Keywords
Last Name

Gregory A. Grillone, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentOtolaryngology-Head & Neck Surgery
Address820 Harrison Ave
Boston MA 02118
Phone(617) 414-1777
ORCID ORCID Icon0000-0002-7243-7522
Other Positions
TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentSurgery

 Research Expertise & Professional Interests
1. PROSPECTIVE RESEARCH:
a) Retrospective Review of Long Term Voice Quality Following Augmentation of the Vocal Fold with Cymetra Using the Minihole Laryngoplasty Technique. IRB approval obtained this year. Chart review in progress.
b) Feasibility of Using Manual Robotic Instrumentation for Microlaryngeal Surgery. The objective of this study is to evaluate effectiveness of a proprietary robotic instrument for use in microlaryngeal surgery. The first phase of this study will utilize a larynx model/mannequin. Subsequent phases will utilize animal and cadaver models. Study is in initial stage of planning.
c) Use of the DaVinci Robotic System in Pharyngeal and Laryngeal Endoscopic Surgery. The object of this study is to evaluate the usefulness of the DaVinci robotic system in performing endoscopic pharyngeal and laryngeal surgery. Currently such procedures are carried out using conventional endoscopic instrumentation. We are in the process of submitting IRB application.
d) Phase 2, Open-label Trial of the Safety and Biological Effect of Pre-operative Peri-lymphatic Ultralow Dose IRX-2 (with Cyclophosphamide, Indomethacin, and Zinc) in Patients with Resectable Cancer of the Head and Neck. This study is in initial planning stage.

2. FUNDED RESEARCH:
a) Spectroscopic Imaging and Diagnosis of Neoplasia
Source: National Institutes of Health (NCI) - 1R01CA097966
P.I.: Gregory Grillone, M.D., F.A.C.S.
This study is the basis of my triologic thesis. The objectives of this research are to develop and test a spectroscopic based algorithm for the evaluation of cancer or pre-cancerous changes in oral cavity epithelium. An in depth study of this approach is being carried out in the oral cavity as well as for a data set previously collected from the esophagus. This study is being carried out in collaboration with the spectroscopy laboratory at MIT. They have developed a portable, clinical device known as the Fast Excitation Emission Matrix (Fast-EEM), which collects reflectance and fluorescence spectra. This instrument is being used to collect spectroscopic data prior to biopsy of oral cavity lesions in patients with suspicious lesions of the oral cavity.

b) Laser Atraumatic Treatment of Ectasias on Vocal Cords
Source: National Institutes of Health (NIDCD) - 1R21DC006853001
PI: Zimmern Wang, M.D.
Our previous studies have shown the efficacy and safety of PDL as an alternative to routine surgeries (that result in more scarring) for treatment of laryngeal papilloma. Specific aims are (1) to further optimize PDL parameters in the cheek pouches of a hamster model; (2) to compare the treatment selectivity and safety between CO2 laser and PDL microvascular targeting (MVT) treatment, in the same model; and (3) to determine whether PDL will produce better and quicker voice improvement than the CO2 laser, in 12 patients with vocal fold small vascular lesions (ectasias).

c) Voice Preserving Treatment of Recurrent Laryngeal Papilloma (RLP)
Source: National Institutes of Health (NIDCD) – 1R01DC006617
P.I. Zimmern Wang, M.D.
This study is a continuation of our effort to develop a new, low cost and less invasive alternative to the currently traumatic surgeries for RLP. Our final objective is to provide a “voice preserving” and long-term effective therapy for RLP that can be delivered in the putpatient setting. This 2 year study will evaluate 30 adults with RLP, using traditional CO2 laser in 15 cases and new PDL-Celecoxib treatment in other 15 cases.

d) Voice Preserving Treatment of Laryngeal Papilloma in Children
Source: National Institutes of Health (NIDCD) – 1R01DC008287
P.I. Zimmern Wang, M.D.

e) Prediction of Cancer Chemoprevention Efficacy with Cell Imaging
Source: National Institutes of Health (NCI) – 1R21CA
P.I. Zimmern Wang, M.D.

f) Harvard Collaborative Oral Cancer Study
Source: National Institutes of Health - Grant #CA 78609
P.I.: Karl T. Kelsey, M.D., M.O.H.,
Site P.I.: Gregory Grillone, M.D., F.A.C.S.

g) Long-term General and Voice Related Quality of Life after Botulinum Toxin Injection for Adductor Spasmodic Dysphonia
Source: Alpha Omega Honor Society
P.I. Gregory A. Grillone, M.D., F.A.C.S.

