Keywords
Last Name

Steven Craig Borkan, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7330
ORCID ORCID Icon0000-0003-3062-9486
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionNephrology

 Research Expertise & Professional Interests
Steven C. Borkan, M.D. is an Associate Professor of Medicine at Boston University and an attending physician in the Renal Section at Boston Medical Center. His interests include education of medical students and house staff, basic research on the cellular mechanisms of ischemic acute renal failure and the care of patients with both general medical and renal diseases. Dr. Borkan is the senior author of almost 40 peer reviewed publications in the area of the cellular stress response to acute ischemia and has been a Principal Investigator for the NIH for about 20 years. Dr. Borkan has also received several awards for excellence in teaching from medical students, house staff and colleagues at Boston Medical Center. Most recently, he was a finalist for the Metcalf Teaching Award at Boston University for full-time faculty and received the Grant V. Rodkey award from the Massachusetts Medical Society for significant contributions to medical student education and mentoring. As a teacher, Dr. Borkan is known for his ability to link challenging clinical problems with physiologic principals in manner that is memorable and enjoyable.

 Self-Described Keywords
  • apoptosis
  • BCL proteins
  • cell biology
  • ischemia
  • kidney
  • mitochondria
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Jaberi A, Seth B, Steenkamp D, Alexanian S, Borkan SC. Sodium-Glucose Cotransporter 2 Inhibitors and Euglycemic Diabetic Ketoacidosis: Metabolic Acidosis With a Twist. Clin Diabetes. 2016 Oct; 34(4):214-216. PMID: 27766015.
    View in: PubMed
  2. Havasi A, Lu W, Cohen HT, Beck LH, Wang Z, Igwebuike C, Borkan SC. Blocking Peptides & Molecular Mimicry as Treatment for Kidney Disease. Am J Physiol Renal Physiol. 2016 Sep 21; ajprenal.00601.2015. PMID: 27654896.
    View in: PubMed
  3. Nolin AC, Mulhern RM, Panchenko MV, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan SC, Havasi A. Proteinuria causes dysfunctional autophagy in the proximal tubule. Am J Physiol Renal Physiol. 2016 Dec 01; 311(6):F1271-F1279. PMID: 27582098.
    View in: PubMed
  4. Borkan SC. The Role of BCL-2 Family Members in Acute Kidney Injury. Semin Nephrol. 2016 May; 36(3):237-50. PMID: 27339388.
    View in: PubMed
  5. Gall JM, Wang Z, Bonegio RG, Havasi A, Liesa M, Vemula P, Borkan SC. Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J Am Soc Nephrol. 2015 May; 26(5):1092-102. PMID: 25201884.
    View in: PubMed
  6. Gordon CE, Borkan SC. Recapturing time: a practical approach to time management for physicians. Postgrad Med J. 2014 May; 90(1063):267-72. PMID: 24599633.
    View in: PubMed
  7. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC. Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death. Mol Cell Biol. 2013 May; 33(10):1916-24. PMID: 23459946.
    View in: PubMed
  8. Gall, JM, Wang, Z, Liesa, M, Molina, A, Havasi, A, Shirihai, O, Schwartz, JH, SC Borkan and Bonegio, RG. . Mitofusin 2 Promotes Renal Epithelial Cell Survival After Metabolic Stress. PLoS One. 2012; 7:e31074.
    View in: External Website
  9. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. PMID: 22292091.
    View in: PubMed
  10. Havasi A, Borkan SC. Apoptosis and acute kidney injury. Kidney Int. 2011 Jul; 80(1):29-40. PMID: 21562469.
    View in: PubMed
  11. Gall JM, Wong V, Pimental DR, Havasi A, Wang Z, Pastorino JG, Bonegio RG, Schwartz JH, Borkan SC. Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int. 2011 Jun; 79(11):1207-16. PMID: 21430642.
    View in: PubMed
  12. Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011 Apr; 79(8):861-70. PMID: 21270764.
    View in: PubMed
  13. Zhou Y, Mao H, Li S, Cao S, Li Z, Zhuang S, Fan J, Dong X, Borkan SC, Wang Y, Yu X. HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J Am Soc Nephrol. 2010 Apr; 21(4):598-609. PMID: 20133478.
