Keywords
Last Name

Lawreen Heller Connors, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4313
ORCID ORCID Icon0000-0002-4672-4296
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

 Research Expertise & Professional Interests
My research focuses on understanding the amyloidogenic nature of transthyretin (TTR), normally a soluble protein present in plasma and cerebral spinal fluid. Both wild-type and specific variant forms of TTR can be amyloidogenic, but disease onset is delayed in what appears to be an age-dependent mechanism. Our investigations are aimed at identifying specific age-related factors required to initiate the disease process; these factors likely include structural features that are both intrinsic and extrinsic to TTR. My research attempts to link protein biochemistry to disease pathology by studying the role of amino acid alterations, post-translational modifications (glycosylation, sulfonation, cysteinylation and phosphorylation) and metabolic processing in TTR amyloid fibril formation. We have precisely defined the molecular composition of numerous amyloidogenic TTR proteins derived from patient serum and tissue samples using mass spectrometry, analytical ultracentrifugation, and electron microscopy. In addition, using a proteomic approach, we have identified several tissue components present in patient specimens which may be effectors of amyloidogenesis. With recombinantly-generated proteins, we are studying the molecular stability of various forms of TTR, as well as the heteroassociations of TTR with these deposited molecular constituents using electrophoretic, chromatographic, and histological techniques. A translational component of our studies involves the study of a variety of compounds, including the small molecules diflunisal and a-tocopherol, as potential inhibitors of TTR aggregation and fibril formation. Furthermore, since TTR-associated amyloid diseases often feature cardiomyopathies, we are also studying the direct and indirect effects of amyloidogenic forms of TTR on cultured primary cardiac cells.

 Self-Described Keywords
  • amyloidosis
  • cardiomyopathy
  • diflunisal
  • transthyretin
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Prokaeva T, Spencer B, Sun F, O'Hara RM, Seldin DC, Connors LH, Sanchorawala V. Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio. Amyloid. 2016 Dec; 23(4):214-220. PMID: 27677679.
    View in: PubMed
  2. Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19; 133(3):282-90. PMID: 26660282.
    View in: PubMed
  3. Sarosiek S, Seldin DC, Connors LH, Spencer B, Murakami A, O'Hara C, Sanchorawala V. Vertebral compression fractures as the initial presentation of AL amyloidosis: case series and review of literature. Amyloid. 2015; 22(3):156-62. PMID: 26104853.
    View in: PubMed
  4. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688. PMID: 25940533.
    View in: PubMed
  5. Greene MJ, Klimtchuk ES, Seldin DC, Berk JL, Connors LH. Cooperative stabilization of transthyretin by clusterin and diflunisal. Biochemistry. 2015 Jan 20; 54(2):268-78. PMID: 25478940.
    View in: PubMed
  6. Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359.
    View in: PubMed
  7. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov; 6(11):1493-507. PMID: 25319546.
    View in: PubMed
  8. Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Res. 2014 Apr; 17(2):97-104. PMID: 24164623.
    View in: PubMed
  9. Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 2013; 1(5):451-63. PMID: 24286032.
    View in: PubMed
  10. Reddi HV, Jenkins S, Theis J, Thomas BC, Connors LH, Van Rhee F, Highsmith WE. Homozygosity for the V122I mutation in transthyretin is associated with earlier onset of cardiac amyloidosis in the African American population in the seventh decade of life. J Mol Diagn. 2014 Jan; 16(1):68-74. PMID: 24184229.
    View in: PubMed
  11. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D, Jiang B, Del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res Cardiol. 2013 Sep; 108(5):378. PMID: 23982491.
    View in: PubMed
  12. Mishra S, Guan J, Plovie E, Seldin DC, Connors LH, Merlini G, Falk RH, MacRae CA, Liao R. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. Am J Physiol Heart Circ Physiol. 2013 Jul 1; 305(1):H95-103. PMID: 23624626.
    View in: PubMed
  13. Tanaka K, Essick EE, Doros G, Tanriverdi K, Connors LH, Seldin DC, Sam F. Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis. J Am Heart Assoc. 2013 Apr; 2(2):e005868. PMID: 23537813.
    View in: PubMed
  14. Girnius S, Skinner M, Spencer B, Prokaeva T, Bartholomew C, O'Hara C, Seldin DC, Connors LH. A new lysozyme tyr54asn mutation causing amyloidosis in a family of Swedish ancestry with gastrointestinal symptoms. Amyloid. 2012 Dec; 19(4):182-5. PMID: 22978355.
    View in: PubMed
  15. Kingsbury JS, Laue TM, Chase SF, Connors LH. Detection of high-molecular-weight amyloid serum protein complexes using biological on-line tracer sedimentation. Anal Biochem. 2012 Jun 15; 425(2):151-6. PMID: 22465331.