 Self-Described Keywords
  • early detection of squamous cell cancer of the head and neck
  • robotic instrumentation in endoscopic laryngeal and pharyngeal surgery
  • Spasmodic dysphonia
  • treatment of squamous cell cancer of the head and neck
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Tsai AC, Krisciunas GP, Brook C, Basa K, Gonzalez M, Crimlisk J, Silva J, Grillone GA. Comprehensive Emergency Airway Response Team (EART) Training and Education: Impact on Team Effectiveness, Personnel Confidence, and Protocol Knowledge. Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):457-63. PMID: 26658070.
    View in: PubMed
  2. Shah BA, Qureshi MM, Jalisi S, Grillone G, Salama A, Cooley T, Zaner K, Sakai O, Truong MT. Analysis of decision making at a multidisciplinary head and neck tumor board incorporating evidence-based National Cancer Comprehensive Network (NCCN) guidelines. Pract Radiat Oncol. 2016 Jul-Aug; 6(4):248-54. PMID: 26777060.
    View in: PubMed
  3. Krisciunas GP, Platt M, Trojanowska M, Grillone GA, Haines PC, Langmore SE. A Novel In Vivo Protocol for Molecular Study of Radiation-Induced Fibrosis in Head and Neck Cancer Patients. Ann Otol Rhinol Laryngol. 2016 Mar; 125(3):228-34. PMID: 26453487.
    View in: PubMed
  4. Wong S, Brook C, Grillone G. Management of Wire Brush Bristle Ingestion: Review of Literature and Presentation of an Algorithm. Ann Otol Rhinol Laryngol. 2016 Feb; 125(2):160-4. PMID: 26282588.
    View in: PubMed
  5. Brook CD, Platt MP, Russell K, Grillone GA, Aliphas A, Noordzij JP. Time to competency, reliability of flexible transnasal laryngoscopy by training level: a pilot study. Otolaryngol Head Neck Surg. 2015 May; 152(5):843-50. PMID: 25788339.
    View in: PubMed
  6. Brook CD, Buch K, Gadaleta D, Jalisi S, Grillone G, Sakai O, Aliphas A. Changes in the jugular bulb associated with sacrifice of the internal jugular vein. Otol Neurotol. 2015 Jan; 36(1):146-50. PMID: 25514783.
    View in: PubMed
  7. Falcone TE, Stein DJ, Jumaily JS, Pearce EN, Holick MF, McAneny DB, Jalisi S, Grillone GA, Stone MD, Devaiah AK, Noordzij JP. Correlating pre-operative vitamin D status with post-thyroidectomy hypocalcemia. Endocr Pract. 2015 Apr; 21(4):348-54. PMID: 25536969.
    View in: PubMed
  8. Qureshi MM, Romesser PB, Jalisi S, Zaner KS, Cooley TP, Grillone G, Kachnic LA, Truong MT. The influence of limited English proficiency on outcome in patients treated with radiotherapy for head and neck cancer. Patient Educ Couns. 2014 Nov; 97(2):276-82. PMID: 25190640.
    View in: PubMed
  9. Platt MP, Davis EM, Grundfast K, Grillone G. Early detection of factual knowledge deficiency and remediation in otolaryngology residency education. Laryngoscope. 2014 Aug; 124(8):E309-11. PMID: 24408058.
    View in: PubMed
  10. Liang C, Marsit CJ, McClean MD, Nelson HH, Christensen BC, Haddad RI, Clark JR, Wein RO, Grillone GA, Houseman EA, Halec G, Waterboer T, Pawlita M, Krane JF, Kelsey KT. Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res. 2012 Oct 1; 72(19):5004-13. PMID: 22991304.
    View in: PubMed
  11. Naidu H, Noordzij JP, Samim A, Jalisi S, Grillone GA. Comparison of efficacy, safety, and cost-effectiveness of in-office cup forcep biopsies versus operating room biopsies for laryngopharyngeal tumors. J Voice. 2012 Sep; 26(5):604-6. PMID: 22521530.
    View in: PubMed
