Keywords
Last Name

Gwynneth D. Offner, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8221
ORCID ORCID Icon0000-0002-3687-9809
Other Positions
TitleAssistant Dean of Admissions
InstitutionBoston University School of Medicine
DepartmentAdmissions

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Gwynneth D. Offner, Ph.D. is the Director of the M.A. in Medical Sciences Program and an Associate Professor in the Department of Medicine. While her primary focus is teaching, advising and mentoring students, Dr. Offner has also directed an NIH-funded research program for nearly 25 years. Dr. Offner grew up in the Washington, D.C. area and came to Boston to attend Wellesley College where she majored in Chemistry. She subsequently received a Ph.D. in Biochemistry from BU School of Medicine and has been on the faculty here since 1986. She teaches in the Biochemistry courses for both medical and graduate students and is Director of the Biochemistry course for M.A. in Medical Sciences students. Her research focuses on the structure and biological functions of a group of glycoproteins called mucins. These proteins serve as part of the non-immune host defense system and have been linked to many diseases including cancer, cystic fibrosis and inflammatory bowel disease.

 Self-Described Keywords
  • medical sciences
  • mucin
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gallan AJ, Offner GD, Symes K. Vertical integration of biochemistry and clinical medicine using a near-peer learning model. Biochem Mol Biol Educ. 2016 Nov 12; 44(6):507-516. PMID: 27123831.
    View in: PubMed
  2. Oppenheim FG, Helmerhorst EJ, Lendenmann U, Offner GD. Anti-candidal activity of genetically engineered histatin variants with multiple functional domains. PLoS One. 2012; 7(12):e51479. PMID: 23251551.
    View in: PubMed
  3. Soares RV, Offner GD, Assis MA, Silva KC, Zenóbio EG. An unusual glycoform of human salivary mucin MG2. Clin Oral Investig. 2012 Jun; 16(3):761-6. PMID: 21538073.
    View in: PubMed
  4. Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55. PMID: 21080726.
    View in: PubMed
  5. Nunes D, Fleming C, Offner G, Craven D, Fix O, Heeren T, Koziel MJ, Graham C, Tumilty S, Skolnik P, Stuver S, Horsburgh CR, Cotton D. Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection. Am J Gastroenterol. 2010 Jun; 105(6):1346-53. PMID: 20179698.
    View in: PubMed
  6. Nunes D, Fleming C, Offner G, O'Brien M, Tumilty S, Fix O, Heeren T, Koziel M, Graham C, Craven DE, Stuver S, Horsburgh CR. HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):538-44. PMID: 16284529.
    View in: PubMed
  7. Chen ZY, Wang X, Zhou Y, Offner G, Tseng CC. Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway. Cancer Res. 2005 Nov 15; 65(22):10394-400. PMID: 16288030.
    View in: PubMed
  8. Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD. Two-hybrid analysis of human salivary mucin MUC7 interactions. Biochim Biophys Acta. 2005 Oct 30; 1746(1):65-72. PMID: 16203048.
    View in: PubMed
  9. Li X, Wang L, Nunes DP, Troxler RF, Offner GD. Suppression of MUC1 synthesis downregulates expression of the epidermal growth factor receptor. Cancer Biol Ther. 2005 Sep; 4(9):968-73. PMID: 16082192.
    View in: PubMed
  10. Soares RV, Lin T, Siqueira CC, Bruno LS, Li X, Oppenheim FG, Offner G, Troxler RF. Salivary micelles: identification of complexes containing MG2, sIgA, lactoferrin, amylase, glycosylated proline-rich protein and lysozyme. Arch Oral Biol. 2004 May; 49(5):337-43. PMID: 15041480.
    View in: PubMed
  11. Li X, Wang L, Nunes DP, Troxler RF, Offner GD. Pro-inflammatory cytokines up-regulate MUC1 gene expression in oral epithelial cells. J Dent Res. 2003 Nov; 82(11):883-7. PMID: 14578499.
    View in: PubMed
  12. Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF. MG2 and lactoferrin form a heterotypic complex in salivary secretions. J Dent Res. 2003 Jun; 82(6):471-5. PMID: 12766201.
