Maria Trojanowska, PhD
Boston University School of Medicine
Dept of Medicine
Rheumatology (Arthritis)

PhD, Polish Academy of Sciences
MSc, University of Warsaw

Boston University School of Medicine
Arthritis Center

Molecular mechanism of vasculopathy and fibrosis in scleroderma
05/06/2014 - 04/30/2018 (PI)
NIH/National Institute of Arthritis & Mu

Preclinical assesment of dimethylfumarate (Tecfidera) as a novel therapeutic for SSC-PAH
04/01/2017 - 03/31/2018 (PI)
Scleroderma Foundation

TGF -beta receptor/Endoglin signaling and the origin of scleroderma fibroblasts
09/01/2015 - 08/31/2017 (PI)
NIH/National Institute of Arthritis & Mu

The Functional Biology of Oncostatin M (OSM) and Interleukin (IL)-6/ Soluble IL-6 Receptor in Endothelial Cells
08/24/2015 - 08/23/2016 (PI)
GlaxoSmithKline Research & Development L

TGF-Beta Receptor Signaling Scleroderma
10/01/2009 - 05/31/2014 (PI)
NIH/National Institute of Arthritis & Mu

The Molecular Mechanisms of Fibrosis
08/10/1994 - 03/31/2013 (PI)
NIH/National Institute of Arthritis & Mu

Yr Title Project-Sub Proj Pubs
2017 The molecular mechanism of vasculopathy and fibrosis in scleroderma 5R01AR042334-23 45
2017 Project 2: Scleroderma-Associated Pulmonary Arterial Hypertension: The Role of the Oxidant State 2P50AR060780-06A1-6919 25
2016 The molecular mechanism of vasculopathy and fibrosis in scleroderma 5R01AR042334-22 45
2015 TGF-beta receptor/Endoglin signaling and the origin of scleroderma fibroblast 2R56AR044883-16
2015 The Role of ER Stress in Systemic Scleroderma 5P50AR060780-05-7134 25
2014 The molecular mechanism of vasculopathy and fibrosis in scleroderma 2R01AR042334-20A1 45
2014 The Role of ER Stress in Systemic Scleroderma 5P50AR060780-04-7134 25
2013 The Role of ER Stress in Systemic Scleroderma 5P50AR060780-03-7134 25
2012 TGF-beta receptor signaling in scleroderma 5R01AR044883-15 33
2012 The molecular mechanisms of fibrosis 5R01AR042334-19 45
Showing 10 of 51 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Stawski L, Marden G, Trojanowska M. The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway. J Immunol. 2018 Jan 01; 200(1):248-259.View Related Profiles. PMID: 29141862.
  2. Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M. Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis. J Invest Dermatol. 2018 Jan; 138(1):78-88.View Related Profiles. PMID: 28870693.
  3. Looney AP, Han R, Stawski L, Marden G, Iwamoto M, Trojanowska M. Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis. Am J Respir Cell Mol Biol. 2017 Jul; 57(1):121-131.View Related Profiles. PMID: 28248553; DOI: 10.1165/rcmb.2016-0200OC;.
  4. Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M. Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis. Arthritis Res Ther. 2017 Jun 13; 19(1):134.View Related Profiles. PMID: 28610597.
  5. Makino K, Makino T, Stawski L, Mantero JC, Lafyatis R, Simms R, Trojanowska M. Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis. J Invest Dermatol. 2017 Aug; 137(8):1671-1681.View Related Profiles. PMID: 28433542.
  6. Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA. Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes. Arthritis Res Ther. 2017 Feb 28; 19(1):39.View Related Profiles. PMID: 28245863; DOI: 10.1186/s13075-017-1237-9;.
  7. Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Toyama T, Taniguchi T, Akamata K, Noda S, Yoshizaki A, Tsuruta D, Trojanowska M, Sato S. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017 Apr 03; 214(4):1129-1151. PMID: 28232470; DOI: 10.1084/jem.20160247;.
  8. Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways. Sci Rep. 2017 Feb 02; 7:41605.View Related Profiles. PMID: 28150703; DOI: 10.1038/srep41605;.
  9. Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Yoshizaki A, Trojanowska M, Sato S. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. J Invest Dermatol. 2017 Mar; 137(3):631-640. PMID: 27777101; DOI: 10.1016/j.jid.2016.08.037;.
  10. Kartha VK, Stawski L, Han R, Haines P, Gallagher G, Noonan V, Kukuruzinska M, Monti S, Trojanowska M. PDGFRß Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas. PLoS One. 2016; 11(4):e0154645.View Related Profiles. PMID: 27128408; PMCID: PMC4851360; DOI: 10.1371/journal.pone.0154645;.
Showing 10 of 135 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 135 publications over 30 distinct years, with a maximum of 10 publications in 2004

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75 E. Newton St Evans Building
Boston MA 02118
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