  12. Truong MT, Kachnic LA, Grillone GA, Bohrs HK, Lee R, Sakai O, Berk JL. Long-term results of conformal radiotherapy for progressive airway amyloidosis. Int J Radiat Oncol Biol Phys. 2012 Jun 1; 83(2):734-9. PMID: 22270158.
    View in: PubMed
  13. Surasi DS, Meibom S, Grillone G, Subramaniam RM. F-18 FDG PET/CT imaging of a parapharyngeal hemangioma. Clin Nucl Med. 2010 Aug; 35(8):612-3. PMID: 20631514.
    View in: PubMed
  14. Davison JM, Ozonoff A, Imsande HM, Grillone GA, Subramaniam RM. Squamous cell carcinoma of the palatine tonsils: FDG standardized uptake value ratio as a biomarker to differentiate tonsillar carcinoma from physiologic uptake. Radiology. 2010 May; 255(2):578-85. PMID: 20413767.
    View in: PubMed
  15. Truong MT, Grillone G, Tschoe C, Chin L, Kachnic LA, Jalisi S. Emerging applications of stereotactic radiotherapy in head and neck cancer. Neurosurg Focus. 2009 Dec; 27(6):E11. PMID: 19951054.
    View in: PubMed
  16. McGee S, Mardirossian V, Elackattu A, Mirkovic J, Pistey R, Gallagher G, Kabani S, Yu CC, Wang Z, Badizadegan K, Grillone G, Feld MS. Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy. Ann Otol Rhinol Laryngol. 2009 Nov; 118(11):817-26. PMID: 19999369.
    View in: PubMed
  17. Langmore SE, Grillone G, Elackattu A, Walsh M. Disorders of swallowing: palliative care. Otolaryngol Clin North Am. 2009 Feb; 42(1):87-105, ix. PMID: 19134493.
    View in: PubMed
  18. McGee S, Mirkovic J, Mardirossian V, Elackattu A, Yu CC, Kabani S, Gallagher G, Pistey R, Galindo L, Badizadegan K, Wang Z, Dasari R, Feld MS, Grillone G. Model-based spectroscopic analysis of the oral cavity: impact of anatomy. J Biomed Opt. 2008 Nov-Dec; 13(6):064034. PMID: 19123680.
    View in: PubMed
  19. Yu CC, Lau C, O'Donoghue G, Mirkovic J, McGee S, Galindo L, Elackattu A, Stier E, Grillone G, Badizadegan K, Dasari RR, Feld MS. Quantitative spectroscopic imaging for non-invasive early cancer detection. Opt Express. 2008 Sep 29; 16(20):16227-39. PMID: 18825262.
    View in: PubMed
  20. Roberts DS, Dowdall JR, Winter L, Sulis CA, Grillone GA, Grundfast KM. Cervical tuberculosis: a decision tree for protecting healthcare workers. Laryngoscope. 2008 Aug; 118(8):1345-9. PMID: 18596478.
    View in: PubMed
  21. McGeeney BE, Barest G, Grillone G. Thunderclap headache from complicated sinusitis. Headache. 2006 Mar; 46(3):517-20. PMID: 16618275.
    View in: PubMed
  22. O'Leary MA, Grillone GA. Injection laryngoplasty. Otolaryngol Clin North Am. 2006 Feb; 39(1):43-54. PMID: 16469654.
    View in: PubMed
  23. Grillone GA, Chan T. Laryngeal dystonia. Otolaryngol Clin North Am. 2006 Feb; 39(1):87-100. PMID: 16469657.
    View in: PubMed
  24. Crimlisk JT, O'Donnell C, Grillone GA. Standardizing adult tracheostomy tube styles: what is the clinical and cost-effective impact? Dimens Crit Care Nurs. 2006 Jan-Feb; 25(1):35-43. PMID: 16501371.
    View in: PubMed
  25. Chan TV, Grillone G. Vocal cord paralysis after laryngeal mask airway ventilation. Laryngoscope. 2005 Aug; 115(8):1436-9. PMID: 16094119.
    View in: PubMed
  26. Yeager LB, Grillone GA. Organ preservation surgery for intermediate size (T2 and T3) laryngeal cancer. Otolaryngol Clin North Am. 2005 Feb; 38(1):11-20, vii. PMID: 15649495.
    View in: PubMed
  27. Savini C, Camurri N, Castelli A, Dell'Amore A, Pacini D, Suarez SM, Grillone G, Di Bartolomeo R. Myocardial protection using HTK solution in minimally invasive mitral valve surgery. Heart Surg Forum. 2005; 8(1):E25-7. PMID: 15769709.