    View in: PubMed
  13. Becerra L, Soares RV, Bruno LS, Siqueira CC, Oppenheim FG, Offner GD, Troxler RF. Patterns of secretion of mucins and non-mucin glycoproteins in human submandibular/sublingual secretion. Arch Oral Biol. 2003 Feb; 48(2):147-54. PMID: 12642234.
    View in: PubMed
  14. Piludu M, Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF, Hand AR. Electron microscopic immunogold localization of salivary mucins MG1 and MG2 in human submandibular and sublingual glands. J Histochem Cytochem. 2003 Jan; 51(1):69-79. PMID: 12502756.
    View in: PubMed
  15. Liu B, Rayment SA, Soares RV, Oppenheim FG, Offner GD, Fives-Taylor P, Troxler RF. Interaction of human salivary mucin MG2, its recombinant N-terminal region and a synthetic peptide with Actinobacillus actinomycetemcomitans. J Periodontal Res. 2002 Dec; 37(6):416-24. PMID: 12472835.
    View in: PubMed
  16. Soares RV, Liu B, Oppenheim FG, Offner GD, Troxler RF. Structural characterisation of cysteines in a bacterial-binding motif of human salivary mucin MG2. Arch Oral Biol. 2002 Aug; 47(8):591-7. PMID: 12221016.
    View in: PubMed
  17. Liu B, Lague JR, Nunes DP, Toselli P, Oppenheim FG, Soares RV, Troxler RF, Offner GD. Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands. J Histochem Cytochem. 2002 Jun; 50(6):811-20. PMID: 12019297.
    View in: PubMed
  18. Rayment SA, Liu B, Soares RV, Offner GD, Oppenheim FG, Troxler RF. The effects of duration and intensity of stimulation on total protein and mucin concentrations in resting and stimulated whole saliva. J Dent Res. 2001 Jun; 80(6):1584-7. PMID: 11499518.
    View in: PubMed
  19. Gipson IK, Moccia R, Spurr-Michaud S, Argüeso P, Gargiulo AR, Hill JA, Offner GD, Keutmann HT. The Amount of MUC5B mucin in cervical mucus peaks at midcycle. J Clin Endocrinol Metab. 2001 Feb; 86(2):594-600. PMID: 11158014.
    View in: PubMed
  20. Offner GD, Troxler RF. Heterogeneity of high-molecular-weight human salivary mucins. Adv Dent Res. 2000 Dec; 14:69-75. PMID: 11842927.
    View in: PubMed
  21. Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF. Salivary mucin: a factor in the lower prevalence of gastroesophageal reflux disease in African-Americans? Am J Gastroenterol. 2000 Nov; 95(11):3064-70. PMID: 11095319.
    View in: PubMed
  22. Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF. Immunoquantification of human salivary mucins MG1 and MG2 in stimulated whole saliva: factors influencing mucin levels. J Dent Res. 2000 Oct; 79(10):1765-72. PMID: 11077992.
    View in: PubMed
  23. Keaveny AP, Offner GD, Bootle E, Nunes DP. No significant difference in antigenicity or tissue transglutaminase substrate specificity of Irish and US wheat gliadins. Dig Dis Sci. 2000 Apr; 45(4):755-62. PMID: 10759247.
    View in: PubMed
  24. Liu B, Rayment SA, Gyurko C, Oppenheim FG, Offner GD, Troxler RF. The recombinant N-terminal region of human salivary mucin MG2 (MUC7) contains a binding domain for oral Streptococci and exhibits candidacidal activity. Biochem J. 2000 Feb 1; 345 Pt 3:557-64. PMID: 10642514.
    View in: PubMed
  25. Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. J Dent Res. 2000 Feb; 79(2):732-9. PMID: 10728974.
    View in: PubMed
  26. Nunes DP, Afdhal NH, Offner GD. A recombinant bovine gallbladder mucin polypeptide binds biliary lipids and accelerates cholesterol crystal appearance time. Gastroenterology. 1999 Apr; 116(4):936-42. PMID: 10092316.
    View in: PubMed
  27. Offner GD, Nunes DP, Keates AC, Afdhal NH, Troxler RF. The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem Biophys Res Commun. 1998 Oct 9; 251(1):350-5. PMID: 9790959.
    View in: PubMed
  28. Liu B, Offner GD, Nunes DP, Oppenheim FG, Troxler RF. MUC4 is a major component of salivary mucin MG1 secreted by the human submandibular gland. Biochem Biophys Res Commun. 1998 Sep 29; 250(3):757-61. PMID: 9784419.
