Ramon GB Bonegio, MD
Clinical Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Nephrology

MBBCh, Boston University
MD, University of the Witwatersrand
BSc, University of the Witwatersrand



I am a physician- scientist who trained in internal medicine and nephrology at the University of the Witwatersrand in South Africa before moving to Boston to complete a nephrology fellowship and PhD in molecular medicine. Since 2003 I have focused my clinical activities on the diagnosis and management of patients with lupus-nephritis and immune complex glomerulonephritis and in 2011 joined with Dr. Robert Lafyatis (rheumatology), Dr. Michael York (rheumatology), Dr Hanni Menn-Josephy (nephrology), Dr. Ian Rifkin (nephrology), and Dr. Christina Lam (dermatology) to establish the Boston Medical Center Lupus Program which I currently co-direct. Since establishing the Lupus Program, our center has participated in four clinical trials involving lupus patients which has allowed us to develop the infrastructure required for the acquisition of patient informed consents, sample collection and storage, and for the management of the information systems required to maintain a database of relevant clinical characteristics that are linked to each sample.

I have a longstanding interest in autoimmune disease in general and in lupus nephritis in particular and run a basic science laboratory of my own that is funded to investigate the pathobiology of immune-complex glomerulonephritis. We use cell culture systems and mouse models of autoimmunity to define pathways that are required for the development or progression of autoimmunity and use this understanding develop new therapeutics.

My basic science work has given me a unique perspective of the requirements that basic scientists and clinicians have to translate basic science breakthroughs to the clinical arena. In the last two years I have worked with our trial manager Dr Britte Zlatanova to established an autoimmune patient registry at Boston Medical Center that now includes over 100 lupus patients and appropriate control samples. I work in collaboration with several pharmaceutical companies and investigators from Boston University Medical Center, the University of Massachusetts, Pittsburg University, and University of Pennsylvania to share this valuable clinical material in order to develop the understanding the biology of autoimmunity and inflammation in anticipation that this will lead to new therapies that are more effective and less toxic..

Expertise includes: Lupus nephritis, Autoimmune kidney disease, Glomerulonephritis, Toxicity of immunosuppression, Genetics of immune-mediated kidney disease

Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of BMS-188667 (Abatacept) or Placebo on a Background of Mycophenolate Mofetil (MMF) and Corticosteroids
08/01/2013 - 07/31/2016 (PI)
Bristol-Myers Squibb


A Multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety and tolerability of BIIB023 in subjects with Lupus Nephritis
04/01/2013 - 05/25/2016 (PI)
Biogen Idec



A PHASE II, OPEN-LABEL EXTENSION STUDY OF PATIENTS PREVIOUSLY ENROLLED IN STUDY GA300
02/26/2018 - 02/25/2021 (PI)
Genentech, Inc.

A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Effica…
11/11/2015 - 11/11/2019 (PI)
Astrazeneca Pharmaceuticals

TULIP D3461C000007
06/14/2018 - 04/26/2019 (PI)
Astrazeneca Pharmaceuticals

AUR-VCS-2016-01
10/11/2017 - 04/12/2019 (PI)
Aurinia Pharmaceuticals Inc.

GA30044
07/06/2017 - 03/19/2019 (PI)
Genentech, Inc.

Endogenous RNA Ligands for Toll-like Receptors in Immune-complex Nephritis
07/01/2012 - 06/30/2018 (PI)
NIH-NIDDK
4R01 DK095058-05

Endogenous RNA Ligands for Toll-like Receptors in Immune-complex Nephritis
07/01/2012 - 06/30/2018 (PI)
NIH-NIDDK
5R01 DK095058-04


Title


Yr Title Project-Sub Proj Pubs
2016 Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis 4R01DK095058-05 11
2015 Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis 5R01DK095058-04 11
2014 Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis 5R01DK095058-03 11
2013 Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis 5R01DK095058-02 11
2012 Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis 1R01DK095058-01 11

