Maria Trojanowska | Profiles RNS

Maria Trojanowska, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Rheumatology

PhD, Polish Academy of Sciences
MSc, University of Warsaw

Websites

	Program in Inflammatory Disorders Faculty
	Scleroderma Center of Research Translation
	Researcher Spotlight: Maria Trojanowska, PhD
	ResearchGate
	LinkedIn
	Google Scholar

ORCID : 0000-0001-9550-7178

Dr. Trojanowska’s research is aimed at understanding the molecular and cellular mechanisms that regulate ECM synthesis in healthy tissues and in pathological conditions such as fibrosis and tumorigenesis. The majority of her studies focus on the pathogenesis of scleroderma, an autoimmune disease characterized by vascular abnormalities and a prominent fibrosis of the skin. Her laboratory uses molecular and cellular approaches and various experimental models to elucidate the mechanisms responsible for uncontrolled ECM deposition and vessel degeneration in scleroderma. The second area of investigation is related to activation of tumor stroma. These studies examine the molecular mechanisms that mediate controlled regulation of ECM turnover in healthy connective tissue and are responsible for dysregulation of this process during tumorigenesis. Recent studies together with Dr. Lafyatis are examining the role of ER stress in systemic sclerosis.

Director
Boston University Chobanian & Avedisian School of Medicine
Arthritis & Autoimmune Diseases Research Center

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Lymphatic ERG signaling in scleroderma fibrosis
07/07/2022 - 05/31/2027 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR080950-02

GATA-6 in pulmonary arterial hypertension
03/05/2020 - 01/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL150638-04

Functional characterization of aberrant PD-1+TIGIT+ T cell subsets expanded in SSc patients
08/01/2022 - 09/30/2023 (Subcontract PI)
National Jewish Health Scleroderma Fdn

Regulation of lymphatic system in scleroderma
04/01/2020 - 09/30/2022 (PI)
Scleroderma Foundation

Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis
09/22/2017 - 08/31/2022 (Subcontract PI)
University of Pittsburgh NIH NIAMS
5P50AR060780-10

Molecular mechanism of vasculopathy and fibrosis in scleroderma
05/06/2014 - 04/30/2020 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR042334-24

Preclinical assesment of dimethylfumarate (Tecfidera) as a novel therapeutic for SSC-PAH
04/01/2017 - 09/30/2019 (PI)
Scleroderma Foundation

TGF -beta receptor/Endoglin signaling and the origin of scleroderma fibroblasts
09/01/2015 - 08/31/2017 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
2R56AR044883-16

NIAMS: CORT
09/01/2011 - 08/31/2017 (Sub-Project Level Key Person)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P50AR060780-05

The Functional Biology of Oncostatin M (OSM) and Interleukin (IL)-6/ Soluble IL-6 Receptor in Endothelial Cells
08/24/2015 - 08/23/2016 (PI)
GlaxoSmithKline Research & Development Limited

Showing 10 of 12 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Lymphatic ERG signaling in scleroderma fibrosis	5R01AR080950-02
2023	GATA-6 in pulmonary arterial hypertension	5R01HL150638-04
2022	Lymphatic ERG signaling in scleroderma fibrosis	1R01AR080950-01
2022	GATA-6 in pulmonary arterial hypertension	5R01HL150638-03
2021	GATA-6 in pulmonary arterial hypertension	5R01HL150638-02
2021	Project 2: Scleroderma-Associated Pulmonary Arterial Hypertension: The Role of the Oxidant State	5P50AR060780-10-6919	80
2020	GATA-6 in pulmonary arterial hypertension	1R01HL150638-01
2020	Project 2: Scleroderma-Associated Pulmonary Arterial Hypertension: The Role of the Oxidant State	5P50AR060780-09-6919	80
2019	Project 2: Scleroderma-Associated Pulmonary Arterial Hypertension: The Role of the Oxidant State	5P50AR060780-08-6919	80
2018	The molecular mechanism of vasculopathy and fibrosis in scleroderma	5R01AR042334-24	71

Showing 10 of 63 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Chakraborty A, Kim A, AlAbdullatif S, Campbell JD, Alekseyev YO, Kaplan U, Dambal V, Ligresti G, Trojanowska M. Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport. Res Sq. 2024 Jan 24.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Alekseyev, Yuriy

PMID: 38343832; PMCID: PMC10854286; DOI: 10.21203/rs.3.rs-3808970/v1;

Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. Sci Rep. 2023 Apr 22; 13(1):6593.View Related Profiles.

Ichihara, Asako
Seta, Francesca
Trojanowska, Maria
Lafyatis, Robert
Lenna, Stefania

PMID: 37087509; PMCID: PMC10122657; DOI: 10.1038/s41598-023-33779-8;

El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Correction: Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2023 Jan 23; 25(1):11.View Related Profiles.

Bujor, Andreea
Sam, Flora
Lui, Justin
Trojanowska, Maria

PMID: 36691037; PMCID: PMC9869504; DOI: 10.1186/s13075-023-02993-0;

Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. bioRxiv. 2023 Jan 20.View Related Profiles.

Raslan, Ahmed
Bujor, Andreea
Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho
Varelas, Xaralabos

PMID: 36712020; PMCID: PMC9882122; DOI: 10.1101/2023.01.17.523179;

El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2022 Nov 11; 24(1):251.View Related Profiles.

Bujor, Andreea
Sam, Flora
Lui, Justin
Trojanowska, Maria

PMID: 36369212; PMCID: PMC9650849; DOI: 10.1186/s13075-022-02943-2;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Sep 28; 13(1):5687.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 36171208; PMCID: PMC9519969; DOI: 10.1038/s41467-022-33197-w;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Jul 25; 13(1):4170.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 35879310; PMCID: PMC9314350; DOI: 10.1038/s41467-022-31890-4;

Huang M, Smith A, Watson M, Bhandari R, Baugh LM, Ivanovska I, Watkins T, Lang I, Trojanowska M, Black LD, Pioli PA, Garlick J, Whitfield ML. Self-Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis. Arthritis Rheumatol. 2022 Jul; 74(7):1245-1256. PMID: 35212485; PMCID: PMC9340654; DOI: 10.1002/art.42097;

Ferdous A, Singh S, Luo Y, Abedin MJ, Jiang N, Perry CE, Evers BM, Gillette TG, Kyba M, Trojanowska M, Hill JA. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circ Res. 2021 10 29; 129(10):949-964. PMID: 34544261; PMCID: PMC8556348; DOI: 10.1161/CIRCRESAHA.121.318986;

Lenna S, Tan FK, Trojanowska M. Letter of Retraction. J Immunol. 2021 06 01; 206(11):2763.View Related Profiles.