    View in: PubMed
  29. Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD. Molecular characterization of a major high molecular weight mucin from human sublingual gland. Glycobiology. 1997 Oct; 7(7):965-73. PMID: 9363439.
    View in: PubMed
  30. Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem J. 1997 May 15; 324 ( Pt 1):295-303. PMID: 9164870.
    View in: PubMed
  31. Salomons H, Keaveny AP, Henihan R, Offner G, Sengupta A, Lamorte WW, Afdhal NH. Nitric oxide and gallbladder motility in prairie dogs. Am J Physiol. 1997 Apr; 272(4 Pt 1):G770-8. PMID: 9142907.
    View in: PubMed
  32. Zijlstra AI, Offner GD, Afdhal NH, van Overveld M, Tytgat GN, Groen AK. The pronase resistance of cholesterol-nucleating glycoproteins in human bile. Gastroenterology. 1996 Jun; 110(6):1926-35. PMID: 8964420.
    View in: PubMed
  33. Troxler RF, Offner GD, Zhang F, Iontcheva I, Oppenheim FG. Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem Biophys Res Commun. 1995 Dec 26; 217(3):1112-9. PMID: 8554565.
    View in: PubMed
  34. Afdhal NH, Ostrow JD, Koehler R, Niu N, Groen AK, Veis A, Nunes DP, Offner GD. Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation. Gastroenterology. 1995 Nov; 109(5):1661-72. PMID: 7557151.
    View in: PubMed
  35. Afdhal NH, Niu N, Nunes DP, Bansil R, Cao XX, Gantz D, Small DM, Offner GD. Mucin-vesicle interactions in model bile: evidence for vesicle aggregation and fusion before cholesterol crystal formation. Hepatology. 1995 Sep; 22(3):856-65. PMID: 7657293.
    View in: PubMed
  36. Nunes DP, Keates AC, Afdhal NH, Offner GD. Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats. Biochem J. 1995 Aug 15; 310 ( Pt 1):41-8. PMID: 7646470.
    View in: PubMed
  37. Offner GD, Gong D, Afdhal NH. Identification of a 130-kilodalton human biliary concanavalin A binding protein as aminopeptidase N. Gastroenterology. 1994 Mar; 106(3):755-62. PMID: 7907074.
    View in: PubMed
  38. Troxler RF, Offner GD, Jiang JW, Wu BL, Skare JC, Milunsky A, Wyandt HE. Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33. Hum Genet. 1993 Dec; 92(6):563-6. PMID: 8262516.
    View in: PubMed
  39. Afdhal NH, Gong D, Niu N, Turner B, LaMont JT, Offner GD. Cholesterol cholelithiasis in the prairie dog: role of mucin and nonmucin glycoproteins. Hepatology. 1993 Apr; 17(4):693-700. PMID: 8477974.
    View in: PubMed
  40. Schmid K, Hediger MA, Brossmer R, Collins JH, Haupt H, Marti T, Offner GD, Schaller J, Takagaki K, Walsh MT, et al. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):663-7. PMID: 1731338.
    View in: PubMed
  41. Trackman PC, Pratt AM, Wolanski A, Tang SS, Offner GD, Troxler RF, Kagan HM. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Biochemistry. 1991 Aug 20; 30(33):8282. PMID: 1678281.
    View in: PubMed
  42. Schacter BA, Cripps V, Troxler RF, Offner GD. Structural studies on bovine spleen heme oxygenase. Immunological and structural diversity among mammalian heme oxygenase enzymes. Arch Biochem Biophys. 1990 Nov 1; 282(2):404-12. PMID: 1700666.
    View in: PubMed
  43. Afdhal NH, Offner GD, Smith BF. Characterization of bovine gallbladder mucin. Amino acid sequences of tryptic peptides from the glycosylated domain of the protein core. Gastroenterology. 1990 Nov; 99(5):1493-501. PMID: 2210258.
    View in: PubMed
  44. Afdhal NH, Offner GD, Murray FE, Troxler RF, Smith BF. Isolation and characterization of peptides from the protein core of bovine gallbladder mucin. Gastroenterology. 1990 Jun; 98(6):1633-41. PMID: 2186955.
