Victoria L.M. Herrera, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, University Philippines
BS, University Philippines



Victoria Herrera, MD, is a Professor of Medicine at Chobanian and Avedisian School of Medicine, Whitaker Cardiovascular Institute, Associate Director for Medicine at BU Nanotechnology Innovation Center. Dr. Herrera is a graduate of the University of the Philippines College of Medicine - magna cum laude, and former Visiting International Fellow at Harvard University Graduate School of Arts and Sciences. She completed Pediatrics Residencey at Univerfity of Massachusetts Medical Center and Boston Children's Hospital, Harvard Medical School; Fellowship in Pediatric Cardiology and Molecular Cardiology at Boston Children's Hospital, Harvard Medical School, and Hypertension Molecular Genetics at Chobanian and Avedisian School of Medicine. Dr. Herrera serves as reviewer for Journals and for the NIH: former CVB Cardiovascular Study Section member, Hypertension Study Section, and current ad hoc reviewer for Cancer BioTherapeutics and Development SBIR Study Section. Dr. Herrera is co-inventor in multiple patents on novel targeted therapies for cancer and stroke, and nanodelivery systems.

As an NIH physician scientist awardee, research interests focus on the understanding of molecular bases of complex diseases via translational research coupled with animal modeling that recapitulate complex disease phenotypes respectively with spontaneous progression to end-organ disease and comorbidities. These animal modeling insights provide novel approaches to identification and testing of novel therapeutic and/or theranostic paradigms prioritized for their respective potentials to become clinically relevant game changers. Research expertise span the integration of basic and clinical sciences, translation of nanotechnologies into nanomedicines, and the design of clinically relevant preclinical and translational efficacy and safety studies relevant to novel approaches for ARDS, Covid19-ARDS, stroke, cardiovascular disease and cancer.

A graduate of the University of the Philippines College of Medicine, Dr. Herrera served as the founding scientific advisor to the Philippine General Hospital Child Protection Unity and the Child Protection Network in the Philippines.

Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Humanized anti-DEspR antibody therapy for Acute Respiratory Distress Syndrome (ARDS)
09/01/2019 - 11/30/2021 (Co-Investigator)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-07

Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs)
01/01/2019 - 12/31/2020 (Multi-PI)
PI: Victoria L.M. Herrera, MD
NIH/National Heart, Lung, and Blood Institute
5R21HL144253-02

Fully humanized anti-DEspR antibody therapy for acute lung injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
01/01/2018 - 04/30/2019 (Co-Investigator)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-06

Decreasing stroke risk by restoring microvascular repair
02/01/2015 - 01/31/2017 (PI)
Ellison Foundation


Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease: Role in Cardio- and Cerebro- Vascular Diseases
08/15/2008 - 05/31/2013 (PI)
NIH/National Institute on Aging
5R01AG032649-04

Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease: Role in Cardio- and Cerebro- Vascular Diseases
09/30/2009 - 08/31/2011 (PI)
NIH/National Institute on Aging
3R01AG032649-02S1

Environmental Toxicants: Fetal Basis, Adult-Onset Stroke
01/01/2006 - 12/31/2008 (PI)
NIH/National Institute of Environmental Health Sciences
5 R21 ES13870 02

Integrated Molecular Analysis of Nicotine-Hypertension-Hyperlipidemia Interaction in CHD
03/01/2002 - 04/30/2006 (PI)
Philip Morris Inc

Molecular Genetics of the ET-1/AngII Receptor
04/01/2002 - 03/31/2006 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL69937 02

Hypertension/Atherosclerosis Paradigms
08/15/1999 - 07/31/2004 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL62857 04

Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 5R21HL144253-02
2019 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 1R21HL144253-01
2018 Novel targeted therapy for pancreatic cancer 1R43CA221555-01A1
2011 Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease 5R01AG032649-04 4
2010 Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease 5R01AG032649-03 4
2009 Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease 3R01AG032649-02S1 4
2009 Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease 5R01AG032649-02 4
2008 Juvenile Protective Factor Deficits in Endothelial Aging, Dysfunction and Disease 1R01AG032649-01 4
2007 Environmental Toxicants in Fetal Basis of Adult-onset Stroke 5R21ES013870-02 1
2006 Environmental Toxicants: Fetal Basis, Adult-onset Stroke 1R21ES013870-01A1 1
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Cross AL, Wright HL, Choi J, Edwards SW, Ruiz-Opazo N, Herrera VLM. Circulating neutrophil extracellular trap-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor+ subtype. Clin Exp Immunol. 2024 Oct 16; 218(2):163-168.View Related Profiles. PMID: 39110036
     
  2. Herrera VLM, Bosch NA, Lok JJ, Nguyen MQ, Lenae KA, deKay JT, Ryzhov SV, Seder DB, Ruiz-Opazo N, Walkey AJ. Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR?+?CD11b?+], mediate multi-organ failure in COVID-19-an observational study. Transl Med Commun. 2023; 8(1):12.View Related Profiles. PMID: 37096233; PMCID: PMC10111078; DOI: 10.1186/s41231-023-00143-x;
     
