Robert A. Lafyatis, MD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology

MD, University of Cincinnati




Dr. Lafyatis carries out patient oriented research into the cause and treatment of systemic sclerosis. This includes early phase clinical trials into new therapeutic agents in patients with systemic sclerosis. He has been investigating the mechanisms of actions and markers of response for novel therapeutics, such as the B cell depleting agent, rituximab and the immunosuppressant agent, mycophenlate. Additional studies are aimed at identifying biomarkers in systemic sclerosis using microarray gene expression analysis of skin and blood in scleroderma patients. Ongoing biomarker studies include investigation into molecular markers of pulmonary hypertension in systemic sclerosis. Dr. Lafyatis also carries out basic research into the cause of fibrosis and vasculopathy in systemic sclerosis using patient samples and murine disease models. His studies have provided key insights into one widely used model of systemic sclerosis, the tight skin mouse. His studies are currently focused on understanding how autoimmunity and the innate immune system lead to fibrosis and vascular damage. This has recently led to the discovery of increased interferon-regulated gene expression in white blood cells of patients with systemic sclerosis. Ongoing research is aimed at better understanding the cause of altered gene expression by monocytes and other cells in the innate immune system.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




A Phase 1 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy volunteers and Subjects with Systemic Lupus Erythematosus
04/09/2015 - 04/08/2020 (Co-Investigator)
PI: Christina Lam, MD
Biogen Idec


A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Diffuse Cutaneous Systemic Sclerosis
12/01/2015 - 11/30/2019 (Co-Investigator)
PI: Robert W. Simms, MD
Corbus Pharmaceuticals Holdings, Inc.


Scleroderma Clinical Repository (SCaR)
10/01/2014 - 09/30/2019 (PI)
Regeneron Pharmaceuticals, Inc.


ASSET: A Phase II study to evaluate subcutaneous abatacept vs. placebo in diffuse cutaneous systemic sclerosis - a double-blind, placebo-controlled, randomized controlled trial [IMI101-344]
03/31/2015 - 06/30/2019 (Subcontract PI)
Regents of the University of Michigan Bristol-Myers Squibb


Randomized, double-blind, placebo-controlled trial of IL1-Trap, Rilonacept, in Systemic Sclerosis-A Phase I/II Biomarker Trial
12/01/2011 - 02/05/2019 (PI)
Regeneron Pharmaceuticals, Inc.


Scleroderma Workshop
02/01/2010 - 01/31/2018 (PI)
MedImmune, Inc.


Nox4 Inhibitor in Systemic Sclerosis
11/14/2014 - 11/13/2017 (PI)
Mistral Therapeutics, Inc.


NIAMS: CORT
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P50AR060780-05

Rheumatic Diseases Research Core Centers
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P30AR061271-05

A Randomized, Double-Blind, Placebo-Controlled Trial of Topical C-82 in Systemic Sclerosis-A Phase I/II Biomarker and Safety Trial
04/02/2015 - 04/01/2017 (PI)
PRISM Pharma Co Ltd


Showing 10 of 42 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Mapping Age-Related Changes in the Lung 7U01HL145550-03
2021 NIAMS: Center for Research Translation (CORT) 3P50AR060780-09S1 80
2021 Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis 5P50AR060780-10 80
2021 Administrative Core 5P50AR060780-10-6914 80
2021 Project 1: Systemic Sclerosis Skin Biomarkers & Therapeutics 5P50AR060780-10-6918 80
2021 Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis 3P50AR060780-10S1 80
2020 Mapping Age-Related Changes in the Lung 5U01HL145550-02
2020 Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis 5P50AR060780-09 80
2020 Administrative Core 5P50AR060780-09-6914 80
2020 Project 1: Systemic Sclerosis Skin Biomarkers & Therapeutics 5P50AR060780-09-6918 80
Showing 10 of 70 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Domsic RT, Gao S, Laffoon M, Wisniewski S, Zhang Y, Steen V, Lafyatis R, Medsger TA. Defining the optimal disease duration of early diffuse systemic sclerosis for clinical trial design. Rheumatology (Oxford). 2021 Oct 02; 60(10):4662-4670. PMID: 33506859
     