Trojanowska, Maria
Lenna, Stefania

PMID: 34045319; PMCID: PMC8459722; DOI: 10.4049/jimmunol.2100171;

Showing 10 of 181 results. Show More

Miura S, Watanabe Y, Saigusa R, Yamashita T, Nakamura K, Hirabayashi M, Miyagawa T, Yoshizaki A, Trojanowska M, Sato S, Asano Y. Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma. Arthritis Res Ther. 2021 05 08; 23(1):137. PMID: 33964960; PMCID: PMC8106158; DOI: 10.1186/s13075-021-02520-z;

Farina A, Rosato E, York M, Gewurz BE, Trojanowska M, Farina GA. Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma. Front Immunol. 2021; 12:651013.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael

PMID: 33953718; PMCID: PMC8089375; DOI: 10.3389/fimmu.2021.651013;

Nakamura K, Taniguchi T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Takahashi T, Toyama T, Ichimura Y, Yoshizaki A, Trojanowska M, Fujiu K, Nagai R, Sato S, Asano Y. Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-like Vasculopathy in KLF5+/- ;Fli-1+/- Mice. Arthritis Rheumatol. 2020 12; 72(12):2136-2146. PMID: 32627966; PMCID: PMC7722222; DOI: 10.1002/art.41423;

Mazzotta C, Marden G, Farina A, Bujor A, Trojanowski MA, Trojanowska M. FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells. Microcirculation. 2021 01; 28(1):e12660.View Related Profiles.

Bujor, Andreea
Mazzotta, Celestina
Trojanowski, Marcin
Trojanowska, Maria

PMID: 32979864; PMCID: PMC7988617; DOI: 10.1111/micc.12660;

Marden G, Wan Q, Wilks J, Nevin K, Feeney M, Wisniacki N, Trojanowski M, Bujor A, Stawski L, Trojanowska M. The role of the oncostatin M/OSM receptor ß axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Res Ther. 2020 07 31; 22(1):179.View Related Profiles.

Bujor, Andreea
Trojanowski, Marcin
Trojanowska, Maria

PMID: 32736577; PMCID: PMC7393919; DOI: 10.1186/s13075-020-02266-0;

Bujor AM, El Adili F, Parvez A, Marden G, Trojanowska M. Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects. Front Immunol. 2020; 11:800.View Related Profiles.

Bujor, Andreea
El Adili, Fatima
Trojanowska, Maria

PMID: 32508810; PMCID: PMC7248379; DOI: 10.3389/fimmu.2020.00800;

Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD, Pioli PA, Whitfield ML, Garlick J. Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues. Arthritis Rheumatol. 2020 05; 72(5):791-801.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria

PMID: 31705627

Stochmal A, Czuwara J, Trojanowska M, Rudnicka L. Antinuclear Antibodies in Systemic Sclerosis: an Update. Clin Rev Allergy Immunol. 2020 Feb; 58(1):40-51. PMID: 30607749

Yamashita T, Asano Y, Saigusa R, Taniguchi T, Hirabayashi M, Miyagawa T, Nakamura K, Miura S, Yoshizaki A, Trojanowska M, Sato S. Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy. J Invest Dermatol. 2019 05; 139(5):1150-1160. PMID: 30508546; PMCID: PMC6604062; DOI: 10.1016/j.jid.2018.11.016;

Stawski L, Trojanowska M. Oncostatin M and its role in fibrosis. Connect Tissue Res. 2019 01; 60(1):40-49.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria

PMID: 30056769; PMCID: PMC6349219; DOI: 10.1080/03008207.2018.1500558;

Saigusa R, Asano Y, Taniguchi T, Hirabayashi M, Nakamura K, Miura S, Yamashita T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Trojanowska M, Sato S. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells. Arthritis Res Ther. 2018 02 07; 20(1):23. PMID: 29415756; PMCID: PMC5803841; DOI: 10.1186/s13075-018-1521-3;

Stawski L, Marden G, Trojanowska M. The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway. J Immunol. 2018 Jan 01; 200(1):248-259.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria

PMID: 29141862; PMCID: PMC5736431; DOI: 10.4049/jimmunol.1601968;

Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M. Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis. J Invest Dermatol. 2018 01; 138(1):78-88.View Related Profiles.

Szymaniak, Aleksander
Stawski, Lukasz
Trojanowska, Maria
Simms, Robert
Varelas, Xaralabos

PMID: 28870693; PMCID: PMC5742036; DOI: 10.1016/j.jid.2017.08.024;

Looney AP, Han R, Stawski L, Marden G, Iwamoto M, Trojanowska M. Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis. Am J Respir Cell Mol Biol. 2017 Jul; 57(1):121-131.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria

PMID: 28248553; PMCID: PMC5516275; DOI: 10.1165/rcmb.2016-0200OC;

Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M. Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis. Arthritis Res Ther. 2017 Jun 13; 19(1):134.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria

PMID: 28610597; PMCID: PMC5470189; DOI: 10.1186/s13075-017-1356-3;

Makino K, Makino T, Stawski L, Mantero JC, Lafyatis R, Simms R, Trojanowska M. Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis. J Invest Dermatol. 2017 Aug; 137(8):1671-1681.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria
Lafyatis, Robert
Simms, Robert

PMID: 28433542; PMCID: PMC5560111; DOI: 10.1016/j.jid.2017.03.032;

Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA. Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes. Arthritis Res Ther. 2017 Feb 28; 19(1):39.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael
Lenna, Stefania

PMID: 28245863; PMCID: PMC5331713; DOI: 10.1186/s13075-017-1237-9;

Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Toyama T, Taniguchi T, Akamata K, Noda S, Yoshizaki A, Tsuruta D, Trojanowska M, Sato S. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017 Apr 03; 214(4):1129-1151. PMID: 28232470; PMCID: PMC5379967; DOI: 10.1084/jem.20160247;

Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways. Sci Rep. 2017 02 02; 7:41605.View Related Profiles.

