Shinobu Matsuura | Profiles RNS

Shinobu Matsuura, DVM, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Cardiovascular Medicine

PhD, University of Tokyo
DVM, Universidade de São Paulo

Pronouns: she/her/hers

Websites

	MyNCBI
	Boston University Chobanian & Avedisian School of Medicine

ORCID : 0000-0002-3914-5376

My career goal is to apply my knowledge in veterinary medicine to most effectively use animal models to develop therapies that can significant translational potential and potential to impact patient outcomes. I have a career-long interest in hematology research, which emerged from my experience treating canine patients with hematological malignancies. My major research focus is hematopoietic stem cell biology and the de-regulation of those processes in malignancy. My current project explores the potential to target stem cells in myeloproliferative neoplasms driven by the JAK2V617F mutation through integrins. Given the experience accumulated on therapeutic targeting of integrins, I am excited by the significant translational potential of this project.

I graduated School of Veterinary Medicine and completed Residency in Internal Medicine at the University of São Paulo (USP), Brazil. My training in research consists of a graduate degree at the University of Tokyo, Japan, under the guidance of Dr. Hajime Tsujimoto, and postdoctoral training at the laboratories of Dr. Dong-Er Zhang at the Scripps Research Institute and at the University of California, San Diego under a F32 award, and Dr. Katya Ravid at Boston University. I was promoted Instructor of Medicine at the Boston University Chobanian and Avedisian School of Medicine in 2016 and Assistant Professor in 2021. I am a PI of the career development SERCA K01 award, from the Office of Research Infrastructure (ORIP)/NIH, a training mechanism specifically designed for veterinarians pursuing basic research.

Diversity, Equity, Inclusion and Accessibility

As a Japanese immigrant that grew up in Brazil, diversity and inclusion became part of my identity. Professionally, I also find myself as a minority of DVM graduate among PhD and MDs. Those experiences helped shape my commitment to enhance diversity and inclusion in the society and in the workplace, to give a fair chance to all individuals, regardless of their background and social status. An institutional culture that values diversity and inclusion are a foundation for a resilient and vibrant workplace, driving innovation and excellence through challenging of ideas, action, and rewarding on results, not entitlement.

Targeting the JAK2V617F Hematopoietic Stem Cell Through Integrins-Based Combination Therapy
03/01/2023 - 03/01/2025 (PI)
MPN Research Foundation

Targeting JAK2V617F stem cells in primary myelofibrosis
12/15/2022 - 11/30/2024 (PI)
NIH/Office of the Director
1R03OD031959-01A1

The bone marrow extracellular matrix: scaffold of hematopoiesis
02/01/2019 - 01/31/2024 (PI)
NIH/Office of the Director
3K01OD025290-05S1

Title

Targeting the JAK2V617F Hematopoietic Stem Cell through Integrins-Based Combination Therapy
03/01/2023 - 02/28/2025 (PI)
MPN Research Foundation and the Leukemia & Lymphoma Society

Role of JAK2 in cerebrovascular and microglial dysfunction in Alzhemeir’s disease
02/01/2023 - 01/31/2024 (Co-PI)
Boston University Chobanian and Avedisian School of Medicine

Exploring Integrin-targeting biologics for primary myelofibrosis
07/01/2022 - 06/30/2023 (PI)
BU CTSI
UL1 TR001430

Mechanistically Interrogate at the Gene Expression Level the effect of Anti-b1 Integrin Antibody on JAK2V617F+ Stem Cells
05/01/2022 - 12/31/2022 (PI)
BU CAMED Genome Science Institute

Yr	Title	Project-Sub Proj	Pubs
2024	Targeting beta1 integrin in JAK2V617F+ stem cells	5R03OD031959-02
2023	Targeting beta1 integrin in JAK2V617F+ stem cells	1R03OD031959-01A1
2023	The bone marrow extracellular matrix: scaffold of hematopoiesis	5K01OD025290-05
2023	The bone marrow extracellular matrix: scaffold of hematopoiesis	3K01OD025290-05S1
2022	The bone marrow extracellular matrix: scaffold of hematopoiesis	5K01OD025290-04
2021	The bone marrow extracellular matrix: scaffold of hematopoiesis	5K01OD025290-03	1
2020	The bone marrow extracellular matrix: scaffold of hematopoiesis	5K01OD025290-02	1
2019	The bone marrow extracellular matrix: scaffold of hematopoiesis	1K01OD025290-01A1	1
2010	Novel molecular targets of RUNX in hematopoietic stem/progenitor cells	5F32HL091641-04	9
2009	Novel molecular targets of RUNX in hematopoietic stem/progenitor cells	5F32HL091641-03	9

Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349.View Related Profiles.