    View in: PubMed
  28. Grillone GA, Kasznica P. Isolated sphenoid sinus disease. Otolaryngol Clin North Am. 2004 Apr; 37(2):435-51. PMID: 15064073.
    View in: PubMed
  29. Meyers SW, Bercovitch L, Polley K, Taira J, DeCamp N, Mahalingam M, Grillone G, Grande D. Massive exophytic abscesses and fibrotic masses of the chin: a variant of the follicular occlusion triad. J Am Acad Dermatol. 2003 May; 48(5 Suppl):S47-50. PMID: 12734472.
    View in: PubMed
  30. Ishoo E, Shah UK, Grillone GA, Stram JR, Fuleihan NS. Predicting airway risk in angioedema: staging system based on presentation. Otolaryngol Head Neck Surg. 1999 Sep; 121(3):263-8. PMID: 10471868.
    View in: PubMed
  31. Smith DK, Grillone GA, Fuleihan N. Use of postoperative chest x-ray after elective adult tracheotomy. Otolaryngol Head Neck Surg. 1999 Jun; 120(6):848-51. PMID: 10352438.
    View in: PubMed
  32. Ranucci M, Mazzucco A, Pessotto R, Grillone G, Casati V, Porreca L, Maugeri R, Meli M, Magagna P, Cirri S, Giomarelli P, Lorusso R, de Jong A. Heparin-coated circuits for high-risk patients: a multicenter, prospective, randomized trial. Ann Thorac Surg. 1999 Apr; 67(4):994-1000. PMID: 10320241.
    View in: PubMed
  33. Dolan R, Hartshorn K, Andry C, Tablante J, Grillone G, McAvoy D, Suntra C. In vivo correlation of neutrophil receptor expression, ischemia-reperfusion injury, and selective 5-lipoxygenase inhibition in guinea pigs. Arch Otolaryngol Head Neck Surg. 1998 Dec; 124(12):1377-80. PMID: 9865762.
    View in: PubMed
  34. Nogueira CP, Dolan RW, Gooey J, Byahatti S, Vaughan CW, Fuleihan NS, Grillone G, Baker E, Domanowski G. Inactivation of p53 and amplification of cyclin D1 correlate with clinical outcome in head and neck cancer. Laryngoscope. 1998 Mar; 108(3):345-50. PMID: 9504605.
    View in: PubMed
  35. Licameli GR, Grillone GA. Inferior pole peritonsillar abscess. Otolaryngol Head Neck Surg. 1998 Jan; 118(1):95-9. PMID: 9450835.
    View in: PubMed
  36. Prout MN, Sidari JN, Witzburg RA, Grillone GA, Vaughan CW. Head and neck cancer screening among 4611 tobacco users older than forty years. Otolaryngol Head Neck Surg. 1997 Feb; 116(2):201-8. PMID: 9051065.
    View in: PubMed
  37. Gillams AR, Fuleihan N, Grillone G, Carter AP. Magnetization transfer contrast MR in lesions of the head and neck. AJNR Am J Neuroradiol. 1996 Feb; 17(2):355-60. PMID: 8938310.
    View in: PubMed
  38. Grillone GA, Blitzer A, Brin MF, Annino DJ, Saint-Hilaire MH. Treatment of adductor laryngeal breathing dystonia with botulinum toxin type A. Laryngoscope. 1994 Jan; 104(1 Pt 1):30-2. PMID: 8295454.
    View in: PubMed
  39. Berg AM, Troxler RF, Grillone G, Kasznica J, Kane K, Cohen AS, Skinner M. Localized amyloidosis of the larynx: evidence for light chain composition. Ann Otol Rhinol Laryngol. 1993 Nov; 102(11):884-9. PMID: 8239352.
    View in: PubMed
  40. Grillone G, Myssiorek D. Otolaryngologic manifestations of phenytoin toxicity. Clin Otolaryngol Allied Sci. 1992 Apr; 17(2):185-91. PMID: 1587038.
    View in: PubMed
  41. Galli R, Gatti M, Ghiselli A, Grillone G, Pierangeli A, Zanoni A. [Assessment of various factors involved in bacterial infection in open heart surgery]. Minerva Anestesiol. 1978 Jan-Feb; 44(1):65-74. PMID: 643198.
    View in: PubMed
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