mitigate Maladaptive Inward Arterial Remodeling in Drug-Coated Balloon Therapy. J Biomech Eng. 2023 Dec 01; 145(12). PMID: 37542712; PMCID: PMC10578076; DOI: 10.1115/1.4063122;
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Romano MF, Zhou X, Balachandra AR, Jadick MF, Qiu S, Nijhawan DA, Joshi PS, Mohammad S, Lee PH, Smith MJ, Paul AB, Mian AZ, Small JE, Chin SP, Au R, Kolachalama VB. Deep learning for risk-based stratification of cognitively impaired individuals. iScience. 2023 Sep 15; 26(9):107522.View Related Profiles. PMID: 37646016; PMCID: PMC10460987; DOI: 10.1016/j.isci.2023.107522;
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Idrees N, Haroon S, Zhang Y, Mangio JC, Siracuse JJ, Francis JM, Ganguli S, Daly K, Diamond M, Vilvendhan R, Cabral H, Dember LM, Farber A, Kolachalama VB, Chitalia VC. Contrast Venography Versus Intravenous Ultrasound in Hemodialysis Arteriovenous Access Dysfunction. Kidney Int Rep. 2023 Sep; 8(9):1887-1891.View Related Profiles. PMID: 37705907; PMCID: PMC10496077; DOI: 10.1016/j.ekir.2023.06.013;
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Tseng AE, Carossino M, Gertje HP, O'Connell AK, Gummuluru S, Kolachalama VB, Balasuriya UBR, Connor JH, Bennett RS, Liu DX, Hensley LE, Crossland NA. Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeys. Vet Pathol. 2023 Jul; 60(4):473-487.View Related Profiles. PMID: 37170900
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Zhang JD, Xue C, Kolachalama VB, Donald WA. Interpretable Machine Learning on Metabolomics Data Reveals Biomarkers for Parkinson's Disease. ACS Cent Sci. 2023 May 24; 9(5):1035-1045. PMID: 37252351; PMCID: PMC10214508; DOI: 10.1021/acscentsci.2c01468;
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Costello KE, Felson DT, Jafarzadeh SR, Guermazi A, Roemer FW, Segal NA, Lewis CE, Nevitt MC, Lewis CL, Kolachalama VB, Kumar D. Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study. Br J Sports Med. 2023 Aug; 57(16):1018-1024.View Related Profiles. PMID: 36868795; PMCID: PMC10423491; DOI: 10.1136/bjsports-2022-106142;
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De Anda-Duran I, Kolachalama VB, Carmichael OT, Hwang PH, Fernandez C, Au R, Bazzano LA, Libon DJ. Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study. J Alzheimers Dis. 2023; 94(1):101-113.View Related Profiles. PMID: 37212094; PMCID: PMC10443183; DOI: 10.3233/JAD-220931;
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Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, Kumar D. Relation of gait measures with mild unilateral knee pain during walking using machine learning. Sci Rep. 2022 Dec 23; 12(1):22200.View Related Profiles. PMID: 36564397; PMCID: PMC9789148; DOI: 10.1038/s41598-022-21142-2;
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Shazly T, Torres WM, Secemsky EA, Chitalia VC, Jaffer FA, Kolachalama VB. Understudied factors in drug-coated balloon design and evaluation: A biophysical perspective. Bioeng Transl Med. 2023 Jan; 8(1):e10370.View Related Profiles. PMID: 36684110; PMCID: PMC9842065; DOI: 10.1002/btm2.10370;
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Amini S, Hao B, Zhang L, Song M, Gupta A, Karjadi C, Kolachalama VB, Au R, Paschalidis IC. Automated detection of mild cognitive impairment and dementia from voice recordings: A natural language processing approach. Alzheimers Dement. 2023 Mar; 19(3):946-955.View Related Profiles. PMID: 35796399; PMCID: PMC10148688; DOI: 10.1002/alz.12721;
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Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404.View Related Profiles. PMID: 35725739; PMCID: PMC9209452; DOI: 10.1038/s41467-022-31037-5;
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De Anda-Duran I, Alonso CF, Libon DJ, Carmichael OT, Kolachalama VB, Suglia SF, Au R, Bazzano LA. Carotid Intima-Media Thickness and Midlife Cognitive Function: Impact of Race and Social Disparities in the Bogalusa Heart Study. Neurology. 2022 May 03; 98(18):e1828-e1836.View Related Profiles. PMID: 35228334; PMCID: PMC9109147; DOI: 10.1212/WNL.0000000000200155;