  3. Herrera VLM, Gromisch CM, Decano JL, Pasion KA, Tan GLA, Hua N, Takahashi CE, Greer DM, Ruiz-Opazo N. Anti-DEspR antibody treatment improves survival and reduces neurologic deficits in a hypertensive, spontaneous intracerebral hemorrhage (hsICH) rat model. Sci Rep. 2023 Feb 15; 13(1):2703.View Related Profiles. PMID: 36792616; PMCID: PMC9932093; DOI: 10.1038/s41598-023-28149-3;
     
  4. Herrera VLM, Bosch NA, Lok JJ, Nguyen MQ, Lenae KA, deKay JT, Ryzhov SV, Seder DB, Ruiz-Opazo N, Walkey AJ. Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR+CD11b+], mediate multi-organ failure in COVID-19 - an observational study. Res Sq. 2023 Feb 01.View Related Profiles. PMID: 36778407; PMCID: PMC9915800; DOI: 10.21203/rs.3.rs-2479844/v1;
     
  5. Whitaker RD, Decano JL, Gormley C, Beigie CA, Meisel C, Tan GA, Moran AM, Giordano NJ, Park Y, Huang P, Andersson S, Gantz D, Grant AK, Ruiz-Opazo N, Herrera VLM, Wong JY. Janus USPION modular platform (JUMP) for theranostic ultrasound-mediated targeted intratumoral microvascular imaging and DNA/miRNA delivery. Theranostics. 2022; 12(18):7646-7667.View Related Profiles. PMID: 36451861; PMCID: PMC9706579; DOI: 10.7150/thno.78454;
     
  6. Carstensen S, Müller M, Tan GLA, Pasion KA, Hohlfeld JM, Herrera VLM, Ruiz-Opazo N. "Rogue" neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury - studies in human, macaque and rat LPS-inflammation models. Front Immunol. 2022; 13:1008390.View Related Profiles. PMID: 36275710; PMCID: PMC9581391; DOI: 10.3389/fimmu.2022.1008390;
     
  7. Herrera VLM, Takahashi CE, Nguyen MQ, Mosaddeghi JZ, Denis R, Greer DM, Ruiz-Opazo N. "Rogue" [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage. Front Neurol. 2022; 13:935579.View Related Profiles. PMID: 35959408; PMCID: PMC9358208; DOI: 10.3389/fneur.2022.935579;
     
  8. Herrera VLM, Walkey AJ, Nguyen MQ, Gromisch CM, Mosaddhegi JZ, Gromisch MS, Jundi B, Lukassen S, Carstensen S, Denis R, Belkina AC, Baron RM, Pinilla-Vera M, Mueller M, Kimberly WT, Goldstein JN, Lehmann I, Shih AR, Eils R, Levy BD, Ruiz-Opazo N. A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS. Sci Rep. 2022 Apr 04; 12(1):5583.View Related Profiles. PMID: 35379853; PMCID: PMC8977568; DOI: 10.1038/s41598-022-09343-1;
     
  9. deKay JT, Emery IF, Rud J, Eldridge A, Lord C, Gagnon DJ, May TL, Herrera VLM, Ruiz-Opazo N, Riker RR, Sawyer DB, Ryzhov S, Seder DB. DEspRhigh neutrophils are associated with critical illness in COVID-19. Sci Rep. 2021 11 17; 11(1):22463.View Related Profiles. PMID: 34789851; PMCID: PMC8599677; DOI: 10.1038/s41598-021-01943-7;
     
  10. Herrera VLM, Walkey AJ, Nguyen MQ, Gromisch CM, Mosaddhegi JZ, Gromisch MS, Jundi B, Lukassen S, Carstensen S, Denis R, Belkina AC, Baron RM, Pinilla-Vera M, Muller M, Kimberly WT, Goldstein JN, Lehmann I, Shih AR, Eils R, Levy BD, Ruiz-Opazo N. Increased Neutrophil-Subset Associated With Severity/Mortality In ARDS And COVID19-ARDS Expresses The Dual Endothelin-1/VEGFsignal-Peptide Receptor (DEspR): An Actionable Therapeutic Target. Res Sq. 2021 Sep 13.View Related Profiles. PMID: 34545358; PMCID: PMC8452107; DOI: 10.21203/rs.3.rs-846250/v1;
     
Showing 10 of 104 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 104 publications over 34 distinct years, with a maximum of 6 publications in 1994 and 2007 and 2013

YearPublications
19872
19882
19902
19911
19921
19931
19946
19951
19961
19973
19985
19991
20015
20022
20033
20044
20054
20064
20076
20083
20094
20105
20114
20124
20136
20142
20152
20164
20174
20181
20213
20224
20233
20241


Recent (within 3 months)

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The Brink 8/22/2024

1996 University of the Philippines Medical Alumni Association: Outstanding Overseas Researcher
1989-1992 Syntex : Syntex Scholars Award for Excellence in Cardiovascular Research
1987-1992 NIH: Physician Scientist Award
1985 Boston Children's Hospital, Harvard Medical School: Wolbach Research Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

angiogenesis
transgenic rat models
ultrasound gene transfer
ultrasound molecular imaging
neutrophil-mediated secondary tissue injury
DEspR
Translational Medical Research
Nanomedicine, Theranostic
Acute Respiratory Distress Syndrome
Intracerebral Hemorrhage
Pancreatic Cancer
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Boston MA 02118
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