Ward, Christina
Ravid, Katya
Matsuura, Shinobu

PMID: 38165047; PMCID: PMC10922533; DOI: 10.1002/ajh.27184;

Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498.View Related Profiles.

Ravid, Katya
Gerstenfeld, Louis
Matsuura, Shinobu

PMID: 35880162; PMCID: PMC9307716; DOI: 10.3389/fonc.2022.929498;

Matsuura S, Balduini A, Onisto M. Editorial: Mechanisms of Cell Adhesion in Hematopoietic Stem Cells. Front Cell Dev Biol. 2021; 9:826554. PMID: 34993206; PMCID: PMC8724261; DOI: 10.3389/fcell.2021.826554;

Yang X, Chitalia SV, Matsuura S, Ravid K. Integrins and their role in megakaryocyte development and function. Exp Hematol. 2022 02; 106:31-39.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu

PMID: 34910941; PMCID: PMC8795491; DOI: 10.1016/j.exphem.2021.11.007;

Lim KH, Matsuura S, Xu B. Editorial: Novel Treatment Strategies for Myeloproliferative Neoplasms. Front Oncol. 2021; 11:762928. PMID: 34604100; PMCID: PMC8479092; DOI: 10.3389/fonc.2021.762928;

Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles.

Thompson, Cristal
Ravid, Katya
Matsuura, Shinobu
Chitalia, Vipul

PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;

Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles.

Ward, Christina
Thompson, Cristal
Ravid, Katya
Matsuura, Shinobu

PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;

Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. Int J Hematol. 2019 Dec; 110(6):699-708.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu
Chitalia, Vipul

PMID: 31637674; PMCID: PMC7503219; DOI: 10.1007/s12185-019-02751-6;

Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JAK2V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. JACC Basic Transl Sci. 2019 Oct; 4(6):684-697.View Related Profiles.

Ravid, Katya
Walsh, Kenneth
Matsuura, Shinobu

PMID: 31709318; PMCID: PMC6834960; DOI: 10.1016/j.jacbts.2019.05.013;

Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 03; 29(3):1063-1072.View Related Profiles.

Francis, Jean
Ravid, Katya
Belghasem, Mostafa
Matsuura, Shinobu
Kolachalama, Vijaya
Chitalia, Vipul

PMID: 29343519; PMCID: PMC5827608; DOI: 10.1681/ASN.2017080929;

Showing 10 of 38 results. Show More

Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles.

Gautam, Amitabh
Sherr, David
Francis, Jean
Henderson, Joel
Walker, Joshua
Ravid, Katya
Belghasem, Mostafa
Rushmore, Richard
Matsuura, Shinobu
Kolachalama, Vijaya
Chitalia, Vipul

PMID: 29167396; PMCID: PMC5854487; DOI: 10.1126/scitranslmed.aam8475;

Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017 08 10; 130(6):829-831.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu
Chitalia, Vipul

PMID: 28592432; PMCID: PMC5553577; DOI: 10.1182/blood-2017-04-777417;

Leiva O, Ng SK, Chitalia S, Balduini A, Matsuura S, Ravid K. The role of the extracellular matrix in primary myelofibrosis. Blood Cancer J. 2017 Feb 03; 7(2):e525.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu

PMID: 28157219; PMCID: PMC5386340; DOI: 10.1038/bcj.2017.6;

Lucero HA, Patterson S, Matsuura S, Ravid K. Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods. 2016; 3(4).View Related Profiles.

Ravid, Katya
Patterson, Shenia
Matsuura, Shinobu

PMID: 28008415; PMCID: PMC5172452; DOI: 10.14440/jbm.2016.152;

Matsuura S, Patterson S, Lucero H, Leiva O, Grant AK, Herrera VL, Ravid K. In vivo magnetic resonance imaging of a mouse model of myelofibrosis. Blood Cancer J. 2016 11 11; 6(11):e497.View Related Profiles.