Seta, Francesca
Browning, Jeffrey
Stawski, Lukasz
Trojanowska, Maria

PMID: 28150703; PMCID: PMC5288696; DOI: 10.1038/srep41605;

Miyagawa T, Trojanowska M, Asano Y, Saigusa R, Sato S et. al. 298 Fli1-deficient adipocytes promote the spontaneous development of dermal fibrosis and vasculopathy mimicking systemic sclerosis through adipocytes-to-myofibroblast transdifferentiation and defective vasculogenesis. Journal of Investigative Dermatology. 2017; 137(10):S44. View Publication
Yamashita T, Asano Y, Yoshizaki A, Trojanowska M, Sato S. 892 The combination of bosentan with bFGF accelerates wound healing in endothelial cell-specific Fli1 knockout mice mimicking scleroderma vasculopathy. Journal of Investigative Dermatology. 2017; 137(5). View Publication
Yamashita T, Asano Y, Miyagawa T, Hirabayashi M, Nakamura K, Saigusa R, Toyama T, Takahashi T, Ichimura Y, Taniguchi T, Yoshizaki A, Trojanowska M, Sato S. Cyclophosphamide improves vascular abnormalities in endothelial cell-specific Fli1 knockout mice mimicking scleroderma-related vasculopathy. Journal of Dermatological Science. 2017; 86(2):e5. View Publication
Nakamura K, Asano Y, Miyagawa T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Taniguchi T, Yoshizaki A, Trojanowska M, Sato S. 897 Abnormally activated angiogenesis and impaired vasculogenesis underlie the vasculopathy in Fli1/Klf5 double-heterozygote knockout mice, a new animal model of systemic sclerosis. Journal of Investigative Dermatology. 2017; 137(5). View Publication
Miura S, Asano Y, Saigusa R, Yamashita T, Nakamura K, Hirabayashi M, Miyagawa T, Yoshizaki A, Trojanowska M, Sato S. 305 Fli1 deficiency alters the phenotype of dermal dendritic cells, promoting the development of dermal fibrosis in bleomycin-treated mice. Journal of Investigative Dermatology. 2017; 137(10):S245. View Publication
Trojanowska M. Pulmonary Hypertension Associated With Scleroderma and Connective Tissue Disease: Potential Molecular and Cellular Targets. 2017. View Publication
Nakamura K, Asano Y, Miyagawa T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Taniguchi T, Yoshizaki A, Trojanowska M, Sato S. A new animal model of systemic sclerosis exhibits delayed wound healing due to accelerated angiogenesis and defective vasculogenesis. Journal of Dermatological Science. 2017; 86(2):e53. View Publication
Saigusa R, Asano Y, Yoshizaki A, Sato S, Trojanowska M. 005 Fli1-deficient B cells induce scleroderma-like vascular disorganization via activating pro-angiogenic gene program in dermal microvascular endothelial cells – A possible role in scleroderma vasculopathy. Journal of Investigative Dermatology. 2017; 137(5). View Publication
Varga J, Trojanowska M, Kuwana M. Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities. 2017. View Publication

Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Yoshizaki A, Trojanowska M, Sato S. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. J Invest Dermatol. 2017 Mar; 137(3):631-640. PMID: 27777101; PMCID: PMC5380226; DOI: 10.1016/j.jid.2016.08.037;

Kartha VK, Stawski L, Han R, Haines P, Gallagher G, Noonan V, Kukuruzinska M, Monti S, Trojanowska M. PDGFRß Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas. PLoS One. 2016; 11(4):e0154645.View Related Profiles.

Gallagher, George
Stawski, Lukasz
Kukuruzinska, Maria
Trojanowska, Maria
Han, Rong
Monti, Stefano
Noonan, Vikki

PMID: 27128408; PMCID: PMC4851360; DOI: 10.1371/journal.pone.0154645;

Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Yoshizaki A, Trojanowska M, Sato S. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. Journal of Investigative Dermatology. 2016; 137(3). View Publication
Taniguchi T, Asano Y, Trojanowska M, Akamata K, Sato S et. al. Myeloid Fli1 deficiency induces tissue fibrosis, vasculopathy, and immune abnormalities recapitulating systemic sclerosis. Journal of Dermatological Science. 2016; 84(1):e2. View Publication
Toyama T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Takahashi T, Ichimura Y, Taniguchi T, Yoshizaki A, Trojanowska M, Sato S, Kadono T. Fasudil ameliorates fibrosis, vasculopathy, and immune abnormalities in animal models of systemic sclerosis. Journal of Dermatological Science. 2016; 84(1):e11.
Looney AP, Han R, Seta F, Stawski L, Feghali-Bostwick CA, Browning J, Trojanowska M. Experimental Biology. Dimethyl Fumarate Ameliorates Pulmonary Hypertension in vivo and Prevents Fibrosis via ßTRCP Mediated Degradation of ß-catenin and TAZ. 2016.

Lenna S, Assassi S, Farina GA, Mantero JC, Scorza R, Lafyatis R, Farber HW, Trojanowska M. The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients. Arthritis Res Ther. 2015; 17:363.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Trojanowska, Maria
Lafyatis, Robert

PMID: 26669670; PMCID: PMC4704539; DOI: 10.1186/s13075-015-0881-1;

Krisciunas GP, Platt M, Trojanowska M, Grillone GA, Haines PC, Langmore SE. A Novel In Vivo Protocol for Molecular Study of Radiation-Induced Fibrosis in Head and Neck Cancer Patients. Ann Otol Rhinol Laryngol. 2016 Mar; 125(3):228-34.View Related Profiles.

Krisciunas, Gintas
Grillone, Gregory
Trojanowska, Maria
Platt, Michael
Langmore, Susan

PMID: 26453487; DOI: 10.1177/0003489415607527;

Akamata K, Asano Y, Yamashita T, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S. Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli-1-knockout mice by increasing Fli-1 DNA binding ability. Arthritis Rheumatol. 2015 May; 67(5):1335-44. PMID: 25707716; PMCID: PMC4784268; DOI: 10.1002/art.39062;

Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J. Systemic sclerosis. Nat Rev Dis Primers. 2015 04 23; 1:15002.View Related Profiles.

