Keywords
Last Name

Kevan L. Hartshorn, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-5638
ORCID ORCID Icon0000-0002-7196-7433
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionHematology & Medical Oncology

 Research Expertise & Professional Interests
Expertise includes: Innate immunity to respiratory infection; Neutrophil Biology; Influenza Virus; Gastrointestinal cancer.

 Self-Described Keywords
  • Gastrointestinal cancer
  • Innate Immunity
  • Neutrophils
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. De Luna X, Hartshorn KL. Influenza Casts a Lung Shadow. Am J Pathol. 2017 Apr; 187(4):697-699. PMID: 28222276.
    View in: PubMed
  2. Elias R, Karantanos T, Sira E, Hartshorn KL. Immunotherapy comes of age: Immune aging & checkpoint inhibitors. J Geriatr Oncol. 2017 Feb 17. PMID: 28223073.
    View in: PubMed
  3. Chua MM, Ortega CE, Sheikh A, Lee M, Abdul-Rassoul H, Hartshorn KL, Dominguez I. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017 Jan 28; 10(1). PMID: 28134850.
    View in: PubMed
  4. Phull P, Quillen K, Hartshorn KL. Acute Oxaliplatin-induced Hemolytic Anemia, Thrombocytopenia, and Renal Failure: Case Report and a Literature Review. Clin Colorectal Cancer. 2016 Nov 23. PMID: 27989485.
    View in: PubMed
  5. White MR, Tripathi S, Verma A, Kingma P, Takahashi K, Jensenius J, Thiel S, Wang G, Crouch EC, Hartshorn KL. Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production. Innate Immun. 2017 Jan; 23(1):77-88. PMID: 27856789.
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  6. Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150. PMID: 27661103.
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  7. Lee SY, Sissoko M, Hartshorn KL. Update on the Management of Pancreatic Cancer in Older Adults. Curr Oncol Rep. 2016 Oct; 18(10):60. PMID: 27492426.
    View in: PubMed
  8. Chelimeda S, Bejarano T, Lowe R, Soliman M, Zhao Q, Hartshorn KL. Long-Term Survival after Resection of Lung Metastases from Hepatocellular Cancer: Report of a Case and Review of the Literature. Case Rep Oncol. 2016 Sep-Dec; 9(3):559-564. PMID: 27790121.
    View in: PubMed
  9. Hsieh IN, Hartshorn KL. The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy. Pharmaceuticals (Basel). 2016; 9(3). PMID: 27608030.
    View in: PubMed
  10. Khatri K, Klein JA, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J. Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions. Mol Cell Proteomics. 2016 Jun; 15(6):1895-912. PMID: 26984886.
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  11. Hoeksema M, van Eijk M, Haagsman HP, Hartshorn KL. Histones as mediators of host defense, inflammation and thrombosis. Future Microbiol. 2016; 11(3):441-53. PMID: 26939619.
    View in: PubMed
  12. Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. PLoS One. 2015; 10(8):e0133454. PMID: 26308522.
    View in: PubMed
  13. Hoeksema M, Tripathi S, White M, Qi L, Taubenberger J, van Eijk M, Haagsman H, Hartshorn KL. Arginine-rich histones have strong antiviral activity for influenza A viruses. Innate Immun. 2015 Oct; 21(7):736-45. PMID: 26138524.
    View in: PubMed
  14. Tripathi S, Wang G, White M, Qi L, Taubenberger J, Hartshorn KL. Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses. PLoS One. 2015; 10(4):e0124706. PMID: 25909853.
    View in: PubMed
  15. Kalman RS, Hartshorn K, Farraye FA. Does a personal or family history of malignancy preclude the use of immunomodulators and biologics in IBD. Inflamm Bowel Dis. 2015 Feb; 21(2):428-35. PMID: 25251059.
    View in: PubMed
  16. Qi L, Pujanauski LM, Davis AS, Schwartzman LM, Chertow DS, Baxter D, Scherler K, Hartshorn KL, Slemons RD, Walters KA, Kash JC, Taubenberger JK. Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin. MBio. 2014; 5(6):e02116. PMID: 25406382.
    View in: PubMed
  17. Zhu V, de Las Morenas A, Janicek M, Hartshorn K. Hypercalcemia from metastatic pancreatic neuroendocrine tumor secreting 1,25-dihydroxyvitamin D. J Gastrointest Oncol. 2014 Aug; 5(4):E84-7. PMID: 25083313.
    View in: PubMed
  18. Tripathi S, Verma A, Kim EJ, White MR, Hartshorn KL. LL-37 modulates human neutrophil responses to influenza A virus. J Leukoc Biol. 2014 Nov; 96(5):931-8. PMID: 25082153.