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Chang GH, Park LK, Le NA, Jhun RS, Surendran T, Lai J, Seo H, Promchotichai N, Yoon G, Scalera J, Capellini TD, Felson DT, Kolachalama VB. Subchondral Bone Length in Knee Osteoarthritis: A Deep Learning-Derived Imaging Measure and Its Association With Radiographic and Clinical Outcomes. Arthritis Rheumatol. 2021 12; 73(12):2240-2248.View Related Profiles. PMID: 33973737; PMCID: PMC8581065; DOI: 10.1002/art.41808;
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Zhang JD, Baker MJ, Liu Z, Kabir KMM, Kolachalama VB, Yates DH, Donald WA. Medical diagnosis at the point-of-care by portable high-field asymmetric waveform ion mobility spectrometry: a systematic review and meta-analysis. J Breath Res. 2021 07 28; 15(4). PMID: 34252887; PMCID: PMC10422980; DOI: 10.1088/1752-7163/ac135e;
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Xu D, Zhou F, Sun W, Chen L, Lan L, Li H, Xiao F, Li Y, Kolachalama VB, Li Y, Wang X, Xu H. Relationship Between Serum Severe Acute Respiratory Syndrome Coronavirus 2 Nucleic Acid and Organ Damage in Coronavirus 2019 Patients: A Cohort Study. Clin Infect Dis. 2021 07 01; 73(1):68-75. PMID: 32720678; PMCID: PMC7454386; DOI: 10.1093/cid/ciaa1085;
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Zheng Y, Cassol CA, Jung S, Veerapaneni D, Chitalia VC, Ren KYM, Bellur SS, Boor P, Barisoni LM, Waikar SS, Betke M, Kolachalama VB. Deep-Learning-Driven Quantification of Interstitial Fibrosis in Digitized Kidney Biopsies. Am J Pathol. 2021 08; 191(8):1442-1453.View Related Profiles. PMID: 34033750; PMCID: PMC8453248; DOI: 10.1016/j.ajpath.2021.05.005;
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Weizenbaum EL, Fulford D, Torous J, Pinsky E, Kolachalama VB, Cronin-Golomb A. Smartphone-Based Neuropsychological Assessment in Parkinson's Disease: Feasibility, Validity, and Contextually Driven Variability in Cognition. J Int Neuropsychol Soc. 2022 Apr; 28(4):401-413.View Related Profiles. PMID: 33998438; PMCID: PMC10474573; DOI: 10.1017/S1355617721000503;
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Zhou X, Qiu S, Joshi PS, Xue C, Killiany RJ, Mian AZ, Chin SP, Au R, Kolachalama VB. Enhancing magnetic resonance imaging-driven Alzheimer's disease classification performance using generative adversarial learning. Alzheimers Res Ther. 2021 03 14; 13(1):60.View Related Profiles. PMID: 33715635; PMCID: PMC7958452; DOI: 10.1186/s13195-021-00797-5;
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Amini S, Zhang L, Hao B, Gupta A, Song M, Karjadi C, Lin H, Kolachalama VB, Au R, Paschalidis IC. An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test. J Alzheimers Dis. 2021; 83(2):581-589.View Related Profiles. PMID: 34334396; PMCID: PMC9049046; DOI: 10.3233/JAD-210299;
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Chang GH, Felson DT, Qiu S, Guermazi A, Capellini TD, Kolachalama VB. Correction to: Assessment of knee pain from MR imaging using a convolutional Siamese network. Eur Radiol. 2020 Dec; 30(12):6968.View Related Profiles. PMID: 32700018
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Qiu S, Joshi PS, Miller MI, Xue C, Zhou X, Karjadi C, Chang GH, Joshi AS, Dwyer B, Zhu S, Kaku M, Zhou Y, Alderazi YJ, Swaminathan A, Kedar S, Saint-Hilaire MH, Auerbach SH, Yuan J, Sartor EA, Au R, Kolachalama VB. Development and validation of an interpretable deep learning framework for Alzheimer's disease classification. Brain. 2020 06 01; 143(6):1920-1933.View Related Profiles. PMID: 32357201; PMCID: PMC7296847; DOI: 10.1093/brain/awaa137;