Trojanowska, Maria
Simms, Robert

PMID: 27189141; DOI: 10.1038/nrdp.2015.2;

Taniguchi T, Asano Y, Akamata K, Noda S, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S. Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Arthritis Rheumatol. 2015 Feb; 67(2):517-26. PMID: 25385187; PMCID: PMC4342755; DOI: 10.1002/art.38948;

Han R, Pacifici M, Iwamoto M, Trojanowska M. Endothelial Erg expression is required for embryogenesis and vascular integrity. Organogenesis. 2015; 11(2):75-86.View Related Profiles.

Trojanowska, Maria
Han, Rong

PMID: 26061019; PMCID: PMC4594436; DOI: 10.1080/15476278.2015.1031435;

Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I, Nakamura K, Yamashita T, Saigusa R, Akamata K, Takahashi T, Ichimura Y, Toyama T, Tsuruta D, Trojanowska M, Nagai R, Sato S. Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis. Nat Commun. 2014; 5:5797. PMID: 25504335; PMCID: PMC4268882; DOI: 10.1038/ncomms6797;

Stawski L, Haines P, Fine A, Rudnicka L, Trojanowska M. MMP-12 deficiency attenuates angiotensin II-induced vascular injury, M2 macrophage accumulation, and skin and heart fibrosis. PLoS One. 2014; 9(10):e109763.View Related Profiles.

Fine, Alan
Stawski, Lukasz
Trojanowska, Maria

PMID: 25302498; PMCID: PMC4193823; DOI: 10.1371/journal.pone.0109763;

Lenna S, Han R, Trojanowska M. Endoplasmic reticulum stress and endothelial dysfunction. IUBMB Life. 2014 Aug; 66(8):530-7.View Related Profiles.

Trojanowska, Maria
Han, Rong
Lenna, Stefania

PMID: 25130181; PMCID: PMC4181710; DOI: 10.1002/iub.1292;

Kudo H, Jinnin M, Asano Y, Trojanowska M, Nakayama W, Inoue K, Honda N, Kajihara I, Makino K, Fukushima S, Ihn H. Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis. Arthritis Rheumatol. 2014 Jun; 66(6):1636-47. PMID: 24470401; PMCID: PMC4123870; DOI: 10.1002/art.38380;

van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30; 370(5):433-43.View Related Profiles.

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PMID: 24350901; PMCID: PMC4040466; DOI: 10.1056/NEJMoa1114576;

Leach HG, Chrobak I, Han R, Trojanowska M. Endothelial cells recruit macrophages and contribute to a fibrotic milieu in bleomycin lung injury. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1093-101.View Related Profiles.

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PMID: 23885794; PMCID: PMC3931119; DOI: 10.1165/rcmb.2013-0152OC;

Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, Faggioni A, Lafyatis R, Trojanowska M, Farina GA. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014 Apr; 134(4):954-64.View Related Profiles.

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PMID: 24129067; PMCID: PMC3961515; DOI: 10.1038/jid.2013.423;

Asano Y, Trojanowska M. Fli1 represses transcription of the human a2(I) collagen gene by recruitment of the HDAC1/p300 complex. PLoS One. 2013; 8(9):e74930. PMID: 24058639; PMCID: PMC3772867; DOI: 10.1371/journal.pone.0074930;

Chrobak I, Lenna S, Stawski L, Trojanowska M. Interferon-? promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) ß2. J Cell Physiol. 2013 Aug; 228(8):1774-83.View Related Profiles.

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PMID: 23359533; PMCID: PMC4072032; DOI: 10.1002/jcp.24337;

Lenna S, Farina AG, Martyanov V, Christmann RB, Wood TA, Farber HW, Scorza R, Whitfield ML, Lafyatis R, Trojanowska M. Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum. 2013 May; 65(5):1357-66.View Related Profiles.

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PMID: 23400395; PMCID: PMC3636187; DOI: 10.1002/art.37891;

Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C, Trojanowska M. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol. 2013 Jun; 182(6):2391-406.View Related Profiles.

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Lenna S, Chrobak I, Farina GA, Rodriguez-Pascual F, Lamas S, Lafyatis R, Scorza R, Trojanowska M. HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One. 2013; 8(2):e56123.View Related Profiles.

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PMID: 23441162; PMCID: PMC3575387; DOI: 10.1371/journal.pone.0056123;

Chan ES, Liu H, Fernandez P, Luna A, Perez-Aso M, Bujor AM, Trojanowska M, Cronstein BN. Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism. Arthritis Res Ther. 2013; 15(3):R58.View Related Profiles.

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PMID: 23663495; PMCID: PMC4060252; DOI: 10.1186/ar4229;

Lenna S, Trojanowska M. The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis. Curr Opin Rheumatol. 2012 Nov; 24(6):663-8.View Related Profiles.

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PMID: 22918530; PMCID: PMC3828639; DOI: 10.1097/BOR.0b013e3283588dbb;

Bujor AM, Haines P, Padilla C, Christmann RB, Junie M, Sampaio-Barros PD, Lafyatis R, Trojanowska M. Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1. Int J Mol Med. 2012 Dec; 30(6):1473-80.View Related Profiles.

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Haines P, Hant FN, Lafyatis R, Trojanowska M, Bujor AM. Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation. J Cell Mol Med. 2012 Sep; 16(9):2238-46.View Related Profiles.

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PMID: 22277251; PMCID: PMC3822993; DOI: 10.1111/j.1582-4934.2012.01537.x;

Stawski L, Han R, Bujor AM, Trojanowska M. Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis. Arthritis Res Ther. 2012; 14(4):R194.View Related Profiles.

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PMID: 22913887; PMCID: PMC3580592; DOI: 10.1186/ar4028;

Markiewicz M, Znoyko S, Stawski L, Ghatnekar A, Gilkeson G, Trojanowska M. A role for estrogen receptor-a and estrogen receptor-ß in collagen biosynthesis in mouse skin. J Invest Dermatol. 2013 Jan; 133(1):120-7.View Related Profiles.

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PMID: 22895361; PMCID: PMC3502697; DOI: 10.1038/jid.2012.264;

Samuel GH, Lenna S, Bujor AM, Lafyatis R, Trojanowska M. Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis. J Dermatol Sci. 2012 Sep; 67(3):166-72.View Related Profiles.

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PMID: 22771321; PMCID: PMC3423203; DOI: 10.1016/j.jdermsci.2012.06.001;

Nakerakanti S, Trojanowska M. The Role of TGF-ß Receptors in Fibrosis. Open Rheumatol J. 2012; 6:156-62.View Related Profiles.