    View in: PubMed
  19. White MR, Kandel R, Tripathi S, Condon D, Qi L, Taubenberger J, Hartshorn KL. Alzheimer's associated ß-amyloid protein inhibits influenza A virus and modulates viral interactions with phagocytes. PLoS One. 2014; 9(7):e101364. PMID: 24988208.
    View in: PubMed
  20. Nikolaidis NM, White MR, Allen K, Tripathi S, Qi L, McDonald B, Taubenberger J, Seaton BA, McCormack FX, Crouch EC, Hartshorn KL. Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L1036-44. PMID: 24705721.
    View in: PubMed
  21. Nelson B, Zhou X, White M, Hartshorn K, Takahashi K, Kinane TB, Anandaiah A, Koziel H. Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro. J Leukoc Biol. 2014 May; 95(5):715-722. PMID: 24399838.
    View in: PubMed
  22. Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA. Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation. Biochemistry. 2013 Nov 26; 52(47):8527-38. PMID: 24224757.
    View in: PubMed
  23. Tripathi S, White MR, Hartshorn KL. The amazing innate immune response to influenza A virus infection. Innate Immun. 2015 Jan; 21(1):73-98. PMID: 24217220.
    View in: PubMed
  24. Takahashi K, Moyo P, Chigweshe L, Chang WC, White MR, Hartshorn KL. Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study. Virus Res. 2013 Dec 26; 178(2):495-501. PMID: 24140629.
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  25. Parekh A, Truong MT, Pashtan I, Qureshi MM, Martin NE, Nawaz O, Cerda S, Willins J, Hartshorn KL, Kachnic LA. Acute gastrointestinal toxicity and tumor response with preoperative intensity modulated radiation therapy for rectal cancer. Gastrointest Cancer Res. 2013 Sep; 6(5-6):137-43. PMID: 24312687.
    View in: PubMed
  26. Hartshorn KL. Why does pandemic influenza virus kill? Am J Pathol. 2013 Oct; 183(4):1125-7. PMID: 23916382.
    View in: PubMed
  27. Gally F, Kosmider B, Weaver MR, Pate KM, Hartshorn KL, Oberley-Deegan RE. FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1; 305(1):L64-72. PMID: 23624787.
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  28. Shao C, Shi X, White M, Huang Y, Hartshorn K, Zaia J. Comparative glycomics of leukocyte glycosaminoglycans. FEBS J. 2013 May; 280(10):2447-61. PMID: 23480678.
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  29. Volandes AE, Paasche-Orlow MK, Mitchell SL, El-Jawahri A, Davis AD, Barry MJ, Hartshorn KL, Jackson VA, Gillick MR, Walker-Corkery ES, Chang Y, López L, Kemeny M, Bulone L, Mann E, Misra S, Peachey M, Abbo ED, Eichler AF, Epstein AS, Noy A, Levin TT, Temel JS. Randomized controlled trial of a video decision support tool for cardiopulmonary resuscitation decision making in advanced cancer. J Clin Oncol. 2013 Jan 20; 31(3):380-6. PMID: 23233708.
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  30. Wilkes G, Hartshorn K. Clinical update: colon, rectal, and anal cancers. Semin Oncol Nurs. 2012 Nov; 28(4):e1-22. PMID: 23107187.
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  31. Bohac GC, Guaqueta D, Cheng DM, Aschengrau A, Hartshorn KL. Disparity in the use of combined modality therapy for rectal cancer in the older adult. J Geriatr Oncol. 2013 Jan; 4(1):90-7. PMID: 24071497.
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  32. Tripathi S, Tecle T, Verma A, Crouch E, White M, Hartshorn KL. The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins. J Gen Virol. 2013 Jan; 94(Pt 1):40-9. PMID: 23052388.
    View in: PubMed
  33. Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J Immunol. 2012 Sep 1; 189(5):2478-87. PMID: 22851708.
    View in: PubMed
  34. van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. J Biol Chem. 2012 Aug 3; 287(32):26666-77. PMID: 22685299.
    View in: PubMed
  35. Kosmider B, Messier EM, Janssen WJ, Nahreini P, Wang J, Hartshorn KL, Mason RJ. Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respir Res. 2012; 13:43. PMID: 22672594.
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  36. Oiknine-Djian E, Houri-Haddad Y, Weiss EI, Ofek I, Greenbaum E, Hartshorn K, Zakay-Rones Z. High molecular weight constituents of cranberry interfere with influenza virus neuraminidase activity in vitro. Planta Med. 2012 Jun; 78(10):962-7. PMID: 22588835.
