Keywords
Last Name

Tien Hsu, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7599
ORCID ORCID Icon0000-0003-2308-4297
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise includes: Cell biology; Cancer biology; Epithelial morphogenesis; Cell migration; Tumor suppressor gene; Drosophila genetics.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Bader HL, Hsu T. Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model. BMC Cancer. 2016 Oct 12; 16(1):797. PMID: 27733136.
    View in: PubMed
  2. Romani P, Papi A, Ignesti M, Soccolini G, Hsu T, Gargiulo G, Spisni E, Cavaliere V. Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov; 389(11):1171-1182. PMID: 27449069.
    View in: PubMed
  3. Hsu T, Steeg PS, Zollo M, Wieland T. Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified. Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb; 388(2):109-17. PMID: 25585611.
    View in: PubMed
  4. Lin CH, Dammai V, Adryan B, Hsu T. Interaction between Nm23 and the tumor suppressor VHL. Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb; 388(2):143-52. PMID: 24915993.
    View in: PubMed
  5. Ignesti M, Barraco M, Nallamothu G, Woolworth JA, Duchi S, Gargiulo G, Cavaliere V, Hsu T. Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biol. 2014; 12:12. PMID: 24528630.
    View in: PubMed
  6. Bader HL, Hsu T. Systemic VHL gene functions and the VHL disease. FEBS Lett. 2012 Jun 4; 586(11):1562-9. PMID: 22673568.
    View in: PubMed
  7. Hsu T. Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms. Oncogene. 2012 May 3; 31(18):2247-57. PMID: 21996733.
    View in: PubMed
  8. Liby TA, Spyropoulos P, Buff Lindner H, Eldridge J, Beeson C, Hsu T, Muise-Helmericks RC. Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells. Int J Cancer. 2012 Feb 1; 130(3):532-43. PMID: 21351097.
    View in: PubMed
  9. Hsu T. NME genes in epithelial morphogenesis. Naunyn Schmiedebergs Arch Pharmacol. 2011 Oct; 384(4-5):363-72. PMID: 21336542.
    View in: PubMed
  10. Hsouna A, Nallamothu G, Kose N, Guinea M, Dammai V, Hsu T. Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis. Mol Cell Biol. 2010 Aug; 30(15):3779-94. PMID: 20516215.
    View in: PubMed
  11. Duchi S, Fagnocchi L, Cavaliere V, Hsouna A, Gargiulo G, Hsu T. Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. Development. 2010 May; 137(9):1493-503. PMID: 20388653.
    View in: PubMed
  12. Woolworth JA, Nallamothu G, Hsu T. The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis. Mol Cell Biol. 2009 Sep; 29(17):4679-90. PMID: 19581292.
    View in: PubMed
  13. Nallamothu G, Dammai V, Hsu T. Developmental function of Nm23/awd: a mediator of endocytosis. Mol Cell Biochem. 2009 Sep; 329(1-2):35-44. PMID: 19373545.
    View in: PubMed
  14. Champion KJ, Guinea M, Dammai V, Hsu T. Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Cancer Res. 2008 Jun 15; 68(12):4649-57. PMID: 18559510.
    View in: PubMed
  15. Bu S, Kapanadze B, Hsu T, Trojanowska M. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem. 2008 Jul 11; 283(28):19593-602. PMID: 18482992.
    View in: PubMed
  16. Chen Z, Luo HY, Basran RK, Hsu TH, Mang DW, Nuntakarn L, Rosenfield CG, Patrinos GP, Hardison RC, Steinberg MH, Chui DH. A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F. Mol Cell Biol. 2008 Jul; 28(13):4386-93. PMID: 18443038.
    View in: PubMed
  17. Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T. Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis. 2008 Apr; 29(4):696-703. PMID: 18212329.
    View in: PubMed
  18. Nallamothu G, Woolworth JA, Dammai V, Hsu T. Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Mol Cell Biol. 2008 Mar; 28(6):1964-73. PMID: 18212059.
    View in: PubMed
  19. Hsouna A, Lawal HO, Izevbaye I, Hsu T, O'Donnell JM. Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev Biol. 2007 Aug 1; 308(1):30-43. PMID: 17585895.
    View in: PubMed
  20. Hsu T, Adereth Y, Kose N, Dammai V. Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem. 2006 Apr 28; 281(17):12069-80. PMID: 16505488.
    View in: PubMed
  21. Adereth Y, Dammai V, Kose N, Li R, Hsu T. RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. Nat Cell Biol. 2005 Dec; 7(12):1240-7. PMID: 16273094.
    View in: PubMed
  22. Pei H, Li C, Adereth Y, Hsu T, Watson DK, Li R. Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res. 2005 Aug 15; 65(16):7205-13. PMID: 16103071.
    View in: PubMed
  23. Adereth Y, Champion KJ, Hsu T, Dammai V. Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase. Biotechniques. 2005 Jun; 38(6):864, 866, 868. PMID: 16018545.
    View in: PubMed
  24. Cavaliere V, Donati A, Hsouna A, Hsu T, Gargiulo G. dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev Dyn. 2005 Mar; 232(3):845-54. PMID: 15712201.
    View in: PubMed
  25. Hsouna A, Watson DK, Hsu T. Developmental expression pattern of D-ets4, the Drosophila homologue of human Pdef. Gene Expr Patterns. 2004 Dec; 5(2):285-9. PMID: 15567727.
    View in: PubMed
  26. Hsu T, Trojanowska M, Watson DK. Ets proteins in biological control and cancer. J Cell Biochem. 2004 Apr 1; 91(5):896-903. PMID: 15034925.
    View in: PubMed
  27. Dammai V, Adryan B, Lavenburg KR, Hsu T. Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Genes Dev. 2003 Nov 15; 17(22):2812-24. PMID: 14630942.
    View in: PubMed
  28. Lavenburg KR, Ivey J, Hsu T, Muise-Helmericks RC. Coordinated functions of Akt/PKB and ETS1 in tubule formation. FASEB J. 2003 Dec; 17(15):2278-80. PMID: 14525946.
    View in: PubMed
  29. Dammai V, Hsu T. EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis. Anat Rec A Discov Mol Cell Evol Biol. 2003 May; 272(1):377-82. PMID: 12704693.
    View in: PubMed
  30. Bagni C, Bray S, Gogos JA, Kafatos FC, Hsu T. The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mech Dev. 2002 Sep; 117(1-2):265-8. PMID: 12204268.
    View in: PubMed
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