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PMID: 22802914; PMCID: PMC3396054; DOI: 10.2174/1874312901206010156;

Trojanowska M. Mediators of fibrosis. Open Rheumatol J. 2012; 6:70-1. PMID: 22802903; PMCID: PMC3395879; DOI: 10.2174/1874312901206010070;

Maring JA, Trojanowska M, ten Dijke P. Role of endoglin in fibrosis and scleroderma. Int Rev Cell Mol Biol. 2012; 297:295-308. PMID: 22608563; PMCID: PMC3824608; DOI: 10.1016/B978-0-12-394308-8.00008-X;

Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P, Trojanowska M. Endoglin promotes TGF-ß/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol. 2011 Dec; 226(12):3340-8.View Related Profiles.

Bujor, Andreea
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PMID: 21344387; PMCID: PMC3381731; DOI: 10.1002/jcp.22690;

Haines P, Samuel GH, Cohen H, Trojanowska M, Bujor AM. Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway. J Dermatol Sci. 2011 Dec; 64(3):210-6.View Related Profiles.

Bujor, Andreea
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PMID: 21925842; PMCID: PMC3826600; DOI: 10.1016/j.jdermsci.2011.08.005;

Nakerakanti SS, Bujor AM, Trojanowska M. CCN2 is required for the TGF-ß induced activation of Smad1-Erk1/2 signaling network. PLoS One. 2011; 6(7):e21911.View Related Profiles.

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PMID: 21760921; PMCID: PMC3132735; DOI: 10.1371/journal.pone.0021911;

Bujor AM, Asano Y, Haines P, Lafyatis R, Trojanowska M. The c-Abl tyrosine kinase controls protein kinase Cd-induced Fli-1 phosphorylation in human dermal fibroblasts. Arthritis Rheum. 2011 Jun; 63(6):1729-37.View Related Profiles.

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PMID: 21321929; PMCID: PMC3381734; DOI: 10.1002/art.30284;

Hattori T, Stawski L, Nakerakanti SS, Trojanowska M. Fli1 is a negative regulator of estrogen receptor a in dermal fibroblasts. J Invest Dermatol. 2011 Jul; 131(7):1469-76.View Related Profiles.

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Markiewicz M, Nakerakanti SS, Kapanadze B, Ghatnekar A, Trojanowska M. Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. Microcirculation. 2011 Jan; 18(1):1-11.View Related Profiles.

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PMID: 21166920; PMCID: PMC3058265; DOI: 10.1111/j.1549-8719.2010.00058.x;

Samuel GH, Bujor AM, Nakerakanti SS, Hant FN, Trojanowska M. Autocrine transforming growth factor ß signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. Fibrogenesis Tissue Repair. 2010; 3:25.View Related Profiles.

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PMID: 21134273; PMCID: PMC3008687; DOI: 10.1186/1755-1536-3-25;

Asano Y, Bujor AM, Trojanowska M. The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis. J Dermatol Sci. 2010 Sep; 59(3):153-62.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria

PMID: 20663647; PMCID: PMC3826615; DOI: 10.1016/j.jdermsci.2010.06.008;

Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthritis Rheum. 2010 Jul; 62(7):2117-26.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria

PMID: 20309867; PMCID: PMC3034368; DOI: 10.1002/art.27463;

Trojanowska M. Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat Rev Rheumatol. 2010 Aug; 6(8):453-60. PMID: 20585340; PMCID: PMC3824624; DOI: 10.1038/nrrheum.2010.102;

Wang B, Carter RE, Jaffa MA, Nakerakanti S, Lackland D, Lopes-Virella M, Trojanowska M, Luttrell LM, Jaffa AA. Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes. J Med Genet. 2010 Jun; 47(6):391-7.View Related Profiles.

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PMID: 20522428; PMCID: PMC3828650; DOI: 10.1136/jmg.2009.073098;

Lenna S, Townsend DM, Tan FK, Kapanadze B, Markiewicz M, Trojanowska M, Scorza R. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol. 2010 May 1; 184(9):4654-61. PMID: 20335527; PMCID: PMC3836507; DOI: 10.4049/jimmunol.0903188;

Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK, Trojanowska M. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol. 2010 Apr; 176(4):1983-98.View Related Profiles.

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Trojanowska, Maria

PMID: 20228226; PMCID: PMC2843486; DOI: 10.2353/ajpath.2010.090593;

Bujor AM, Nakerakanti S, Morris E, Hant FN, Trojanowska M. Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Exp Dermatol. 2010 Apr; 19(4):347-54.View Related Profiles.

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PMID: 20201953; PMCID: PMC3826663; DOI: 10.1111/j.1600-0625.2010.01065.x;

Stawski L, Trojanowska M. Role of Fli1 in proliferation and migration of human dermal microvascular endothelial cells. Clinical and experimental rheumatology. 2010; 28(5):S78.
Bu S, Chrobak IM, Luttrell L, Trojanowska M. beta-arrestin 1 is a novel regulator of profibrotic TGF beta/S1P(1) signaling. Clinical and experimental rheumatology. 2010; 28(5):S59.
Buhaescu I, Lafyatis R, Trojanowska M, Bujor AM. The role of PTEN down-regulation on PPM1A expression in scleroderma fibroblasts. Clinical and experimental rheumatology. 2010; 28(5):S60.
Ghatnekar A, Stawski L, Wirrig E, Markiewicz M, Asano Y, Harley R, Silver R, Trojanowska M. The Role of GATA-6 in the pathogenesis of pulmonary arterial hypertension in scleroderma. Clinical and experimental rheumatology. 2010; 28(5):S65.