    View in: PubMed
  45. Lin S, Offner GD, Troxler RF. Studies on Cyanidium caldarium Phycobiliprotein Pigment Mutants. Plant Physiol. 1990 Jun; 93(2):772-7. PMID: 16667535.
    View in: PubMed
  46. Trackman PC, Pratt AM, Wolanski A, Tang SS, Offner GD, Troxler RF, Kagan HM. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Biochemistry. 1990 May 22; 29(20):4863-70. PMID: 1973052.
    View in: PubMed
  47. vanderSpek JC, Offner GD, Troxler RF, Oppenheim FG. Molecular cloning of human submandibular histatins. Arch Oral Biol. 1990; 35(2):137-43. PMID: 2344289.
    View in: PubMed
  48. Troxler RF, Offner GD, Xu T, Vanderspek JC, Oppenheim FG. Structural relationship between human salivary histatins. J Dent Res. 1990 Jan; 69(1):2-6. PMID: 2303595.
    View in: PubMed
  49. Troxler RF, Lin S, Offner GD. Heme regulates expression of phycobiliprotein photogenes in the unicellular rhodophyte, Cyanidium caldarium. J Biol Chem. 1989 Dec 5; 264(34):20596-601. PMID: 2584231.
    View in: PubMed
  50. Franzblau C, Pratt CA, Faris B, Colannino NM, Offner GD, Mogayzel PJ, Troxler RF. Role of tropoelastin fragmentation in elastogenesis in rat smooth muscle cells. J Biol Chem. 1989 Sep 5; 264(25):15115-9. PMID: 2768256.
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  51. Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem. 1988 Jun 5; 263(16):7472-7. PMID: 3286634.
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  52. Offner GD, Brecher P, Sawlivich WB, Costello CE, Troxler RF. Characterization and amino acid sequence of a fatty acid-binding protein from human heart. Biochem J. 1988 May 15; 252(1):191-8. PMID: 3421901.
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  53. Colclasure GC, Lloyd WS, Lamkin M, Gonnerman W, Troxler RF, Offner GD, Bürgi W, Schmid K, Nimberg RB. Human serum alpha 2HS-glycoprotein modulates in vitro bone resorption. J Clin Endocrinol Metab. 1988 Jan; 66(1):187-92. PMID: 3335602.
    View in: PubMed
  54. Wright J, Yoshimoto S, Offner GD, Blanchard RA, Troxler R, Tauber AI. Structural characterization of the isoenzymatic forms of human myeloperoxidase. Biochim Biophys Acta. 1987 Sep 2; 915(1):68-76. PMID: 3040106.
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  55. Lamkin MS, Colclasure C, Rodrick M, Troxler RF, Offner GD, Lloyd WS, Schmid K, Nimberg RB. Three forms of BRP-2 (bone resorptive proteins) from human cancer ascites fluid and their relationship to human serum alpha-2 HS-glycoprotein. Calcif Tissue Int. 1987 Sep; 41(3):171-5. PMID: 3117344.
    View in: PubMed
  56. Oppenheim FG, Hay DI, Smith DJ, Offner GD, Troxler RF. Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides. J Dent Res. 1987 Feb; 66(2):462-6. PMID: 3476566.
    View in: PubMed
  57. Offner GD, Troxler RF, Brecher P. Characterization of a fatty acid-binding protein from rat heart. J Biol Chem. 1986 Apr 25; 261(12):5584-9. PMID: 3957934.
    View in: PubMed
  58. Yoshioka Y, Gejyo F, Marti T, Rickli EE, Bürgi W, Offner GD, Troxler RF, Schmid K. The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein. J Biol Chem. 1986 Feb 5; 261(4):1665-76. PMID: 3944104.
    View in: PubMed
  59. Oppenheim FG, Yang YC, Diamond RD, Hyslop D, Offner GD, Troxler RF. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion. J Biol Chem. 1986 Jan 25; 261(3):1177-82. PMID: 3944083.
    View in: PubMed
  60. Oppenheim FG, Offner GD, Troxler RF. Amino acid sequence of a proline-rich phosphoglycoprotein from parotid secretion of the subhuman primate Macaca fascicularis. J Biol Chem. 1985 Sep 5; 260(19):10671-9. PMID: 4030765.
