Keywords
Last Name

Andrea Havasi, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7330
ORCID ORCID Icon0000-0002-8758-0823
Other Positions
TitleActive Staff Hospital Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
Andrea Havasi, M.D. is an Assistant Professor of Medicine at Boston University. She is board certified in Internal Medicine and Nephrology. As a recipient of the National Kidney Foundation Research Fellow Award, she undertook research training at BMC investigating the cytoprotective mechanisms of heat shock proteins in ischemic renal cell injury and apoptosis. She joined the Renal Section Faculty in 2008, and continues basic and translational research in the area of renal cell injury and proteinuric kidney diseases using cell culture and animal models. She is the recipient of the American Heart Association Scientist Development Grant and NIH K08 award. Dr. Havasi is the Co-Director of the Mitochondria Research Affinity Collaborative (mtARC) at the Boston University School of Medicine. Her clinical roles include a weekly clinic and attending time on the consult and dialysis/transplant services.

Current research interest: Proteinuria and renal fibrosis
Mechanisms of proteinuria induced tubular damage, interstitial fibrosis and inflammation in progressive kidney diseases.
Proteinuria is associated with progressive chronic kidney disease. It is well known that exposure of proximal tubular epithelial cells to large amounts of albumin leads to the development of tubular atrophy and fibrosis. However, the possible pathogenic role of albumin in this process has not been fully elucidated. Development of new therapeutic tools to prevent or slow the progression of proteinuric chronic kidney disease requires clear understanding of the effect of proteinuria on tubular cell function.

 Self-Described Keywords
  • Proteinuric renal disease
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Havasi A, Lu W, Cohen HT, Beck LH, Wang Z, Igwebuike C, Borkan SC. Blocking Peptides & Molecular Mimicry as Treatment for Kidney Disease. Am J Physiol Renal Physiol. 2016 Sep 21; ajprenal.00601.2015. PMID: 27654896.
    View in: PubMed
  2. Menn-Josephy H, Lee CS, Nolin A, Christov M, Rybin DV, Weinberg JM, Henderson J, Bonegio R, Havasi A. Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts. Am J Nephrol. 2016; 44(4):289-299. PMID: 27626625.
    View in: PubMed
  3. Nolin AC, Mulhern RM, Panchenko MV, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan SC, Havasi A. Proteinuria causes dysfunctional autophagy in the proximal tubule. Am J Physiol Renal Physiol. 2016 Dec 01; 311(6):F1271-F1279. PMID: 27582098.
    View in: PubMed
  4. Havasi A, Stern L, Lo S, Sun F, Sanchorawala V. Validation of new renal staging system in AL amyloidosis treated with high dose melphalan and stem cell transplantation. Am J Hematol. 2016 Oct; 91(10):E458-60. PMID: 27356490.
    View in: PubMed
  5. Havasi A, Dong Z. Autophagy and Tubular Cell Death in the Kidney. Semin Nephrol. 2016 May; 36(3):174-88. PMID: 27339383.
    View in: PubMed
  6. Bever KM, Masha LI, Sun F, Stern L, Havasi A, Berk JL, Sanchorawala V, Seldin DC, Sloan JM. Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis. Haematologica. 2016 Jan; 101(1):86-90. PMID: 26452981.
    View in: PubMed
  7. Stern L, Havasi A. Renal transplantation in amyloidosis and MIDD. Front Biosci (Elite Ed). 2015; 7:149-57. PMID: 25553370.
    View in: PubMed
  8. Gall JM, Wang Z, Bonegio RG, Havasi A, Liesa M, Vemula P, Borkan SC. Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J Am Soc Nephrol. 2015 May; 26(5):1092-102. PMID: 25201884.
    View in: PubMed
  9. Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle. 2014; 13(12):1885-901. PMID: 24739512.
    View in: PubMed
  10. Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct; 84(4):776-85. PMID: 23657144.
    View in: PubMed
  11. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC. Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death. Mol Cell Biol. 2013 May; 33(10):1916-24. PMID: 23459946.
    View in: PubMed
  12. Havasi A, Haegele JA, Gall JM, Blackmon S, Ichimura T, Bonegio RG, Panchenko MV. Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Am J Pathol. 2013 Jan; 182(1):152-62. PMID: 23159946.
    View in: PubMed
  13. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. PMID: 22292091.
    View in: PubMed
  14. Havasi A, Borkan SC. Apoptosis and acute kidney injury. Kidney Int. 2011 Jul; 80(1):29-40. PMID: 21562469.
    View in: PubMed
  15. Gall JM, Wong V, Pimental DR, Havasi A, Wang Z, Pastorino JG, Bonegio RG, Schwartz JH, Borkan SC. Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int. 2011 Jun; 79(11):1207-16. PMID: 21430642.
    View in: PubMed
  16. Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011 Apr; 79(8):861-70. PMID: 21270764.
    View in: PubMed
  17. Wang Z, Havasi A, Gall J, Bonegio R, Li Z, Mao H, Schwartz JH, Borkan SC. GSK3beta promotes apoptosis after renal ischemic injury. J Am Soc Nephrol. 2010 Feb; 21(2):284-94. PMID: 20093356.
    View in: PubMed
  18. Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol. 2009 Sep; 20(9):1919-28. PMID: 19696224.
    View in: PubMed
  19. Havasi A, Wang Z, Gall JM, Spaderna M, Suri V, Canlas E, Martin JL, Schwartz JH, Borkan SC. Hsp27 inhibits sublethal, Src-mediated renal epithelial cell injury. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F760-8. PMID: 19553351.
    View in: PubMed
  20. Havasi A, Li Z, Wang Z, Martin JL, Botla V, Ruchalski K, Schwartz JH, Borkan SC. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2008 May 2; 283(18):12305-13. PMID: 18299320.
    View in: PubMed
  21. Thorevska N, Tilluckdharry L, Tickoo S, Havasi A, Amoateng-Adjepong Y, Manthous CA. Patients' understanding of advance directives and cardiopulmonary resuscitation. J Crit Care. 2005 Mar; 20(1):26-34. PMID: 16015514.
    View in: PubMed
  22. Thorevska N, Tilluckdharry L, Ticko S, Havasi A, Amoateng-Adjepong Y, Manthous CA. Informed consent for invasive medical procedures from the patient's perspective. Conn Med. 2004 Feb; 68(2):101-5. PMID: 15007870.
    View in: PubMed
  23. Salloum A, Rao S, Havasi A, Miljkovic G, Amoateng-Adjepong Y. Aspergillus rib and vertebral osteomyelitis in a former intravenous drug user. Am J Med. 2004 Feb 1; 116(3):208-9. PMID: 14749170.
    View in: PubMed
  24. Geiszt M, Dagher MC, Molnár G, Havasi A, Faure J, Paclet MH, Morel F, Ligeti E. Characterization of membrane-localized and cytosolic Rac-GTPase-activating proteins in human neutrophil granulocytes: contribution to the regulation of NADPH oxidase. Biochem J. 2001 May 1; 355(Pt 3):851-8. PMID: 11311150.
    View in: PubMed
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