Trojanowska M. Noncanonical transforming growth factor beta signaling in scleroderma fibrosis. Curr Opin Rheumatol. 2009 Nov; 21(6):623-9. PMID: 19713852; PMCID: PMC4020352; DOI: 10.1097/BOR.0b013e32833038ce;

Kapanadze B, Morris E, Smith E, Trojanowska M. Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene. J Cell Mol Med. 2010 May; 14(5):1156-65. PMID: 19432820; PMCID: PMC3822752; DOI: 10.1111/j.1582-4934.2009.00773.x;

Asano Y, Trojanowska M. Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta. Mol Cell Biol. 2009 Apr; 29(7):1882-94. PMID: 19158279; PMCID: PMC2655609; DOI: 10.1128/MCB.01320-08;

Asano Y, Markiewicz M, Kubo M, Szalai G, Watson DK, Trojanowska M. Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin. Mol Cell Biol. 2009 Jan; 29(2):425-34. PMID: 19001092; PMCID: PMC2612518; DOI: 10.1128/MCB.01278-08;

Trojanowska M. Role of PDGF in fibrotic diseases and systemic sclerosis. Rheumatology (Oxford). 2008 Oct; 47 Suppl 5:v2-4. PMID: 18784131; DOI: 10.1093/rheumatology/ken265;

Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, ten Dijke P, Trojanowska M. Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum. 2008 Aug; 58(8):2528-37.View Related Profiles.

Trojanowska, Maria
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PMID: 18668566; DOI: 10.1002/art.23698;

Bu S, Kapanadze B, Hsu T, Trojanowska M. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem. 2008 Jul 11; 283(28):19593-602.View Related Profiles.

Trojanowska, Maria
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PMID: 18482992; PMCID: PMC2443671; DOI: 10.1074/jbc.M802417200;

Bujor AM, Pannu J, Bu S, Smith EA, Muise-Helmericks RC, Trojanowska M. Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. J Invest Dermatol. 2008 Aug; 128(8):1906-14.View Related Profiles.

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PMID: 18323784; DOI: 10.1038/jid.2008.39;

Varga JA, Trojanowska M. Fibrosis in systemic sclerosis. Rheum Dis Clin North Am. 2008 Feb; 34(1):115-43; vii. PMID: 18329536; DOI: 10.1016/j.rdc.2007.11.002;

Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T. Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis. 2008 Apr; 29(4):696-703.View Related Profiles.

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PMID: 18212329; PMCID: PMC2288647; DOI: 10.1093/carcin/bgn019;

Saha A, Hammond CE, Trojanowska M, Smolka AJ. Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G795-807. PMID: 18202112; DOI: 10.1152/ajpgi.00431.2007;

Saha A, Hammond CE, Trojanowska M, Smolka A. 857 Differential Regulation of H,K-ATPase Gene Expression By Helicobacter pylori and IL1ß. Gastroenterology. 2008; 134(4). View Publication
Liu H, Fernandez P, Luna A, Blackburn M, Trojanowska M, Cronstein BN, Chan E. Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating II-13 and Fli1 expression. Purinergic Signalling. 2008; 4:S63-S64.
Fernandez P, Luna A, Trojanowska M, Cronstein BN, Chan ESL. Adenosine A(2A) receptor occupancy stimulates wound matrix production by modulating IL-13 and FLI1 expression. Wound Repair and Regeneration. 2008; 16(2):A28.

Ghatnekar A, Trojanowska M. GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts. Biochim Biophys Acta. 2008 Mar; 1779(3):145-51. PMID: 18177748; PMCID: PMC2295212; DOI: 10.1016/j.bbagrm.2007.11.012;

Trojanowska M, Varga J. Molecular pathways as novel therapeutic targets in systemic sclerosis. Curr Opin Rheumatol. 2007 Nov; 19(6):568-73. PMID: 17917537

Asano Y, Czuwara J, Trojanowska M. Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation. J Biol Chem. 2007 Nov 30; 282(48):34672-83. PMID: 17884818

Markiewicz M, Asano Y, Znoyko S, Gong Y, Watson DK, Trojanowska M. Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin. J Dermatol Sci. 2007 Sep; 47(3):217-26. PMID: 17601707; PMCID: PMC2717737; DOI: 10.1016/j.jdermsci.2007.05.008;

Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M. Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem. 2007 Apr 6; 282(14):10405-13.View Related Profiles.

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Mayes MD, Trojanowska M. Genetic factors in systemic sclerosis. Arthritis Res Ther. 2007; 9 Suppl 2:S5. PMID: 17767743; PMCID: PMC2072883; DOI: 10.1186/ar2189;

Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M. Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma. Arthritis Rheum. 2006 Sep; 54(9):3011-21. PMID: 16947635

Nakerakanti SS, Kapanadze B, Yamasaki M, Markiewicz M, Trojanowska M. Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program. J Biol Chem. 2006 Sep 1; 281(35):25259-69.View Related Profiles.

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Gardner H, Shearstone JR, Bandaru R, Crowell T, Lynes M, Trojanowska M, Pannu J, Smith E, Jablonska S, Blaszczyk M, Tan FK, Mayes MD. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum. 2006 Jun; 54(6):1961-73. PMID: 16736506

Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K. Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways. J Invest Dermatol. 2006 Mar; 126(3):551-60. PMID: 16374482

Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K. Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors. J Cell Physiol. 2006 Mar; 206(3):718-27. PMID: 16245312

Znoyko I, Trojanowska M, Reuben A. Collagen binding alpha2beta1 and alpha1beta1 integrins play contrasting roles in regulation of Ets-1 expression in human liver myofibroblasts. Mol Cell Biochem. 2006 Jan; 282(1-2):89-99. PMID: 16317516

Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6. PMID: 16278291

Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA. Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1624-34. PMID: 16272194

Znoyko I, Sohara N, Spicer SS, Trojanowska M, Reuben A. Expression of oncostatin M and its receptors in normal and cirrhotic human liver. J Hepatol. 2005 Nov; 43(5):893-900. PMID: 16169119

Bhattacharyya S, Ghosh AK, Pannu J, Mori Y, Takagawa S, Chen G, Trojanowska M, Gilliam AC, Varga J. Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta. Arthritis Rheum. 2005 Apr; 52(4):1248-58. PMID: 15818659

Znoyko I, Sohara N, Spicer SS, Trojanowska M, Reuben A. Comparative studies of oncostatin M expression in the tissues of adult rodents. Anat Rec A Discov Mol Cell Evol Biol. 2005 Mar; 283(1):182-6. PMID: 15674824

Tourkina E, Gooz P, Pannu J, Bonner M, Scholz D, Hacker S, Silver RM, Trojanowska M, Hoffman S. Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling. J Biol Chem. 2005 Apr 8; 280(14):13879-87. PMID: 15691837

Pannu J, Trojanowska M. Recent advances in fibroblast signaling and biology in scleroderma. Curr Opin Rheumatol. 2004 Nov; 16(6):739-45. PMID: 15577613

Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001. PMID: 15485866

Sato M, Shegogue D, Hatamochi A, Yamazaki S, Trojanowska M. Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts. Matrix Biol. 2004 Oct; 23(6):353-61. PMID: 15533756

Arman M, Calvo J, Trojanowska ME, Cockerill PN, Santana M, López-Cabrera M, Vives J, Lozano F. Transcriptional regulation of human CD5: important role of Ets transcription factors in CD5 expression in T cells. J Immunol. 2004 Jun 15; 172(12):7519-29. PMID: 15187131

Pannu J, Gore-Hyer E, Yamanaka M, Smith EA, Rubinchik S, Dong JY, Jablonska S, Blaszczyk M, Trojanowska M. An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. Arthritis Rheum. 2004 May; 50(5):1566-77. PMID: 15146427

Hsu T, Trojanowska M, Watson DK. Ets proteins in biological control and cancer. J Cell Biochem. 2004 Apr 1; 91(5):896-903.View Related Profiles.

Trojanowska, Maria
Hsu, Tien

PMID: 15034925; PMCID: PMC2265084

Shegogue D, Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem. 2004 May 28; 279(22):23166-75. PMID: 15047702

Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K. Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene. 2004 Mar 4; 23(9):1656-67. PMID: 15001984

Trojanowska M. What did we learn by studying scleroderma fibroblasts? Clin Exp Rheumatol. 2004 Jan-Feb; 22(3 Suppl 33):S59-63. PMID: 15344599

Markiewicz M, Smith EA, Rubinchik S, Dong JY, Trojanowska M, LeRoy EC. The 72-kilodalton IE-1 protein of human cytomegalovirus (HCMV) is a potent inducer of connective tissue growth factor (CTGF) in human dermal fibroblasts. Clin Exp Rheumatol. 2004 Jan-Feb; 22(3 Suppl 33):S31-4. PMID: 15344595

Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol. 2003 Aug; 163(2):571-81. PMID: 12875977; PMCID: PMC1868228

Atamas SP, Luzina IG, Choi J, Tsymbalyuk N, Carbonetti NH, Singh IS, Trojanowska M, Jimenez SA, White B. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):743-9. PMID: 12805086

Gore-Hyer E, Pannu J, Smith EA, Grotendorst G, Trojanowska M. Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. Arthritis Rheum. 2003 Mar; 48(3):798-806. PMID: 12632435

Sato M, Markiewicz M, Yamanaka M, Bielawska A, Mao C, Obeid LM, Hannun YA, Trojanowska M. Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82. PMID: 12515830

Znoyko IY, Trojanowska MN, Reuben A. Integrin signaling plays a role in the induction of Ets1 gene expression in cultured human hepatic stellate cells (HSCs). Gastroenterology. 2003; 124(4). View Publication

Gore-Hyer E, Shegogue D, Markiewicz M, Lo S, Hazen-Martin D, Greene EL, Grotendorst G, Trojanowska M. TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol. 2002 Oct; 283(4):F707-16. PMID: 12217862

Sohara N, Znoyko I, Levy MT, Trojanowska M, Reuben A. Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. J Hepatol. 2002 Aug; 37(2):214-21. PMID: 12127426

Sato M, Shegogue D, Gore EA, Smith EA, McDermott PJ, Trojanowska M. Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol. 2002 Apr; 118(4):704-11. PMID: 11918720

Chen R, Huang C, Morinelli TA, Trojanowska M, Paul RV. Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. J Am Soc Nephrol. 2002 Apr; 13(4):887-93. PMID: 11912247

Czuwara-Ladykowska J, Sementchenko VI, Watson DK, Trojanowska M. Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. J Biol Chem. 2002 Jun 7; 277(23):20399-408. PMID: 11919190

Trojanowska M. Molecular aspects of scleroderma. Front Biosci. 2002 Mar 1; 7:d608-18. PMID: 11861221

Sohara N, Trojanowska M, Reuben A. Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts. J Hepatol. 2002 Feb; 36(2):191-9. PMID: 11830330

Czuwara-Ladykowska J, Gore EA, Shegogue DA, Smith EA, Trojanowska M. Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts. Br J Dermatol. 2001 Oct; 145(4):569-75. PMID: 11703282

Czuwara-Ladykowska J, Makiela B, Smith EA, Trojanowska M, Rudnicka L. The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis. Arthritis Res. 2001; 3(5):311-8. PMID: 11549373; PMCID: PMC64844

Ihn H, Ihn Y, Trojanowska M. Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression. J Invest Dermatol. 2001 Aug; 117(2):301-8. PMID: 11511308

Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem. 2001 Jun 15; 276(24):20839-48. PMID: 11278621

Trojanowska M. Ets factors and regulation of the extracellular matrix. Oncogene. 2000 Dec 18; 19(55):6464-71. PMID: 11175362

Douillet CD, Velarde V, Christopher JT, Mayfield RK, Trojanowska ME, Jaffa AA. Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2829-37. PMID: 11087238

Chen SJ, Yuan W, Lo S, Trojanowska M, Varga J. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta. J Cell Physiol. 2000 Jun; 183(3):381-92. PMID: 10797313

Levy MT, Trojanowska M, Reuben A. Oncostatin M: a cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells. J Hepatol. 2000 Feb; 32(2):218-26. PMID: 10707861

Shirasaki F, Makhluf HA, LeRoy C, Watson DK, Trojanowska M. Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter. Oncogene. 1999 Dec 16; 18(54):7755-64. PMID: 10618716

Chen SJ, Yuan W, Mori Y, Levenson A, Trojanowska M, Varga J. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. J Invest Dermatol. 1999 Jan; 112(1):49-57. PMID: 9886263

Trojanowska M, LeRoy EC, Eckes B, Krieg T. Pathogenesis of fibrosis: type 1 collagen and the skin. J Mol Med (Berl). 1998 Mar; 76(3-4):266-74. PMID: 9535560

Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol. 1998 Jan; 110(1):47-51. PMID: 9424086

Ihn H, LeRoy EC, Trojanowska M. Oncostatin M stimulates transcription of the human alpha2(I) collagen gene via the Sp1/Sp3-binding site. J Biol Chem. 1997 Sep 26; 272(39):24666-72. PMID: 9305936

