Keywords
Last Name

Ramon GB Bonegio, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7331
ORCID ORCID Icon0000-0002-1286-141X
Other Positions
TitleActive Staff Hospital Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
I am a physician- scientist who trained in internal medicine and nephrology at the University of the Witwatersrand in South Africa before moving to Boston to complete a nephrology fellowship and PhD in molecular medicine. Since 2003 I have focused my clinical activities on the diagnosis and management of patients with lupus-nephritis and immune complex glomerulonephritis and in 2011 joined with Dr. Robert Lafyatis (rheumatology), Dr. Michael York (rheumatology), Dr Hanni Menn-Josephy (nephrology), Dr. Ian Rifkin (nephrology), and Dr. Christina Lam (dermatology) to establish the Boston Medical Center Lupus Program which I currently co-direct. Since establishing the Lupus Program, our center has participated in four clinical trials involving lupus patients which has allowed us to develop the infrastructure required for the acquisition of patient informed consents, sample collection and storage, and for the management of the information systems required to maintain a database of relevant clinical characteristics that are linked to each sample.

I have a longstanding interest in autoimmune disease in general and in lupus nephritis in particular and run a basic science laboratory of my own that is funded to investigate the pathobiology of immune-complex glomerulonephritis. We use cell culture systems and mouse models of autoimmunity to define pathways that are required for the development or progression of autoimmunity and use this understanding develop new therapeutics.

My basic science work has given me a unique perspective of the requirements that basic scientists and clinicians have to translate basic science breakthroughs to the clinical arena. In the last two years I have worked with our trial manager Dr Britte Zlatanova to established an autoimmune patient registry at Boston Medical Center that now includes over 100 lupus patients and appropriate control samples. I work in collaboration with several pharmaceutical companies and investigators from Boston University Medical Center, the University of Massachusetts, Pittsburg University, and University of Pennsylvania to share this valuable clinical material in order to develop the understanding the biology of autoimmunity and inflammation in anticipation that this will lead to new therapies that are more effective and less toxic..

Expertise includes: Lupus nephritis, Autoimmune kidney disease, Glomerulonephritis, Toxicity of immunosuppression, Genetics of immune-mediated kidney disease

 Self-Described Keywords
  • Lupus nephritis
  • Autoimmune kidney disease
  • Avoiding toxicity of immunosuppression
  • Clinical trials in autoimmune disease
  • Mechanisms of autoimmune kidney disease
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Menn-Josephy H, Lee CS, Nolin A, Christov M, Rybin DV, Weinberg JM, Henderson J, Bonegio R, Havasi A. Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts. Am J Nephrol. 2016; 44(4):289-299. PMID: 27626625.
    View in: PubMed
  2. Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 Aug 15; 197(4):1044-53. PMID: 27354219.
    View in: PubMed
  3. Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH. Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis. 2016 May; 67(5):775-8. PMID: 26744127.
    View in: PubMed
  4. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57. PMID: 26315890.
    View in: PubMed
  5. Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79. PMID: 25595782.
    View in: PubMed
  6. Gall JM, Wang Z, Bonegio RG, Havasi A, Liesa M, Vemula P, Borkan SC. Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J Am Soc Nephrol. 2015 May; 26(5):1092-102. PMID: 25201884.
    View in: PubMed
  7. Yasuda K, Watkins AA, Kochar GS, Wilson GE, Laskow B, Richez C, Bonegio RG, Rifkin IR. Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One. 2014; 9(7):e103478. PMID: 25076492.
    View in: PubMed
  8. Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014 Jul; 142(3):363-73. PMID: 24456224.
    View in: PubMed
  9. Watkins AA, Bonegio RG, Rifkin IR. Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. Methods Mol Biol. 2014; 1169:143-58. PMID: 24957237.
    View in: PubMed
  10. Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1; 191(5):2104-14. PMID: 23918976.
    View in: PubMed
  11. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC. Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death. Mol Cell Biol. 2013 May; 33(10):1916-24. PMID: 23459946.
    View in: PubMed
  12. Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
    View in: PubMed
  13. Havasi A, Haegele JA, Gall JM, Blackmon S, Ichimura T, Bonegio RG, Panchenko MV. Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Am J Pathol. 2013 Jan; 182(1):152-62. PMID: 23159946.
    View in: PubMed
  14. Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W. Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26; 2(1):52-61. PMID: 22840396.
    View in: PubMed
  15. Bonegio R, Susztak K. Notch signaling in diabetic nephropathy. Exp Cell Res. 2012 May 15; 318(9):986-92. PMID: 22414874.
    View in: PubMed
  16. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. PMID: 22292091.
    View in: PubMed
  17. Beck LH, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011 Aug; 22(8):1543-50. PMID: 21784898.
    View in: PubMed
  18. Gall JM, Wong V, Pimental DR, Havasi A, Wang Z, Pastorino JG, Bonegio RG, Schwartz JH, Borkan SC. Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int. 2011 Jun; 79(11):1207-16. PMID: 21430642.
    View in: PubMed
  19. Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May; 79(10):1099-112. PMID: 21270765.
    View in: PubMed
  20. Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011 Apr; 79(8):861-70. PMID: 21270764.
    View in: PubMed
  21. Wang Z, Havasi A, Gall J, Bonegio R, Li Z, Mao H, Schwartz JH, Borkan SC. GSK3beta promotes apoptosis after renal ischemic injury. J Am Soc Nephrol. 2010 Feb; 21(2):284-94. PMID: 20093356.
    View in: PubMed
  22. Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806. PMID: 20007534.
    View in: PubMed
  23. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17. PMID: 19648272.
    View in: PubMed
  24. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2; 361(1):11-21. PMID: 19571279.
    View in: PubMed
  25. Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol. 2009 Jan 1; 182(1):340-6. PMID: 19109165.
    View in: PubMed
  26. Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol. 2006 Sep 1; 177(5):3028-34. PMID: 16920939.
    View in: PubMed
  27. Bonegio RG, Fuhro R, Ragno G, Robert Valeri C, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit Immobil Biotechnol. 2006; 34(2):145-57. PMID: 16537171.
    View in: PubMed
  28. Bonegio RG, Fuhro R, Wang Z, Valeri CR, Andry C, Salant DJ, Lieberthal W. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J Am Soc Nephrol. 2005 Jul; 16(7):2063-72. PMID: 15917339.
    View in: PubMed
  29. Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004 Apr 19; 199(8):1121-31. PMID: 15096538.
    View in: PubMed
  30. Bonegio R, Lieberthal W. Role of apoptosis in the pathogenesis of acute renal failure. Curr Opin Nephrol Hypertens. 2002 May; 11(3):301-8. PMID: 11981260.
    View in: PubMed
  31. Panz VR, Bonegio R, Raal FJ, Maher H, Hsu HC, Joffe BI. Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation1. Transplantation. 2002 Feb 27; 73(4):587-90. PMID: 11889436.
    View in: PubMed
  32. Kahn D, van Rensburg M, Botha JF, Bonegio R, Naicker S, Botha JR, Haalkett J, Pascoe MD. HIV infection following transplantation: the South African experience. Transplant Proc. 2001 Nov-Dec; 33(7-8):3649-50. PMID: 11750550.
    View in: PubMed
  33. Bonegio RG, Driver HS, King LM, Laburn HP, Shapiro CM. Circadian temperature rhythm blunting and sleep composition. Acta Physiol Scand Suppl. 1988; 574:44-7. PMID: 3245467.
    View in: PubMed
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