    View in: PubMed
  16. Ward JE, Ren R, Toraldo G, Soohoo P, Guan J, O'Hara C, Jasuja R, Trinkaus-Randall V, Liao R, Connors LH, Seldin DC. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15; 118(25):6610-7. PMID: 21998211.
    View in: PubMed
  17. Weng L, Spencer BH, SoohHoo PT, Connors LH, O'Hara CJ, Seldin DC. Dysregulation of miRNAs in AL amyloidosis. Amyloid. 2011 Sep; 18(3):128-35. PMID: 21834602.
    View in: PubMed
  18. Connors LH, Doros G, Sam F, Badiee A, Seldin DC, Skinner M. Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy. Amyloid. 2011 Jun; 18 Suppl 1:157-9. PMID: 21838471.
    View in: PubMed
  19. Seldin DC, Andrea N, Berenbaum I, Berk JL, Connors L, Dember LM, Doros G, Fennessey S, Finn K, Girnius S, Lerner A, Libbey C, Meier-Ewert HK, O'Connell R, O'Hara C, Quillen K, Ruberg FL, Sam F, Segal A, Shelton A, Skinner M, Sloan JM, Wiesman JF, Sanchorawala V. High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution. Amyloid. 2011 Jun; 18 Suppl 1:127-9. PMID: 21838459.
    View in: PubMed
  20. Ward JE, SooHoo P, Toraldo G, Jasuja R, Connors LH, O'Hara C, Seldin DC. Metabolic phenotype in an AL amyloidosis transgenic mouse model. Amyloid. 2011 Jun; 18 Suppl 1:40-1. PMID: 21838426.
    View in: PubMed
  21. Hovey BM, Ward JE, Soo Hoo P, O'Hara CJ, Connors LH, Seldin DC. Preclinical development of siRNA therapeutics for AL amyloidosis. Gene Ther. 2011 Dec; 18(12):1150-6. PMID: 21562591.
    View in: PubMed
  22. Greene MJ, Sam F, Soo Hoo PT, Patel RS, Seldin DC, Connors LH. Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy. Am J Pathol. 2011 Jan; 178(1):61-8. PMID: 21224044.
    View in: PubMed
  23. Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry. 2010 Nov 16; 49(45):9848-57. PMID: 20936823.
    View in: PubMed
  24. Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82. PMID: 20870723.
    View in: PubMed
  25. Shi J, Guan J, Jiang B, Brenner DA, Del Monte F, Ward JE, Connors LH, Sawyer DB, Semigran MJ, Macgillivray TE, Seldin DC, Falk R, Liao R. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4188-93. PMID: 20150510.
    View in: PubMed
  26. Connors LH, Prokaeva T, Lim A, Théberge R, Falk RH, Doros G, Berg A, Costello CE, O'Hara C, Seldin DC, Skinner M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J. 2009 Oct; 158(4):607-14. PMID: 19781421.
    View in: PubMed
  27. Laine L, Connors L, Griffin MR, Curtis SP, Kaur A, Cannon CP. Prescription rates of protective co-therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Aliment Pharmacol Ther. 2009 Oct; 30(7):767-74. PMID: 19594486.
    View in: PubMed
  28. Bodi K, Prokaeva T, Spencer B, Eberhard M, Connors LH, Seldin DC. AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences. Amyloid. 2009 Mar; 16(1):1-8. PMID: 19291508.
    View in: PubMed
  29. Tam M, Seldin DC, Forbes BM, Connors LH, Skinner M, Oran B, Quillen K, Sanchorawala V. Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature review. Amyloid. 2009; 16(2):103-7. PMID: 20536404.
    View in: PubMed
  30. Buxbaum J, Koziol J, Connors LH. Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity. Amyloid. 2008 Dec; 15(4):255-61. PMID: 19065297.
    View in: PubMed
  31. Biolo A, Ramamurthy S, Connors LH, O'Hara CJ, Meier-Ewert HK, Soo Hoo PT, Sawyer DB, Seldin DC, Seldin DS, Sam F. Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition. Circ Heart Fail. 2008 Nov; 1(4):249-57. PMID: 19808299.
    View in: PubMed
  32. Lavatelli F, Perlman DH, Spencer B, Prokaeva T, McComb ME, Théberge R, Connors LH, Bellotti V, Seldin DC, Merlini G, Skinner M, Costello CE. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics. 2008 Aug; 7(8):1570-83. PMID: 18474516.
    View in: PubMed
  33. Kingsbury JS, Laue TM, Klimtchuk ES, Théberge R, Costello CE, Connors LH. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem. 2008 May 2; 283(18):11887-96. PMID: 18326041.