Ihn H, Trojanowska M. Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. Nucleic Acids Res. 1997 Sep 15; 25(18):3712-7. PMID: 9278495; PMCID: PMC146953

Ichiki Y, Smith EA, LeRoy EC, Trojanowska M. Basic fibroblast growth factor inhibits basal and transforming growth factor-beta induced collagen alpha 2(I) gene expression in scleroderma and normal fibroblasts. J Rheumatol. 1997 Jan; 24(1):90-5. PMID: 9002017

Makhluf HA, Stepniakowska J, Hoffman S, Smith E, LeRoy EC, Trojanowska M. IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts. J Invest Dermatol. 1996 Dec; 107(6):856-9. PMID: 8941674

Ihn H, Ohnishi K, Tamaki T, LeRoy EC, Trojanowska M. Transcriptional regulation of the human alpha2(I) collagen gene. Combined action of upstream stimulatory and inhibitory cis-acting elements. J Biol Chem. 1996 Oct 25; 271(43):26717-23. PMID: 8900150

Ludwicka A, Ohba T, Trojanowska M, Yamakage A, Strange C, Smith EA, Leroy EC, Sutherland S, Silver RM. Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol. 1995 Oct; 22(10):1876-83. PMID: 8991985

Tamaki T, Ohnishi K, Hartl C, LeRoy EC, Trojanowska M. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the alpha 2(I) collagen gene in human fibroblasts. J Biol Chem. 1995 Mar 3; 270(9):4299-304. PMID: 7876190

Ichiki Y, Smith E, LeRoy EC, Trojanowska M. Different effects of basic fibroblast growth factor and transforming growth factor-beta on the two platelet-derived growth factor receptors' expression in scleroderma and healthy human dermal fibroblasts. J Invest Dermatol. 1995 Jan; 104(1):124-7. PMID: 7798629

Lubinus M, Meier KE, Smith EA, Gause KC, LeRoy EC, Trojanowska M. Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts. J Biol Chem. 1994 Apr 1; 269(13):9822-5. PMID: 7511594

Feldman SR, Trojanowska M, Smith EA, Leroy EC. Differential responses of human papillary and reticular fibroblasts to growth factors. Am J Med Sci. 1993 Apr; 305(4):203-7. PMID: 8475944

Kikuchi K, LeRoy EC, Trojanowska M. Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts. J Dermatol. 1992 Nov; 19(11):660-3. PMID: 1293150

Ludwicka A, Trojanowska M, Smith EA, Baumann M, Strange C, Korn JH, Smith T, Leroy EC, Silver RM. Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma. J Rheumatol. 1992 Nov; 19(11):1716-23. PMID: 1491389

Kikuchi K, Hartl CW, Smith EA, LeRoy EC, Trojanowska M. Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation. Biochem Biophys Res Commun. 1992 Aug 31; 187(1):45-50. PMID: 1520334

Kikuchi K, Yamakage A, Smith EA, LeRoy EC, Trojanowska M. Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts. J Invest Dermatol. 1992 Aug; 99(2):201-5. PMID: 1321201

Yamakage A, Kikuchi K, Smith EA, LeRoy EC, Trojanowska M. Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. J Exp Med. 1992 May 1; 175(5):1227-34. PMID: 1314885; PMCID: PMC2119209

LeRoy EC, Trojanowska M, Smith EA. The pathogenesis of scleroderma (systemic sclerosis, SSc). Clin Exp Rheumatol. 1991 Mar-Apr; 9(2):173-7. PMID: 2060163

Ishikawa O, LeRoy EC, Trojanowska M. Mitogenic effect of transforming growth factor beta 1 on human fibroblasts involves the induction of platelet-derived growth factor alpha receptors. J Cell Physiol. 1990 Oct; 145(1):181-6. PMID: 2170429

LeRoy EC, Trojanowska MI, Smith EA. Cytokines and human fibrosis. Eur Cytokine Netw. 1990 Oct-Nov; 1(4):215-9. PMID: 1966552

Ishikawa O, Yamakage A, LeRoy EC, Trojanowska M. Persistent effect of TGF-beta 1 on extracellular matrix gene expression in human dermal fibroblasts. Biochem Biophys Res Commun. 1990 May 31; 169(1):232-8. PMID: 2350346

Leroy EC, Smith EA, Kahaleh MB, Trojanowska M, Silver RM. A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer? Arthritis Rheum. 1989 Jul; 32(7):817-25. PMID: 2665755

Trojanowska M, Wu LT, LeRoy EC. Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts. Oncogene. 1988 Oct; 3(4):477-81. PMID: 3078955

Miller ES, Karam J, Dawson M, Trojanowska M, Gauss P, Gold L. Translational repression: biological activity of plasmid-encoded bacteriophage T4 RegA protein. J Mol Biol. 1987 Apr 05; 194(3):397-410. PMID: 3498046

Takehara K, Grotendorst GR, Trojanowska M, Leroy EC. Ascorbate effects on type I procollagen synthesis by human adult skin fibroblasts: different migration positions of type I procollagen chains on SDS polyacrylamide gel after incubation with ascorbate. Coll Relat Res. 1987 Feb; 6(6):455-66. PMID: 3581751

Miller ES, Karam J, Dawson M, Trojanowska M, Gauss P, Gold L. Translational repression: Biological activity of plasmid-encoded bacteriophage T4 RegA protein. Journal of Molecular Biology. 1987; 194(3):397-410. View Publication

Trojanowska M, Miller ES, Karam J, Stormo G, Gold L. The bacteriophage T4 regA gene: primary sequence of a translational repressor. Nucleic Acids Res. 1984 Aug 10; 12(15):5979-93. PMID: 6473098; PMCID: PMC320051

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 181 publications over 38 distinct years, with a maximum of 17 publications in 2017

Bar chart showing 181 publications over 38 distinct years, with a maximum of 17 publications in 2017

Year	Publications
1984	1
1987	3
1988	1
1989	1
1990	3
1991	1
1992	5
1993	1
1994	1
1995	3
1996	2
1997	3
1998	2
1999	2
2000	4
2001	4
2002	7
2003	5
2004	10
2005	6
2006	6
2007	6
2008	11
2009	3
2010	12
2011	6
2012	9
2013	9
2014	4
2015	6
2016	6
2017	17
2018	3
2020	6
2021	4
2022	4
2023	3
2024	1