Keywords
Last Name

C. Robert Horsburgh Jr, MD

TitleProfessor
InstitutionBoston University School of Public Health
DepartmentEpidemiology
Address715 Albany St Talbot Building
Boston MA 02118
Phone(617) 638-7775
ORCID ORCID Icon0000-0001-6838-7895
Other Positions
TitleProfessor of Epidemiology
InstitutionBoston University School of Public Health
DepartmentEpidemiology

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Disease

TitleProfessor
InstitutionBoston University School of Public Health
DepartmentBiostatistics

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Dr. Horsburgh has 30 years of experience in public health and medicine. He currently holds faculty positions in the Department of Biostatistics and the Department of Medicine. Dr. Horsburgh teaches courses in the Epidemiology of AIDS and the Epidemiology of Tuberculosis. He has focused his research on tuberculosis, nontuberculous mycobacterial infections and opportunistic infections in AIDS and has served as the National Steering Committee Co-Chairman of the Tuberculosis Trials Consortium and the Tuberculosis Epidemiologic Studies Consortium. He is currently the Chairman of the Steering Committee of RESIST-TB, an international organization dedicated to improving MDR-TB treatment through Clinical Trials.



 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Daley CL, Horsburgh CR. Editorial Commentary: Treatment for Multidrug-Resistant Tuberculosis: It''s Worse Than We Thought! Clin Infect Dis. 2014 Oct 15; 59(8):1064-5.
    View in: PubMed
  2. Horsburgh CR. Tuberculosis. Eur Respir Rev. 2014 Mar 1; 23(131):36-9.
    View in: PubMed
  3. Linas BP, Barter DM, Leff JA, Dilorenzo M, Schackman BR, Horsburgh CR, Assoumou SA, Salomon JA, Weinstein MC, Kim AY, Freedberg KA. The cost-effectiveness of improved hepatitis C virus therapies in HIV/hepatitis C virus coinfected patients. AIDS. 2014 Jan 28; 28(3):365-76.
    View in: PubMed
  4. Brigden G, Nyang''wa BT, du Cros P, Varaine F, Hughes J, Rich M, Horsburgh CR, Mitnick CD, Nuermberger E, McIlleron H, Phillips PP, Balasegaram M. Principles for designing future regimens for multidrug-resistant tuberculosis. Bull World Health Organ. 2014 Jan 1; 92(1):68-74.
    View in: PubMed
  5. Shea KM, Kammerer JS, Winston CA, Navin TR, Horsburgh CR. Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup. Am J Epidemiol. 2014 Jan 15; 179(2):216-25.
    View in: PubMed
  6. Horsburgh CR, Shea KM, Phillips P, Lavalley M. Randomized clinical trials to identify optimal antibiotic treatment duration. Trials. 2013; 14:88.
    View in: PubMed
  7. O'Donnell MR, Padayatchi N, Kvasnovsky C, Werner L, Master I, Horsburgh CR. Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection. Emerg Infect Dis. 2013 Mar; 19(3):416-24.
    View in: PubMed
  8. Hochberg NS, Horsburgh CR. Prevention of tuberculosis in older adults in the United States: obstacles and opportunities. Clin Infect Dis. 2013 May; 56(9):1240-7.
    View in: PubMed
  9. Horsburgh CR, Haxaire-Theeuwes M, Lienhardt C, Wingfield C, McNeeley D, Pyne-Mercier L, Keshavjee S, Varaine F. Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2013 Feb; 17(2):146-52.
    View in: PubMed
  10. Reed C, Bliss C, Stuver SO, Heeren T, Tumilty S, Horsburgh CR, Samet JH, Cotton DJ. Predictors of active injection drug use in a cohort of patients infected with hepatitis C virus. Am J Public Health. 2013 Jan; 103(1):105-11.
    View in: PubMed
  11. Sterling TR, Villarino ME, Borisov AS, Shang N, Gordin F, Bliven-Sizemore E, Hackman J, Hamilton CD, Menzies D, Kerrigan A, Weis SE, Weiner M, Wing D, Conde MB, Bozeman L, Horsburgh CR, Chaisson RE. Three months of rifapentine and isoniazid for latent tuberculosis infection. N Engl J Med. 2011 Dec 8; 365(23):2155-66.
    View in: PubMed
  12. Kabali C, von Reyn CF, Brooks DR, Waddell R, Mtei L, Bakari M, Matee M, Pallangyo K, Arbeit RD, Horsburgh CR. Completion of isoniazid preventive therapy and survival in HIV-infected, TST-positive adults in Tanzania. Int J Tuberc Lung Dis. 2011 Nov; 15(11):1515-21, i.