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  37. Larvie M, Shoup T, Chang WC, Chigweshe L, Hartshorn K, White MR, Stahl GL, Elmaleh DR, Takahashi K. Mannose-binding lectin binds to amyloid ß protein and modulates inflammation. J Biomed Biotechnol. 2012; 2012:929803. PMID: 22536027.
    View in: PubMed
  38. Wang J, Nikrad MP, Travanty EA, Zhou B, Phang T, Gao B, Alford T, Ito Y, Nahreini P, Hartshorn K, Wentworth D, Dinarello CA, Mason RJ. Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 2012; 7(3):e29879. PMID: 22396727.
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  39. Doss M, Ruchala P, Tecle T, Gantz D, Verma A, Hartshorn A, Crouch EC, Luong H, Micewicz ED, Lehrer RI, Hartshorn KL. Hapivirins and diprovirins: novel ?-defensin analogs with potent activity against influenza A virus. J Immunol. 2012 Mar 15; 188(6):2759-68. PMID: 22345650.
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  40. Numata M, Kandasamy P, Nagashima Y, Posey J, Hartshorn K, Woodland D, Voelker DR. Phosphatidylglycerol suppresses influenza A virus infection. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):479-87. PMID: 22052877.
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  41. Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92. PMID: 21965658.
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  42. Sever-Chroneos Z, Murthy A, Davis J, Florence JM, Kurdowska A, Krupa A, Tichelaar JW, White MR, Hartshorn KL, Kobzik L, Whitsett JA, Chroneos ZC. GM-CSF modulates pulmonary resistance to influenza A infection. Antiviral Res. 2011 Nov; 92(2):319-28. PMID: 21925209.
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  43. Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O'Donnell E. Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection. J Infect Dis. 2011 Aug 15; 204(4):592-600. PMID: 21791661.
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  44. van Eijk M, Bruinsma L, Hartshorn KL, White MR, Rynkiewicz MJ, Seaton BA, Hemrika W, Romijn RA, van Balkom BW, Haagsman HP. Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses. J Biol Chem. 2011 Jun 10; 286(23):20137-51. PMID: 21489996.
    View in: PubMed
  45. Qi L, Kash JC, Dugan VG, Jagger BW, Lau YF, Sheng ZM, Crouch EC, Hartshorn KL, Taubenberger JK. The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding. Virology. 2011 Apr 10; 412(2):426-34. PMID: 21334038.
    View in: PubMed
  46. Wang J, Nikrad MP, Phang T, Gao B, Alford T, Ito Y, Edeen K, Travanty EA, Kosmider B, Hartshorn K, Mason RJ. Innate immune response to influenza A virus in differentiated human alveolar type II cells. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):582-91. PMID: 21239608.
    View in: PubMed
  47. Chang WC, White MR, Moyo P, McClear S, Thiel S, Hartshorn KL, Takahashi K. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010; 11:64. PMID: 21182784.
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  48. Kachnic LA, Tsai HK, Coen JJ, Blaszkowsky LS, Hartshorn K, Kwak EL, Willins JD, Ryan DP, Hong TS. Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy. Int J Radiat Oncol Biol Phys. 2012 Jan 1; 82(1):153-8. PMID: 21095071.
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  49. Chang WC, Hartshorn KL, White MR, Moyo P, Michelow IC, Koziel H, Kinane BT, Schmidt EV, Fujita T, Takahashi K. Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin. Biochem Pharmacol. 2011 Feb 1; 81(3):388-95. PMID: 21035429.
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  50. Hansen S, Selman L, Palaniyar N, Ziegler K, Brandt J, Kliem A, Jonasson M, Skjoedt MO, Nielsen O, Hartshorn K, Jørgensen TJ, Skjødt K, Holmskov U. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity. J Immunol. 2010 Nov 15; 185(10):6096-104. PMID: 20956340.
    View in: PubMed
  51. Hartshorn KL, White MR, Rynkiewicz M, Sorensen G, Holmskov U, Head J, Crouch EC. Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L384-92. PMID: 20601494.
    View in: PubMed
  52. Hartshorn KL, White MR, Smith K, Sorensen G, Kuroki Y, Holmskov U, Head J, Crouch EC. Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity. Scand J Immunol. 2010 Jul; 72(1):22-30. PMID: 20591072.
    View in: PubMed
  53. Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: Structural determinants of pattern recognition by lung collectins. Innate Immun. 2010 Jun; 16(3):143-50. PMID: 20423923.
    View in: PubMed
  54. Tecle T, Tripathi S, Hartshorn KL. Review: Defensins and cathelicidins in lung immunity. Innate Immun. 2010 Jun; 16(3):151-9. PMID: 20418263.
    View in: PubMed
  55. Hartshorn KL. Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense. Front Biosci (Schol Ed). 2010; 2:527-46. PMID: 20036966.