Ravid, Katya
Patterson, Shenia
Matsuura, Shinobu
Herrera, Victoria

PMID: 27834941; PMCID: PMC5148061; DOI: 10.1038/bcj.2016.97;

Lam K, Muselman A, Du R, Yan M, Matsuura S, Zhang DE. Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization. Blood Cancer J. 2016 Mar 25; 6:e407. PMID: 27015284; PMCID: PMC4817102; DOI: 10.1038/bcj.2016.20;

Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501.View Related Profiles.

Ravid, Katya
Koupenova-Zamor, Milka
Toselli, Paul
Trackman, Philip
Mi, Rongjuan
Matsuura, Shinobu

PMID: 26755713; PMCID: PMC4797025; DOI: 10.1182/blood-2015-02-629667;

Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 4; 212(5):649-63.View Related Profiles.

Ravid, Katya
Patterson, Shenia
Matsuura, Shinobu

PMID: 25870200; PMCID: PMC4419349; DOI: 10.1084/jem.20141528;

Kawarai S, Hisasue M, Matsuura S, Ito T, Inoue Y, Neo S, Fujii Y, Madarame H, Shirota K, Tsuchiya R. Canine pemphigus foliaceus with concurrent immune-mediated thrombocytopenia. J Am Anim Hosp Assoc. 2015 Jan-Feb; 51(1):56-63. PMID: 25415212; DOI: 10.5326/JAAHA-MS-6044;

Lam K, Muselman A, Du R, Harada Y, Scholl AG, Yan M, Matsuura S, Weng S, Harada H, Zhang DE. Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice. Blood. 2014 Oct 2; 124(14):2203-12. PMID: 25150295; PMCID: PMC4183983; DOI: 10.1182/blood-2014-02-554543;

Kawarai S, Matsuura S, Yamamoto S, Kiuchi A, Kanemaki N, Madarame H, Shirota K. A case of cutaneous sterile pyogranuloma/granuloma syndrome in a maltese. J Am Anim Hosp Assoc. 2014 Jul-Aug; 50(4):278-83. PMID: 24855086; DOI: 10.5326/JAAHA-MS-6009;

Komeno Y, Yan M, Matsuura S, Lam K, Lo MC, Huang YJ, Tenen DG, Downing JR, Zhang DE. Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice. Blood. 2014 Jun 12; 123(24):3760-9. PMID: 24771859; PMCID: PMC4055923; DOI: 10.1182/blood-2013-08-521252;

Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL. Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells. Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23):9368-73.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu

PMID: 23613587; PMCID: PMC3677442; DOI: 10.1073/pnas.1304889110;

Eliades A, Papadantonakis N, Matsuura S, Mi R, Bais MV, Trackman P, Ravid K. Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide. Cell Cycle. 2013 Apr 15; 12(8):1242-50.View Related Profiles.

Ravid, Katya
Bais, Manish
Trackman, Philip
Mi, Rongjuan
Matsuura, Shinobu

PMID: 23518500; PMCID: PMC3674089; DOI: 10.4161/cc.24312;

Ahn EE, Higashi T, Yan M, Matsuura S, Hickey CJ, Lo MC, Shia WJ, DeKelver RC, Zhang DE. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster. J Biol Chem. 2013 Feb 22; 288(8):5381-8. PMID: 23322776; PMCID: PMC3581430; DOI: 10.1074/jbc.M112.447227;

Eliades A, Matsuura S, Ravid K. Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes. J Cell Physiol. 2012 Oct; 227(10):3355-62.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu

PMID: 22331622; PMCID: PMC3357446; DOI: 10.1002/jcp.24071;

Matsuura S, Komeno Y, Stevenson KE, Biggs JR, Lam K, Tang T, Lo MC, Cong X, Yan M, Neuberg DS, Zhang DE. Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. Blood. 2012 Nov 8; 120(19):4028-37. PMID: 22919028; PMCID: PMC3496957; DOI: 10.1182/blood-2012-01-404533;

Papadantonakis N, Matsuura S, Ravid K. Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection. Blood. 2012 Aug 30; 120(9):1774-81.View Related Profiles.

