Vijaya Kolachalama, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Computational Biomedicine

BS, Indian Institute of Technology, Kharagpur, India
PhD, University of Southampton, UK




Kolachalama laboratory research areas:

1) Machine learning and computer vision for precision medicine:

Artificial intelligence is poised to help deliver precision medicine, yet achieving this goal is nontrivial. Machine learning and image processing techniques along with developments in software and hardware technologies allow us to consider questions across scales. We leverage these tools for pattern recognition and understanding pathophysiological mechanisms that would pave way towards developing biomedical technologies that are of diagnostic and prognostic relevance. Current application areas include Alzheimer's disease, cardiovascular disease, chronic kidney disease, colorectal cancer and osteoarthritis.

2) Device-artery interactions, interfacial mechanics and drug delivery:

We use a multidisciplinary approach to quantify device-artery interactions and the interfacial mechanisms driving the performance of these devices. Our main focus has been on endovascular devices. Previous studies by us and our collaborators have explained the role of physiologic factors in modulating spatiotemporal arterial distribution patterns for drug-eluting devices as a function of intrinsic device design, relative device position and pulsatile nature of blood flow. We have extended models simulating idealized settings of physiology to real world issues and further examine arterial tissue response that varies due to procedural settings, device composition, arterial wall ultrastructure and disease, physiologic changes within complex vascular anatomies, vascular injury and the mode of drug delivery.

2018 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Junior Faculty Fellow
2018-2019 Boston University: Digital Health Initiative Research Incubation Award
2018 Boston University School of Medicine: Whitaker Cardiovascular Institute Pilot Award
2018-2018 Boston University: CTSI Pilot Award
2017-2017 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Hariri Research Award
2017-2020 American Heart Association: Scientist Development Grant
2008-2010 US Food and Drug Administration: ORISE Fellowship
2005 Massachusetts Institute of Technology: Young Researcher Fellowship


Mechanisms of drug-coated balloon therapy
07/01/2017 - 06/30/2020 (PI)
American Heart Association


Novel antibody design using deep learning
01/01/2018 - 01/01/2019 (PI)
Visterra, Inc.





Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chang GH, Azar DA, Lyle C, Chitalia VC, Shazly T, Kolachalama VB. Intrinsic coating morphology modulates acute drug transfer in drug-coated balloon therapy. Sci Rep. 2019 May 02; 9(1):6839.View Related Profiles. PMID: 31048704.
     
  2. Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899.
     
  3. Gopal DM, Ayalon N, Wang YC, Siwik D, Sverdlov A, Donohue C, Perez A, Downing J, Apovian C, Silva V, Panagia M, Kolachalama V, Ho JE, Liang CS, Gokce N, Colucci WS. Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients. J Am Heart Assoc. 2019 Apr 02; 8(7):e011100.View Related Profiles. PMID: 30929550.
     
  4. Xue C, Lott JT, Kolachalama VB. Estimation of Size and Contact Angle of Evaporating Sessile Liquid Drops Using Texture Analysis. Langmuir. 2019 Mar 12; 35(10):3672-3679. PMID: 30707587.
     
  5. Qiu S, Chang GH, Panagia M, Gopal DM, Au R, Kolachalama VB. Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst). 2018; 10:737-749.View Related Profiles. PMID: 30480079.
     
  6. Kumaradevan S, Lee SY, Richards S, Lyle C, Zhao Q, Tapan U, Jiangliu Y, Ghumman S, Walker J, Belghasem M, Arinze N, Kuhnen A, Weinberg J, Francis J, Hartshorn K, Kolachalama VB, Cifuentes D, Rahimi N, Chitalia VC. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ß-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Am J Pathol. 2018 08; 188(8):1921-1933.View Related Profiles. PMID: 30029779; DOI: 10.1016/j.ajpath.2018.05.007;.
     
  7. Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 Mar; 29(3):1063-1072.View Related Profiles. PMID: 29343519; DOI: 10.1681/ASN.2017080929;.
     
  8. Kolachalama VB, Singh P, Lin CQ, Mun D, Belghasem ME, Henderson JM, Francis JM, Salant DJ, Chitalia VC. Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks. Kidney Int Rep. 2018 Mar; 3(2):464-475.View Related Profiles. PMID: 29725651.
     
  9. Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort. J Alzheimers Dis. 2018; 63(3):1119-1127.View Related Profiles. PMID: 29710704.
     
  10. Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; DOI: 10.1126/scitranslmed.aam8475;.
     
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 12 distinct years, with a maximum of 5 publications in 2018

YearPublications
20072
20082
20092
20112
20123
20132
20142
20152
20164
20172
20185
20194
Contact for Mentoring:

72 East Concord Street, Evans 636
Boston MA 02118
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