    View in: PubMed
  13. Larson EM, O'Donnell M, Chamblee S, Horsburgh CR, Marsh BJ, Moreland JD, Johnson LS, von Reyn CF. Dual skin tests with Mycobacterium avium sensitin and PPD to detect misdiagnosis of latent tuberculosis infection. Int J Tuberc Lung Dis. 2011 Nov; 15(11):1504-9, i.
    View in: PubMed
  14. Leegaard A, Riis A, Kornum JB, Prahl JB, Thomsen VØ, Sørensen HT, Horsburgh CR, Thomsen RW. Diabetes, glycemic control, and risk of tuberculosis: a population-based case-control study. Diabetes Care. 2011 Dec; 34(12):2530-5.
    View in: PubMed
  15. O'Donnell MR, Zelnick J, Werner L, Master I, Loveday M, Horsburgh CR, Padayatchi N. Extensively drug-resistant tuberculosis in women, KwaZulu-Natal, South Africa. Emerg Infect Dis. 2011 Oct; 17(10):1942-5.
    View in: PubMed
  16. Linas BP, Wong AY, Freedberg KA, Horsburgh CR. Priorities for screening and treatment of latent tuberculosis infection in the United States. Am J Respir Crit Care Med. 2011 Sep 1; 184(5):590-601.
    View in: PubMed
  17. Baranoski AS, Horsburgh CR, Cupples LA, Aschengrau A, Stier EA. Risk factors for nonadherence with Pap testing in HIV-infected women. J Womens Health (Larchmt). 2011 Nov; 20(11):1635-43.
    View in: PubMed
  18. von Reyn CF, Kimambo S, Mtei L, Arbeit RD, Maro I, Bakari M, Matee M, Lahey T, Adams LV, Black W, Mackenzie T, Lyimo J, Tvaroha S, Waddell R, Kreiswirth B, Horsburgh CR, Pallangyo K. Disseminated tuberculosis in human immunodeficiency virus infection: ineffective immunity, polyclonal disease and high mortality. Int J Tuberc Lung Dis. 2011 Aug; 15(8):1087-92.
    View in: PubMed
  19. Lahey T, Mitchell BK, Arbeit RD, Sheth S, Matee M, Horsburgh CR, MacKenzie T, Mtei L, Bakari M, Vuola JM, Pallangyo K, von Reyn CF. Polyantigenic interferon-? responses are associated with protection from TB among HIV-infected adults with childhood BCG immunization. PLoS One. 2011; 6(7):e22074.
    View in: PubMed
  20. Kabali C, Cheng DM, Brooks DR, Bridden C, Horsburgh CR, Samet JH. Recent cigarette smoking and HIV disease progression: no evidence of an association. AIDS Care. 2011 Aug; 23(8):947-56.
    View in: PubMed
  21. Horsburgh CR, Rubin EJ. Clinical practice. Latent tuberculosis infection in the United States. N Engl J Med. 2011 Apr 14; 364(15):1441-8.
    View in: PubMed
  22. Garg S, Hoenig M, Edwards EM, Bliss C, Heeren T, Tumilty S, Walley AY, Koziel MJ, Skolnik PR, Horsburgh CR, Cotton D. Incidence and predictors of acute kidney injury in an urban cohort of subjects with HIV and hepatitis C virus coinfection. AIDS Patient Care STDS. 2011 Mar; 25(3):135-41.
    View in: PubMed
  23. Reichmann WM, Gagnon D, Horsburgh CR, Losina E. Evaluation of exposure-specific risks from two independent samples: a simulation study. BMC Med Res Methodol. 2011; 11:1.
    View in: PubMed
  24. Rorie JA, Smith A, Evans T, Horsburgh CR, Brooks DR, Goodman R, Bunte D, Strunin L, de la Rosa D, Geller A. Using resident health advocates to improve public health screening and follow-up among public housing residents, Boston, 2007-2008. Prev Chronic Dis. 2011 Jan; 8(1):A15.
    View in: PubMed
  25. Mitnick C, Horsburgh CR. Encouraging news for multidrug-resistant tuberculosis treatment. Am J Respir Crit Care Med. 2010 Dec 1; 182(11):1337-8.