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  56. White MR, Boland P, Tecle T, Gantz D, Sorenson G, Tornoe I, Holmskov U, McDonald B, Crouch EC, Hartshorn KL. Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain. J Innate Immun. 2010; 2(3):267-79. PMID: 20375547.
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  57. Hartshorn KL. New look at an old problem: bacterial superinfection after influenza. Am J Pathol. 2010 Feb; 176(2):536-9. PMID: 20019194.
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  58. Hartshorn KL, White MR, Tecle T, Sorensen G, Holmskov U, Crouch EC. Viral aggregating and opsonizing activity in collectin trimers. Am J Physiol Lung Cell Mol Physiol. 2010 Jan; 298(1):L79-88. PMID: 19837850.
    View in: PubMed
  59. Doss M, White MR, Tecle T, Hartshorn KL. Human defensins and LL-37 in mucosal immunity. J Leukoc Biol. 2010 Jan; 87(1):79-92. PMID: 19808939.
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  60. Doss M, White MR, Tecle T, Gantz D, Crouch EC, Jung G, Ruchala P, Waring AJ, Lehrer RI, Hartshorn KL. Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D. J Immunol. 2009 Jun 15; 182(12):7878-87. PMID: 19494312.
    View in: PubMed
  61. Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger PH, Head J. Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21; 48(15):3335-45. PMID: 19249874.
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  62. Wilkes G, Hartshorn K. Colon, rectal, and anal cancers. Semin Oncol Nurs. 2009 Feb; 25(1):32-47. PMID: 19217504.
    View in: PubMed
  63. Wang J, Oberley-Deegan R, Wang S, Nikrad M, Funk CJ, Hartshorn KL, Mason RJ. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol. 2009 Feb 1; 182(3):1296-304. PMID: 19155475.
    View in: PubMed
  64. White MR, Helmerhorst EJ, Ligtenberg A, Karpel M, Tecle T, Siqueira WL, Oppenheim FG, Hartshorn KL. Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol Immunol. 2009 Feb; 24(1):18-24. PMID: 19121065.
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  65. White M, Kingma P, Tecle T, Kacak N, Linders B, Heuser J, Crouch E, Hartshorn K. Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus. J Immunol. 2008 Dec 1; 181(11):7936-43. PMID: 19017984.
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  66. Hartshorn KL, Webby R, White MR, Tecle T, Pan C, Boucher S, Moreland RJ, Crouch EC, Scheule RK. Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D. Respir Res. 2008; 9:65. PMID: 18811961.
    View in: PubMed
  67. White MR, Doss M, Boland P, Tecle T, Hartshorn KL. Innate immunity to influenza virus: implications for future therapy. Expert Rev Clin Immunol. 2008 Jul 01; 4(4):497-514. PMID: 19756245.
    View in: PubMed
  68. Tecle T, White MR, Sorensen G, Gantz D, Kacak N, Holmskov U, Smith K, Crouch EC, Hartshorn KL. Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus. Biochem J. 2008 Jun 1; 412(2):323-9. PMID: 18302538.
    View in: PubMed
  69. White MR, Tecle T, Crouch EC, Hartshorn KL. Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1293-9. PMID: 17720872.
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  70. Tecle T, White MR, Gantz D, Crouch EC, Hartshorn KL. Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses. J Immunol. 2007 Jun 15; 178(12):8046-52. PMID: 17548642.
    View in: PubMed
  71. Mikerov AN, White M, Hartshorn K, Wang G, Floros J. Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells. Med Microbiol Immunol. 2008 Mar; 197(1):9-12. PMID: 17520282.
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  72. Tecle T, White MR, Crouch EC, Hartshorn KL. Inhibition of influenza viral neuraminidase activity by collectins. Arch Virol. 2007; 152(9):1731-42. PMID: 17514488.
    View in: PubMed
  73. Hartshorn KL, White MR, Tecle T, Tornoe I, Sorensen GL, Crouch EC, Holmskov U. Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D. Respir Res. 2007; 8:9. PMID: 17280604.
    View in: PubMed
  74. Kingma PS, Zhang L, Ikegami M, Hartshorn K, McCormack FX, Whitsett JA. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D. J Biol Chem. 2006 Aug 25; 281(34):24496-505. PMID: 16787926.
    View in: PubMed
  75. Hartshorn KL, White MR, Tecle T, Holmskov U, Crouch EC. Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D. J Immunol. 2006 Jun 1; 176(11):6962-72. PMID: 16709857.
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  76. Crouch EC, Smith K, McDonald B, Briner D, Linders B, McDonald J, Holmskov U, Head J, Hartshorn K. Species differences in the carbohydrate binding preferences of surfactant protein D. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):84-94. PMID: 16514117.
