Keywords
Last Name

Laurence H. Beck Jr, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7330
ORCID ORCID Icon0000-0003-1482-4089
Other Positions
TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
Laurence H. Beck, Jr., MD, PhD, completed his Internal Medicine residency and Nephrology fellowship at Boston Medical Center. He joined the Renal Section in 2006, and continues to conduct basic science research in the laboratory of Dr. David Salant on the pathogenesis of membranous nephropathy. His clinical roles include a weekly clinic and attending time on the consult and dialysis/transplant services. He also has expertise in immune-mediated glomerular disease.

 Self-Described Keywords
  • anti-phospholipase A2 receptor autoantibodies
  • membranous nephropathy
  • PLA2R
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Havasi A, Lu W, Cohen HT, Beck LH, Wang Z, Igwebuike C, Borkan SC. Blocking Peptides & Molecular Mimicry as Treatment for Kidney Disease. Am J Physiol Renal Physiol. 2016 Sep 21; ajprenal.00601.2015. PMID: 27654896.
    View in: PubMed
  2. Waldman M, Beck LH, Braun M, Wilkins K, Balow JE, Austin HA. Membranous nephropathy: Pilot study of a novel regimen combining cyclosporine and Rituximab. KI Rep. 2016 Jul; 1(2):73-84. PMID: 27942609.
    View in: PubMed
  3. Francis JM, Beck LH, Salant DJ. Membranous Nephropathy: A Journey From Bench to Bedside. Am J Kidney Dis. 2016 Jul; 68(1):138-47. PMID: 27085376.
    View in: PubMed
  4. Gupta G, Fattah H, Ayalon R, Kidd J, Gehr T, Quintana LF, Kimball P, Sadruddin S, Massey HD, Kumar D, King AL, Beck LH. Pre-transplant phospholipase A2 receptor autoantibody concentration is associated with clinically significant recurrence of membranous nephropathy post-kidney transplantation. Clin Transplant. 2016 Apr; 30(4):461-9. PMID: 26854647.
    View in: PubMed
  5. El-Husseini A, Saxon D, Jennings S, Cornea V, Beck L, Sawaya BP. Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges. Am J Nephrol. 2016; 43(2):65-70. PMID: 26914654.
    View in: PubMed
  6. Larsen CP, Cossey LN, Beck LH. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Mod Pathol. 2016 Apr; 29(4):421-6. PMID: 26847174.
    View in: PubMed
  7. Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH. Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis. 2016 May; 67(5):775-8. PMID: 26744127.
    View in: PubMed
  8. Abudayyeh A, Truong LD, Beck LH, Weber DM, Rezvani K, Abdelrahim M. Membranous nephropathy in autologous hematopoietic stem cell transplant: autologous graft-versus-host disease or autoimmunity induction? Clin Kidney J. 2015 Aug; 8(4):440-4. PMID: 26251713.
    View in: PubMed
  9. Kattah A, Ayalon R, Beck LH, Sethi S, Sandor DG, Cosio FG, Gandhi MJ, Lorenz EC, Salant DJ, Fervenza FC. Anti-phospholipase A2 receptor antibodies in recurrent membranous nephropathy. Am J Transplant. 2015 May; 15(5):1349-59. PMID: 25766759.
    View in: PubMed
  10. Beck LH. Lessons from a rare disease: IgG subclass and disease severity in alloimmune antenatal membranous nephropathy. Kidney Int. 2015 Mar; 87(3):494-7. PMID: 25723631.
    View in: PubMed
  11. Menn-Josephy H, Beck LH. Recurrent glomerular disease in the kidney allograft. Front Biosci (Elite Ed). 2015; 7:135-48. PMID: 25553369.
    View in: PubMed
  12. Tomas NM, Beck LH, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11; 371(24):2277-87. PMID: 25394321.
    View in: PubMed
  13. Beck LH. The dominant humoral epitope in phospholipase A2 receptor-1: presentation matters when serving up a slice of p. J Am Soc Nephrol. 2015 Feb; 26(2):237-9. PMID: 25288604.