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Azar D, Lott JT, Jabbarzadeh E, Shazly T, Kolachalama VB. Surface Modification Using Ultraviolet-Ozone Treatment Enhances Acute Drug Transfer in Drug-Coated Balloon Therapy. Langmuir. 2020 05 05; 36(17):4645-4653. PMID: 32271583; PMCID: PMC9337626; DOI: 10.1021/acs.langmuir.0c00298;
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Richard D, Liu Z, Cao J, Kiapour AM, Willen J, Yarlagadda S, Jagoda E, Kolachalama VB, Sieker JT, Chang GH, Muthuirulan P, Young M, Masson A, Konrad J, Hosseinzadeh S, Maridas DE, Rosen V, Krawetz R, Roach N, Capellini TD. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk. Cell. 2020 04 16; 181(2):362-381.e28. PMID: 32220312; PMCID: PMC7179902; DOI: 10.1016/j.cell.2020.02.057;
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Wollacott AM, Xue C, Qin Q, Hua J, Bohnuud T, Viswanathan K, Kolachalama VB. Quantifying the nativeness of antibody sequences using long short-term memory networks. Protein Eng Des Sel. 2019 12 31; 32(7):347-354. PMID: 31504835; PMCID: PMC7372931; DOI: 10.1093/protein/gzz031;
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Joshi PS, Heydari M, Kannan S, Alvin Ang TF, Qin Q, Liu X, Mez J, Devine S, Au R, Kolachalama VB. Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer's disease status. Alzheimers Dement (N Y). 2019; 5:964-973.View Related Profiles. PMID: 31921970; PMCID: PMC6944730; DOI: 10.1016/j.trci.2019.11.006;
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Walker JA, Richards S, Belghasem ME, Arinze N, Yoo SB, Tashjian JY, Whelan SA, Lee N, Kolachalama VB, Francis J, Ravid K, Sherr D, Chitalia VC. Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease. Kidney Int. 2020 03; 97(3):538-550.View Related Profiles. PMID: 31932072; PMCID: PMC9721455; DOI: 10.1016/j.kint.2019.09.029;
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Azar D, Torres WM, Davis LA, Shaw T, Eberth JF, Kolachalama VB, Lessner SM, Shazly T. Geometric determinants of local hemodynamics in severe carotid artery stenosis. Comput Biol Med. 2019 11; 114:103436. PMID: 31521900; PMCID: PMC6817414; DOI: 10.1016/j.compbiomed.2019.103436;
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Zhu H, Tao Q, Ang TFA, Massaro J, Gan Q, Salim S, Zhu RY, Kolachalama VB, Zhang X, Devine S, Auerbach SH, DeCarli C, Au R, Qiu WQ. Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e199826.View Related Profiles. PMID: 31433485; PMCID: PMC6707010; DOI: 10.1001/jamanetworkopen.2019.9826;
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Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899; PMCID: PMC6481807; DOI: 10.1371/journal.pone.0213422;
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Kannan S, Morgan LA, Liang B, Cheung MG, Lin CQ, Mun D, Nader RG, Belghasem ME, Henderson JM, Francis JM, Chitalia VC, Kolachalama VB. Segmentation of Glomeruli Within Trichrome Images Using Deep Learning. Kidney Int Rep. 2019 Jul; 4(7):955-962.View Related Profiles. PMID: 31317118; PMCID: PMC6612039; DOI: 10.1016/j.ekir.2019.04.008;
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Gopal DM, Ayalon N, Wang YC, Siwik D, Sverdlov A, Donohue C, Perez A, Downing J, Apovian C, Silva V, Panagia M, Kolachalama V, Ho JE, Liang CS, Gokce N, Colucci WS. Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients. J Am Heart Assoc. 2019 04 02; 8(7):e011100.View Related Profiles. PMID: 30929550; PMCID: PMC6509711; DOI: 10.1161/JAHA.118.011100;
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Xue C, Lott JT, Kolachalama VB. Estimation of Size and Contact Angle of Evaporating Sessile Liquid Drops Using Texture Analysis. Langmuir. 2019 Mar 12; 35(10):3672-3679. PMID: 30707587; PMCID: PMC9351812; DOI: 10.1021/acs.langmuir.8b04043;
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Qiu S, Chang GH, Panagia M, Gopal DM, Au R, Kolachalama VB. Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst). 2018; 10:737-749.View Related Profiles. PMID: 30480079; PMCID: PMC6240705; DOI: 10.1016/j.dadm.2018.08.013;