    View in: PubMed
  61. Akiyama K, Yoshioka Y, Schmid K, Offner GD, Troxler RF, Tsuda R, Hara M. The amino acid sequence of human beta-microseminoprotein. Biochim Biophys Acta. 1985 Jun 10; 829(2):288-94. PMID: 3995056.
    View in: PubMed
  62. Akiyama K, Tsuda R, Hara M, Yoshioka Y, Schmid K, Offner GD, Troxler RF. [The amino acid sequence of human seminal plasma beta-microseminoprotein (beta-MSP)--forensic immunological studies of body fluids and secretions, report XXVI]. Nihon Hoigaku Zasshi. 1985 Apr; 39(2):181-6. PMID: 2418237.
    View in: PubMed
  63. Belford HS, Triffleman EG, Offner GD, Troxler RF, Oppenheim FG. Biosynthesis of salivary proteins in the parotid gland of the subhuman primate, Macaca fascicularis. Cell-free translation of the mRNA for a proline-rich glycoprotein and partial amino acid sequence and processing of its signal peptide. J Biol Chem. 1984 Mar 25; 259(6):3977-84. PMID: 6200480.
    View in: PubMed
  64. Offner GD, Troxler RF. Primary structure of allophycocyanin from the unicellular rhodophyte, Cyanidium caldarium. The complete amino acid sequences of the alpha and beta subunits. J Biol Chem. 1983 Aug 25; 258(16):9931-40. PMID: 6885776.
    View in: PubMed
  65. Gejyo F, Chang JL, Bürgi W, Schmid K, Offner GD, Troxler RF, Van Halbeek H, Dorland L, Gerwig GJ, Vliegenthart JF. Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary structure of its heteroglycan. J Biol Chem. 1983 Apr 25; 258(8):4966-71. PMID: 6833285.
    View in: PubMed
  66. Belford HS, Offner GD, Troxler RF. Phycobiliprotein synthesis in the unicellular rhodophyte, Cyanidium caldarium. Cell-free translation of the mRNAs for the alpha and beta subunit polypeptides of phycocyanin. J Biol Chem. 1983 Apr 10; 258(7):4503-10. PMID: 6833263.
    View in: PubMed
  67. Oppenheim FG, Offner GD, Troxler RF. Phosphoproteins in the parotid saliva from the subhuman primate Macaca fascicularis. Isolation and characterization of a proline-rich phosphoglycoprotein and the complete covalent structure of a proline-rich phosphopeptide. J Biol Chem. 1982 Aug 25; 257(16):9271-82. PMID: 7107568.
    View in: PubMed
  68. Troxler RF, Ehrhardt MM, Brown-Mason AS, Offner GD. Primary structure of phycocyanin from the unicellular rhodophyte Cyanidium caldarium. II. Complete amino acid sequence of the beta subunit. J Biol Chem. 1981 Dec 10; 256(23):12176-84. PMID: 7028751.
    View in: PubMed
  69. Offner GD, Brown-Mason AS, Ehrhardt MM, Troxler RF. Primary structure of phycocyanin from the unicellular rhodophyte Cyanidium caldarium. I. Complete amino acid sequence of the alpha subunit. J Biol Chem. 1981 Dec 10; 256(23):12167-75. PMID: 7298651.
    View in: PubMed
  70. Brown SB, Holroyd JA, Troxler RF, Offner GD. Bile pigment synthesis in plants. Incorporation of haem into phycocyanobilin and phycobiliproteins in Cyanidium caldarium. Biochem J. 1981 Jan 15; 194(1):137-47. PMID: 7305974.
    View in: PubMed
  71. Brown AS, Offner GD, Ehrhardt MM, Troxler RF. Phycobilin-apoprotein linkages in the alpha and beta subunits of phycocyanin from the unicellular rhodophyte, Cyanidium caldarium. Amino acid sequences of 35S-labeled chromopeptides. J Biol Chem. 1979 Aug 25; 254(16):7803-11. PMID: 468790.
    View in: PubMed
  72. Troxler RF, Offner GD. delta-Aminolevulinic acid synthesis in a Cyanidium caldarium mutant unable to make chlorophyll a and phycobiliproteins. Arch Biochem Biophys. 1979 Jun; 195(1):53-65. PMID: 475388.
    View in: PubMed
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