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  77. Lee RM, White MR, Hartshorn KL. Influenza a viruses upregulate neutrophil toll-like receptor 2 expression and function. Scand J Immunol. 2006 Feb; 63(2):81-9. PMID: 16476006.
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  78. Hartshorn KL, Ligtenberg A, White MR, Van Eijk M, Hartshorn M, Pemberton L, Holmskov U, Crouch E. Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochem J. 2006 Jan 15; 393(Pt 2):545-53. PMID: 16190864.
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  79. Meschi J, Crouch EC, Skolnik P, Yahya K, Holmskov U, Leth-Larsen R, Tornoe I, Tecle T, White MR, Hartshorn KL. Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication. J Gen Virol. 2005 Nov; 86(Pt 11):3097-107. PMID: 16227233.
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  80. White MR, Crouch E, Vesona J, Tacken PJ, Batenburg JJ, Leth-Larsen R, Holmskov U, Hartshorn KL. Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus. Am J Physiol Lung Cell Mol Physiol. 2005 Oct; 289(4):L606-16. PMID: 15951332.
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  81. Crouch E, Tu Y, Briner D, McDonald B, Smith K, Holmskov U, Hartshorn K. Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus. J Biol Chem. 2005 Apr 29; 280(17):17046-56. PMID: 15711012.
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  82. Leth-Larsen R, Garred P, Jensenius H, Meschi J, Hartshorn K, Madsen J, Tornoe I, Madsen HO, Sørensen G, Crouch E, Holmskov U. A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 2005 Feb 1; 174(3):1532-8. PMID: 15661913.
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  83. Kandel R, Hartshorn KL. Novel strategies for prevention and treatment of influenza. Expert Opin Ther Targets. 2005 Feb; 9(1):1-22. PMID: 15757479.
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  84. White MR, Crouch E, van Eijk M, Hartshorn M, Pemberton L, Tornoe I, Holmskov U, Hartshorn KL. Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L831-40. PMID: 15608147.
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  85. Tacken PJ, Hartshorn KL, White MR, van Kooten C, van de Winkel JG, Reid KB, Batenburg JJ. Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein. J Immunol. 2004 Apr 15; 172(8):4934-40. PMID: 15067073.
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  86. Mogues T, Etzerodt M, Hall C, Engelich G, Graversen JH, Hartshorn KL. Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity. J Biomed Biotechnol. 2004; 2004(2):73-78. PMID: 15240916.
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  87. van Eijk M, White MR, Batenburg JJ, Vaandrager AB, van Golde LM, Haagsman HP, Hartshorn KL. Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):871-9. PMID: 14672916.
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  88. van Eijk M, White MR, Crouch EC, Batenburg JJ, Vaandrager AB, Van Golde LM, Haagsman HP, Hartshorn KL. Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain. J Immunol. 2003 Aug 1; 171(3):1431-40. PMID: 12874235.
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  89. Hartshorn KL, White MR, Mogues T, Ligtenberg T, Crouch E, Holmskov U. Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1066-76. PMID: 12871854.
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  90. Hartshorn KL, White MR, Crouch EC. Contributions of the N- and C-terminal domains of surfactant protein d to the binding, aggregation, and phagocytic uptake of bacteria. Infect Immun. 2002 Nov; 70(11):6129-39. PMID: 12379690.
    View in: PubMed
  91. Hartshorn KL, Holmskov U, Hansen S, Zhang P, Meschi J, Mogues T, White MR, Crouch EC. Distinctive anti-influenza properties of recombinant collectin 43. Biochem J. 2002 Aug 15; 366(Pt 1):87-96. PMID: 11971759.
    View in: PubMed
  92. van Eijk M, van de Lest CH, Batenburg JJ, Vaandrager AB, Meschi J, Hartshorn KL, van Golde LM, Haagsman HP. Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):739-47. PMID: 12034574.
    View in: PubMed
  93. Engelich G, White M, Hartshorn KL. Role of the respiratory burst in co-operative reduction in neutrophil survival by influenza A virus and Escherichia coli. J Med Microbiol. 2002 Jun; 51(6):484-90. PMID: 12018655.
    View in: PubMed
  94. Zhang L, Hartshorn KL, Crouch EC, Ikegami M, Whitsett JA. Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein. J Biol Chem. 2002 Jun 21; 277(25):22453-9. PMID: 11956209.
    View in: PubMed
  95. LeVine AM, Hartshorn K, Elliott J, Whitsett J, Korfhagen T. Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L563-72. PMID: 11839553.
    View in: PubMed
  96. LeVine AM, Whitsett JA, Hartshorn KL, Crouch EC, Korfhagen TR. Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J Immunol. 2001 Nov 15; 167(10):5868-73. PMID: 11698462.