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Pellerin A, Tan Y, Lu S, Bonegio RG, Rifkin IR. Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways. J Immunol. 2023 Nov 01; 211(9):1308-1319.View Related Profiles. PMID: 37721418
     
  2. Mattocks KM, Kroll-Desrosiers A, Crowley S, Tuozzo K, Rifkin I, Moore D, Walker L, Bonegio R. Using RE-AIM to examine implementation of a tele-nephrology program for veterans living in rural areas. Front Health Serv. 2023; 3:1205951.View Related Profiles. PMID: 37780402; PMCID: PMC10533984; DOI: 10.3389/frhs.2023.1205951;
     
  3. Tatsumoto N, Saito S, Rifkin IR, Bonegio RG, Leal DN, Sen GC, Arditi M, Yamashita M. EGF-Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis. Lab Invest. 2023 Sep; 103(9):100190.View Related Profiles. PMID: 37268107; PMCID: PMC10527264; DOI: 10.1016/j.labinv.2023.100190;
     
  4. Pellerin A, Yasuda K, Cohen-Bucay A, Sandra V, Shukla P, Jr BKH, Nündel K, Viglianti GA, Xie Y, Klein U, Tan Y, Bonegio RG, Rifkin IR. Monoallelic IRF5 deficiency in B cells prevents murine lupus. JCI Insight. 2021 08 09; 6(15).View Related Profiles. PMID: 34197340; PMCID: PMC8410043; DOI: 10.1172/jci.insight.141395;
     
  5. Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure. Am J Pathol. 2020 04; 190(4):799-816.View Related Profiles. PMID: 32220420; PMCID: PMC7217334; DOI: 10.1016/j.ajpath.2019.12.009;
     
  6. Bonegio RG, Lin JD, Beaudette-Zlatanova B, York MR, Menn-Josephy H, Yasuda K. Lupus-Associated Immune Complexes Activate Human Neutrophils in an Fc?RIIA-Dependent but TLR-Independent Response. J Immunol. 2019 02 01; 202(3):675-683.View Related Profiles. PMID: 30610165; PMCID: PMC6344272; DOI: 10.4049/jimmunol.1800300;
     
  7. Wang Z, Salih E, Igwebuike C, Mulhern R, Bonegio RG, Havasi A, Borkan SC. Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI. J Am Soc Nephrol. 2019 01; 30(1):50-62.View Related Profiles. PMID: 30573638; PMCID: PMC6317607; DOI: 10.1681/ASN.2018040401;
     
  8. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC. Correction for Wang et al., "Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death". Mol Cell Biol. 2017 10 01; 37(19).View Related Profiles. PMID: 28899998; PMCID: PMC5599719; DOI: 10.1128/MCB.00258-17;
     
  9. Rifkin IR, Bonegio RG. Editorial: Podocytes as Active Participants in Lupus Nephritis. Arthritis Rheumatol. 2017 08; 69(8):1517-1520.View Related Profiles. PMID: 28544537
     
  10. Menn-Josephy H, Lee CS, Nolin A, Christov M, Rybin DV, Weinberg JM, Henderson J, Bonegio R, Havasi A. Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts. Am J Nephrol. 2016; 44(4):289-299.View Related Profiles. PMID: 27626625; PMCID: PMC5069171; DOI: 10.1159/000449511;
     
Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 19 distinct years, with a maximum of 4 publications in 2009 and 2011 and 2012 and 2014

YearPublications
19881
20011
20022
20041
20051
20062
20094
20101
20114
20124
20133
20144
20153
20162
20172
20192
20201
20211
20233


2012-2017 NIDDK: Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis
2000-2001 Boston University Medical Center: Excellence in Teaching Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Autoimmune kidney disease
Avoiding toxicity of immunosuppression
Clinical trials in autoimmune disease
Lupus nephritis
Mechanisms of autoimmune kidney disease
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