Robert A. Lafyatis, MD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology

MD, University of Cincinnati




Dr. Lafyatis carries out patient oriented research into the cause and treatment of systemic sclerosis. This includes early phase clinical trials into new therapeutic agents in patients with systemic sclerosis. He has been investigating the mechanisms of actions and markers of response for novel therapeutics, such as the B cell depleting agent, rituximab and the immunosuppressant agent, mycophenlate. Additional studies are aimed at identifying biomarkers in systemic sclerosis using microarray gene expression analysis of skin and blood in scleroderma patients. Ongoing biomarker studies include investigation into molecular markers of pulmonary hypertension in systemic sclerosis. Dr. Lafyatis also carries out basic research into the cause of fibrosis and vasculopathy in systemic sclerosis using patient samples and murine disease models. His studies have provided key insights into one widely used model of systemic sclerosis, the tight skin mouse. His studies are currently focused on understanding how autoimmunity and the innate immune system lead to fibrosis and vascular damage. This has recently led to the discovery of increased interferon-regulated gene expression in white blood cells of patients with systemic sclerosis. Ongoing research is aimed at better understanding the cause of altered gene expression by monocytes and other cells in the innate immune system.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Diffuse Cutaneous Systemic Sclerosis
12/01/2015 - 11/30/2021 (Co-Investigator)
PI: Robert W. Simms, MD
Corbus Pharmaceuticals Holdings, Inc.


A Phase 1 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy volunteers and Subjects with Systemic Lupus Erythematosus
04/09/2015 - 04/08/2020 (Co-Investigator)
PI: Christina Lam, MD
Biogen Idec


Scleroderma Clinical Repository (SCaR)
10/01/2014 - 09/30/2019 (PI)
Regeneron Pharmaceuticals, Inc.


ASSET: A Phase II study to evaluate subcutaneous abatacept vs. placebo in diffuse cutaneous systemic sclerosis - a double-blind, placebo-controlled, randomized controlled trial [IMI101-344]
03/31/2015 - 06/30/2019 (Subcontract PI)
Regents of the University of Michigan Bristol-Myers Squibb


Randomized, double-blind, placebo-controlled trial of IL1-Trap, Rilonacept, in Systemic Sclerosis-A Phase I/II Biomarker Trial
12/01/2011 - 02/05/2019 (PI)
Regeneron Pharmaceuticals, Inc.


Scleroderma Workshop
02/01/2010 - 01/31/2018 (PI)
MedImmune, Inc.


Nox4 Inhibitor in Systemic Sclerosis
11/14/2014 - 11/13/2017 (PI)
Mistral Therapeutics, Inc.


NIAMS: CORT
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P50AR060780-05

Rheumatic Diseases Research Core Centers
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P30AR061271-05

A Randomized, Double-Blind, Placebo-Controlled Trial of Topical C-82 in Systemic Sclerosis-A Phase I/II Biomarker and Safety Trial
04/02/2015 - 04/01/2017 (PI)
PRISM Pharma Co Ltd


Showing 10 of 42 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Administrative Core 1P50AR080612-01-9844
2022 Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis 1P50AR080612-01
2022 Cell epigenetics & communication in systemic sclerosis and localized scleroderma skin disease 1P50AR080612-01-9847
2022 Mapping Age-Related Changes in the Lung 5U01HL145550-04
2021 Mapping Age-Related Changes in the Lung 7U01HL145550-03
2021 Administrative Core 5P50AR060780-10-6914 80
2021 NIAMS: Center for Research Translation (CORT) 3P50AR060780-09S1 80
2021 Project 1: Systemic Sclerosis Skin Biomarkers & Therapeutics 5P50AR060780-10-6918 80
2021 Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis 5P50AR060780-10 80
2021 Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesis 3P50AR060780-10S1 80
Showing 10 of 74 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Rodor J, Chen SH, Scanlon JP, Monteiro JP, Caudrillier A, Sweta S, Stewart KR, Shmakova A, Dobie R, Henderson BEP, Stewart K, Hadoke PWF, Southwood M, Moore SD, Upton PD, Morrell NW, Li Z, Chan SY, Handen A, Lafyatis R, de Rooij LPMH, Henderson NC, Carmeliet P, Spiroski AM, Brittan M, Baker AH. Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension. Cardiovasc Res. 2022 Aug 24; 118(11):2519-2534. PMID: 34528097; PMCID: PMC9400412; DOI: 10.1093/cvr/cvab296;
     
  2. Lafyatis R, Valenzi E. Assessment of disease outcome measures in systemic sclerosis. Nat Rev Rheumatol. 2022 Sep; 18(9):527-541. PMID: 35859133
     
  3. Papazoglou A, Huang M, Bulik M, Lafyatis A, Tabib T, Morse C, Sembrat J, Rojas M, Valenzi E, Lafyatis R. Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease. Arthritis Rheumatol. 2022 Jul 18. PMID: 35849803
     
  4. Lafyatis R, Tabib T. Reply. Arthritis Rheumatol. 2022 May 29. PMID: 35644044
     
  5. Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat Immunol. 2022 Jun; 23(6):868-877. PMID: 35618829; PMCID: PMC9179227; DOI: 10.1038/s41590-022-01210-5;
     
  6. Rice LM, Mantero JC, Stratton EA, Warburton R, Roberts K, Hill N, Simms RW, Domsic R, Farber HW, Lafyatis R. Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis. Arthritis Res Ther. 2022 May 23; 24(1):118.View Related Profiles. PMID: 35606822; PMCID: PMC9125924; DOI: 10.1186/s13075-022-02816-8;
     
  7. Snyder ME, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, Tabib T, Lafyatis R, Chen K, Trejo Bittar HE, Lendermon E, Pilewski J, Johnson B, Kilaru S, Zhang Y, Sanchez PG, Alder JK, Sims PA, McDyer JF. Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. J Exp Med. 2022 Apr 04; 219(4). PMID: 35285873; PMCID: PMC8924935; DOI: 10.1084/jem.20212059;
     
  8. Xue D, Tabib T, Morse C, Yang Y, Domsic RT, Khanna D, Lafyatis R. Expansion of Fc? Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis. Arthritis Rheumatol. 2022 02; 74(2):329-341. PMID: 34042322; PMCID: PMC8626521; DOI: 10.1002/art.41813;
     
  9. Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL. Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing. Nat Commun. 2021 12 17; 12(1):7338. PMID: 34921143; PMCID: PMC8683505; DOI: 10.1038/s41467-021-27619-4;
     
  10. Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. J Invest Dermatol. 2022 Jun; 142(6):1597-1606.e9. PMID: 34808238; PMCID: PMC9120259; DOI: 10.1016/j.jid.2021.10.025;
     
Showing 10 of 219 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 219 publications over 33 distinct years, with a maximum of 17 publications in 2016

YearPublications
19881
19897
19908
19919
19921
19932
19944
19961
19971
19982
19992
20001
20024
20031
20043
20052
20067
20078
20084
20098
201014
20115
201210
201310
20149
20159
201617
20179
201810
201913
202013
202116
20228

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75 E. Newton St Evans Building
Boston MA 02118
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