Vijaya Kolachalama, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Computational Biomedicine

BS, Indian Institute of Technology, Kharagpur, India
PhD, University of Southampton, UK



Kolachalama laboratory research areas:

1) Machine learning and computer vision for precision medicine:

Artificial intelligence is poised to help deliver precision medicine, yet achieving this goal is nontrivial. Machine learning and image processing techniques along with developments in software and hardware technologies allow us to consider questions across scales. We leverage these tools for pattern recognition and understanding pathophysiological mechanisms that would pave way towards developing biomedical technologies that are of diagnostic and prognostic relevance. Current focus areas include computational pathology, cardiovascular diseases and Alzheimer’s disease.

2) Device-artery interactions, interfacial mechanics and drug delivery:

We use a multidisciplinary approach to quantify device-artery interactions and the interfacial mechanisms driving the performance of these devices. Our main focus has been on endovascular devices. Previous studies by us and our collaborators have explained the role of physiologic factors in modulating spatiotemporal arterial distribution patterns for drug-eluting devices as a function of intrinsic device design, relative device position and pulsatile nature of blood flow. We have extended models simulating idealized settings of physiology to real world issues and further examine arterial tissue response that varies due to procedural settings, device composition, arterial wall ultrastructure and disease, physiologic changes within complex vascular anatomies, vascular injury and the mode of drug delivery.

2018 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Junior Faculty Fellow
2018-2020 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Digital Health Initiative Research Incubation Award
2018-2018 Boston University: CTSI Pilot Award
2017-2017 Hariri Institute for Computing and Computational Science & Engineering, Boston University: Hariri Research Award
2017-2020 American Heart Association: Scientist Development Grant
2008-2010 US Food and Drug Administration: ORISE Fellowship
2005 Massachusetts Institute of Technology: Young Researcher Fellowship


MECHANISMS OF DRUG-COATED BALLOON THERAPY
07/01/2017 - 06/30/2020 (PI)
American Heart Association

NOVEL ANTIBODY DESIGN USING DEEP LEARNING
01/01/2018 - 01/01/2019 (PI)
Visterra, Inc.




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kumaradevan S, Lee SY, Richards S, Lyle C, Zhao Q, Tapan U, Jiangliu Y, Ghumman S, Walker J, Belghasem M, Arinze N, Kuhnen A, Weinberg J, Francis J, Hartshorn K, Kolachalama VB, Cifuentes D, Rahimi N, Chitalia VC. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ß-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Am J Pathol. 2018 Aug; 188(8):1921-1933.View Related Profiles. PMID: 30029779; DOI: 10.1016/j.ajpath.2018.05.007;.
     
  2. Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 Mar; 29(3):1063-1072.View Related Profiles. PMID: 29343519; DOI: 10.1681/ASN.2017080929;.
     
  3. Kolachalama VB, Singh P, Lin CQ, Mun D, Belghasem ME, Henderson JM, Francis JM, Salant DJ, Chitalia VC. Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks. Kidney Int Rep. 2018 Mar; 3(2):464-475.View Related Profiles. PMID: 29725651.
     
  4. Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort. J Alzheimers Dis. 2018; 63(3):1119-1127.View Related Profiles. PMID: 29710704.
     
  5. Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; DOI: 10.1126/scitranslmed.aam8475;.
     
  6. Tapan U, Lee SY, Weinberg J, Kolachalama VB, Francis J, Charlot M, Hartshorn K, Chitalia V. Racial differences in colorectal cancer survival at a safety net hospital. Cancer Epidemiol. 2017 08; 49:30-37.View Related Profiles. PMID: 28538169.
     
  7. Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150.View Related Profiles. PMID: 27661103; DOI: 10.18632/oncotarget.12107;.
     
  8. Mandal PK, Sarifuddin, Kolachalama VB. Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition. Cardiovasc Eng Technol. 2016 Dec; 7(4):406-419. PMID: 27443840.
     
  9. O'Brien CC, Kolandaivelu K, Brown J, Lopes AC, Kunio M, Kolachalama VB, Edelman ER. Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants. PLoS One. 2016; 11(2):e0149178. PMID: 26906566; PMCID: PMC4764338; DOI: 10.1371/journal.pone.0149178;.
     
  10. O'Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Ann Biomed Eng. 2016 Jul; 44(7):2251-60. PMID: 26732391; PMCID: PMC4893976; DOI: 10.1007/s10439-015-1518-x;.
     
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 11 distinct years, with a maximum of 4 publications in 2016 and 2018

YearPublications
20072
20082
20092
20112
20123
20132
20142
20152
20164
20172
20184
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72 East Concord Street, Evans 636
Boston MA 02118
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