Professor Ian Matthias Sanne is a South African born infectious diseases doctor and has been involved in HIV and TB research since qualifying as internist in 1996. Since 2003 he has led the Wits HIV Research Group Clinical Trials Unit, and from 2003- 2012 led the Adult Treatment Research Site. He currently holds the AIDS Clinical Trials Group International Vice-Chair position and is responsible for overseeing the network’s research at 25 international sites in 13 countries and assisting in the prioritization of the research agenda. The focus of his research attention is an integrated program of HIV and TB research from prospective phase I-IV clinical trials, conducted predominantly through international collaborations with the NIH, EDCTP, Global TB Alliance and the Medical Research Council of South Africa. The key focus in the ACTG collaboration is prospective research to inform diagnostic, prevention and treatment interventions to optimize the diagnosis and treatment of HIV and tuberculosis. In addition through programs of implementation sciences and monitoring evaluation data produced as part of the Right to Care PEPFAR implementation program epidemiologic and health economic evaluation of health care interventions. The overall aim is to develop evidence based health system strengthening interventions to address the public health emergencies facing the resource poor setting. At the intersection of clinical care, and clinical trial administration, Professor Sanne continues to provide expertise to the ACTG leadership from the experience gained as the founding Director and Chief Executive Officer of Right to Care.