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Kumaradevan S, Lee SY, Richards S, Lyle C, Zhao Q, Tapan U, Jiangliu Y, Ghumman S, Walker J, Belghasem M, Arinze N, Kuhnen A, Weinberg J, Francis J, Hartshorn K, Kolachalama VB, Cifuentes D, Rahimi N, Chitalia VC. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ß-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Am J Pathol. 2018 08; 188(8):1921-1933.View Related Profiles. PMID: 30029779; PMCID: PMC6099425; DOI: 10.1016/j.ajpath.2018.05.007;
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Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 03; 29(3):1063-1072.View Related Profiles. PMID: 29343519; PMCID: PMC5827608; DOI: 10.1681/ASN.2017080929;
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Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort. J Alzheimers Dis. 2018; 63(3):1119-1127.View Related Profiles. PMID: 29710704
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Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; PMCID: PMC5854487; DOI: 10.1126/scitranslmed.aam8475;
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Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150.View Related Profiles. PMID: 27661103; PMCID: PMC5342068; DOI: 10.18632/oncotarget.12107;
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Mandal PK, Sarifuddin, Kolachalama VB. Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition. Cardiovasc Eng Technol. 2016 Dec; 7(4):406-419. PMID: 27443840
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O'Brien CC, Kolandaivelu K, Brown J, Lopes AC, Kunio M, Kolachalama VB, Edelman ER. Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants. PLoS One. 2016; 11(2):e0149178. PMID: 26906566; PMCID: PMC4764338; DOI: 10.1371/journal.pone.0149178;
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O'Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Ann Biomed Eng. 2016 Jul; 44(7):2251-60. PMID: 26732391; PMCID: PMC4893976; DOI: 10.1007/s10439-015-1518-x;
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Ferdous J, Kolachalama VB, Kolandaivelu K, Shazly T. Degree of bioresorbable vascular scaffold expansion modulates loss of essential function. Acta Biomater. 2015 Oct; 26:195-204. PMID: 26277377; PMCID: PMC4584207; DOI: 10.1016/j.actbio.2015.08.009;
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Kolandaivelu K, O'Brien CC, Shazly T, Edelman ER, Kolachalama VB. Enhancing physiologic simulations using supervised learning on coarse mesh solutions. J R Soc Interface. 2015 Mar 6; 12(104):20141073. PMID: 25652458; PMCID: PMC4345474; DOI: 10.1098/rsif.2014.1073;
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Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama VB, Shazly T. Effect of spinal cord compression on local vascular blood flow and perfusion capacity. PLoS One. 2014; 9(9):e108820. PMID: 25268384; PMCID: PMC4182502; DOI: 10.1371/journal.pone.0108820;
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Martorell J, Santomá P, Kolandaivelu K, Kolachalama VB, Melgar-Lesmes P, Molins JJ, Garcia L, Edelman ER, Balcells M. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Cardiovasc Res. 2014 Jul 1; 103(1):37-46. PMID: 24841070; PMCID: PMC4670884; DOI: 10.1093/cvr/cvu124;
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Kolachalama VB, Pacetti SD, Franses JW, Stankus JJ, Zhao HQ, Shazly T, Nikanorov A, Schwartz LB, Tzafriri AR, Edelman ER. Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy. Circulation. 2013 May 21; 127(20):2047-55. PMID: 23584359; PMCID: PMC3748613; DOI: 10.1161/CIRCULATIONAHA.113.002051;
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O'Brien CC, Kolachalama VB, Barber TJ, Simmons A, Edelman ER. Impact of flow pulsatility on arterial drug distribution in stent-based therapy. J Control Release. 2013 Jun 10; 168(2):115-24. PMID: 23541929; PMCID: PMC3697861; DOI: 10.1016/j.jconrel.2013.03.014;