  2. Rodor J, Chen SH, Scanlon JP, Monteiro JP, Caudrillier A, Sweta S, Stewart KR, Shmakova A, Dobie R, Henderson BEP, Stewart K, Hadoke PWF, Southwood M, Moore SD, Upton PD, Morrell NW, Li Z, Chan SY, Handen A, Lafyatis R, de Rooij LPMH, Henderson NC, Carmeliet P, Spiroski AM, Brittan M, Baker AH. Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension. Cardiovasc Res. 2021 Sep 16. PMID: 34528097
     
  3. Blobner BM, Saloman JL, Shelton Ohlsen CA, Brand R, Lafyatis R, Bottino R, Wijkstrom M, Zureikat AH, Lee KK, Singhi AD, Ross MA, Stolz D, Whitcomb DC. Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 Nov 01; 321(5):G449-G460. PMID: 34523348
     
  4. Moghbeli K, Valenzi E, Naramore R, Sembrat JC, Chen K, Rojas MM, Wenzel SE, Lafyatis R, Modena B, Weathington NM. Beta-agonist Exposure Preferentially Impacts Lung Macrophage Cyclic AMP Related Gene Expression in Asthma and Asthma COPD Overlap Syndrome. Am J Physiol Lung Cell Mol Physiol. 2021 09 08. PMID: 34494468
     
  5. Lescoat A, Roofeh D, Kuwana M, Lafyatis R, Allanore Y, Khanna D. Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies. Clin Rev Allergy Immunol. 2021 Sep 01. PMID: 34468946
     
  6. Cruz T, Jia M, Sembrat J, Tabib T, Agostino N, Bruno TC, Vignali D, Sanchez P, Lafyatis R, Mora AL, Benos P, Rojas M. Reduced Proportion and Activity of Natural Killer Cells in the Lung of Patients with Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 09 01; 204(5):608-610. PMID: 34077698
     
  7. Tabib T, Huang M, Morse N, Papazoglou A, Behera R, Jia M, Bulik M, Monier DE, Benos PV, Chen W, Domsic R, Lafyatis R. Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin. Nat Commun. 2021 07 19; 12(1):4384. PMID: 34282151; PMCID: PMC8289865; DOI: 10.1038/s41467-021-24607-6;
     
  8. Ruffin AT, Cillo AR, Tabib T, Liu A, Onkar S, Kunning SR, Lampenfeld C, Atiya HI, Abecassis I, Kürten CHL, Qi Z, Soose R, Duvvuri U, Kim S, Oesterrich S, Lafyatis R, Coffman LG, Ferris RL, Vignali DAA, Bruno TC. B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma. Nat Commun. 2021 06 07; 12(1):3349. PMID: 34099645; PMCID: PMC8184766; DOI: 10.1038/s41467-021-23355-x;
     
  9. Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. J Clin Invest. 2021 06 01; 131(11). PMID: 33905372; PMCID: PMC8159699; DOI: 10.1172/JCI136459;
     
  10. Xue D, Tabib T, Morse C, Yang Y, Domsic R, Khanna D, Lafyatis R. Expansion of FCGR3A+ macrophages, FCN1+ mo-DC, and plasmacytoid dendritic cells associated with severe skin disease in systemic sclerosis. Arthritis Rheumatol. 2021 May 27. PMID: 34042322
     
Showing 10 of 209 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 209 publications over 32 distinct years, with a maximum of 17 publications in 2016

YearPublications
19881
19897
19908
19919
19921
19932
19944
19961
19971
19982
19992
20001
20024
20031
20043
20052
20067
20078
20084
20098
201014
20115
201210
201310
20149
20159
201617
20179
201810
201913
202012
202115

Contact for Mentoring:

75 E. Newton St Evans Building
Boston MA 02118
Google Map


Lafyatis's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department