    View in: PubMed
  26. O'Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, Werner L, Naidoo K, Master I, Osburn G, Kvasnovsky C, Shean K, Pai M, Van der Walt M, Horsburgh CR, Dheda K. High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med. 2010 Oct 19; 153(8):516-22.
    View in: PubMed
  27. Lahey T, Sheth S, Matee M, Arbeit R, Horsburgh CR, Mtei L, Mackenzie T, Bakari M, Vuola JM, Pallangyo K, von Reyn CF. Interferon ? responses to mycobacterial antigens protect against subsequent HIV-associated tuberculosis. J Infect Dis. 2010 Oct 15; 202(8):1265-72.
    View in: PubMed
  28. Lahey T, Arbeit RD, Bakari M, Horsburgh CR, Matee M, Waddell R, Mtei L, Vuola JM, Pallangyo K, von Reyn CF. Immunogenicity of a protective whole cell mycobacterial vaccine in HIV-infected adults: a phase III study in Tanzania. Vaccine. 2010 Nov 10; 28(48):7652-8.
    View in: PubMed
  29. O'Donnell MR, Chamblee S, von Reyn CF, Ellerbrock TV, Johnson J, Marsh BJ, Moreland JD, Narita M, Pedrosa M, Johnson LS, Horsburgh CR. Racial disparities in primary and reactivation tuberculosis in a rural community in the southeastern United States. Int J Tuberc Lung Dis. 2010 Jun; 14(6):733-40.
    View in: PubMed
  30. Horsburgh CR, O'Donnell M, Chamblee S, Moreland JL, Johnson J, Marsh BJ, Narita M, Johnson LS, von Reyn CF. Revisiting rates of reactivation tuberculosis: a population-based approach. Am J Respir Crit Care Med. 2010 Aug 1; 182(3):420-5.
    View in: PubMed
  31. von Reyn CF, Mtei L, Arbeit RD, Waddell R, Cole B, Mackenzie T, Matee M, Bakari M, Tvaroha S, Adams LV, Horsburgh CR, Pallangyo K. Prevention of tuberculosis in Bacille Calmette-Guérin-primed, HIV-infected adults boosted with an inactivated whole-cell mycobacterial vaccine. AIDS. 2010 Mar 13; 24(5):675-85.
    View in: PubMed
  32. Horsburgh CR. Evidence-based prevention of MDR-TB: an intervention whose time has come. Int J Tuberc Lung Dis. 2010 Mar; 14(3):259.
    View in: PubMed
  33. Nunes D, Fleming C, Offner G, Craven D, Fix O, Heeren T, Koziel MJ, Graham C, Tumilty S, Skolnik P, Stuver S, Horsburgh CR, Cotton D. Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection. Am J Gastroenterol. 2010 Jun; 105(6):1346-53.
    View in: PubMed
  34. Strunin L, Douyon M, Chavez M, Bunte D, Horsburgh CR. The GirlStars program: challenges to recruitment and retention in a physical activity and health education program for adolescent girls living in public housing. Prev Chronic Dis. 2010 Mar; 7(2):A42.
    View in: PubMed
  35. Horsburgh CR, Goldberg S, Bethel J, Chen S, Colson PW, Hirsch-Moverman Y, Hughes S, Shrestha-Kuwahara R, Sterling TR, Wall K, Weinfurter P. Latent TB infection treatment acceptance and completion in the United States and Canada. Chest. 2010 Feb; 137(2):401-9.
    View in: PubMed
  36. Raj A, Reed E, Santana MC, Walley AY, Welles SL, Horsburgh CR, Flores SA, Silverman JG. The associations of binge alcohol use with HIV/STI risk and diagnosis among heterosexual African American men. Drug Alcohol Depend. 2009 Apr 1; 101(1-2):101-6.
    View in: PubMed
  37. Horsburgh CR. Primary transmission of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected persons: what does the future hold in store? J Infect Dis. 2008 Dec 1; 198(11):1577-8.
    View in: PubMed
  38. Bakari M, Arbeit RD, Mtei L, Lyimo J, Waddell R, Matee M, Cole BF, Tvaroha S, Horsburgh CR, Soini H, Pallangyo K, von Reyn CF. Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum culture. BMC Infect Dis. 2008; 8:32.
    View in: PubMed
  39. Walley AY, Cheng DM, Libman H, Nunes D, Horsburgh CR, Saitz R, Samet JH. Recent drug use, homelessness and increased short-term mortality in HIV-infected persons with alcohol problems. AIDS. 2008 Jan 30; 22(3):415-20.