    View in: PubMed
  14. Wang Z, Havasi A, Gall J, Bonegio R, Li Z, Mao H, Schwartz JH, Borkan SC. GSK3beta promotes apoptosis after renal ischemic injury. J Am Soc Nephrol. 2010 Feb; 21(2):284-94. PMID: 20093356.
    View in: PubMed
  15. Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol. 2009 Sep; 20(9):1919-28. PMID: 19696224.
    View in: PubMed
  16. Havasi A, Wang Z, Gall JM, Spaderna M, Suri V, Canlas E, Martin JL, Schwartz JH, Borkan SC. Hsp27 inhibits sublethal, Src-mediated renal epithelial cell injury. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F760-8. PMID: 19553351.
    View in: PubMed
  17. Miller TA, Icli B, Cote GM, Lebrasseur NK, Borkan SC, Pimentel DR, Peng X, Sawyer DB. Palmitate alters neuregulin signaling and biology in cardiac myocytes. Biochem Biophys Res Commun. 2009 Jan 30; 379(1):32-7. PMID: 19070592.
    View in: PubMed
  18. Mao H, Li Z, Zhou Y, Li Z, Zhuang S, An X, Zhang B, Chen W, Nie J, Wang Z, Borkan SC, Wang Y, Yu X. HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F202-14. PMID: 18417540.
    View in: PubMed
  19. Havasi A, Li Z, Wang Z, Martin JL, Botla V, Ruchalski K, Schwartz JH, Borkan SC. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2008 May 2; 283(18):12305-13. PMID: 18299320.
    View in: PubMed
  20. Borkan SC. Michael Reese's Mission Commander. Acad Med. 2006 Jun; 81(6):556. PMID: 16728805.
    View in: PubMed
  21. Li G, Yang Q, Krishnan S, Alexander EA, Borkan SC, Schwartz JH. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec; 13(12):2109-17. PMID: 16710359.
    View in: PubMed
  22. Ruchalski K, Mao H, Li Z, Wang Z, Gillers S, Wang Y, Mosser DD, Gabai V, Schwartz JH, Borkan SC. Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem. 2006 Mar 24; 281(12):7873-80. PMID: 16407317.
    View in: PubMed
  23. Schaefer KL, Wada K, Takahashi H, Matsuhashi N, Ohnishi S, Wolfe MM, Turner JR, Nakajima A, Borkan SC, Saubermann LJ. Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 2005 Mar 15; 65(6):2251-9. PMID: 15781638.
    View in: PubMed
  24. Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, Sawyer DB. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005 Apr 1; 280(13):13148-52. PMID: 15671027.
    View in: PubMed
  25. Sinha D, Wang Z, Ruchalski KL, Levine JS, Krishnan S, Lieberthal W, Schwartz JH, Borkan SC. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. Am J Physiol Renal Physiol. 2005 Apr; 288(4):F703-13. PMID: 15572521.
    View in: PubMed
  26. Mao H, Wang Y, Li Z, Ruchalski KL, Yu X, Schwartz JH, Borkan SC. Hsp72 interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion. J Biol Chem. 2004 Apr 9; 279(15):15472-80. PMID: 14718530.
    View in: PubMed
  27. Ruchalski K, Mao H, Singh SK, Wang Y, Mosser DD, Li F, Schwartz JH, Borkan SC. HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1483-93. PMID: 12930708.
    View in: PubMed
  28. Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC. hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells. J Biol Chem. 2003 May 16; 278(20):18214-20. PMID: 12611892.
    View in: PubMed
  29. Li F, Mao HP, Ruchalski KL, Wang YH, Choy W, Schwartz JH, Borkan SC. Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C917-26. PMID: 12176748.
    View in: PubMed
  30. Wang YH, Knowlton AA, Li FH, Borkan SC. Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones. 2002 Apr; 7(2):137-45. PMID: 12380681.
    View in: PubMed
  31. Borkan SC. Extracorporeal therapies for acute intoxications. Crit Care Clin. 2002 Apr; 18(2):393-420, vii. PMID: 12053840.
    View in: PubMed
  32. Borkan SC, Gullans SR. Molecular chaperones in the kidney. Annu Rev Physiol. 2002; 64:503-27. PMID: 11826277.
    View in: PubMed
  33. Wang YH, Li F, Schwartz JH, Flint PJ, Borkan SC. c-Src and HSP72 interact in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1667-75. PMID: 11600431.