    View in: PubMed
  14. Timmermans SA, Damoiseaux JG, Heerings-Rewinkel PT, Ayalon R, Beck LH, Schlumberger W, Salant DJ, van Paassen P, Tervaert JW. Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. Am J Clin Pathol. 2014 Jul; 142(1):29-34. PMID: 24926082.
    View in: PubMed
  15. Beck LH, Salant DJ. Membranous nephropathy: from models to man. J Clin Invest. 2014 Jun 2; 124(6):2307-14. PMID: 24892704.
    View in: PubMed
  16. Behnert A, Schiffer M, Müller-Deile J, Beck LH, Mahler M, Fritzler MJ. Antiphospholipase A2 receptor autoantibodies: a comparison of three different immunoassays for the diagnosis of idiopathic membranous nephropathy. J Immunol Res. 2014; 2014:143274. PMID: 24812637.
    View in: PubMed
  17. Hladunewich MA, Cattran D, Beck LH, Odutayo A, Sethi S, Ayalon R, Leung N, Reich H, Fervenza FC. A pilot study to determine the dose and effectiveness of adrenocorticotrophic hormone (H.P. Acthar® Gel) in nephrotic syndrome due to idiopathic membranous nephropathy. Nephrol Dial Transplant. 2014 Aug; 29(8):1570-7. PMID: 24714414.
    View in: PubMed
  18. Ayalon R, Beck LH. Membranous nephropathy: not just a disease for adults. Pediatr Nephrol. 2015 Jan; 30(1):31-9. PMID: 24375012.
    View in: PubMed
  19. Ma H, Sandor DG, Beck LH. The role of complement in membranous nephropathy. Semin Nephrol. 2013 Nov; 33(6):531-42. PMID: 24161038.
    View in: PubMed
  20. Timmermans SA, Ayalon R, van Paassen P, Beck LH, van Rie H, Wirtz JJ, Verseput GH, Frenken LA, Salant DJ, Cohen Tervaert JW. Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy. Am J Kidney Dis. 2013 Dec; 62(6):1223-5. PMID: 24021909.
    View in: PubMed
  21. Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH, Somers MJ, Trachtman H, Waldman M. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis. Am J Kidney Dis. 2013 Sep; 62(3):403-41. PMID: 23871408.
    View in: PubMed
  22. Borza DB, Zhang JJ, Beck LH, Meyer-Schwesinger C, Luo W. Mouse models of membranous nephropathy: the road less travelled by. Am J Clin Exp Immunol. 2013; 2(2):135-45. PMID: 23885331.
    View in: PubMed
  23. Beck LH. Monoclonal anti-PLA2R and recurrent membranous nephropathy: another piece of the puzzle. J Am Soc Nephrol. 2012 Dec; 23(12):1911-3. PMID: 23138482.
    View in: PubMed
  24. Irazabal MV, Eirin A, Lieske J, Beck LH, Sethi S, Borland TM, Dillon JJ, Nachman PH, Nasr SH, Cornell LD, Leung N, Cattran DC, Fervenza FC. Low- and high-molecular-weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: a prospective study. Nephrol Dial Transplant. 2013 Jan; 28(1):137-46. PMID: 22987142.
    View in: PubMed
  25. Bomback AS, Canetta PA, Beck LH, Ayalon R, Radhakrishnan J, Appel GB. Treatment of resistant glomerular diseases with adrenocorticotropic hormone gel: a prospective trial. Am J Nephrol. 2012; 36(1):58-67. PMID: 22722778.
    View in: PubMed
  26. Khosroshahi A, Ayalon R, Beck LH, Salant DJ, Bloch DB, Stone JH. IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor. Int J Rheumatol. 2012; 2012:139409. PMID: 22654915.
    View in: PubMed
  27. Beck LH. Monoclonal antibodies for the treatment of the C3 glomerulopathies. Clin J Am Soc Nephrol. 2012 May; 7(5):704-6. PMID: 22498497.