    View in: PubMed
  34. Connors LH, Jiang Y, Budnik M, Théberge R, Prokaeva T, Bodi KL, Seldin DC, Costello CE, Skinner M. Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains. Biochemistry. 2007 Dec 11; 46(49):14259-71. PMID: 18004879.
    View in: PubMed
  35. Prokaeva T, Spencer B, Kaut M, Ozonoff A, Doros G, Connors LH, Skinner M, Seldin DC. Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival. Arthritis Rheum. 2007 Nov; 56(11):3858-68. PMID: 17968927.
    View in: PubMed
  36. Kos CA, Ward JE, Malek K, Sanchorawala V, Wright DG, O'Hara C, Connors L, Skinner M, Seldin DC. Association of acquired von Willebrand syndrome with AL amyloidosis. Am J Hematol. 2007 May; 82(5):363-7. PMID: 17205535.
    View in: PubMed
  37. Rosenzweig M, Skinner M, Prokaeva T, Théberge R, Costello C, Drachman BM, Connors LH. A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. Amyloid. 2007 Mar; 14(1):65-71. PMID: 17453626.
    View in: PubMed
  38. Kingsbury JS, Théberge R, Karbassi JA, Lim A, Costello CE, Connors LH. Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry. Anal Chem. 2007 Mar 1; 79(5):1990-8. PMID: 17261023.
    View in: PubMed
  39. Kingsbury JS, Klimtchuk ES, Théberge R, Costello CE, Connors LH. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin. Protein Expr Purif. 2007 Jun; 53(2):370-7. PMID: 17317215.
    View in: PubMed
  40. Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V. Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol. 2006 Dec; 169(6):1939-52. PMID: 17148659.
    View in: PubMed
  41. Akar H, Seldin DC, Magnani B, O'Hara C, Berk JL, Schoonmaker C, Cabral H, Dember LM, Sanchorawala V, Connors LH, Falk RH, Skinner M. Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis. Amyloid. 2005 Dec; 12(4):210-5. PMID: 16399645.
    View in: PubMed
  42. Ng B, Connors LH, Davidoff R, Skinner M, Falk RH. Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis. Arch Intern Med. 2005 Jun 27; 165(12):1425-9. PMID: 15983293.
    View in: PubMed
  43. Chung CM, Chiu JD, Connors LH, Gursky O, Lim A, Dykstra AB, Liepnieks J, Benson MD, Costello CE, Skinner M, Walsh MT. Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophys J. 2005 Jun; 88(6):4232-42. PMID: 15792972.
    View in: PubMed
  44. Trinkaus-Randall V, Walsh MT, Steeves S, Monis G, Connors LH, Skinner M. Cellular response of cardiac fibroblasts to amyloidogenic light chains. Am J Pathol. 2005 Jan; 166(1):197-208. PMID: 15632012.
    View in: PubMed
  45. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004 Apr 30; 94(8):1008-10. PMID: 15044325.
    View in: PubMed
  46. Connors LH, Yamashita T, Yazaki M, Skinner M, Benson MD. A rare transthyretin mutation (Asp18Glu) associated with cardiomyopathy. Amyloid. 2004 Mar; 11(1):61-6. PMID: 15185501.
    View in: PubMed
  47. Connors LH, Lim A, Prokaeva T, Roskens VA, Costello CE. Tabulation of human transthyretin (TTR) variants, 2003. Amyloid. 2003 Sep; 10(3):160-84. PMID: 14640030.
    View in: PubMed
  48. Lim A, Prokaeva T, McComb ME, Connors LH, Skinner M, Costello CE. Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis. Protein Sci. 2003 Aug; 12(8):1775-85. PMID: 12876326.
    View in: PubMed
  49. Yazaki M, Connors LH, Eagle RC, Leff SR, Skinner M, Benson MD. Transthyretin amyloidosis associated with a novel variant (Trp41Leu) presenting with vitreous opacities. Amyloid. 2002 Dec; 9(4):263-7. PMID: 12557756.
    View in: PubMed
  50. Lim A, Prokaeva T, McComb ME, O'Connor PB, Théberge R, Connors LH, Skinner M, Costello CE. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. Anal Chem. 2002 Feb 15; 74(4):741-51. PMID: 11866053.
    View in: PubMed
  51. Liao R, Jain M, Teller P, Connors LH, Ngoy S, Skinner M, Falk RH, Apstein CS. Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts. Circulation. 2001 Oct 2; 104(14):1594-7. PMID: 11581134.
    View in: PubMed
  52. Segal R, Poznansky MC, Connors L, Sands K, Barlam T. Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training. Int J STD AIDS. 2001 Jul; 12(7):453-9. PMID: 11394981.