    View in: PubMed
  97. Engelich G, Wright DG, Hartshorn KL. Acquired disorders of phagocyte function complicating medical and surgical illnesses. Clin Infect Dis. 2001 Dec 15; 33(12):2040-8. PMID: 11698988.
    View in: PubMed
  98. White MR, Crouch E, Chang D, Hartshorn KL. Increased antiviral and opsonic activity of a highly multimerized collectin chimera. Biochem Biophys Res Commun. 2001 Aug 10; 286(1):206-13. PMID: 11485330.
    View in: PubMed
  99. Choufani EB, Lazar HL, Hartshorn KL. Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 2. Chemotherapy-responsive right artial metastasis from colon carcinoma. J Clin Oncol. 2001 Aug 1; 19(15):3574-5. PMID: 11481366.
    View in: PubMed
  100. Engelich G, White M, Hartshorn KL. Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst. J Leukoc Biol. 2001 Jan; 69(1):50-6. PMID: 11200067.
    View in: PubMed
  101. Kandel R, Hartshorn KL. Prophylaxis and treatment of influenza virus infection. BioDrugs. 2001; 15(5):303-23. PMID: 11437694.
    View in: PubMed
  102. Hartshorn KL, White MR, Voelker DR, Coburn J, Zaner K, Crouch EC. Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity. Biochem J. 2000 Oct 15; 351 Pt 2:449-58. PMID: 11023831.
    View in: PubMed
  103. White MR, Crouch E, Chang D, Sastry K, Guo N, Engelich G, Takahashi K, Ezekowitz RA, Hartshorn KL. Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera. J Immunol. 2000 Aug 15; 165(4):2108-15. PMID: 10925296.
    View in: PubMed
  104. Engelich G, Swan N, Hartshorn KL. Raised plasma parathyroid hormone related peptide in gastric adenocarcinoma. J Clin Pathol. 2000 Aug; 53(8):643-4. PMID: 11002775.
    View in: PubMed
  105. Dolan R, Hartshorn K, McAvoy D. Circulating neutrophil CD18 receptor expression and ischemic flap neutrophil infiltration in a guinea pig model. Otolaryngol Head Neck Surg. 2000 Mar; 122(3):374-7. PMID: 10699814.
    View in: PubMed
  106. Crouch E, Hartshorn K, Ofek I. Collectins and pulmonary innate immunity. Immunol Rev. 2000 Feb; 173:52-65. PMID: 10719667.
    View in: PubMed
  107. Hartshorn KL, White MR, Ezekowitz RA, Sastry K, Crouch E. Development of chimeric collectins with enhanced activity against influenza A virus. Adv Exp Med Biol. 2000; 479:49-59. PMID: 10897409.
    View in: PubMed
  108. Hartshorn KL, Sastry KN, Chang D, White MR, Crouch EC. Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. Am J Physiol Lung Cell Mol Physiol. 2000 Jan; 278(1):L90-8. PMID: 10645895.
    View in: PubMed
  109. Hartshorn KL, White MR. Influenza A virus up-regulates neutrophil adhesion molecules and adhesion to biological surfaces. J Leukoc Biol. 1999 May; 65(5):614-22. PMID: 10331489.
    View in: PubMed
  110. Colamussi ML, White MR, Crouch E, Hartshorn KL. Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria. Blood. 1999 Apr 1; 93(7):2395-403. PMID: 10090951.
    View in: PubMed
  111. Akpek G, Hartshorn KL. Failure of oral nitrate and calcium channel blocker therapy to prevent 5-fluorouracil-related myocardial ischemia: a case report. Cancer Chemother Pharmacol. 1999; 43(2):157-61. PMID: 9923822.
    View in: PubMed
  112. Dolan R, Hartshorn K, Andry C, Tablante J, Grillone G, McAvoy D, Suntra C. In vivo correlation of neutrophil receptor expression, ischemia-reperfusion injury, and selective 5-lipoxygenase inhibition in guinea pigs. Arch Otolaryngol Head Neck Surg. 1998 Dec; 124(12):1377-80. PMID: 9865762.
    View in: PubMed
  113. Dolan R, Hartshorn K, Andry C, McAvoy D. Systemic neutrophil intrinsic 5-lipoxygenase activity and CD18 receptor expression linked to reperfusion injury. Laryngoscope. 1998 Sep; 108(9):1386-9. PMID: 9738763.
    View in: PubMed
  114. Hartshorn KL, Crouch E, White MR, Colamussi ML, Kakkanatt A, Tauber B, Shepherd V, Sastry KN. Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria. Am J Physiol. 1998 Jun; 274(6 Pt 1):L958-69. PMID: 9609735.