Ravid, Katya
Matsuura, Shinobu

PMID: 22767499; PMCID: PMC3433087; DOI: 10.1182/blood-2012-02-402594;

Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, Zhang DE. Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood. 2012 Aug 16; 120(7):1473-84. PMID: 22740448; PMCID: PMC3423785; DOI: 10.1182/blood-2011-12-395335;

Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR, Zhang DE. PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood. 2012 May 24; 119(21):4953-62. PMID: 22498736; PMCID: PMC3367897; DOI: 10.1182/blood-2011-04-347476;

Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875; DOI: 10.1182/blood-2011-04-350694;

Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011 Apr 22; 42(2):185-98. PMID: 21504830; PMCID: PMC3137374; DOI: 10.1016/j.molcel.2011.03.014;

Kawarai S, Masuda K, Ohmori K, Matsuura S, Yasuda N, Nagata M, Sakaguchi M, Tsujimoto H. Cultivation and characterization of canine skin-derived mast cells. J Vet Med Sci. 2010 Feb; 72(2):131-40. PMID: 19940396

Ide K, Matsuura S, Fujino Y, Ohno K, Tsujimoto H. Investigation of various methods for the cryopreservation of canine bone marrow-derived CD34(+) cells. J Vet Med Sci. 2008 Nov; 70(11):1211-7. PMID: 19057140

Takeuchi Y, Matsuura S, Fujino Y, Nakajima M, Takahashi M, Nakashima K, Sakai Y, Uetsuka K, Ohno K, Nakayama H, Tsujimoto H. Hypereosinophilic syndrome in two cats. J Vet Med Sci. 2008 Oct; 70(10):1085-9. PMID: 18981665

Kitamura Y, Koto H, Matsuura S, Kawabata T, Tsuchiya H, Kusuhara H, Tsujimoto H, Sugiyama Y. Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies. Drug Metab Dispos. 2008 May; 36(5):807-10. PMID: 18299336; DOI: 10.1124/dmd.107.017624;

Matsuura S, Koto H, Ide K, Fujino Y, Setoguchi-Mukai A, Ohno K, Tsujimoto H. Induction of chemoresistance in a cultured canine cell line by retroviral transduction of the canine multidrug resistance 1 gene. Am J Vet Res. 2007 Jan; 68(1):95-100. PMID: 17199425

Fukushima K, Okai Y, Matsuura S, Tsujimoto H, Endo Y. Molecular cloning of feline lung resistance-related protein (LRP) cDNA and its expression in a feline lymphoma cell line and adriamycin-resistant subline. J Vet Med Sci. 2006 Aug; 68(8):885-90. PMID: 16953094

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 38 publications over 17 distinct years, with a maximum of 6 publications in 2012

Bar chart showing 38 publications over 17 distinct years, with a maximum of 6 publications in 2012

Year	Publications
2006	1
2007	1
2008	3
2009	1
2011	1
2012	6
2013	3
2014	4
2015	1
2016	4
2017	3
2018	1
2019	2
2020	2
2021	3
2022	1
2024	1

2015 American Society of Biochemistry and Molecular Biology (ASBMB): Best Thematic Poster Award

2010 Annual Meeting of the American Society of Hematology (ASH): Travel Award

2007 Federation of American Societies for Experimental Biology (FASEB), : Best Poster Award

2005 Japanese College of Veterinary Internal Medicine: Best Science Presentation Award

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Hematopoietic Stem Cell
Hematological Malignancies
Hematology
Lysyl Oxidase, Collagen
Megakaryocytes
Platelets
Thrombosis
Myelofibrosis
Flow Cytometry
Mouse
Myeloproliferative Disorders
JAK2 Protein Tyrosine Kinase
Integrins
Biologics

I believe that an individual mentoring experience is essential for research education.
I have experience in undergraduate and graduate mentoring. My teaching philosophy is to create an inquisitive environment to nurture curiosity and learning.

Available to Mentor as: (Review Mentor Role Definitions):

Diversity Mentor
Education Mentor
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Email (see 'Contact Info')

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.358.8245

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