    View in: PubMed
  53. Chung CM, Connors LH, Benson MD, Walsh MT. Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis. Amyloid. 2001 Jun; 8(2):75-83. PMID: 11409037.
    View in: PubMed
  54. Lim A, Makhov AM, Bond J, Inouye H, Connors LH, Griffith JD, Erickson BW, Kirschner DA, Costello CE. Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties. J Struct Biol. 2000 Jun; 130(2-3):363-70. PMID: 10940239.
    View in: PubMed
  55. Connors LH, Richardson AM, Théberge R, Costello CE. Tabulation of transthyretin (TTR) variants as of 1/1/2000. Amyloid. 2000 Mar; 7(1):54-69. PMID: 10842707.
    View in: PubMed
  56. Théberge R, Connors LH, Skinner M, Costello CE. Detection of transthyretin variants using immunoprecipitation and matrix-assisted laser desorption/ionization bioreactive probes: a clinical application of mass spectrometry. J Am Soc Mass Spectrom. 2000 Feb; 11(2):172-5. PMID: 10689671.
    View in: PubMed
  57. Connors LH, Théberge R, Skare J, Costello CE, Falk RH, Skinner M. A new transthyretin variant (Ser23Asn) associated with familial amyloidosis in a Portuguese patient. Amyloid. 1999 Jun; 6(2):114-8. PMID: 10439117.
    View in: PubMed
  58. Wally J, Kica G, Zhang Y, Ericsson T, Connors LH, Benson MD, Liepnieks JJ, Murray J, Skinner M, Comenzo RL. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. Biochim Biophys Acta. 1999 May 31; 1454(1):49-56. PMID: 10354514.
    View in: PubMed
  59. Théberge R, Connors L, Skare J, Skinner M, Falk RH, Costello CE. A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient. Amyloid. 1999 Mar; 6(1):54-8. PMID: 10211412.
    View in: PubMed
  60. Théberge R, Connors L, Skinner M, Skare J, Costello CE. Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Anal Chem. 1999 Jan 15; 71(2):452-9. PMID: 9949732.
    View in: PubMed
  61. Connors LH, Ericsson T, Skare J, Jones LA, Lewis WD, Skinner M. A simple screening test for variant transthyretins associated with familial transthyretin amyloidosis using isoelectric focusing. Biochim Biophys Acta. 1998 Sep 30; 1407(3):185-92. PMID: 9748569.
    View in: PubMed
  62. Cohen AS, Connors LH. The pathogenesis and biochemistry of amyloidosis. J Pathol. 1987 Jan; 151(1):1-10. PMID: 3550020.
    View in: PubMed
  63. Skinner M, Stone P, Shirahama T, Connors LH, Calore J, Cohen AS. The association of an elastase with amyloid fibrils. Proc Soc Exp Biol Med. 1986 Feb; 181(2):211-4. PMID: 3633118.
    View in: PubMed
  64. Connors LH, Shirahama T, Skinner M, Fenves A, Cohen AS. In vitro formation of amyloid fibrils from intact beta 2-microglobulin. Biochem Biophys Res Commun. 1985 Sep 30; 131(3):1063-8. PMID: 2413854.
    View in: PubMed
  65. Gertz MA, Skinner M, Cohen AS, Connors LH, Kyle RA. Isolation and characterization of a kappa amyloid fibril protein. Scand J Immunol. 1985 Sep; 22(3):245-50. PMID: 2864740.
    View in: PubMed
  66. Gertz MA, Skinner M, Connors LH, Falk RH, Cohen AS, Kyle RA. Selective binding of nifedipine to amyloid fibrils. Am J Cardiol. 1985 Jun 1; 55(13 Pt 1):1646. PMID: 4003315.
    View in: PubMed
  67. Skinner M, Connors LH, Rubinow A, Libbey C, Sipe JD, Cohen AS. Lowered prealbumin levels in patients with familial amyloid polyneuropathy (FAP) and their non-affected but at risk relatives. Am J Med Sci. 1985 Jan; 289(1):17-21. PMID: 4038581.
    View in: PubMed
  68. Connors LH, Gertz MA, Skinner M, Cohen AS. Nephelometric measurement of human serum prealbumin and correlation with acute-phase proteins CRP and SAA: results in familial amyloid polyneuropathy. J Lab Clin Med. 1984 Oct; 104(4):538-45. PMID: 6090552.
    View in: PubMed
  69. Skinner M, Schneller SI, Connors LH, Kagan HM, Stone PJ, Shirahama T, Sipe JD, O'Connor C, Calore JD, Franzblau C, et al. Observations on the amyloid-degrading activity of serum and its relationship to human neutrophil elastase. Trans Assoc Am Physicians. 1983; 96:437-43. PMID: 6437036.
    View in: PubMed
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