    View in: PubMed
  115. Hartshorn KL, White MR, Shepherd V, Reid K, Jensenius JC, Crouch EC. Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. Am J Physiol. 1997 Dec; 273(6 Pt 1):L1156-66. PMID: 9435570.
    View in: PubMed
  116. Hartshorn K, Chang D, Rust K, White M, Heuser J, Crouch E. Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A. Am J Physiol. 1996 Nov; 271(5 Pt 1):L753-62. PMID: 8944718.
    View in: PubMed
  117. Brown-Augsburger P, Hartshorn K, Chang D, Rust K, Fliszar C, Welgus HG, Crouch EC. Site-directed mutagenesis of Cys-15 and Cys-20 of pulmonary surfactant protein D. Expression of a trimeric protein with altered anti-viral properties. J Biol Chem. 1996 Jun 7; 271(23):13724-30. PMID: 8662732.
    View in: PubMed
  118. Hartshorn KL, Reid KB, White MR, Jensenius JC, Morris SM, Tauber AI, Crouch E. Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies. Blood. 1996 Apr 15; 87(8):3450-61. PMID: 8605364.
    View in: PubMed
  119. Hartshorn KL, Liou LS, White MR, Kazhdan MM, Tauber JL, Tauber AI. Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins. J Immunol. 1995 Apr 15; 154(8):3952-60. PMID: 7706733.
    View in: PubMed
  120. Little R, White MR, Hartshorn KL. Interferon-alpha enhances neutrophil respiratory burst responses to stimulation with influenza A virus and FMLP. J Infect Dis. 1994 Oct; 170(4):802-10. PMID: 7930721.
    View in: PubMed
  121. Kazhdan M, White MR, Tauber AI, Hartshorn KL. Human neutrophil respiratory burst response to influenza A virus occurs at an intracellular location. J Leukoc Biol. 1994 Jul; 56(1):59-64. PMID: 8027671.
    View in: PubMed
  122. Liou LS, Sastry R, Hartshorn KL, Lee YM, Okarma TB, Tauber AI, Sastry KN. Bovine conglutinin gene exon structure reveals its evolutionary relationship to surfactant protein-D. J Immunol. 1994 Jul 1; 153(1):173-80. PMID: 8207234.
    View in: PubMed
  123. Hartshorn KL, Crouch EC, White MR, Eggleton P, Tauber AI, Chang D, Sastry K. Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses. J Clin Invest. 1994 Jul; 94(1):311-9. PMID: 8040272.
    View in: PubMed
  124. Liou LS, Sastry R, Hartshorn KL, Lee YM, Okarma TB, Tauber AI, Sastry KN. Bovine conglutinin (BC) mRNA expressed in liver: cloning and characterization of the BC cDNA reveals strong homology to surfactant protein-D. Gene. 1994 Apr 20; 141(2):277-81. PMID: 8163202.
    View in: PubMed
  125. Hartshorn KL, Sastry K, Brown D, White MR, Okarma TB, Lee YM, Tauber AI. Conglutinin acts as an opsonin for influenza A viruses. J Immunol. 1993 Dec 1; 151(11):6265-73. PMID: 8245465.
    View in: PubMed
  126. Hartshorn KL, Sastry K, White MR, Anders EM, Super M, Ezekowitz RA, Tauber AI. Human mannose-binding protein functions as an opsonin for influenza A viruses. J Clin Invest. 1993 Apr; 91(4):1414-20. PMID: 7682571.
    View in: PubMed
  127. Oh SK, Cerda S, Lee BG, Blanchard GC, Walker JE, Hartshorn K. Partial purification and identification of an immunosuppressive factor in AIDS sera. AIDS Res Hum Retroviruses. 1993 Apr; 9(4):365-73. PMID: 7685613.
    View in: PubMed
  128. Daigneault DE, Hartshorn KL, Liou LS, Abbruzzi GM, White MR, Oh SK, Tauber AI. Influenza A virus binding to human neutrophils and cross-linking requirements for activation. Blood. 1992 Dec 15; 80(12):3227-34. PMID: 1334733.
    View in: PubMed
  129. Hartshorn KL, Daigneault DE, White MR, Tauber AI. Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins. J Leukoc Biol. 1992 Mar; 51(3):230-6. PMID: 1311744.
    View in: PubMed
  130. Hartshorn KL, Daigneault DE, White MR, Tuvin M, Tauber JL, Tauber AI. Comparison of influenza A virus and formyl-methionyl-leucyl-phenylalanine activation of the human neutrophil. Blood. 1992 Feb 15; 79(4):1049-57. PMID: 1310628.
    View in: PubMed
  131. Karnad AB, Hartshorn KL, Tauber AI. Effect of nisoldipine on priming and activation of the human neutrophil respiratory burst. Agents Actions. 1990 Aug; 31(1-2):79-85. PMID: 2285025.