    View in: PubMed
  40. Raj A, Reed E, Santana MC, Welles SL, Horsburgh CR, Flores SA, Silverman JG. History of incarceration and gang involvement are associated with recent sexually transmitted disease/HIV diagnosis in African American men. J Acquir Immune Defic Syndr. 2008 Jan 1; 47(1):131-4.
    View in: PubMed
  41. Reed C, Stuver SO, Tumilty S, Nunes D, Murray JE, Graham CS, James Koziel M, Craven DE, Skolnik PR, Horsburgh CR. Predictors of treatment for hepatitis C virus (HCV) infection in drug users. Subst Abus. 2008; 29(1):5-15.
    View in: PubMed
  42. Digenis-Bury EC, Brooks DR, Chen L, Ostrem M, Horsburgh CR. Use of a population-based survey to describe the health of Boston public housing residents. Am J Public Health. 2008 Jan; 98(1):85-91.
    View in: PubMed
  43. Patel S, Parsyan AE, Gunn J, Barry MA, Reed C, Sharnprapai S, Horsburgh CR. Risk of progression to active tuberculosis among foreign-born persons with latent tuberculosis. Chest. 2007 Jun; 131(6):1811-6.
    View in: PubMed
  44. Graham CS, Wells A, Edwards EM, Herren T, Tumilty S, Stuver SO, Samet JH, Nunes D, Horsburgh CR, Koziel MJ. Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfection. J Infect Dis. 2007 Mar 15; 195(6):847-56.
    View in: PubMed
  45. Matee M, Lahey T, Vuola JM, Mtei L, Cole BF, Bakari M, Arbeit RD, Horsburgh CR, Pallangyo K, von Reyn CF. Baseline mycobacterial immune responses in HIV-infected adults primed with bacille Calmette-Guérin during childhood and entering a tuberculosis booster vaccine trial. J Infect Dis. 2007 Jan 1; 195(1):118-23.
    View in: PubMed
  46. Conwell DS, Mosher A, Khan A, Tapy J, Sandman L, Vernon A, Horsburgh CR. Factors associated with loss to follow-up in a large tuberculosis treatment trial (TBTC Study 22). Contemp Clin Trials. 2007 May; 28(3):288-94.
    View in: PubMed
  47. Shieh FK, Snyder G, Horsburgh CR, Bernardo J, Murphy C, Saukkonen JJ. Predicting non-completion of treatment for latent tuberculous infection: a prospective survey. Am J Respir Crit Care Med. 2006 Sep 15; 174(6):717-21.
    View in: PubMed
  48. Parsyan AE, Saukkonen J, Barry MA, Sharnprapai S, Horsburgh CR. Predictors of failure to complete treatment for latent tuberculosis infection. J Infect. 2007 Mar; 54(3):262-6.
    View in: PubMed
  49. Khan A, Sterling TR, Reves R, Vernon A, Horsburgh CR. Lack of weight gain and relapse risk in a large tuberculosis treatment trial. Am J Respir Crit Care Med. 2006 Aug 1; 174(3):344-8.
    View in: PubMed
  50. Reed C, von Reyn CF, Chamblee S, Ellerbrock TV, Johnson JW, Marsh BJ, Johnson LS, Trenschel RJ, Horsburgh CR. Environmental risk factors for infection with Mycobacterium avium complex. Am J Epidemiol. 2006 Jul 1; 164(1):32-40.
    View in: PubMed
  51. Solages A, Vita JA, Thornton DJ, Murray J, Heeren T, Craven DE, Horsburgh CR. Endothelial function in HIV-infected persons. Clin Infect Dis. 2006 May 1; 42(9):1325-32.
    View in: PubMed
  52. Sterling TR, Bethel J, Goldberg S, Weinfurter P, Yun L, Horsburgh CR. The scope and impact of treatment of latent tuberculosis infection in the United States and Canada. Am J Respir Crit Care Med. 2006 Apr 15; 173(8):927-31.
    View in: PubMed
  53. Nunes D, Fleming C, Offner G, O'Brien M, Tumilty S, Fix O, Heeren T, Koziel M, Graham C, Craven DE, Stuver S, Horsburgh CR. HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):538-44.
    View in: PubMed
  54. Mtei L, Matee M, Herfort O, Bakari M, Horsburgh CR, Waddell R, Cole BF, Vuola JM, Tvaroha S, Kreiswirth B, Pallangyo K, von Reyn CF. High rates of clinical and subclinical tuberculosis among HIV-infected ambulatory subjects in Tanzania. Clin Infect Dis. 2005 May 15; 40(10):1500-7.