    View in: PubMed
  28. Surindran S, Ayalon R, Hasan N, Beck LH, Salant DJ, Barisoni L, Skolnik EY, Beara-Lasic L. Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy. Clin Kidney J. 2012 Apr; 5(2):162-165. PMID: 22833809.
    View in: PubMed
  29. Blosser CD, Ayalon R, Nair R, Thomas C, Beck LH. Very early recurrence of anti-Phospholipase A2 receptor-positive membranous nephropathy after transplantation. Am J Transplant. 2012 Jun; 12(6):1637-42. PMID: 22390840.
    View in: PubMed
  30. Laurence H. Beck, David J. Salant. Tubulointerstitial Diseases of the Kidney. Harrison's Principles of Internal Medicine; Longo, Fauci, Kasper, Hauser, Jameson, and Loscalzo, eds. McGraw-Hill. New York. 2012; 2367-2374.
  31. Beck LH. Childhood membranous nephropathy and dietary antigens. Am J Kidney Dis. 2012 Feb; 59(2):174-6. PMID: 22014402.
    View in: PubMed
  32. Beck LH, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011 Aug; 22(8):1543-50. PMID: 21784898.
    View in: PubMed
  33. Fervenza FC, Downer G, Beck LH, Sethi S. IgG4-related tubulointerstitial nephritis with membranous nephropathy. Am J Kidney Dis. 2011 Aug; 58(2):320-4. PMID: 21705127.
    View in: PubMed
  34. Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E, Marasà M, Beck LH, Salant DJ, Benigni A, D'Agati V, Remuzzi G. Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis. 2011 Aug; 58(2):272-5. PMID: 21658826.
    View in: PubMed
  35. Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol. 2011 Jun; 22(6):1137-43. PMID: 21566055.
    View in: PubMed
  36. Hofstra JM, Beck LH, Beck DM, Wetzels JF, Salant DJ. Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011 Jun; 6(6):1286-91. PMID: 21474589.
    View in: PubMed
  37. Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May; 79(10):1099-112. PMID: 21270765.
    View in: PubMed
  38. Chakera A, Lasserson D, Beck LH, Roberts IS, Winearls CG. Membranous nephropathy after use of UK-manufactured skin creams containing mercury. QJM. 2011 Oct; 104(10):893-6. PMID: 21062753.
    View in: PubMed
  39. Beck LH. Membranous nephropathy and malignancy. Semin Nephrol. 2010 Nov; 30(6):635-44. PMID: 21146128.
    View in: PubMed
  40. Beck LH, Salant DJ. Membranous nephropathy: recent travels and new roads ahead. Kidney Int. 2010 May; 77(9):765-70. PMID: 20182413.
    View in: PubMed
  41. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2; 361(1):11-21. PMID: 19571279.
    View in: PubMed
  42. Beck LH, Salant DJ. Treatment of membranous lupus nephritis: where are we now? J Am Soc Nephrol. 2009 Apr; 20(4):690-1. PMID: 19279123.
    View in: PubMed
  43. Beck LH, Salant DJ. Glomerular and tubulointerstitial diseases. Prim Care. 2008 Jun; 35(2):265-96, vi. PMID: 18486716.
    View in: PubMed
  44. Beck LH, Goodwin AM, D'Amore PA. Culture of large vessel endothelial cells on floating collagen gels promotes a phenotype characteristic of endothelium in vivo. Differentiation. 2004 Apr; 72(4):162-70. PMID: 15157239.
    View in: PubMed
  45. Hirschi KK, Rohovsky SA, Beck LH, Smith SR, D'Amore PA. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res. 1999 Feb 19; 84(3):298-305. PMID: 10024303.
    View in: PubMed
  46. Beck LH. Changes in renal function with aging. Clin Geriatr Med. 1998 May; 14(2):199-209. PMID: 9536101.
    View in: PubMed
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