    View in: PubMed
  132. Hartshorn KL, Wright J, Collamer MA, White MR, Tauber AI. Human neutrophil stimulation by influenza virus: relationship of cytoplasmic pH changes to cell activation. Am J Physiol. 1990 Jun; 258(6 Pt 1):C1070-6. PMID: 2113768.
    View in: PubMed
  133. Hartshorn KL, Karnad AB, Tauber AI. Influenza A virus and the neutrophil: a model of natural immunity. J Leukoc Biol. 1990 Feb; 47(2):176-86. PMID: 2406357.
    View in: PubMed
  134. Hartshorn KL, Collamer M, White MR, Schwartz JH, Tauber AI. Characterization of influenza A virus activation of the human neutrophil. Blood. 1990 Jan 1; 75(1):218-26. PMID: 2153030.
    View in: PubMed
  135. Karnad AB, Hartshorn KL, Wright J, Myers JB, Schwartz JH, Tauber AI. Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. Blood. 1989 Nov 15; 74(7):2519-26. PMID: 2553166.
    View in: PubMed
  136. Tauber AI, Karnad AB, Hartshorn KL, Myers JB, Schwartz JH. Parameters of neutrophil activation: models of priming and deactivation. Prog Clin Biol Res. 1989; 297:297-309. PMID: 2685824.
    View in: PubMed
  137. Hartshorn KL, Collamer M, Auerbach M, Myers JB, Pavlotsky N, Tauber AI. Effects of influenza A virus on human neutrophil calcium metabolism. J Immunol. 1988 Aug 15; 141(4):1295-301. PMID: 3135328.
    View in: PubMed
  138. Hartshorn KL, Tauber AI. The influenza virus--infected phagocyte. A model of deactivation. Hematol Oncol Clin North Am. 1988 Jun; 2(2):301-15. PMID: 2455702.
    View in: PubMed
  139. Blumberg RS, Paradis T, Hartshorn KL, Vogt M, Ho DD, Hirsch MS, Leban J, Sato VL, Schooley RT. Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus. J Infect Dis. 1987 Dec; 156(6):878-84. PMID: 3479500.
    View in: PubMed
  140. Blumberg RS, Hartshorn KL, Ardman B, Kaplan JC, Paradis T, Vogt M, Hirsch MS, Schooley RT. Dot immunobinding assay for detection of human immunodeficiency virus-associated antigens. J Clin Microbiol. 1987 Oct; 25(10):1989-92. PMID: 3312291.
    View in: PubMed
  141. Vogt MW, Hartshorn KL, Furman PA, Chou TC, Fyfe JA, Coleman LA, Crumpacker C, Schooley RT, Hirsch MS. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science. 1987 Mar 13; 235(4794):1376-9. PMID: 2435003.
    View in: PubMed
  142. Hartshorn KL, Vogt MW, Chou TC, Blumberg RS, Byington R, Schooley RT, Hirsch MS. Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon. Antimicrob Agents Chemother. 1987 Feb; 31(2):168-72. PMID: 3471180.
    View in: PubMed
  143. Hartshorn KL, Neumeyer D, Vogt MW, Schooley RT, Hirsch MS. Activity of interferons alpha, beta, and gamma against human immunodeficiency virus replication in vitro. AIDS Res Hum Retroviruses. 1987; 3(2):125-33. PMID: 3113463.
    View in: PubMed
  144. Schooley RT, Blumberg RS, Vogt M, Hartshorn K, Hirsch MS. Therapeutic perspectives in human immunodeficiency virus infection. J Exp Pathol. 1987; 3(4):661-80. PMID: 3331652.
    View in: PubMed
  145. Hartshorn KL, Sandstrom EG, Neumeyer D, Paradis TJ, Chou TC, Schooley RT, Hirsch MS. Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon. Antimicrob Agents Chemother. 1986 Jul; 30(1):189-91. PMID: 3019235.
    View in: PubMed
  146. Blumberg RS, Sandstrom EG, Paradis TJ, Neumeyer DN, Sarngadharan MG, Hartshorn KL, Byington RE, Hirsch MS, Schooley RT. Detection of human T-cell lymphotropic virus type III-related antigens and anti-human T-cell lymphotropic virus type III antibodies by anticomplementary immunofluorescence. J Clin Microbiol. 1986 Jun; 23(6):1072-7. PMID: 2423552.
    View in: PubMed
  147. Ho DD, Hartshorn KL, Rota TR, Andrews CA, Kaplan JC, Schooley RT, Hirsch MS. Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro. Lancet. 1985 Mar 16; 1(8429):602-4. PMID: 2857946.
    View in: PubMed
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