    View in: PubMed
  55. Ellerbrock TV, Chamblee S, Bush TJ, Johnson JW, Marsh BJ, Lowell P, Trenschel RJ, Von Reyn CF, Johnson LS, Horsburgh CR. Human immunodeficiency virus infection in a rural community in the United States. Am J Epidemiol. 2004 Sep 15; 160(6):582-8.
    View in: PubMed
  56. Horsburgh CR. Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med. 2004 May 13; 350(20):2060-7.
    View in: PubMed
  57. Fleming CA, Christiansen D, Nunes D, Heeren T, Thornton D, Horsburgh CR, Koziel MJ, Graham C, Craven DE. Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection. Clin Infect Dis. 2004 Feb 15; 38(4):572-8.
    View in: PubMed
  58. Tobin-D'Angelo MJ, Blass MA, del Rio C, Halvosa JS, Blumberg HM, Horsburgh CR. Hospital water as a source of Mycobacterium avium complex isolates in respiratory specimens. J Infect Dis. 2004 Jan 1; 189(1):98-104.
    View in: PubMed
  59. Stratford D, Chamblee S, Ellerbrock TV, Johnson RJ, Abbott D, Reyn CF, Horsburgh CR. Integration of a participatory research strategy into a rural health survey. J Gen Intern Med. 2003 Jul; 18(7):586-8.
    View in: PubMed
  60. Fisk TL, Hon HM, Lennox JL, Fordham von Reyn C, Horsburgh CR. Detection of latent tuberculosis among HIV-infected patients after initiation of highly active antiretroviral therapy. AIDS. 2003 May 2; 17(7):1102-4.
    View in: PubMed
  61. Benator D, Bhattacharya M, Bozeman L, Burman W, Cantazaro A, Chaisson R, Gordin F, Horsburgh CR, Horton J, Khan A, Lahart C, Metchock B, Pachucki C, Stanton L, Vernon A, Villarino ME, Wang YC, Weiner M, Weis S. Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet. 2002 Aug 17; 360(9332):528-34.
    View in: PubMed
  62. von Reyn CF, Arbeit RD, Horsburgh CR, Ristola MA, Waddell RD, Tvaroha SM, Samore M, Hirschhorn LR, Lumio J, Lein AD, Grove MR, Tosteson AN. Sources of disseminated Mycobacterium avium infection in AIDS. J Infect. 2002 Apr; 44(3):166-70.
    View in: PubMed
  63. Espey DK, Djomand G, Diomande I, Dosso M, Saki MZ, Kanga JM, Spiegel RA, Marston BJ, Gorelkin L, Meyers WM, Portaels F, Deming MS, Horsburgh CR. A pilot study of treatment of Buruli ulcer with rifampin and dapsone. Int J Infect Dis. 2002 Mar; 6(1):60-5.
    View in: PubMed
  64. Vernon A, Burman W, Horsburgh CR. Another step on the path to better TB therapies. Int J Tuberc Lung Dis. 2002 Jan; 6(1):1-2.
    View in: PubMed
  65. von Reyn CF, Horsburgh CR, Olivier KN, Barnes PF, Waddell R, Warren C, Tvaroha S, Jaeger AS, Lein AD, Alexander LN, Weber DJ, Tosteson AN. Skin test reactions to Mycobacterium tuberculosis purified protein derivative and Mycobacterium avium sensitin among health care workers and medical students in the United States. Int J Tuberc Lung Dis. 2001 Dec; 5(12):1122-8.
    View in: PubMed
  66. Horsburgh CR, Gettings J, Alexander LN, Lennox JL. Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000. Clin Infect Dis. 2001 Dec 1; 33(11):1938-43.
    View in: PubMed
  67. Bruce BB, Blass MA, Blumberg HM, Lennox JL, del Rio C, Horsburgh CR. Risk of Cryptosporidium parvum transmission between hospital roommates. Clin Infect Dis. 2000 Oct; 31(4):947-50.
    View in: PubMed
  68. Horsburgh CR, Feldman S, Ridzon R. Practice guidelines for the treatment of tuberculosis. Clin Infect Dis. 2000 Sep; 31(3):633-9.
    View in: PubMed
  69. Horsburgh CR. A large, simple trial of a tuberculosis vaccine. Clin Infect Dis. 2000 Jun; 30 Suppl 3:S213-6.
    View in: PubMed
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