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Ferdous J, Kolachalama VB, Shazly T. Impact of polymer structure and composition on fully resorbable endovascular scaffold performance. Acta Biomater. 2013 Apr; 9(4):6052-61. PMID: 23261926; PMCID: PMC4104616; DOI: 10.1016/j.actbio.2012.12.011;
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Baker AB, Gibson WJ, Kolachalama VB, Golomb M, Indolfi L, Spruell C, Zcharia E, Vlodavsky I, Edelman ER. Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance. J Am Coll Cardiol. 2012 Apr 24; 59(17):1551-60. PMID: 22516446; PMCID: PMC4191917; DOI: 10.1016/j.jacc.2011.11.057;
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Kniazeva T, Epshteyn AA, Hsiao JC, Kim ES, Kolachalama VB, Charest JL, Borenstein JT. Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device. Lab Chip. 2012 May 7; 12(9):1686-95. PMID: 22418858; PMCID: PMC3320667; DOI: 10.1039/c2lc21156d;
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Shazly T, Kolachalama VB, Ferdous J, Oberhauser JP, Hossainy S, Edelman ER. Assessment of material by-product fate from bioresorbable vascular scaffolds. Ann Biomed Eng. 2012 Apr; 40(4):955-65. PMID: 22042625; PMCID: PMC4616251; DOI: 10.1007/s10439-011-0445-8;
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Kolandaivelu K, Swaminathan R, Gibson WJ, Kolachalama VB, Nguyen-Ehrenreich KL, Giddings VL, Coleman L, Wong GK, Edelman ER. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Circulation. 2011 Apr 5; 123(13):1400-9. PMID: 21422389; PMCID: PMC3131199; DOI: 10.1161/CIRCULATIONAHA.110.003210;
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Tzafriri AR, Vukmirovic N, Kolachalama VB, Astafieva I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. J Control Release. 2010 Mar 19; 142(3):332-8. PMID: 19925836; PMCID: PMC2994187; DOI: 10.1016/j.jconrel.2009.11.007;
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Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release. 2009 Jan 5; 133(1):24-30. PMID: 18926864; PMCID: PMC2836846; DOI: 10.1016/j.jconrel.2008.09.075;
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Kolachalama VB, Bressloff NW, Nair PB, Shearman CP. Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part II: Application to graft design. IEEE Trans Biomed Eng. 2008 Mar; 55(3):1176-84. PMID: 18334411; DOI: 10.1109/TBME.2007.912398;
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Kolachalama VB, Bressloff NW, Nair PB, Shearman CP. Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part I: Application to stent design. IEEE Trans Biomed Eng. 2007 May; 54(5):802-12. PMID: 17518276; DOI: 10.1109/TBME.2006.889188;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2007 | 2 |
| 2008 | 2 |
| 2009 | 2 |
| 2011 | 2 |
| 2012 | 3 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 2 |
| 2016 | 4 |
| 2017 | 2 |
| 2018 | 6 |
| 2019 | 10 |
| 2020 | 5 |
| 2021 | 9 |
| 2022 | 10 |
| 2023 | 13 |
| 2024 | 23 |
2024 The Framingham Heart Study:
Executive Committee
2024 Indian Institute of Technology, Kharagpur:
Young Alumni Achiever Award
2022 The Institute of Electrical and Electronics Engineers:
Senior Member
2021 Karen Toffler Charitable Trust:
Toffler Scholar in Neuroscience
2021 Department of Medicine, Boston University School of Medicine:
Evans Junior Faculty Merit Award
2020 Faculty of Computing & Data Sciences, Boston University:
Founding Member
2020 Department of Medicine, Boston University School of Medicine:
Outstanding Research Collaborator
2019 Institute for Health System Innovation & Policy, Boston University:
Institute Fellow
2019 American Heart Association:
Fellow
2018 Hariri Institute for Computing and Computational Science & Engineering, Boston University:
Junior Faculty Fellow
2008 United States Food and Drug Administration:
ORISE Fellowship
2005 Massachusetts Institute of Technology:
Young Researcher Fellowship
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