Flora Sam, MD
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

MD, University of the Witwatersrand



Dr. Sam is a clinical heart failure cardiologist and a physician-scientist. She is translational researcher and is PI of her NIH funded lab. She is an expert in cardiac myocyte biology and in mechanisms of myocardial remodeling in cardiomyopathy, both in humans and animal models. She is a recognized expert in "heart failure with preserved ejection fraction" (HFpEF) /diastolic heart failure and "heart failure with reduced ejection fraction" (HFrEF)/systolic heart failure and cardiomyopathies

The Sam lab is focused on three major areas of investigation:
1) Pro-inflammatory and pro-fibrotic mechanisms that mediate cardiac remodeling in heart failure, cardiac hypertrophy and hypertension.
2) Investigating the relationship between matrix markers and heart failure in humans with cardiac amyloid and scleroderma.
3) Investigating cross talk between adipocyte-derived factors, myokines and cardiokines in heart failure.

all of which are directed to novel pathways to provide therapeutic insights into drug development

Active Staff Hospital Privileges
Boston Medical Center
Medicine



2016 Heart Failure Society of America: Fellow of the Heart Failure Society of America (FHFSA)
2011 American Society of Clinical Investigation: Member, American Society of Clinical Investigation (ASCI)
2009 American Heart Association: Fellow of the American Heart Association (FAHA)
2003 American College of Cardiology: Fellow of the American College of Cardiology (FACC)


Dual ETA/ETB antagonist macitentan inhibits the progression from left ventricular (LV) hypertrophy to heart failure in a murine model of diastolic heart failure
10/15/2014 - 10/14/2019 (PI)
Actelion Pharmaceuticals, Ltd.


Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
06/01/2016 - 05/31/2018 (PI)
NIH/National Heart, Lung, and Blood Inst
4R01HL117153-04

Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
09/01/2013 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL117153-03

Follistatin-Like 1 and the Cardiac Secretome in Human Heart Failure
04/15/2010 - 03/31/2014 (PI)
NIH/National Heart, Lung, and Blood Inst
5R21HL102631-02

The REVIVE Study
06/01/2002 - 07/31/2003 (PI)
Abbott Laboratories

A Placebo Controlled Trial of Bidil Added to Standard Therapy in African-American Patients with Heart Failure
11/01/2001 - 10/30/2002 (PI)
NitroMed Inc


Role of Aldosterone in Cardiac Remodeling
06/01/2005 - 04/30/2010 (PI)
NIH-NHLBI
5 R01 HL079099-03 (A)

Fixed-does isosorbide dinitrate and hydralazine in a mouse left ventricular pressure overload model
02/01/2006 - 01/31/2007 (PI)
Nitromed

Oxidative Stress/AE in Heart Failure
08/01/2000 - 07/31/2005 (PI)
NIH-NHLBI
5 K23 HL004423-05

Aldosterone in Transition from Hypetrophy
07/01/2002 - 06/30/2005 (PI)
American Heart Assoc



Yr Title Project-Sub Proj Pubs
2016 Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He 4R01HL117153-04 3
2014 Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He 5R01HL117153-02 3
2013 Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He 1R01HL117153-01A1 3
2011 Follistatin-like 1 and the cardiac secretome in human heart failure 5R21HL102631-02 7
2011 Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis 5R21HL095891-02 13
2011 Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis 5R21HL095891-02 13
2010 Follistatin-like 1 and the cardiac secretome in human heart failure 1R21HL102631-01 7
2010 Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis 1R21HL095891-01A1 13
2009 Role of Aldosterone in Cardiac Remodeling 3R01HL079099-04S1 18
2009 Role of Aldosterone in Cardiac Remodeling 5R01HL079099-05 18
Showing 10 of 24 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Valero-Munoz M, Li S, Wilson RM, Boldbaatar B, Iglarz M, Sam F. Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Nov; 9(11).View Related Profiles. PMID: 27810862.
  2. Tanaka K, Valero-Muñoz M, Wilson RM, Essick EE, Fowler CT, Nakamura K, van den Hoff M, Ouchi N, Sam F. Follistatin like 1 Regulates Hypertrophy in Heart Failure with Preserved Ejection Fraction. JACC Basic Transl Sci. 2016 Jun; 1(4):207-221.View Related Profiles. PMID: 27430031.
  3. Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan; 9(1):e002724.View Related Profiles. PMID: 26721917; PMCID: PMC4698901; DOI: 10.1161/CIRCHEARTFAILURE.115.002724;.
  4. Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19; 133(3):282-90.View Related Profiles. PMID: 26660282; PMCID: PMC4718760; DOI: 10.1161/CIRCULATIONAHA.115.018852;.
  5. Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2016 Apr; 93:149-55. PMID: 26593722; PMCID: PMC4846552; DOI: 10.1016/j.yjmcc.2015.11.015;.
  6. Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR. Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 1; 132(9):852-72.View Related Profiles. PMID: 26195497; DOI: 10.1161/CIR.0000000000000226;.
  7. Tahir U, Sam F. Withdrawal of heart failure medications in peripartum cardiomyopathy after myocardial recovery. Int J Cardiol. 2015 Jul 1; 190:212-3.View Related Profiles. PMID: 25920029; DOI: 10.1016/j.ijcard.2015.04.169;.
  8. Tahir U, Doros G, Sam F. Delayed myocardial recovery in peripartum cardiomyopathy. Int J Cardiol. 2015 Apr 1; 184:310-2.View Related Profiles. PMID: 25731846; DOI: 10.1016/j.ijcard.2015.02.064;.
  9. Brogan A, Ding Y, Pimentel DR, Sam F. Non-invasive imaging for cardiac amyloidosis - delaying the obvious? Int J Cardiol. 2014 Dec 15; 177(2):e87-9.View Related Profiles. PMID: 25456697.
  10. Tanaka K, Wilson RM, Essick EE, Duffen JL, Scherer PE, Ouchi N, Sam F. Effects of adiponectin on calcium-handling proteins in heart failure with preserved ejection fraction. Circ Heart Fail. 2014 Nov; 7(6):976-85.View Related Profiles. PMID: 25149095; PMCID: PMC4241144; DOI: 10.1161/CIRCHEARTFAILURE.114.001279;.
Showing 10 of 61 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 61 publications over 17 distinct years, with a maximum of 9 publications in 2011 and 2013

YearPublications
19982
19991
20001
20013
20043
20053
20063
20074
20081
20096
20105
20119
20121
20139
20142
20155
20163

I serve as a mentor to postgraduate trainees (doctoral and medical students), residents-in-training, post-doctoral fellows, clinical fellows and junior faculty. My role is to assist in the professional advancement that is aligned with the individual's goal as the mentee enters into the next stage of their career, such as academia, pharma, research or clinical medicine.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')


88 E. Newton St Newton Pavilion
Boston MA 02118
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