    View in: PubMed
  34. Wang Y, Shia MA, Christensen TG, Borkan SC. Hepatic alpha 2 mu-globulin localizes to the cytosol of rat proximal tubule cells. Kidney Int. 2000 Mar; 57(3):1015-26. PMID: 10720954.
    View in: PubMed
  35. Lader AS, Wang Y, Jackson GR, Borkan SC, Cantiello HF. cAMP-activated anion conductance is associated with expression of CFTR in neonatal mouse cardiac myocytes. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C436-50. PMID: 10666040.
    View in: PubMed
  36. Prat AG, Cunningham CC, Jackson GR, Borkan SC, Wang Y, Ausiello DA, Cantiello HF. Actin filament organization is required for proper cAMP-dependent activation of CFTR. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1160-9. PMID: 10600767.
    View in: PubMed
  37. Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC. Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int. 1999 Jun; 55(6):2224-35. PMID: 10354271.
    View in: PubMed
  38. Cantiello HF, Jackson GR, Grosman CF, Prat AG, Borkan SC, Wang Y, Reisin IL, O'Riordan CR, Ausiello DA. Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator. Am J Physiol. 1998 Mar; 274(3 Pt 1):C799-809. PMID: 9530112.
    View in: PubMed
  39. Borkan SC, Wang YH, Lieberthal W, Burke PR, Schwartz JH. Heat stress ameliorates ATP depletion-induced sublethal injury in mouse proximal tubule cells. Am J Physiol. 1997 Mar; 272(3 Pt 2):F347-55. PMID: 9087678.
    View in: PubMed
  40. Borkan SC, Wang YH, Lam KT, Brecher P, Schwartz JH. Hepatic alpha 2 mu-globulin: a potential metabolic role in the rat proximal tubule. Am J Physiol. 1996 Sep; 271(3 Pt 2):F527-38. PMID: 8853414.
    View in: PubMed
  41. Wang YH, Borkan SC. Prior heat stress enhances survival of renal epithelial cells after ATP depletion. Am J Physiol. 1996 Jun; 270(6 Pt 2):F1057-65. PMID: 8764325.
    View in: PubMed
  42. Borkan SC, Emami A, Schwartz JH. Heat stress protein-associated cytoprotection of inner medullary collecting duct cells from rat kidney. Am J Physiol. 1993 Sep; 265(3 Pt 2):F333-41. PMID: 8214091.
    View in: PubMed
  43. Emami A, Schwartz JH, Borkan SC. Transient ischemia or heat stress induces a cytoprotectant protein in rat kidney. Am J Physiol. 1991 Apr; 260(4 Pt 2):F479-85. PMID: 2012203.
    View in: PubMed
  44. Lesky LG, Borkan SC. Strategies to improve teaching in the ambulatory medicine setting. Arch Intern Med. 1990 Oct; 150(10):2133-7. PMID: 2222098.
    View in: PubMed
  45. Borkan SC, Schwartz JH. Role of oxygen free radical species in in vitro models of proximal tubular ischemia. Am J Physiol. 1989 Jul; 257(1 Pt 2):F114-25. PMID: 2750916.
    View in: PubMed
  46. Lam KT, Borkan S, Claffey KP, Schwartz JH, Chobanian AV, Brecher P. Properties and differential regulation of two fatty acid binding proteins in the rat kidney. J Biol Chem. 1988 Oct 25; 263(30):15762-8. PMID: 3170609.
    View in: PubMed
  47. Borkan S, Northrup TE, Cohen JJ, Garella S. Renal response to metabolic alkalosis induced by isovolemic hemofiltration in the dog. Kidney Int. 1987 Sep; 32(3):322-8. PMID: 3669492.
    View in: PubMed
  48. Borkan SC. Hemoperfusion for N-acetylprocainamide intoxication. Ann Intern Med. 1986 Dec; 105(6):965-6. PMID: 2430494.
    View in: PubMed
  49. Moulton BC, Koenig BB, Borkan SC. Uterine lysosomal enzyme activity during ovum implantation and early decidualization. Biol Reprod. 1978 Aug; 19(1):167-70. PMID: 687703.
    View in: PubMed
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